Article
Biochemistry & Molecular Biology
Bingqiao Shen, Huan Yu, Mingui Zhang, Junjue Chen, Yang Zhang, Shushu Xu, Ruiqi Han, Shouyue Huang, Ping Huang, Yisheng Zhong
Summary: Traumatic optic neuropathy (TON) is a complication of injuries to the head, orbit, and face, resulting in irreversible vision loss. Although it is known that TON can cause the loss of retinal ganglion cells, there is no reliable animal model available to study the underlying mechanisms. Thus, the development of an animal model to investigate the pathology of TON would be of great interest to the scientific community.
Article
Genetics & Heredity
Xiaolin Qu, Kaixin Zhu, Zhenxing Li, Danfeng Zhang, Lijun Hou
Summary: This study revealed the differentially expressed m6A modification in the early stage of traumatic optic neuropathy (TON), which may provide novel insights into the mechanism and treatment of TON. The expression of m6A-related genes was upregulated after TON, with a total of 2,810 m6A peaks identified as differentially upregulated. Furthermore, hypermethylated and hypomethylated profiles of mRNA transcripts were also identified.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Casey J. Keuthan, Julie A. Schaub, Meihan Wei, Weixiang Fang, Sarah Quillen, Elizabeth Kimball, Thomas V. Johnson, Hongkai Ji, Donald J. Zack, Harry A. Quigley
Summary: The level of intraocular pressure (IOP) is a major risk factor for glaucomatous optic neuropathy. This study found that the unmyelinated optic nerve region is differentially susceptible to IOP-induced damage compared to the myelinated region. Gene expression patterns in the unmyelinated optic nerve showed significant differences compared to the myelinated optic nerve and retina. Changes in gene expression induced by optic nerve injury were more extensive in the myelinated region than the unmyelinated region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Eunyoung Park, Johnathan G. Lyon, Melissa Alvarado-Velez, Martha I. Betancur, Nassir Mokarram, Jennifer H. Shin, Ravi V. Bellamkonda
Summary: Traumatic brain injury leads to compromised brain function due to neuronal death, with immune cells and neural stem cells playing key roles in the recovery process. Excessive inflammation and loss of NSCs can exacerbate TBI progression. Electrical stimulation may promote anti-inflammatory responses and increase NSCs and astrocytes, leading to enhanced neuroregeneration.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Annelies Van Dyck, Ilse Bollaerts, An Beckers, Sophie Vanhunsel, Nynke Glorian, Jessie van Houcke, Tjakko J. van Ham, Lies De Groef, Lien Andries, Lieve Moons
Summary: The study demonstrates that inducing intraocular inflammation can promote axonal regrowth after optic nerve injury in zebrafish. Additionally, acute depletion of microglia and macrophages in the retina compromises optic nerve regeneration, highlighting the importance of altered glial cell interactions in the regenerative process.
Article
Radiology, Nuclear Medicine & Medical Imaging
Christiaan M. de Bloeme, Robin W. Jansen, Sophia Goericke, Steven T. L. Grauwels, Sabien van Elst, Petra Ketteler, Herve J. Brisse, Paolo Galluzzi, Liesbeth Cardoen, Selma Sirin, Meriam Koob, Philippe Maeder, Paul van der Valk, Annette C. Moll, Pim de Graaf, Marcus C. de Jong
Summary: This study evaluated the diagnostic accuracy of nerve thickening on MRI for predicting early-stage postlaminar optic nerve invasion in retinoblastoma and successfully incorporated measurements into a multiparametric model. The prediction model established showed improved sensitivity and specificity for detecting PLONI, which can help clinicians in determining postlaminar optic nerve invasion and the risk of metastatic disease in retinoblastoma patients.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Jianhua Qiu, Masen Boucher, Grace Conley, Yue Li, Jingdong Zhang, Nicholas Morriss, William P. Meehan, Rebekah Mannix
Summary: This study reveals that mild traumatic brain injury can cause vision impairments and permanent degeneration of the optic nerve in a continuous process over months.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Z. Z. Chauhan, Joseph G. G. Chacko, Alireza Ghaffarieh, Chloe M. M. Moulin, Daniel Pelaez, Sami H. H. Uwaydat, Sanjoy K. K. Bhattacharya
Summary: The purpose of this study was to identify changes in mitochondrial optic nerve (ON) lipids associated with sonication-induced traumatic optic neuropathy (TON). Using a mouse model, the researchers analyzed lipid alterations in the ON mitochondria following sonication. They found temporal changes in triglyceride metabolism, which may mediate optic nerve damage by depleting mitochondrial triglycerides.
Article
Ophthalmology
Jay Jiyong Kwak, Dong Hyun Lee, Sung Chul Lee, Christopher Seungkyu Lee
Summary: This study investigated the association between visual field defects and blood vessel network (BVN) formation in optic disc melanocytomas (ODMs) using optical coherence tomography angiography (OCTA). The results showed that the location of BVN absence within ODMs corresponded to the location of visual field defect and the location of fluorescein angiography (FA) hypofluorescence. Visual field defect was more severe in the incomplete BVN group than in the complete BVN group, and it was more significantly associated with the area of BVN absence than the tumor area.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Neurosciences
Sahil H. Shah, Lucio M. Schiapparelli, Satoshi Yokota, Yuanhui Ma, Xin Xia, Sahana Shankar, Sarah Saturday, Michael Nahmou, Catalina Sun, John Yates, Hollis T. Cline, Jeffrey L. Goldberg
Summary: In this study, a new in vivo quantitative measure of newly synthesized proteins was developed and applied to examine the changes in the retina after optic nerve injury. The results revealed a dynamic translational response within broader proteostasis regulation, enhancing our understanding of the cellular response to injury.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Alex J. Wright, Joanna H. Queen, Emilio P. Supsupin, Alice Z. Chuang, John J. Chen, Rod Foroozan, Ore-Ofe O. Adesina
Summary: The purpose of this study was to determine if certain radiographic and clinical characteristics can predict visual outcomes in patients with indirect traumatic optic neuropathy (iTON). Through a retrospective case series, data on demographics, comorbidities, hemorrhage, and other factors were collected, and it was found that initial visual acuity is a significant predictor of final visual outcomes.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaotong Lou, Yuanyuan Hu, Hong Zhang, Jia Liu, Yin Zhao
Summary: The study suggests that a polydopamine-based nanoplatform can protect retina ganglion cells from oxidative damage, reduce inflammatory response, maintain retinal function, and potentially improve cell survival by altering gene expression through transcriptome analysis. Additionally, the nanoplatform can deliver neuroprotective drugs to synergistically promote cell survival and axon regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Ophthalmology
Kristina Hess, Kristin Raming, Peter Charbel Issa, Philipp Herrmann, Frank G. Holz, Maximilian Pfau
Summary: This study revealed a significant association between aging and ONHD with GCL thinning in patients with PXE, but not with the number of anti-VEGF injections.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Kasturi Bhattacharjee, Deepak Soni, Vatsalya Venkatraman, Aditi Mehta Grewal, Obaidur Rehman, Pragya Bhattacharjee, Harsha Bhattacharjee
Summary: Navigation-guided transcaruncular orbital optic canal decompression (NGTcOCD) can improve visual outcomes in patients with indirect traumatic optic neuropathy (TON) and is associated with visual prognosis, visual evoked potential (VEP), and DeLano type of optic canal and Onodi cells.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Neurosciences
Xiang Tu, Cheng Xiong, Hui Qi, Yangming Ou, Jing Rao, Yueqi Sun, Yunping Fan, Guiqin Liu
Summary: This study retrospectively analyzed the clinical efficacy and prognostic factors of transnasal endoscopic optic decompression in 13 patients with traumatic optic neuropathy (TON) from June 2020 to April 2022 in China. After surgery, 9 patients showed improvement in visual acuity, resulting in a total effective rate of 69.2%. The presence of residual light perception and surgery within 7 days were important factors influencing the prognosis.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Keiko Nakashima, Yukie Hirahara, Taro Koike, Susumu Tanaka, Keizo Gamo, Souichi Oe, Shinichi Hayashi, Ryohei Seki-Omura, Yousuke Nakano, Chisato Ohe, Takashi Yoshida, Yosky Kataoka, Masayuki Tsuda, Tatsuyuki Yamashita, Koichi Honke, Masaaki Kitada
Summary: In this study, the distribution of specific sulfatide species in the kidneys was evaluated, and their physiological functions were investigated. It was found that sulfatide species with specific ceramide structures were expressed in intercalated cells and might be involved in the excretion of NH3 and protons into the urine.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Cell Biology
Ryohei Seki-Omura, Shinichi Hayashi, Souichi Oe, Taro Koike, Yousuke Nakano, Yukie Hirahara, Susumu Tanaka, Masaaki Kitada
Summary: Urodele amphibians, like the Iberian ribbed newt, are known for their exceptional regeneration ability. In this study, neurosphere formation in post-metamorphic P. waltl brain- and spinal cord-derived cells was reported, showing potential for spinal cord regeneration studies.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2022)