Article
Radiology, Nuclear Medicine & Medical Imaging
William Gondoputro, Matthijs J. Scheltema, Alexander Blazevski, Paul Doan, James E. Thompson, Amer Amin, Bart Geboers, Shikha Agrawal, Amila Siriwardana, Pim J. Van Leeuwen, Matthias N. Van Oosterom, Fijs W. B. Van Leeuwen, Louise Emmett, Phillip D. Stricker
Summary: The safety and feasibility of robot-assisted 99mTc-based PSMA-radioguided surgery for the intraoperative detection of lymph node metastases were evaluated. The results showed that this surgical method can improve lymph node detection and has a certain degree of accuracy.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Summary: The study shows that robot-assisted minimally invasive surgery combined with PSMA-radioguidance is effective in resecting PSMA-avid lesions, offering potential benefits for the treatment of patients with prostate cancer.
Review
Chemistry, Physical
He Wang, Zhangxin He, Xiao-Ang Liu, Yuhua Huang, Jianquan Hou, Weijie Zhang, Dan Ding
Summary: With the advent of precision medicine, PSMA-targeted theranostic strategies have had a significant impact on prostate cancer research. PSMA, as a specific membrane antigen target, is widely expressed in prostate cancer tissues and is correlated with tumor aggressiveness. Phototheranostics, including near-infrared fluorescence imaging, photoacoustic imaging, and photodynamic therapy, have shown great potential for PSMA-targeted treatment and diagnosis. However, there are still challenges and opportunities for the clinical translation of phototheranostics in the field of prostate cancer.
Review
Urology & Nephrology
Wei Diao, Yuan Cao, Dunyan Su, Zhiyun Jia
Summary: This study found that the use of Ga-68-PSMA tracers altered the management of over half of PCa patients with BCR, including those with early BCR. These tracers may be used to guide individualized treatment in patients with BCR, particularly those with early BCR.
Review
Radiology, Nuclear Medicine & Medical Imaging
Muhammad Junaid Niaz, Michael Sun, Myrto Skafida, Muhammad Obaid Niaz, Jana Ivanidze, Joseph R. Osborne, Elisabeth O'Dwyer
Summary: This article discusses the advantages and limitations of PET imaging tracers Ga-68/F-18 PSMA, C-11-Choline, and F-18-fluciclovine for prostate cancer. PSMA PET shows higher sensitivity in detecting primary and recurrent cancer, influencing treatment planning by improving disease delineation.
Article
Biophysics
Agostino Cilibrizzi, Julie Tzu-Wen Wang, Siham Memdouh, Antonella Iacovone, Kate McElroy, Noor Jaffar, Jennifer Denise Young, Robert C. Hider, Philip Blower, Khuloud Al-Jamal, Vincenzo Abbate
Summary: A series of NIR fluorescent probes targeting prostate-specific membrane antigen (PSMA) were developed, and PSMA-Cy7.5_2 demonstrated high affinity for PSMA in vitro, but its tumor accumulation in vivo was not significant.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hilda A. de Barros, Matthias N. van Oosterom, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Summary: Recent advances in image-guided prostate cancer surgery involve integrating fluorescence imaging with radioguided surgery, using prostate-specific membrane antigen targeting. This combination of radio- and fluorescence signals enhances detection accuracy and provides real-time visualization. In this study, we successfully integrated indocyanine green fluorescence imaging into a Tc-99m-prostate-specific membrane antigen-targeted radioguided surgery workflow.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Urology & Nephrology
Sophie Knipper, Mehrdad Mehdi Irai, Ricarda Simon, Daniel Koehler, Isabel Rauscher, Matthias Eiber, Fijs W. B. van Leeuwen, Pim van Leeuwen, Hilda de Barros, Henk van der Poel, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias M. Heck, Thomas Horn, Tobias Maurer
Summary: This study evaluated the oncological outcomes of salvage PSMA-RGS in patients with recurrent oligometastatic prostate cancer and identified predictive preoperative factors for improved outcomes. The results showed that the 3-month and 2-year tumor survival rates were 32% and 58%, respectively. Preoperative PSA, number of PSMA-avid lesions, and localization of lesions were independent predictors of biochemical recurrence after PSMA-RGS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Yun Lee, Yong-il Kim
Summary: This study conducted a meta-analysis on the therapeutic effects of Ac-225-PSMA RLT in patients with mCRPC. The results showed that around 61% of patients had more than a 50% PSA decline and 84% of patients had any PSA decline. The common adverse events in Ac-225-PSMA RLT were xerostomia and severe hematotoxicity.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anne-Claire Berrens, Matthijs Scheltema, Tobias Maurer, Ken Hermann, Freddie C. Hamdy, Sophie Knipper, Paolo Dell'Oglio, Elio Mazzone, Hilda A. de Barros, Jonathan M. Sorger, Matthias N. van Oosterom, Philip D. Stricker, Pim J. van Leeuwen, Daphne D. D. Rietbergen, Renato A. Valdes Olmos, Sergi Vidal-Sicart, Peter R. Carroll, Tessa Buckle, Henk G. van der Poel, Fijs W. B. van Leeuwen
Summary: This study conducted a Delphi consensus to explore expert views on PSMA-targeted surgery for prostate cancer. The study identified consensus on the value of PSMA targeting in identifying nodal metastases, as well as knowledge gaps and research needs.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Engineering, Chemical
Indra Gandi Subramani, R. M. Ayub, Subash C. B. Gopinath, Veeradasan Perumal, M. F. M. Fathil, M. K. Md Arshad
Summary: The research introduces a novel approach using a lectin-based capacitive non-faradaic biosensor for detecting PSMA, a promising diagnostic marker for prostate cancer. The study demonstrates the potential of using PSMA expression to differentiate malignant hyperplasia from other benign prostatic diseases. By utilizing gold nanoparticles as signal amplifiers, the study successfully modified the aluminium interdigitated electrode to efficiently sense PSMA, showing a simple fabrication and quantification method for PSMA.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Article
Oncology
Xinning Wang, Aditi Shirke, Ethan Walker, Rongcan Sun, Gopolakrishnan Ramamurthy, Jing Wang, Lingpeng Shan, Joey Mangadlao, Zhipeng Dong, Jing Li, Ziying Wang, Mark Schluchter, Dong Luo, Yu Wang, Shaun Stauffer, Susann Brady-Kalnay, Christopher Hoimes, Zhenghong Lee, James P. Basilion
Summary: Researchers have developed a new PSMA-targeting drug conjugate with potent and selective antitumor activity, showing potential to impact therapeutic management of lethal prostate cancers.
Article
Biochemistry & Molecular Biology
Arsyangela Verena, Zhengxing Zhang, Hsiou-Ting Kuo, Helen Merkens, Jutta Zeisler, Ryan Wilson, Shreya Bendre, Antonio A. W. L. Wong, Francois Benard, Kuo-Shyan Lin
Summary: Tumor heterogeneity limits the effectiveness and reliability of monospecific radiopharmaceuticals for prostate cancer diagnosis and therapy. To address this limitation, researchers developed and evaluated three bispecific radiotracers that target both prostate-specific membrane antigen (PSMA) and fibroblast activation protein (FAP), which are proteins overexpressed in prostate cancer.
Article
Chemistry, Medicinal
Yimin Chen, Xiaojun Zhang, Ming Ni, Xi Gao, Xinlin Wang, Qiang Xie, Jinming Zhang, Mengchao Cui
Summary: By increasing the number of pharmacophores specifically binding to PSMA, the new PSMA tracer [68Ga]Ga-PSMA-D5 has shown better tumor uptake and lower renal uptake in diagnosing prostate cancer. Additionally, [68Ga]Ga-PSMA-D5 exhibits advantages such as high tumor uptake, straightforward synthesis and labeling, and convenient labeling with therapeutic radionuclides, providing potential for targeted radioligand therapy in prostate cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Cell Biology
Jiaxian Chen, Lin Qi, Yongxiang Tang, Guyu Tang, Yu Gan, Yi Cai
Summary: PSMA-based PET imaging and RLT have promising roles in the diagnosis, treatment, and prediction of prognosis of CRPC. PSMA-based PET imaging accurately detects and monitors CRPC lesions, leading to optimal treatment selection. RLT is an effective and well-tolerated therapy that can be combined with PSMA imaging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Urology & Nephrology
Sophie Knipper, Mehrdad Mehdi Irai, Ricarda Simon, Daniel Koehler, Isabel Rauscher, Matthias Eiber, Fijs W. B. van Leeuwen, Pim van Leeuwen, Hilda de Barros, Henk van der Poel, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias M. Heck, Thomas Horn, Tobias Maurer
Summary: This study evaluated the oncological outcomes of salvage PSMA-RGS in patients with recurrent oligometastatic prostate cancer and identified predictive preoperative factors for improved outcomes. The results showed that the 3-month and 2-year tumor survival rates were 32% and 58%, respectively. Preoperative PSA, number of PSMA-avid lesions, and localization of lesions were independent predictors of biochemical recurrence after PSMA-RGS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Samaneh Azargoshasb, Imke Boekestijn, Meta Roestenberg, Gijs H. KleinJan, Jos A. van der Hage, Henk G. van der Poel, Daphne D. D. Rietbergen, Matthias N. van Oosterom, Fijs W. B. van Leeuwen
Summary: This study investigates the impact of signal-to-background ratios (SBR) on surgical performance using kinematics analysis. The results show that below SBR 1.5, task completion time, time spent in fluorescence-imaging mode, and total pathlength increase significantly, and handling errors become more frequent. The values of Dx and DM indicate that proficiency can only be achieved at SBR> 1.55.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jean-Pierre Pouget, Mark Konijnenberg, Uta Eberlein, Gerhard Glatting, Pablo Minguez Gabina, Ken Herrmann, Soren Holm, Lidia Strigari, Fijs W. B. van Leeuwen, Michael Lassmann
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anne-Claire Berrens, Matthias N. van Oosterom, Leon J. Slof, Fijs W. B. van Leeuwen, Henk G. van der Poel, Tessa Buckle
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Anne-Claire Berrens, Maarten L. Donswijk, Esther M. K. Wit, Fijs W. B. van Leeuwen, Pim J. van Leeuwen, Henk G. van der Poel
JOURNAL OF UROLOGY
(2023)
Article
Oncology
Mohamed E. Elsesy, Su Jung Oh-Hohenhorst, Christoph Oing, Alicia Eckhardt, Susanne Burdak-Rothkamm, Malik Alawi, Christian Mueller, Ulrich Schueller, Tobias Maurer, Gunhild von Amsberg, Cordula Petersen, Kai Rothkamm, Wael Y. Mansour
Summary: This study provides preclinical models for castration-resistant prostate cancer (CRPC) that can predict homologous recombination repair (HRR) defects and the sensitivity to olaparib and cisplatin. These models recapitulate the features of primary tumors, enabling individualized drug screening for tailored therapy recommendations.
MOLECULAR ONCOLOGY
(2023)
Review
Parasitology
Clarize Maria de Korne, Lisette van Lieshout, Fijs Willem Bernhard van Leeuwen, Meta Roestenberg
Summary: Imaging technology is essential for diagnosing parasitic diseases and has played a crucial role in developing antiparasitic strategies. The advancement of novel imaging technologies has revolutionized various fields of medicine and has also provided new ways to visualize parasites.
TRENDS IN PARASITOLOGY
(2023)
Article
Medicine, Research & Experimental
Marco Erreni, Francesca D'Autilia, Roberta Avigni, Evangelia Bolli, Sana M. Arnouk, Kiavash Movahedi, Pieterjan Debie, Achille Anselmo, Raffaella Parente, Cecile Vincke, Fijs W. B. van Leeuwen, Paola Allavena, Cecilia Garlanda, Alberto Mantovani, Andrea Doni, Sophie Hernot, Jo A. Van Ginderachter
Summary: Nanobodies (Nbs) have been identified as an elegant alternative to conventional monoclonal antibodies for cancer therapy, but there is a lack of detailed microscopic insight into the in vivo pharmacokinetics of different Nb formats in tumor-bearers, especially for the targeting of pro-tumoral tumor-associated macrophages (TAMs) located in less penetrable tumor regions.
Article
Cell & Tissue Engineering
M. M. Welling, K. Warbroek, C. Khurshid, M. N. van Oosterom, D. D. D. Rietbergen, M. G. J. de Boer, R. G. H. H. Nelissen, F. W. B. van Leeuwen, B. G. Pijls, T. Buckle
Summary: In this study, the ability of a bacteria-specific hybrid tracer (99mTc-UBI29-41-Cy5) to visualize the bacterial load on femoral implants using clinical-grade image guidance methods was evaluated. The results showed that this hybrid tracer allowed effective bacterial staining and combined qualitative real-time fluorescence guidance with nuclear imaging for quantitative monitoring of the effectiveness of cleaning strategies.
BONE & JOINT RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Martin, David Viertl, Anna Janz, Stefan Habringer, Ulrich Keller, Margret Schottelius
Summary: This study investigates the influence of corticosteroids on CXCR4 regulation in diffuse large B cell lymphoma (DLBCL). The results show that corticosteroids consistently induce an upregulation of CXCR4 expression in DBLCL cells, suggesting that they do not lead to downregulation of CXCR4 and may even have a beneficiary effect in DLBCL patients prior to [Lu-177]Lu-PentixaTher RLT.
Article
Oncology
Lukas Lunger, Lisa Steinhelfer, Philipp Korn, Matthias Eiber, Tobias Maurer, Jakob Buechler, Thomas Horn, Jurgen E. Gschwend, Matthias M. Heck
Summary: This study investigated the use of prostate-specific membrane antigen (PSMA)-radioguided surgery (RGS) to remove locoregional lymph node metastases (LNMs) identified on preoperative PSMA positron emission tomography (PET) during open radical prostatectomy (RP) with extended pelvic lymph node dissection (ePLND). The results showed a high success rate (94%) of resecting PSMA-positive LNMs using RGS, with 40% of LNMs located outside the ePLND template. Patients with a lower metastatic burden on preoperative PSMA PET had better postoperative outcomes. The study has limitations including a retrospective analysis and a small sample size.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Article
Oncology
Fabian Falkenbach, Francesca Ambrosini, Pierre Tennstedt, Matthias Eiber, Matthias M. Heck, Felix Preisser, Markus Graefen, Lars Budaeus, Daniel Koehler, Sophie Knipper, Tobias Maurer
Summary: This study found that both BCR risk groups and PSA kinetics are not predictive factors for the success of PSMA-RGS performed at low absolute PSA values. Additionally, indolent low-risk BCR is rarely treated with PSMA-RGS.
Article
Urology & Nephrology
Gisa Mehring, Derya Tilki, Hans Heinzer, Thomas Steuber, Randi M. Pose, Imke Thederan, Lars Budaeus, Georg Salomon, Alexander Haese, Uwe Michl, Tobias Maurer, Hartwig Huland, Markus Graefen, Hendrik Isbarn
Summary: Prostate cancer detection is usually achieved by PSA measurement and further diagnostics. However, some men might harbor significant PCa at a younger age. This study evaluated the histopathological results of men treated with RP in their 40s.
WORLD JOURNAL OF UROLOGY
(2023)