Review
Engineering, Biomedical
Chao Tao, Dong-An Wang
Summary: Advances in tissue engineering have moved beyond reconstructing individual tissues or organs and are now focusing on engineering systemic factors like immune objects and functions. Engineered immune tissues and organs show promise in restoring immune system dysfunctions and aplasia, while also aiming to evade immune-mediated inflammatory responses and rejection elicited by engineered implants.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Angus Weekes, Nicole Bartnikowski, Nigel Pinto, Jason Jenkins, Christoph Meinert, Travis J. Klein
Summary: Current clinical treatment strategies for small diameter blood vessel bypassing in cardiovascular disease management often fail due to lack of suitable grafts and various complications. The rapid advancement of 3D printing and regenerative medicine technologies has the potential to revolutionize cardiovascular disease management by enabling the production of biological vascular grafts with integration, remodeling, and repair capabilities.
ACTA BIOMATERIALIA
(2022)
Review
Nanoscience & Nanotechnology
Parth Chansoria, Karl Schuchard, Rohan A. Shirwaiker
Summary: The recapitulation of multiscale structure-function properties in cells, cell-secreted extracellular matrix, and natural tissues is crucial for engineering biomimetic tissue substitutes. Developing hybrid biofabrication strategies that combine multiple processes to complement each other's strengths and limitations is a key aspect for achieving multiscale biomimicry. Opportunities related to various hybridization schemes and future prospects for scale-up biofabrication have also been discussed in this work.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Priti Gupta, Shilpa Sharma, Shagufta Jabin, Sapana Jadoun
Summary: Regenerative medicine and tissue engineering have great potential in addressing the limitations of traditional medical approaches. Chitosan, as a naturally derived biocompatible biomaterial, has played a significant role in tissue regeneration. It has unique properties and can be applied in various fields, such as agriculture, nutraceuticals, biomedicine, and food. Chitosan is also an important material for developing next-generation hydrogels and bio-scaffolds. Furthermore, chitosan can be easily modified to enhance its mechanical strength, biodegradability, and controlled release of bioactive molecules. Blending chitosan with other polymers or incorporating nanoparticles expands its possibilities in tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemical Research Methods
Manon van Daal, Anne-Floor J. de Kanter, Annelien L. Bredenoord, Nienke de Graeff
Summary: Personalized 3D printed scaffolds are a new generation of implants used in tissue engineering and regenerative medicine. This article explores the ethical challenges and opportunities associated with these implants throughout their life cycle, covering topics such as research and clinical practices, privacy issues, and the inclusion of gender in ethical assessments. The article highlights the importance of addressing these ethical issues for the responsible development and implementation of personalized 3D printed scaffolds in the additive manufacturing and tissue engineering field.
Article
Nanoscience & Nanotechnology
Masahiro Yamada, Tsuyoshi Kimura, Naoko Nakamura, Jun Watanabe, Nadia Kartikasari, Xindie He, Watcharaphol Tiskratok, Hayato Yoshioka, Hidenori Shinno, Hiroshi Egusa
Summary: Researchers have successfully created a smart titanium nanosurface that mimics the surface properties of tooth root cementum, leading to the regeneration of periodontal tissues. This nanosurface induces the formation of dentoalveolar fibrous joints, resulting in the regeneration of functional periodontium.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Engineering, Biomedical
David William Green, Jolanta Anna Watson, Besim Ben-Nissan, Gregory Shaun Watson, Artemis Stamboulis
Summary: Synthetic protocells are engineered versions of natural cells, with potential applications in synthetic biology and tissue engineering. They have the ability to enhance biomaterials and increase cell productivity.Furthermore, synthetic proto-tissues generated by collective symbiosis show autonomous characteristics and can be used for a variety of applications such as drug delivery and renewable fuel production.
Article
Engineering, Biomedical
Qi Feng, Dingguo Li, Qingtao Li, Xiaodong Cao, Hua Dong
Summary: This mini-review summarizes the fabrication strategies, unique characteristics, and applications of microgel assembly in tissue engineering and regenerative medicine, with a focus on 3D printing. The challenges for further applications of microgel assembly are also discussed.
BIOACTIVE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Nikita Voloshin, Pyotr Tyurin-Kuzmin, Maxim Karagyaur, Zhanna Akopyan, Konstantin Kulebyakin
Summary: Immortalized cells are increasingly used in practical medicine due to their advantages, such as the ability to produce larger amounts of cells and use them for longer periods of time. However, they also have drawbacks, like the possibility of malignant transformation or major phenotype change. This review discusses ways to overcome these barriers and highlights specific fields of application where these concerns are minimal.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Izeia Lukin, Itsasne Erezuma, Lidia Maeso, Jon Zarate, Martin Federico Desimone, Taleb H. Al-Tel, Alireza Dolatshahi-Pirouz, Gorka Orive
Summary: Tissue engineering has become a viable medical alternative in response to the increasing lifespan of society. This review focuses on gelatin, a widely used biomaterial in tissue engineering, and discusses ongoing concerns and the latest developments in this field. Advancements in technology, such as 3D bioprinting and gelatin functionalization, have allowed for better replication of native tissue in gelatin-based systems. This breakthrough has implications for both the manufacturing process, making it more practical and cost-effective, and the future use of gelatin in disease detection and diagnosis rather than treatment.
Article
Polymer Science
Naiwen Tan, Maja Sabalic-Schoener, Linh Nguyen, Francesco D'Aiuto
Summary: Injectable biomaterials have great potential in dental tissue regeneration. This study successfully prepared an injectable thermosensitive beta-TCP and chitosan hydrogel, and demonstrated its feasibility and biocompatibility in periodontal tissue regeneration.
Article
Chemistry, Physical
Ramon Rial, Natalia Hassan, Zhen Liu, Juan M. Ruso
Summary: The study successfully produced hydrogel microparticles with different morphologies and compositions by combining experimental and computational methods, incorporating drug-doped Hydroxyapatite in their inner matrix. The use of a microfluidic system to obtain crosslinked HMPs with homogeneous sizes and morphologies, as well as the adsorption kinetics and desorption profiles of the chosen drug models, were key aspects of the research. The development of these hydrogel microparticles with improved functionalities is crucial for innovative and sustainable solutions in regenerative medicine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Biochemistry & Molecular Biology
Victor J. Costela-Ruiz, Lucia Melguizo-Rodriguez, Chiara Bellotti, Rebeca Illescas-Montes, Deborah Stanco, Carla Renata Arciola, Enrico Lucarelli
Summary: The success of regenerative medicine depends on the appropriate selection of mesenchymal stem cell (MSC) sources, as they influence the regenerative milieu. MSCs from bone marrow, adipose tissue, and dental tissue are all potential candidates for oral and dental regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Biomedical
Michelle Koerselman, Lisanne C. M. Morshuis, Marcel Karperien
Summary: This article discusses the application of small molecules such as peptides, aptamers, and variable antigen-binding domain of heavy chain only antibodies in tissue engineering and regenerative medicine. It compares these biological functionalities with conventional antibodies and provides an overview of recent work in this area. The article focuses on the structural differences, modifications, and conjugation strategies of these biologicals, as well as the clinical trials involving them. The challenges associated with each of these biologicals are also highlighted.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Daniel Salthouse, Katarina Novakovic, Catharien M. U. Hilkens, Ana Marina Ferreira
Summary: This review highlights the importance of the immune response to biomaterials and discusses challenges and opportunities in the development and standardized assessment of the immune response to biomaterials, including the importance of endotoxin levels. It also explores the properties of biomaterials that impact the host immune response and the use of immunomodulatory biomaterials in regenerative medicine. Finally, a standardized in vitro pathway for evaluating the immune response to biomaterials (hydrogels) and their regenerative potential is proposed to ensure safety, consistency, and reduce costs and animal use.
ACTA BIOMATERIALIA
(2023)