Review
Behavioral Sciences
Aida Alvarez, Armand Guardia, Alexandre Gonzalez-Rodriguez, Maria Betriu, Diego Palao, Jose Antonio Monreal, Virginia Soria, Javier Labad
Summary: This study found differences in rates of suicide attempts and completed suicide among individuals with schizophrenia, schizoaffective disorder, delusional disorder, and first-episode psychosis. The rates varied by diagnosis, clinical setting, and geographical region. Northern European countries reported higher rates of completed suicide in studies of schizophrenia and first-episode psychosis.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Genetics & Heredity
Margaret A. A. Hojlo, Merhawi Ghebrelul, Casie A. A. Genetti, Richard Smith, Shira Rockowitz, Emma Deaso, Alan H. H. Beggs, Pankaj B. B. Agrawal, David C. C. Glahn, Joseph Gonzalez-Heydrich, Catherine A. A. Brownstein
Summary: Children and adolescents with early-onset psychosis have more rare genetic variants, and this study found an increased burden of rare variants in the GRIN2A gene in individuals with early-onset psychosis compared to controls. GRIN2A variants have been associated with various neuropsychiatric disorders, highlighting its role in early-onset psychosis.
Review
Clinical Neurology
Peter Phalen, David Kimhy, David Jobes, Melanie Bennett
Summary: This scoping review emphasizes the need for effective treatments for the high suicide rate observed among individuals with psychosis. Two neglected treatment targets for suicide in people with psychotic disorders, emotional distress and emotion dysregulation, are highlighted. The review summarizes the research on these constructs in psychosis and their relationship to suicide, and offers clinical recommendations based on the findings. Emotional distress and emotion dysregulation may hold promise as treatment targets for suicide in people with psychosis.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychiatry
Ji-Su Kim, Seon-Hwa Baek, Honey Kim, Ju-Wan Kim, Hee-Ju Kang, Seunghyong Ryu, Ju-Yeon Lee, Jae-Min Kim, Sung-Wan Kim
Summary: Cognitive function may be associated with a higher level of suicidality in patients with recent-onset schizophrenia. This study found that suicidal ideation was common among patients, and it was related to younger age and longer duration of untreated psychosis. Patients with suicidal ideation had higher scores in general psychopathology, depression, stress, and hopelessness, and lower scores in subjective well-being and resilience. They also performed better in cognitive tests.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Angharad N. de Cates, Gennaro Catone, Steven Marwaha, Paul Bebbington, Clara S. Humpston, Matthew R. Broome
Summary: The study revealed that persecutory ideas, auditory hallucinations, and psychotic symptoms are associated with suicidal behavior, particularly in patients with schizophrenia. Mood instability and depression may play a mediating role in the impact of psychotic phenomena on suicide behavior.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
Alba Toll, Emilio Pechuan, Daniel Berge, Teresa Legido, Laura Martinez-Sadurni, Khadija El-Abidi, Victor Perez-Sola, Anna Mane
Summary: The risk of suicide is high in individuals experiencing first-episode psychosis (FEP), but the factors associated with this risk are not well-understood. This study aimed to identify the sociodemographic and clinical factors that contribute to suicide attempts in FEP patients over a two-year period. The findings revealed that prior suicide attempts, low functionality, depression, and feelings of guilt were significantly associated with suicide attempts. These findings highlight the importance of targeted interventions, particularly during the prodromal stage, in identifying and treating FEP patients with a high suicide risk.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Bochao Danae Lin, Jentien M. Vermeulen, K. Bolhuis, Xiao Chang, Frederike Schirmbeck, Kristel R. van Eijk, Sinan Guloksuz, Matthijs Blankers, W. van den Brink, Lieuwe de Haan, Jurjen J. Luykx
Summary: In this six-year prospective cohort study, researchers investigated the relationship between smoking behavior polygenic scores (PRS) and psychosis. They found that smoking initiation and age at regular smoking initiation were associated with various symptom dimensions of schizophrenia. However, these associations were only observed in unaffected siblings and healthy controls, not in patients. The findings suggest that other genetic risk factors may play a dominant role in patients.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Claire de Oliveira, Joyce Mason, Linda Luu, Tomisin Iwajomo, Frances Simbulan, Paul Kurdyak, Petros Pechlivanoglou
Summary: This study developed a microsimulation model for individuals with chronic psychotic disorders and used the model to examine the impact of a smoking cessation initiative on patient outcomes. The results showed that the smoking cessation program for chronic psychotic disorders can be cost-effective, reducing the risk of chronic conditions and improving survival and quality of life.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Substance Abuse
Panagiotis Spanakis, Emily Peckham, Ben Young, Paul Heron, Della Bailey, Simon Gilbody
Summary: This study evaluated the effectiveness of behavioral smoking cessation interventions in adults with severe mental ill health, finding that face-to-face bespoke interventions were more effective compared to usual care.
Article
Psychology, Clinical
Yongqi Zhong, Steven Pham, Giovanna Porta, Antoine Douaihy, Anna Marsland, David Brent, Nadine M. Melhem
Summary: Young suicide attempters have a higher burden of cardiovascular risk compared to other high-risk individuals. Clinicians should pay attention to cardiovascular risk factors among suicide attempters to reduce their risk for cardiovascular events.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Tapio Paljarvi, Jari Tiihonen, Markku Lateenvuo, Antti Tanskanen, Seena Fazel, Heidi Taipale
Summary: This study aimed to establish the risk of suicide associated with incident psychotic depression (PD) compared to incident non-psychotic severe depression (NPD). The results showed that PD was associated with a twofold increased risk of suicide compared to NPD, with the highest relative risks for impact-related and suffocation-related suicides. This study revealed some characteristics of PD patients in terms of the severity of suicidal ideation and choice of self-harm methods.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
T. Sanchez-Gutierrez, E. Rodriguez-Toscano, L. Roldan, L. Ferraro, M. Parellada, A. Calvo, G. Lopez, M. Rapado-Castro, D. La Barbera, C. La Cascia, G. Tripoli, M. Di Forti, R. M. Murray, D. Quattrone, C. Morgan, J. van Os, P. Garcia-Portilla, S. Al-Halabi, J. Bobes, L. de Haan, M. Bernardo, J. L. Santos, J. Sanjuan, M. Arrojo, A. Ferchiou, A. Szoke, B. P. Rutten, S. Stilo, G. D'Andrea, I. Tarricone, C. M. Diaz-Caneja, C. Arango
Summary: This study analyzed the relationship between tobacco use and first-episode psychosis, age at onset of psychosis, and specific diagnosis of psychosis. The findings showed that patients with first-episode psychosis were more likely to use tobacco and smoke heavily compared to controls. Tobacco use was associated with an earlier age at psychosis onset and a diagnosis of schizophrenia, but these associations were no longer significant after controlling for cannabis use.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Alberto Forte, Maurizio Pompili, Benedetta Imbastaro, Gabriele Pasquale De Luca, Martina Mastrangelo, Benedetta Montalbani, Ross J. Baldessarini
Summary: Clozapine has a unique ability to reduce the risk of suicide and suicide attempts in schizophrenia patients, which is not shared by other modern medicines indicated for schizophrenia or bipolar disorder according to the study.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Review
Psychiatry
Kimberley Davies, Ryan J. Courtney, Miranda Summersby-Mitchell, Rachel Morell, Nancy Briggs, Julia M. Lappin
Summary: This systematic review aimed to identify factors associated with sustained abstinence in people experiencing severe mental illness following a smoking intervention. Results showed that participation in smoking interventions was associated with higher odds of abstinence in the medium-term, but not long-term follow-ups. Limited knowledge on the factors associated with staying quit in smokers experiencing severe mental illness was found.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Emma M. Parrish, Samantha A. Chalker, Mayra Cano, Raeanne C. Moore, Amy E. Pinkham, Philip D. Harvey, Thomas Joiner, Amy Lieberman, Eric Granholm, Colin A. Depp
Summary: This study used ecological momentary assessment to investigate the relationship between perceived burdensomeness (PB) and thwarted belonginess (TB) with suicidal ideation (SI) in individuals with psychotic disorders. The results showed that burdensomeness varied less within participants compared to belongingness, and participants with SI had higher burdensomeness ratings and lower belongingness ratings. Social context, psychotic symptoms, mood, and SI were all found to be related to these interpersonal suicide-related risk factors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Anoop Sankaranarayanan, Rayaz A. Malik
EARLY INTERVENTION IN PSYCHIATRY
(2017)
Article
Psychiatry
Anoop Sankaranarayanan, Vanessa Clark, Amanda Baker, Kerrin Palazzi, Terry J. Lewin, Robyn Richmond, Frances J. Kay-Lambkin, Sacha Filia, David Castle, Jill M. Williams
PSYCHIATRY RESEARCH
(2016)
Article
Multidisciplinary Sciences
Anoop Sankaranarayanan, Serafino Mancuso, Helen Wilding, Suhaila Ghuloum, David Castle
Article
Psychiatry
Anoop Sankaranarayanan, Serafino Mancuso, David Castle
PSYCHIATRY RESEARCH
(2014)
Article
Clinical Neurology
Georgios Ponirakis, Hanadi Al Hamad, Anoop Sankaranarayanan, Adnan Khan, Mani Chandran, Marwan Ramadan, Rhia Tosino, Priya Vitthal Gawhale, Maryam Alobaidi, Essa AlSulaiti, Ahmed Elsotouhy, Marwa Elorrabi, Shafi Khan, Navas Nadukkandiyil, Susan Osman, Noushad Thodi, Hamad Almuhannadi, Hoda Gad, Ziyad R. Mahfoud, Fatima Al-Shibani, Ioannis N. Petropoulos, Ahmed Own, Maryam Al Kuwari, Ashfaq Shuaib, Rayaz A. Malik
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2019)
Letter
Psychiatry
Anoop Sankaranarayanan, Zoe Jenkins, David Castle, Chittaranjan Andrade
SCHIZOPHRENIA RESEARCH
(2020)
Review
Psychiatry
Anoop Sankaranarayanan, Robin Pratt, Aparna Anoop, Angela Smith, David Espinoza, Padmavati Ramachandran, Srinivasan Tirupati
Summary: The systematic review found an association between suicide attempts in individuals with schizophrenia spectrum disorders and low total cholesterol levels. However, there was no significant association found between serum lipid parameters and suicide ideation.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Review
Nutrition & Dietetics
Anoop Sankaranarayanan, Karthika Johnson, Sanop J. Mammen, Helen E. Wilding, Deepali Vasani, Vijaya Murali, Deborah Mitchison, David J. Castle, Phillipa Hay
Summary: Studies have found that individuals with schizophrenia spectrum disorder exhibit disordered eating behaviors such as binge eating, food craving, food addiction, and night eating, with higher prevalence rates compared to the general population. Positive associations were reported between certain disordered eating behaviors and factors such as antipsychotic use, female gender, weight gain, and increased dietary intake.
Review
Psychiatry
Shoba Balaji, Anoop Sankaranarayanan
Summary: This study found that individuals with severe mental illness often have a history of adverse childhood experiences, which are associated with physical health problems, including metabolic syndrome. The study also highlights the importance of social support networks in reducing the impact of adverse childhood experiences on physical health outcomes, including risk factors for metabolic syndrome.
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Psychiatry
Anoop Sankaranarayanan, Hessen Al-Amin, Suhaila Ghutoum
CRISIS-THE JOURNAL OF CRISIS INTERVENTION AND SUICIDE PREVENTION
(2020)
Review
Psychiatry
Anoop Sankaranarayanan, Helen Wilding, Erica Neill, David Castle
PSYCHIATRIC ANNALS
(2018)
Article
Psychiatry
Agatha M. Conrad, Anoop Sankaranarayanan, Terry J. Lewin, Anna Dunbar
AUSTRALASIAN PSYCHIATRY
(2017)
Article
Geriatrics & Gerontology
Navas Nadukkandiyil, Hanadi Khamis Alhamad, Luay Abdel Wahab, Essa Mubarak Al Sulaiti, Anoop Sankaranarayanan
JOURNAL OF CLINICAL GERONTOLOGY & GERIATRICS
(2014)
Article
Criminology & Penology
Agatha Conrad, Megha Mulchandani, Anoop Sankaranarayanan, Terry J. Lewin
JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY
(2014)
