Journal
JOURNAL OF IMMUNOLOGY
Volume 203, Issue 8, Pages 2150-2162Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1900832
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Funding
- Flow Cytometry Core at the University of California San Diego Center for AIDS Research
- Veterans Affairs San Diego Health Care System
- San Diego Veterans Medical Research Foundation
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Hepatic immune system is uniquely challenged to mount a controlled effector response to pathogens while maintaining tolerance to diet and microbial Ags. We have identified a novel population of innate-like, unconventional CD8 alpha alpha+TCR alpha beta(+) T cells in naive mice and in human peripheral blood, called CD8 alpha alpha T-unc, capable of controlling effector T cell responses. They are NK1.1(+) (CD161(+) in human), express NK-inhibitory receptors, and express the promyelocytic leukemia zinc finger (PLZF) transcription factor that distinguishes them from conventional CD8(+) T cells. These cells display a cytotoxic phenotype and use a perforin-dependent mechanism to control Ag-induced or T cell-mediated autoimmune diseases. CD8 alpha alpha T-unc are dependent upon IL-15/IL-2R beta signaling and PLZF for their development and/or survival. They are Foxp3-negative and their regulatory activity is associated with a functionally distinct Qa-1(b)-dependent population coexpressing CD11c and CD244. A polyclonal TCR repertoire, an activated/memory phenotype, and the presence of CD8 alpha alpha Tunc in NKT- and in MAIT-deficient as well as in germ-free mice indicates that these cells recognize diverse self-protein Ags. Our studies reveal a distinct population of unconventional CD8(+) T cells within the natural immune repertoire capable of controlling autoimmunity and also providing a new target for therapeutic intervention.
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