Article
Immunology
Wei Feng, Qing Huang, Yu Wang, Qian Yuan, Xiaoyu Li, Peiyuan Xia, Fengjun Sun
Summary: This study aimed to investigate changes in resistance and epidemiological characteristics of Pseudomonas aeruginosa strains isolated from a respiratory department over a ten-year period. The resistance rate of P. aeruginosa strains to antibiotics decreased significantly from 2006-2007 to 2016-2017. The MLST results showed a decrease in genotypes over the ten-year period.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Reza Khoshbakht, Mona Kabiri, Alireza Neshani, Mohammad Navid Khaksari, Sayyed Majid Sadrzadeh, Seyed Mohammad Mousavi, Kiarash Ghazvini, Mahdis Ghavidel
Summary: This research investigated the trend in antimicrobial resistance changes of E. coli, P. aeruginosa, K. pneumoniae, and A. baumannii in a hospital in Iran. The study found that these bacteria showed increasing levels of antibiotic resistance during the first year of the pandemic, which may have significant implications for global public health.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Microbiology
Maria Guadalupe Martinez-Zavaleta, Diana Fernandez-Rodriguez, Melissa Hernandez-Duran, Claudia A. Colin-Castro, Maria de Lourdes Garcia-Hernandez, Noe Becerra-Lobato, Rafael Franco-Cendejas, Luis Esau Lopez-Jacome
Summary: This study aimed to characterize carbapenemase production in clinical strains of Pseudomonas aeruginosa. The most frequently found carbapenemases were VIM and GES, followed by IMP. Metallo-ss-lactamases were the most prevalent among the identified carbapenemase genes. Searching for carbapenemase genes in resistant isolates is crucial for preventing transmission and guiding antimicrobial treatment.
Article
Microbiology
Yonggang Zhao, Dingqiang Chen, Kaichao Chen, Miaomiao Xie, Jiubiao Guo, Edward Wai Chi Chan, Lu Xie, Jingbo Wang, Enqi Chen, Sheng Chen, Weijun Chen, Lars Jelsbak
Summary: By sequencing and analyzing the genomes of 416 Pseudomonas aeruginosa strains from hospitals in China, the genetic, phenotypic, and transmission characteristics of carbapenem-resistant strains were elucidated, and the molecular signatures responsible for the increased prevalence of CRPA infections in China were identified. These findings may provide new insight into the development of effective strategies for worldwide control of CRPA and minimize the occurrence of untreatable infections in clinical settings.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Yuhui Wang, Jie Ma, Wanxiang Li, Mi Liu, Yansheng Ding
Summary: This retrospective study examined the epidemiological characteristics and antibiotic resistance of Pseudomonas aeruginosa over a 5-year period in a hospital in Shandong Province, China. A total of 3,324 P. aeruginosa strains were isolated, with the highest rates detected in respiratory tract specimens. Resistance was highest in aztreonam, with isolation rates for CRPA, MDRPA, and XDRPA strains showing a slight decrease over the years. Continued efforts in infection control, antimicrobial stewardship, and research on bacterial resistance are crucial in addressing the ongoing issue of drug resistance.
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2021)
Article
Microbiology
Pabllo Antonny Silva Dos Santos, Yan Correa Rodrigues, Davi Josue Marcon, Amalia Raiana Fonseca Lobato, Thalyta Braga Cazuza, Maria Isabel Montoril Gouveia, Marcos Jesse Abrahao Silva, Alex Brito Souza, Luana Nepomuceno Gondim Costa Lima, Ana Judith Pires Garcia Quaresma, Danielle Murici Brasiliense, Karla Valeria Batista Lima
Summary: This study aims to determine the antimicrobial resistance, virulence, and genotyping features of P. aeruginosa strains producing SPM-1 in the Northern region of Brazil. The PCR technique was used to determine the presence of virulence and resistance genes. The Kirby-Bauer disk diffusion method was performed to assess the susceptibility profile of antimicrobials, and the MLST technique was used for genotyping.
Article
Infectious Diseases
Aysegul Copur Cicek, Ayse Erturk, Nebahat Ejder, Erva Rakici, Ugur Kostakoglu, Ilknur Esen Yildiz, Songul Ozyurt, Emine Sonmez
Summary: Researching carbapenem-resistant isolates revealed a high prevalence of bacteria carrying beta-lactamase and metallo-beta-lactamase genes, with more resistance genes and coexistence found in hospital-acquired samples. There was no difference between community and hospital-associated isolates in PFGE results, but a significant difference was observed in terms of fatality rates, indicating the importance of other microorganisms coexisting with resistance genes in patient outcomes.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Chenlu Xiao, Yan Zhu, Zhitao Yang, Dake Shi, Yuxing Ni, Li Hua, Jian Li
Summary: The prevalence of polymyxin-resistant P. aeruginosa in a Chinese teaching hospital was investigated. It was found that most of the resistant isolates were multidrug-resistant, indicating the need for effective infection control measures to prevent further spread of resistance.
Article
Infectious Diseases
Seryoung Kim, Satomi Masai, Keiji Murakami, Momoyo Azuma, Keiko Kataoka, Mayu Sebe, Kazuya Shimizu, Tomoaki Itayama, Niwooti Whangchai, Kanda Whangchai, Ikko Ihara, Hideaki Maseda
Summary: This study established an isolation method to evaluate the infection risk of Pseudomonas aeruginosa in the environment using specific culture conditions and primers. The results showed clear differences between environmental and clinical strains, but both had a high potential resistance risk for non-resistant strains.
Article
Biotechnology & Applied Microbiology
Tian Liu, Shilin Yang, Zixian Wu, Yufei Cai, Jiawei Zhou, Mingjun Liao
Summary: A flurbiprofen-degrading strain LY.1, identified as Pseudomonas aeruginosa (PA), was isolated from the Xunsi River in Wuhan City, China. LY.1 strain exhibited the ability to grow in flurbiprofen-containing medium as the sole carbon source and degrade flurbiprofen into 3-fluoro-4(1-ethylcarboxy) phenylpropionic acid (FCB). Optimal growth conditions for LY.1 strain were found to be at temperatures ranging from 25 to 40 degrees C, pH 6-8, and substrate concentrations between 100 and 800 mg/L.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Infectious Diseases
Ye Xu, Ying Zhang, Xiangkuo Zheng, Kaihang Yu, Yao Sun, Wenli Liao, Huaiyu Jia, Chunquan Xu, Tieli Zhou, Mo Shen
Summary: The study found that the gene CrpP-like is present in Pseudomonas aeruginosa in China with a certain prevalence, but has a small impact on resistance to fluoroquinolones, and may not play a significant role in resistance development.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Aiman M. Momenah, Rafat Ahmed Bakri, Naif A. Jalal, Sami S. Ashgar, Rakan Fahad Felemban, Farkad Bantun, Sumyya H. Hariri, Abeer A. Barhameen, Hani Faidah, Hamdi M. AL-Said
Summary: This study evaluates the antibiotic resistance levels of P. aeruginosa and aims to understand the patterns of resistance in clinical isolates. The highest resistance was found in colistin (97%) followed by piperacillin/tazobactam (75.8%). The antibiotic resistance rate decreased in the later years due to infection control protocols and strict antibiotic prescription policies.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biochemical Research Methods
Kieran Elmes, Astra Heywood, Zhiyi Huang, Alex Gavryushkin
Summary: Large-scale genotype-phenotype screens provide valuable data for identifying molecular alterations associated with a phenotype. This study focuses on the importance of epistatic effects in association studies, and aims to develop a method that can consider three-way interactions. The proposed method, Pint, outperforms known methods in simulated data and demonstrates accuracy in antibiotic resistance testing and siRNA perturbation screens.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Editorial Material
Immunology
Ana Paula Streling, Mohanad M. Al Obaidi, William D. Lainhart, Tirdad Zangeneh, Ayesha Khan, An Q. Dinh, Blake Hanson, Cesar A. Arias, William R. Miller
Summary: A study reported the emergence of non-susceptibility to cefiderocol in a subpopulation of Pseudomonas aeruginosa recovered from a patient without prior exposure to the antibiotic. Whole genome sequencing revealed mutations in major iron transport pathways linked to cefiderocol uptake, highlighting the importance of susceptibility testing before therapy with siderophore cephalosporins.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Food Science & Technology
Magdalena Lopatek, Kinga Wieczorek, Jacek Osek
Summary: This study evaluated the microbiological contamination of raw bivalve molluscan shellfish available on the Polish market. It found that common pathogens including Salmonella spp., L. monocytogenes, V. parahaemolyticus, and S. aureus were frequently present and may exhibit antimicrobial resistance.
