Review
Oncology
Jie Peng, Xiaoyu Li, Mingsheng Huang, Mincai Ma, Qin Huang, Ning Huang, Yuan Cheng
Summary: This meta-analysis evaluated the prognostic value of PNI and CONUT scores in patients with glioblastoma. The results showed that a high PNI score was associated with longer overall survival and progression-free survival, while a low CONUT score was associated with longer overall survival. Multivariate analyses confirmed that high PNI score and low CONUT score were independently associated with longer overall survival. Therefore, PNI and CONUT scores have prognostic value in patients with glioblastoma, but further large-scale studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jin Qian, Jing Wang, Feng Cheng, Hong-feng Guo, Jun Xia, Xin Zhou
Summary: The prognostic value of the controlling nutritional status score (CONUT) in patients with myelodysplastic syndrome (MDS) was evaluated. The results showed that high CONUT score was significantly associated with low hemoglobin levels and indicated poor overall survival. Thrombocytopenia, high CONUT score, and medium and high risk IPSS-R score were identified as independent prognostic factors in MDS patients.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Xinhao Niu, Zhe Zhu, Juan Bao
Summary: The CONUT score is associated with the prognosis of urological cancers, with a higher score indicating poorer survival outcomes for patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Siyi Lu, Zhaoyu Chen, Ran Peng, Qiuxiang Zhang, Yuxia Wang, Xuemin Li, Ruize Qu, Xin Zhou, Wei Fu, Tao Sun, Hao Wang
Summary: This study aimed to investigate the prognosis relevance of the Controlling Nutritional Status (CONUT) score in locally advanced rectal cancer patients treated with neoadjuvant chemoradiotherapy before radical surgery. The CONUT score was found to have good predictive ability for overall survival and was identified as an independent prognostic factor. The preoperative CONUT score may be a useful indicator in clinical scenarios.
Review
Oncology
Jing Lv, Peirui Chen, Jianqiang Wu, Caihong Hu
Summary: This meta-analysis investigated the association between the pretreatment Controlling Nutritional Status (CONUT) score and prognosis in esophageal cancer patients. The results showed that a higher pretreatment CONUT score was associated with worse overall survival, progression-free survival, and cancer-specific survival.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Article
Surgery
Jianping Xiong, Haitao Hu, Wenzhe Kang, Hao Liu, Fuhai Ma, Shuai Ma, Yang Li, Peng Jin, Yantao Tian
Summary: This study demonstrates that the Naples prognostic score (NPS) is closely associated with the prognosis prediction of gastric cancer patients, showing independent prognostic value in both surgery alone and adjuvant chemotherapy groups. NPS exhibits higher accuracy in predicting overall survival compared to other prognostic factors.
FRONTIERS IN SURGERY
(2021)
Article
Multidisciplinary Sciences
Qi Xiao, Xiaoqing Li, Baojun Duan, Xiaofan Li, Sida Liu, Boyu Xu, Shuai Shi, Jin Zhang, Haoyuan Qin, Xianglong Duan, Yansong Pu
Summary: The stomach is the main digestive organ in humans. Patients with gastric cancer often develop digestive problems, which result in poor nutrition. The controlling nutritional status (CONUT) score is a novel tool to evaluate the nutritional status of patients. This study found that the CONUT score is related to postoperative complications, psychological status, and quality of life in patients with gastric cancer.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Zhuoran Liu, Haoge Zhou, Yu Zhou, Menglin Yu, Yonglang Cheng, Jing Li
Summary: This meta-analysis indicates that a high CONUT score is significantly associated with worse overall survival and relapse-free survival in patients with biliary tract cancer. Moreover, a high CONUT score is also correlated with clinical characteristics such as jaundice, poorly differentiated tumor, advanced tumor stage, and complications of Clavien-Dindo classification grade IIIa or higher.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Minami Une, Masaya Ito, Hiroaki Suzuki, Masahiro Toide, Shuichiro Kobayashi, Hiroshi Fukushima, Fumitaka Koga
Summary: In this study, the mutual relationship between the controlling nutritional status (CONUT) score and sarcopenia as prognostic factors in patients with advanced urothelial carcinoma (aUC) was comprehensively examined. The study found that the CONUT score and sarcopenia were significant and independent prognostic biomarkers and incorporating them into established prognostic models increased their predictive accuracy. These objective indices of a patient's general condition may assist in treatment decision-making for patients with aUC.
Article
Oncology
Hao Wang, Tianyi Fang, Xin Yin, Shenghan Lou, Bangling Han, Jialiang Gao, Yufei Wang, Xibo Wang, Daoxu Zhang, Yimin Wang, Yao Zhang, Yingwei Xue
Summary: This study aimed to investigate the applicability of the Naples prognostic score (NPS) in gastric cancer (GC) and construct a new NPS for individualized prognosis prediction. The results showed that the new NPS can accurately predict the prognosis of GC patients and can be combined with clinicopathological characteristics to construct a nomogram model.
Article
Oncology
Harin Kim, Dong-Min Shin, Jae-Hoon Lee, Eun-Suk Cho, Hye Sun Lee, Su-Jin Shin, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
Summary: This study compared various nutritional and inflammatory indicators and found that P-CONUT may be a better prognostic indicator for patients with colorectal cancer, compared to inflammatory markers such as neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Qin Lin, Chen Li, Xiaoxia Lin, Shuchun Lin, Wei Chen, Xiaoqiang Chen, Xiaoting Huang, Desheng Wang
Summary: This study aimed to investigate the prognostic significance of the preoperative controlling nutritional status (CONUT) score in patients with resectable advanced hypopharyngeal cancer. The CONUT score was found to be closely associated with clinicopathological variables and an independent predictor for prognosis.
Review
Immunology
Chuanyang Lu, Qiuni Chen, Linrong Fei, Junhui Wang, Chunling Wang, Liang Yu
Summary: This study investigated the prognostic role of the CONUT score in patients with hematologic malignancies. The results showed that a high CONUT score was associated with worse overall survival and progression-free survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tomoki Konishi, Toshiyuki Kosuga, Hiroyuki Inoue, Hirotaka Konishi, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Hitoshi Fujiwara, Eigo Otsuji
Summary: The study found that the preoperative Prognostic Nutritional Index (PNI) is an important predictor of postoperative survival outcomes in gastric cancer (GC) patients. Patients with PNI <48 showed poorer survival rates both before and immediately after surgery, necessitating appropriate preoperative interventions and postoperative monitoring.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Medicine, General & Internal
Jing Peng, Yan Hao, Bihua Rao, Yunxia Cao
Summary: The high CONUT score in NSCLC patients is positively related to poor prognoses, with a significant correlation to poor overall survival and shortened disease-free/recurrence-free survival. This score can be considered as an effective prognostic marker and is an independent predictor of postoperative complications in NSCLC patients.
Article
Surgery
Qi-Yue Chen, Qing Zhong, Zhi-Yu Liu, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Guang-Tan Lin, Chao-Hui Zheng, Chang-Ming Huang, Jian-Wei Xie
Summary: This study compared the short-term outcomes of robotic total gastrectomy (RTG) and laparoscopic total gastrectomy (LTG) in gastric cancer patients. The results showed that the RTG group had lower intraoperative blood loss, retrieved more extraperigastric lymph nodes, and had fewer errors during surgery compared to the LTG group. Additionally, the RTG group had a higher technical skill score, lower surgery task load index, and there was no significant difference in postoperative morbidity between the two groups.
Article
Surgery
Jun Lu, Dong Wu, Bin-Bin Xu, Zhen Xue, Hua-Long Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: This study aimed to compare the failure patterns after laparoscopic gastrectomy (LG) and open gastrectomy (OG) in locally advanced gastric cancer (LAGC) patients. Results showed a lower early distant recurrence rate in the LG group and a higher distant recurrence risk in the OG group within the first 2 years in stage IIa-IIIb patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Ze-Ning Huang, YuBin Ma, Qi-Yue Chen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Hua-Long Zheng, Chang-Ming Huang
Summary: This study compared the oncologic efficacy of laparoscopic and open surgery for advanced distal gastric cancer patients, showing different outcomes between the two procedures in various situations. Open surgery can reduce recurrence and improve the survival of gastric cancer patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Guo-Sheng Lin, Xiao-Yan Huang, Jun Lu, Dong Wu, Hua-Long Zheng, Bin-Bin Xu, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Guang-Tan Lin, Ze-Ning Huang, Ju-Li Lin, Chang-Ming Huang
Summary: The study found that the immune prognostic index is closely related to the long-term prognosis of elderly gastric cancer. Compared with OG, LG may improve the 5-year survival rate of patients with stage II gastric cancer. This hypothesis needs to be further confirmed by future prospective studies.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Jun Lu, Zhen Xue, Jian-gao Xie, Bin-bin Xu, Hai-bo Yang, Dong Wu, Hua-Long Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Ping Li, Chang-Ming Huang, Chao-Hui Zheng
Summary: This study found that the preoperative muscle-adipose index is a new independent prognostic factor that affects the prognosis of gastric cancer. It is also superior to traditional nutrition and body composition indicators in terms of prognostic evaluation and predictive value of recurrence risk in gastric cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Jun-Peng Lin, Jian-Xian Lin, Yong Weng, Chen-Bin Lv, Chang-Ming Huang
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Wen-Wu Qiu, Qi-Yue Chen, Wen-Ze Zheng, Qi-Chen He, Ze-Ning Huang, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Hua-Long Zheng, Guang-Tan Lin, Guo-Sheng Lin, Chao-Hui Zheng, Chang-Ming Huang, Ping Li
Summary: This study investigated the pattern and time point of recurrence in different age groups of postoperative gastric cancer patients. The results showed differences in recurrence characteristics between the young group and the older group. The young group had better overall survival and disease-free survival than the older group. The cumulative incidence of peritoneal recurrence was higher in the young group, while the cumulative incidence of distant recurrence was consistently lower in the young group.
Article
Oncology
Jun Lu, Dong Wu, Shi Chen, Jiao-bao Huang, Bin-bin Xu, Zhen Xue, Hua-Long Zheng, Guo-sheng Lin, Li-li Shen, Jia Lin, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Jian-Wei Xie, Jun-sheng Peng, Chang-Ming Huang
Summary: This study constructed a novel classifier based on deep learning preoperative hematological indices to predict the adjuvant chemotherapy (AC) benefit and recurrence hazard of locally advanced gastric cancer (LAGC) patients. The classifier showed good predictive performance for individualized treatment decision in AC.
Article
Biochemistry & Molecular Biology
Xiaofang Chen, Yaqin Chen, Bofei Fu, Kunjie Li, Donghong Huang, Chaohui Zheng, Minghuan Liu, Da-Peng Yang
Summary: In this study, CuS nanoparticles were prepared using eggshell membranes as templates and a multifunctional nanofibrous membrane was synthesized. The nanofiber membrane exhibited antibacterial, hemostatic, and wound healing properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Surgery
Ru-Hong Tu, Jian-Xian Lin, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: Laparoscopic gastrectomy after neoadjuvant chemotherapy can achieve improved short-term outcomes without increasing the risk of postoperative complications.
Article
Oncology
Guo-Sheng Lin, Jun Lu, Jia Lin, Hua-Long Zheng, Bin-Bin Xu, Zhen Xue, Dong Wu, Lili Shen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Qi-Yue Chen, Chang-Ming Huang
Summary: The preoperative DDI-to-albumin ratio (DAR) is a new biomarker for predicting long-term survival in gastric cancer (GC). A DAR > 0.0145 aids in the timely detection of early recurrence and peritoneal recurrence after surgery, guiding personalized follow-up strategies.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jia-Bin Wang, You-Xin Gao, Yin-Hua Ye, Tong-Xing Lin, Ping Li, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Ze-Ning Huang, Hua-Long Zheng, Jian-Wei Xie, Chao-Hui Zheng, Chang-Ming Huang
Summary: The study demonstrates that CDK5RAP3 plays a tumor suppressor role in gastric cancer and is related to the infiltration and polarization of macrophages. CDK5RAP3 inhibits TAMs polarization to M2 phenotype and promotes M1 polarization. In addition, CDK5RAP3 reduces monocyte recruitment to tumor tissue by inhibiting the CCL2/CCR2 axis.
CANCER GENE THERAPY
(2023)
Article
Oncology
Jian-Xian Lin, Jun-Peng Lin, Qing-Qi Hong, Peng Zhang, Zi-Zhen Zhang, Liang He, Quan Wang, Liang Shang, Lin-Jun Wang, Ya-Feng Sun, Zhi-Xiong Li, Jun-Jie Liu, Fang-Hui Ding, En-De Lin, Yong-An Fu, Shuang-Ming Lin, Ping Li, Zu-Kai Wang, Chao-Hui Zheng, Chang-Ming Huang, Jian-Wei Xie
Summary: This study developed a nomogram to predict postoperative recurrence of hepatoid adenocarcinoma of the stomach (HAS) and guide individualized surveillance strategies. The nomogram accurately stratified patients into low-, middle-, and high-risk groups of postoperative recurrence. Middle- and high-risk patients had higher rates of recurrence and metastasis, particularly multiple site metastasis, within 36 months after the operation.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fu-Hai Wang, Hua-Long Zheng, Jin-Tao Li, Ping Li, Chao-Hui Zheng, Qi-Yue Chen, Chang-Ming Huang, Jian-Wei Xie
Summary: In this study, a radiomics nomogram based on preoperative CT radiomic features was developed to predict recurrence and adjuvant therapy benefit in high/intermediate-risk gastrointestinal stromal tumors (GISTs). The constructed nomogram showed higher accuracy in predicting recurrence-free survival (RFS) compared to the clinicopathological nomogram. This model can assist clinical decision-making for GIST patients.
Article
Oncology
Jiabin Wang, Qingzhu Qiu, Ningzi Lian, Huagen Wang, Qiaoling Zheng, Yinghong Yang, Yubin Ma, Yajun Zhao, Ping Li, Jianxian Lin, Jun Lu, Qiyue Chen, Longlong Cao, Mi Lin, Changming Huang, Jianwei Xie
Summary: Inhibition of the immune microenvironment is the main cause of tumor recurrence after surgery in patients with gastric cancer. By evaluating immunosuppressive indicators and immune biomarkers, we constructed an immunosuppressive recurrence score and found that it can accurately and reliably predict recurrence. An elevated score is associated with locoregional recurrence and chemotherapy failure.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)