Article
Chemistry, Multidisciplinary
Made Budiarta, Sathi Roy, Tobias Katenkamp, Neus Feliu, Tobias Beck
Summary: Due to its pharmacological properties, ferritin (Ftn) is used as a drug delivery vehicle to reduce the cardiotoxicity of doxorubicin (DOX) in chemotherapy. However, DOX encapsulation in Ftn faces challenges such as precipitation and low protein recovery yield. A new strategy using cysteine-maleimide conjugation for DOX encapsulation in Ftn is proposed and shown to be more efficient. The surface charges of Ftn variants affect the cytotoxicity, DOX loading, and cellular uptake mechanism.
Article
Medicine, Research & Experimental
Yixin Dong, Yuanmeng Ma, Xun Li, Fei Wang, Yu Zhang
Summary: The study successfully designed a multi-functional and targeted drug delivery system using apo-ferritin nanocages and ERK peptide inhibitor HERK, which effectively encapsulated paclitaxel and displayed higher cell cytotoxicity and favorable anti-cancer effects compared to plain apo-ferritin.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Thi Khoa My Nguyen, Mi Ran Ki, Ryeo Gang Son, Kyung Hee Kim, Junghwa Hong, Seung Pil Pack
Summary: In this study, silica-forming peptides were fused to human ferritin heavy chains to generate biosilica nanoparticles with sizes below 50 nm, which were then utilized in a drug delivery system for doxorubicin to efficiently target cancer cells. This new achievement of uniform biosilica nanoparticle generation and ideal pH-dependent drug release design presents a promising strategy for efficient drug delivery to target cells.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Lorenzo Lance David, Aliscia Daniels, Saffiya Habib, Moganavelli Singh
Summary: Nanotechnology has had a significant impact in medicine, particularly in improving diagnostics and therapeutics. This study successfully developed targeted dual-drug gold nanoparticles (AuNPs) with controlled drug release and demonstrated their efficacy in killing cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Ahmed Ahmed, Abdollah Karami, Rana Sabouni, Ghaleb A. Husseini, Vinod Paul
Summary: This study synthesized dual-responsive iron-based MOFs and successfully loaded the anticancer drug DOX into them, demonstrating good colloidal stability with PEG-FA functionalized MOFs. The research confirmed the sensitivity of the nanovehicles to low-frequency ultrasound and showed their release efficiency under different pH values.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Nanoscience & Nanotechnology
Suhrit Ghosh, Ranajit Barman, Raju Bej, Pradip Dey
Summary: This paper presents the synthesis and self-assembly of a polymer-prodrug conjugate, as well as its stimuli-responsive intracellular dual drug delivery. The conjugate forms nanocapsule-like structures in water and releases the active drug in a reducing environment. The encapsulation of a second drug in the conjugate enhances its cell killing efficiency. These findings demonstrate the potential application of such a dual drug delivery approach.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Ji-Hyun Lee, Jung-Kyu Park, Kuk-Hui Son, Jin-Woo Lee
Summary: A dual-drug-releasing PCL/sodium-alginate-based 3D-printed scaffold was developed for effectively treating osteomyelitis and removing biofilm. The scaffold showed a synergistic effect, inhibiting biofilm formation and bacterial activity, without affecting human osteoblast proliferation.
Article
Materials Science, Biomaterials
Chen Ning, Yixin Dong, Kun Yang, Xun Li, Fei Wang, Yu Zhang
Summary: The biocompatible protein nanocarrier with homogeneous particle size is a promising candidate for delivering targeted drugs to tumors. By compatible with ursolic acid (UA), the dose of doxorubicin (DOX) can be reduced to decrease its side effects. The loaded ferritin can specifically enter breast cancer cells MCF-7 and non-small-cell lung cancer cells A549, enhancing their therapeutic effects.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Nutrition & Dietetics
Man Wang, Yahui Zhang, Zuqi Fei, Dongchao Xie, Haihua Zhang, Qizhen Du, Peng Jin
Summary: The study developed hyaluronic acid oligosaccharides-coated paclitaxel-loaded casein nanoparticles to enhance stability and antitumor effects. The carrier showed high efficiency in inhibiting tumor growth, making it an effective drug delivery system.
Article
Biochemical Research Methods
Natalia Pediconi, Francesca Ghirga, Cristina Del Plato, Giovanna Peruzzi, Constantinos M. Athanassopoulos, Mattia Mori, Maria Elisa Crestoni, Davide Corinti, Franco Ugozzoli, Chiara Massera, Alessandro Arcovito, Bruno Botta, Alberto Boffi, Deborah Quaglio, Paola Baiocco
Summary: This study achieved efficient delivery of siRNA by decorating the internal cavity of humanized chimeric Archaeal ferritin with novel cationic compounds. The systems developed here showed promise in targeting cancer cells and silencing specific genes for therapeutic applications.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
David A. Mahvi, Jenny Korunes-Miller, Catalina Bordeianu, Ngoc-Quynh Chu, Abraham D. Geller, Robbie Sabatelle, Samantha Berry, Yin P. Hung, Yolonda L. Colson, Mark W. Grinstaff, Chandrajit P. Raut
Summary: An implantable biodegradable polymer film has been developed for the controlled and extended local delivery of paclitaxel, which has shown significant improvements in survival and recurrence in three different sarcoma models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Sakshi Phogat, Abhishek Saxena, Neha Kapoor, Charu Aggarwal, Archana Tiwari
Summary: Mesoporous synthetic silica is a significant porous material used in drug delivery applications, but the challenging synthetic route, costs, and toxicity make it desirable to find a natural alternative like diatoms. Diatoms, single-cell algae with porous structures, have proven to be a classic replacement for synthetic silica, being obtainable through mining or cell culture. Surface modifications can control drug release from mesoporous systems, making diatoms a potential tool for sustained drug release with their unique characteristics.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
D. Sahoo, T. Mitra, K. Chakraborty, P. Sarkar
Summary: This study developed a new electric field responsive graphene oxide nanoparticle system for on-demand drug delivery, showcasing remote control of dual drugs (aspirin and doxorubicin) release and observing their synergistic antitumor activity in breast cancer cells in vitro.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Polymer Science
Anna Nechaeva, Alexander Artyukhov, Anna Luss, Mikhail Shtilman, Inessa Gritskova, Anton Shulgin, Mikhail Motyakin, Irina Levina, Efrem Krivoborodov, Ilya Toropygin, Evgeniy Chistyakov, Leonid Gurevich, Yaroslav Mezhuev
Summary: This study reports a method for synthesizing nanoaggregates that can covalently immobilize doxorubicin and incorporate paclitaxel simultaneously. The performance of the nanoaggregates can be controlled by adjusting the composition of the copolymers. These novel nanocarriers have potential applications in the delivery and co-delivery of various pharmacological preparations for combined therapy in cancer and other diseases.
Article
Biotechnology & Applied Microbiology
Ki Ha Min, Ki Baek Yeo, Mi-Ran Ki, Sang Ho Jun, Seung Pil Pack
BIOCHEMICAL ENGINEERING JOURNAL
(2020)
Review
Biotechnology & Applied Microbiology
Mi-Ran Ki, Seung Pil Pack
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Engineering, Biomedical
Mohamed A. . A. . Abdelhamid, Seung Pil Pack
Summary: Recent research has shown that biomimetic silica-based biomaterials can be generated by mimicking the biosilicification mechanisms of marine organisms like sponges and diatoms. These materials have potential applications in biocatalysis, biosensors, bioimaging, and more. Coating living cells or viruses with a thin silica layer can provide new opportunities in biotechnology and nanomedicine.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Biomaterials
Mi-Ran Ki, Sung Ho Kim, Thi Khoa My Nguyen, Ryeo Gang Son, Sang Ho Jun, Seung Pil Pack
Summary: This study discovered that bone morphogenetic protein 2 (BMP2) has the ability to deposit silica in the presence of silicic acid, and proposed that this ability can effectively immobilize and transport BMP2 by co-precipitation with a silica matrix. The results showed that BMP2 co-precipitated with silica exhibited advantages in bone regeneration and release compared to free BMP2, with higher thermal stability and sustained release.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Health Care Sciences & Services
Joo Young Chun, Hyun-Jin Kim, Ji-Won Hur, Dooyoung Jung, Heon-Jeong Lee, Seung Pil Pack, Sungkil Lee, Gerard Kim, Chung-Yean Cho, Seung-Moo Lee, Hyeri Lee, Seungmoon Choi, Taesu Cheong, Chul-Hyun Cho
Summary: This study used machine learning techniques to predict the severity of specific anxiety symptoms and VR sickness in patients with SAD based on autonomic physiological signals. The results show that machine learning models can accurately predict the severity of these symptoms in real time during VR interventions.
JMIR SERIOUS GAMES
(2022)
Article
Immunology
Ji Hwa Hong, Sang Hoon Kim, Hyun Gyung Kim, Jun Ho Jang, Ryeo Gang Son, Seung Pil Pack, Young-Ho Park, Philyong Kang, Kang-Jin Jeong, Ji-Su Kim, Hanbyeul Choi, Sun-Uk Kim, Yong Woo Jung
Summary: Research shows that porcine T cells do not recognize human or mouse IL-7 as their survival factor, which is crucial for addressing safety concerns in the development of artificial blood.
Article
Biotechnology & Applied Microbiology
Thi Khoa My Nguyen, Mi Ran Ki, Ryeo Gang Son, Kyung Hee Kim, Junghwa Hong, Seung Pil Pack
BIOCHEMICAL ENGINEERING JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Eui Kyoung Jang, Yohei Koike, Yuko Ide, Kunihiko Tajima, Kenji Kanaori, Seung Pil Pack
CHEMICAL COMMUNICATIONS
(2020)