Article
Biochemistry & Molecular Biology
Loick Christ, Jeremy Couturier, Nicolas Rouhier
Summary: This study discovered the redox properties of the Arabidopsis thaliana mitochondrial class II GRXS15 protein, showing that it is prone to oxidation and forms reversible oxidation forms. These forms may serve as catalytic intermediates of the oxidoreductase activity or as a protective mechanism, preventing irreversible oxidation and allowing Fe-S cluster binding upon reduction.
Article
Integrative & Complementary Medicine
Hang Huang, Chun-Ping Tang, Chang-Qiang Ke, Ren-Geng Shu, Yang Ye
Summary: In this study, new compounds were identified and characterized in the extract of Callicarpa nudiflora using various analytical techniques, including MS, NMR spectroscopy, and computational calculations.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Engineering, Environmental
Mei Qiu, Lihong Qiu, Qi Deng, Zhijia Fang, Lijun Sun, Yaling Wang, Ravi Gooneratne, Jian Zhao
Summary: This study investigated the effects and mechanisms of L-Cysteine hydrochloride (L-CH) as an antimicrobial on the growth of Aspergillus flavus (A. flavus) and Aflatoxin B1 (AFB1) biosynthesis. Results showed that L-CH inhibited A. flavus mycelial growth, affected mycelial morphology, and reduced AFB1 synthesis. The study also revealed that L-CH induced glutathione synthesis which scavenged intracellular reactive oxygen species and downregulated genes related to AFB1 production.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Plant Sciences
Yu-Zhuo Wu, Gui-Yang Xia, Huan Xia, Ling-Yan Wang, Ya-Nan Wang, Li Li, Hong-Cai Shang, Sheng Lin
Summary: In this study, the Seco and nor-seco isodhilarane-type meroterpenoids (SIMs and NSIMs) with highly congested polycyclic skeletons and broad bioactivities were investigated. The configuration revisions of some compounds were made through isolation, analysis, and empirical method based on C-13 NMR chemical shifts. Furthermore, a re-evaluation of the reported SIMs and NSIMs provided insights into determining the C-9 relative configuration. Biological assays showed that some compounds exhibited cytotoxic and hepatoprotective activities.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Materials Science, Ceramics
Guangzhi Zhang, Xiaoxia Li, Na Liu, Lina Xiong, Zhong Chen, Jiaxin Wen, Bin Zeng, Meiling Wang, Shuwang Duo
Summary: The study demonstrated that LZS QDs acted as activators to stimulate the growth of A. oryzae, significantly increasing biomass and extracellular protein content, thus potentially enhancing the production of A. oryzae.
CERAMICS INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Minglu Liu, Meng Hu, Hui Zhou, Zhiyang Dong, Xiuzhen Chen
Summary: In this study, recombinant expression of AN-PEP in Trichoderma reesei was achieved, resulting in the highest yield of rAN-PEP reported to date. It was also found that cultivating the recombinant strain on corn cob, a low-cost agricultural residue, significantly increased the secretion of rAN-PEP. Furthermore, treatment with rAN-PEP during beer brewing showed potential in reducing gluten content and improving beer stability.
MICROBIAL CELL FACTORIES
(2023)
Review
Biochemistry & Molecular Biology
Fangjiao Huang, Xiaoli Han, Xiaohui Xiao, Jinming Zhou
Summary: Cysteine is a crucial amino acid that plays important roles in biological processes. Its unique chemical properties and reactivity have led to extensive research interest. This article summarizes covalent warheads targeting cysteine residue and their application in drug development.
Article
Chemistry, Organic
Fang Wen Jiao, Yin Nan Xing, Tian Yu Liu, Feng Wu, Wei Li, Rui Hua Jiao
Summary: Five new Azaspirenes A-E were discovered in the marine mud-derived endophytic fungus Aspergillus micronesiensis NF666. Their structures were determined through extensive analysis of HRESIMS and NMR data. The antimicrobial activities of these compounds against five pathogens were evaluated using the agar diffusion method. Furthermore, a plausible biosynthetic pathway of Azaspirenes A (1) was proposed in this study.
TETRAHEDRON LETTERS
(2023)
Article
Environmental Sciences
Angela Maria Santiago, Libia de Sousa Conrado Oliveira, Paloma Lima de Oliveira, Raphael Lucas Jacinto Almeida, Newton Carlos Santos, Pablicia Oliveira Galdino
Summary: This study aimed to produce exo-polygalacturonase through solid-state fermentation of dehydrated umbu peels using Aspergillus niger CCT 0916, followed by recovery of the enzyme using a biphasic aqueous system. The dried umbu peel residue showed the highest enzyme activity peak after 44 hours of fermentation, with the maximum recovery rate of 97.14% achieved using a biphasic aqueous system composed of PEG8000 and potassium phosphate salts.
WASTE AND BIOMASS VALORIZATION
(2022)
Article
Biochemistry & Molecular Biology
Linshu Jiao, Huibing Chi, Bingjie Xia, Zhaoxin Lu, Xiaomei Bie, Haizhen Zhao, Fengxia Lu, Meirong Chen
Summary: The thermostability of Acinetobacter soli L-asparaginase was improved by mutating two non-conserved cysteine residues, resulting in enhanced efficiency in food pre-processing.
Article
Chemistry, Medicinal
Yongzhe Zheng, Chang-Qiang Ke, Shuaizhen Zhou, Lu Feng, Chunping Tang, Yang Ye
Summary: A phytochemical investigation of Artemisia atrovirens led to the discovery of several new compounds, with their structures and absolute configurations confirmed through various analytical methods. Testing in vitro showed moderate cytotoxicity of some compounds against HL-60 cell lines.
Article
Chemistry, Physical
Xinxi Gu, Haiqiang Lu, Lijuan Zhang, Xiangchen Meng
Summary: The study isolated a thermophilic strain of Aspergillus fumigatus with potential for enzyme production, including a novel endoglucanase (AfCel5A) characterized for its high hydrolytic activity against CMC-Na. AfCel5A exhibited optimal activity at 80 degrees C and pH 4.0, with good stability across a wide pH range and temperature. It also showed increased total reducing sugar release in combination with beta-mannanse (ManBK).
Article
Biochemistry & Molecular Biology
Diego Moneo-Corcuera, Alvaro Viedma-Poyatos, Konstantinos Stamatakis, Dolores Perez-Sala
Summary: The behavior of desmin, a muscle-specific intermediate filament protein, is affected by oxidants and cysteine-reactive agents. Oxidative stress and lipoxidation disrupt the organization of desmin in muscle cells, and this effect is partially reduced in mutant forms.
Review
Biochemistry & Molecular Biology
Marta Kowalska, Remigiusz Bachor
Summary: This article describes recent advances in cysteine-containing peptide modification techniques based on solution and solid phase derivatization and enrichment strategies, which serve as effective solutions for the analysis of complex mixtures.
Article
Environmental Sciences
Kyriaki Kiskira, Theopisti Lymperopoulou, Ioannis Lourentzatos, Lamprini-Areti Tsakanika, Charalampos Pavlopoulos, Konstantina Papadopoulou, Klaus-Michael Ochsenkuhn, Fotios Tsopelas, Elias Chatzitheodoridis, Gerasimos Lyberatos, Maria Ochsenkuhn-Petropoulou
Summary: Bauxite residue (BR) is a hazardous waste with significant amounts of valuable metals such as scandium. The recovery of scandium from BR using environmentally friendly biometallurgical methods can be an excellent approach for waste management and resource efficiency. In this study, bioleaching of scandium from BR using the fungus Aspergillus niger was investigated. The highest Sc recovery of 46% was achieved in 20 days at 1% pulp density, and biosorption phenomena were observed during the leaching process.
WASTE AND BIOMASS VALORIZATION
(2023)
