Synthesis of Titanium Doped Iron Based Metal-Organic Frameworks and Investigation of Their Biological Activities

In this study, titanium has been successfully doped into the MIL (Material Institute Lavoisier, MIL) family Fe-based metal-organic framework MIL-101(Fe) and NH2-MIL-101(Fe) via an ex situ synthesis method. MIL-101(Fe) materials were characterized by SEM/EDX, XRD, FTIR, TGA, BET surface area and zeta potential analyses. Addition of titanium to all material structures had a significant effect on the BET surface areas. BET surface area of the MIL-101(Fe), Ti/MIL-101(Fe), NH2-MIL-101(Fe) and Ti/NH2-MIL-101(Fe) were determined as 3078, 1544, 1137 and 955 m(2)/g, respectively. Some biological activities of all materials were also investigated. Maximum DPPH scavenging ability of newly synthesized MIL-101(Fe) materials were determined as 89.32% with Ti/MIL-101(Fe). All of the tested compounds demonstrated pBR322 DNA cleavage activity. The in vitro antimicrobial activities of MOFs were screened on common bacteria and fungi. The most effective antimicrobial activity was achieved with NH2-MIL-101(Fe) and Ti/MIL-101(Fe) as 2 mg/L against L. pneumophila subsp. pneumophila.