Article
Biochemistry & Molecular Biology
Cheng-Mei Yang, Tian-Huei Chu, Kuo-Wang Tsai, Shuchen Hsieh, Mei-Lang Kung
Summary: Zingerone nanoparticles (NPs), derived from phytochemical substances, have demonstrated significant inhibition of cell invasion and metastasis, making them a promising adjuvant for cancer treatment.
Review
Immunology
Yi Zhang, Zheng Li, Ying Huang, Bingwen Zou, Yong Xu
Summary: Combining tumor immunotherapy with nanoparticle-based hyperthermia has been found to enhance cancer treatment effectiveness. Tumor immunotherapy activates the immune system to attack cancer cells, while nanoparticle-based hyperthermia selectively kills cells by raising the temperature of tumor cells. The combination of both approaches can amplify anti-tumor responses, improve outcomes, and reduce side effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Sung Joon Park, Hyun Jin Min, Changhwan Yoon, Seong Hee Kim, Jin Hyun Kim, Sei Young Lee
Summary: This study evaluated the role of integrin beta 1 (ITGB1) in perineural invasion, radioresistance, and tumor aggressiveness of oral squamous cell carcinoma (OSCC). It found that ITGB1 was overexpressed in radioresistant OSCC, especially in cancer stem cell-like cells. Inhibiting ITGB1 significantly reduced adhesion to neuronal cells, resistance to radiation, invasion and migration of radioresistant OSCC, as well as the expression of cancer stem cell markers and spheroid formations. These findings suggest that ITGB1 may be a promising therapeutic target for radioresistant OSCC.
CELLULAR SIGNALLING
(2023)
Review
Chemistry, Multidisciplinary
Anirudh Sharma, Erik Cressman, Anilchandra Attaluri, Dara L. Kraitchman, Robert Ivkov
Summary: This article discusses the recent advances in image-guided magnetic hyperthermia therapy for liver cancer, highlighting its potential for personalized treatment and reducing toxicities commonly seen with systemic treatments.
Article
Chemistry, Multidisciplinary
Ghulam Abbas, Saba Maqbool, Muhammad Khuram Shahzad, Muhammad Afzaal, Muhammad Usama Daud, Nazma Goher Fatima, Abdul Ghuffar
Summary: Hyperthermia is a technique used to treat malignancies by raising the temperature of defective tissues. This study explores the use of gold nanoparticles (AuNPs) for hyperthermia treatment, finding that nanorods achieve the highest temperature compared to other shapes, highlighting their effectiveness in this process. The research delves into the effects of nanoparticle shape and surface coating on thermal absorption in hyperthermia, underlining the significance of Au NPs in this treatment.
Review
Medicine, General & Internal
Nai-Wen Su, Yu-Jen Chen
Summary: Metronomic therapy is a low-dose, repeated treatment approach for cancer that targets antiangiogenesis and immunomodulation mechanisms, showing comparative efficacy to traditional chemotherapy but with reduced side effects. In the treatment of oral cavity squamous cell carcinoma and other cancers, metronomic therapy has demonstrated promising results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Leonardo de Oliveira da Rocha, Bruno Solano de Freitas Souza, Ricardo Della Coletta, Daniel W. Lambert, Clarissa A. Gurgel Rocha
Summary: Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In this study, spheroids obtained from OSCC and cancer-associated fibroblast (CAF) lines were used to investigate CIC structures. The spheroids showed the morphological aspects of the tumor microenvironment and CIC structures were found in both homotypic and heterotypic groups, predominantly in the proliferative zone of mixed spheroids. Complex cannibalism events were also observed. This model has the potential for further studies on CIC morphology, formation, and its relationship with tumor prognosis.
Article
Endocrinology & Metabolism
Hongxu Tian, Xinxin Zhu, Jing Liu, Furong Zhao, Yun Wang, Jianli Su
Summary: This study reveals that the upregulation of CTBP2 is associated with the malignant behavior of OSCC cells. Silencing CTBP2 can inhibit the proliferation, migration, and invasion of OSCC cells by suppressing the EMT process and ROCK1 signaling.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Oncology
Leonardo Di Gennaro, Raimondo De Cristofaro, Antonietta Ferretti, Maria Basso, Claudia Riccio, Massimo Cordaro, Carlo Lajolo
Summary: This review discusses the relationship between oral squamous cell carcinoma (OSCC) and venous thromboembolism (VTE). VTE has a significant impact on the mortality rate of cancer patients, and the thrombotic risk in OSCC patients has not been extensively studied, leading to insufficient prevention measures and affecting the effectiveness of oncologic treatment.
Article
Chemistry, Multidisciplinary
Ha Anh Nguyen, Sendos Darwish, Hong Nam Pham, Souad Ammar, Nguyet-Thanh Ha-Duong
Summary: The ability to construct well-defined three-dimensional architectures at the nanoscale is important for various applications. In this study, functional inorganic nanoparticles were grafted onto viral plant capsids, resulting in advanced hierarchical hybrid nanomaterials with robustness and stability. The virus-based materials showed enhanced heating capability and could potentially be used as photothermal therapeutic agents.
Article
Polymer Science
Tenzin Tsering Dongsar, Tenzin Sonam Dongsar, Mohammed A. S. Abourehab, Neelima Gupta, Prashant Kesharwani
Summary: Breast carcinoma is a highly prevalent and deadly cancer in females, causing a significant number of mortalities and incidences. Conventional cancer treatments have limitations in terms of side effects and efficacy. Nanotechnology, specifically magnetic nanoparticles (MNPs), has emerged as an innovative approach for cancer management and detection. This article summarizes the applications of MNPs in cancer therapy, focusing on the potential of MNPs in treating breast cancer.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Oncology
Leonardo de Oliveira Siquara da Rocha, Bruno Solano de Freitas Souza, Daniel W. Lambert, Clarissa de Araujo Gurgel Rocha
Summary: Cell-in-cell structures are common in tumors, including oral squamous cell carcinoma. Cell-in-cell events in oral squamous cell carcinoma are associated with tumor aggressiveness, metastasis, and therapeutic resistance. The lack of standard terminology makes it difficult to classify and understand the behavior and impacts of these structures. Understanding the link between cell-in-cell structures and more aggressive behavior in oral squamous cell carcinoma is crucial for developing effective therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jiaqi Chen, Ziyu Zhu, Qiaoya Pan, Yang Bai, Mengfei Yu, Yi Zhou
Summary: In this study, a novel nanoparticle Co-Fc@HCQ was successfully synthesized, which achieved targeted therapy for oral squamous cell carcinoma by inhibiting autophagy and enhancing the generation of reactive oxygen species.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Oncology
Ling Mao, Xiaoweng Wu, Zhengpeng Gong, Ming Yu, Zhi Huang
Summary: The study revealed that PDIA6 is upregulated in OSCC tissues and its overexpression promotes aerobic glycolysis and the progression of oral squamous cell carcinoma.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Heinrich Botha, Camile S. Farah, Kendrick Koo, Nicola Cirillo, Michael McCullough, Rita Paolini, Antonio Celentano
Summary: Research shows that in oral squamous cell carcinoma, glucose transporter 1 (GLUT-1) and GLUT-3 expression levels are correlated with tumor stage, treatment resistance, and poor prognosis. Other glucose transporters (GLUTs) are relatively understudied and may have the potential to improve patient care with further analysis.
Article
Endocrinology & Metabolism
Silvia Marino, Giovana Carrasco, Boya Li, Karan M. Shah, Darren L. Lath, Antonia Sophocleous, Michelle A. Lawson, Aymen I. Idris
CALCIFIED TISSUE INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Lisa J. Crawford, David C. Campbell, Jonathan J. Morgan, Michelle A. Lawson, Jennifer M. Down, Dharminder Chauhan, Roisin M. McAvera, Treen C. Morris, Claudia Hamilton, Aswini Krishnan, Krishnaraj Rajalingam, Andrew D. Chantry, Alexandra E. Irvine
Review
Cell Biology
Marta Diaz-delCastillo, Andrew D. Chantry, Michelle A. Lawson, Anne-Marie Heegaard
Summary: Multiple myeloma is an incurable bone marrow neoplasia, but the development of novel treatments has led to more patients living long term. Understanding the mechanisms of bone pain and its impact on patients' health-related quality of life is crucial for further research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Louise M. E. Muller, Gemma Migneco, Gina B. Scott, Jenny Down, Sancha King, Basem Askar, Victoria Jennings, Babatunde Oyajobi, Karen Scott, Emma West, Christy Ralph, Adel Samson, Elizabeth J. Ilett, Munitta Muthana, Matt Coffey, Alan Melcher, Christopher Parrish, Gordon Cook, Michelle Lawson, Fiona Errington-Mais
Summary: The study demonstrates that reovirus can reduce MM tumor burden and myeloma-induced bone disease, increase NK cell and CD8(+) T cell numbers, activate these cells, and upregulate effector-memory CD8(+) T cells. Reovirus is able to kill MM cells by activating NK cells and MM-specific CD8(+) T cells, suggesting that reovirus-induced immunotherapy should be combined with agents that enhance antitumor immune responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell & Tissue Engineering
Bethany Ollington, Helen E. Colley, Craig Murdoch
Summary: Primary human macrophages were successfully incorporated into oral mucosal equivalents (OME) in this study, showing immunoresponsiveness to bacterial lipopolysaccharides by upregulation of proinflammatory markers. These advanced OME models will significantly help research in host-pathogen interaction, biomaterial toxicity, and drug delivery studies.
TISSUE ENGINEERING PART C-METHODS
(2021)
Review
Medicine, General & Internal
Rebecca E. Andrews, Janet E. Brown, Michelle A. Lawson, Andrew D. Chantry
Summary: Lytic bone disease in multiple myeloma is primarily caused by increased bone resorption and decreased bone formation, leading to osteolysis. Current treatments mainly target osteoclasts, but new bone anabolics that stimulate osteoblasts show promise in improving patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Emily Waters, Kevin A. Wilkinson, Amy L. Harding, Ruth E. Carmichael, Darren Robinson, Helen E. Colley, Chun Guo
Summary: The SENP3-mediated Fis1 protein deSUMOylation in mitochondrial localization facilitates stress-induced mitophagy.
Review
Dentistry, Oral Surgery & Medicine
Asma El-Howati, Martin H. Thornhill, Helen E. Colley, Craig Murdoch
Summary: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa. The mechanisms of pathogenesis are still not fully understood, but evidence suggests a chronic, dysregulated immune response leading to increased expression of cytokines, chemokines, and adhesion molecules. CD8+ cytotoxic and CD4+ Th1 polarised T cells are the main lymphocytes involved, but recent evidence indicates the involvement of other T cell subsets.
Review
Oncology
Georgia Stewart, Andrew Chantry, Michelle Lawson
Summary: Multiple myeloma is an incurable blood cancer characterized by the growth of malignant plasma cells in the bone marrow. Current therapies can debulk tumor burden initially, but relapse is common due to minimal residual disease and drug resistance, highlighting the need for novel treatment approaches such as oncolytic virus therapies.
Article
Oncology
Luke Tattersall, Karan M. Shah, Darren L. Lath, Archana Singh, Jennifer M. Down, Elena De Marchi, Alex Williamson, Francesco Di Virgilio, Dominique Heymann, Elena Adinolfi, William D. Fraser, Darrell Green, Michelle A. Lawson, Alison Gartland
Summary: The study revealed the role of P2RX7B in osteosarcoma progression and metastasis, showing that its expression enhances cell survival and promotes metastasis. Activation of P2RX7B in in vivo experiments also exacerbated ectopic bone formation and lung metastasis in tumors.
JOURNAL OF BONE ONCOLOGY
(2021)
Article
Dermatology
Amy L. Harding, Helen E. Colley, Inmaculada Barragan Vazquez, Simon Danby, Md Zobaer Hasan, Hirofumi Nakanishi, Tetsuo Furuno, Craig Murdoch
Summary: Skin irritancy is a significant problem that affects millions of people worldwide. New testing methods using human skin equivalents have found evidence of specific activation of c-Src kinase in response to chemical irritants, suggesting the development of rapid screening methods for potential irritants.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Victoria L. Tippett, Luke Tattersall, Norain B. Ab Latif, Karan M. Shah, Michelle A. Lawson, Alison Gartland
Summary: Over the last 40 years, the survival rate of osteosarcoma (OS) has not improved significantly, with patients commonly resistant to traditional MAP chemotherapy. Establishing cell models is crucial for drug discovery due to the rarity of OS. This study systematically searched literature databases to identify MAP resistant OS cell lines and patients, and reported the impact of drug exposure strategies on the expression of resistance associated genes, proteins, and non-coding RNAs. A comparison was made to clinical studies. Further research is needed to understand the relationship between models and resistance markers.
Article
Virology
Simon Tazzyman, Georgia R. R. Stewart, James Yeomans, Adam Linford, Darren Lath, Joe Conner, Munitta Muthana, Andrew D. D. Chantry, Michelle A. A. Lawson
Summary: Multiple myeloma remains largely incurable and requires novel treatment strategies. This study investigated the anti-myeloma effects of a modified herpes simplex virus HSV1716 (SEPREHVIR). The results showed that HSV1716 can induce myeloma cell death and enhance the efficacy of bortezomib treatment. In vivo models also demonstrated the anti-myeloma effects of HSV1716.
Meeting Abstract
Oncology
Marta Diaz-delCastillo, Tim Nemler, Didde M. Thygesen, Norma A. Chavez-Saldana, Juan A. Vazquez-Mora, Oana Palasca, Lars Juhl, Holly Evans, Rebecca E. Andrews, Aritri Mandal, Andrew D. Chantry, Michelle A. Lawson, Thomas Andersen, Juan M. Jimenez-Andrade, Anne-Marie Heegaard
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Endocrinology & Metabolism
Marta Diaz-delCastillo, Danna Kamstrup, Rikke Brix Olsen, Rie Bager Hansen, Thomas Pembridge, Brigita Simanskaite, Juan Miguel Jimenez-Andrade, Michelle A. Lawson, Anne-Marie Heegaard