Article
Chemistry, Multidisciplinary
Tingting Cui, Junyou Chen, Rui Zhao, Yanyan Guo, Jiahui Tang, Yulei Li, Yi-Ming Li, Donald Bierer, Lei Liu
Summary: The synthesis of an Asp lactam derivative of A-183, a selective inhibitor of Factor 7a with good anticoagulant and antithrombotic activity, was achieved by using a removable backbone modification (RBM) strategy. This strategy was also successfully applied to the synthesis of a second Asp lactam derivative, demonstrating its potential as a general method for synthesizing Asp lactam cyclic peptides.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sadegh Shabani, Craig A. Hutton
Summary: This study presents a novel macrolactonisation strategy using Ag(i)-promoted conversion of peptide thioamides to isoimide intermediates, which undergo site-selective intramolecular acyl transfer to generate the macrolactone.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Applied
Hisashi Masui, Shinichiro Fuse
Summary: Peptides have gained increasing importance as drugs and drug candidates. Microflow synthesis, with an inner tube diameter of <=1 mm, offers advantages such as precise control of reaction time and temperature, as well as easy scale-up. The combination of microflow technology, automated synthesis, and online monitoring has improved synthetic efficiency and provided reliable data for machine learning models.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Materials Science, Ceramics
Raman Mnatsakanyan, Artur Aghoyan, Davit Davtyan
Summary: Boron monoposphide (BP) has unique physical and chemical characteristics, making it suitable for various practical applications. However, the difficult synthesis of the single phase of boron monophosphide limits its usage. Additionally, existing methods for synthesizing nanoscale BP often require high temperatures and long synthesis durations. This paper presents a simple, energy-efficient, and straightforward microwave activation synthesis method, which successfully produces pure single-phase BP nanopowder with a narrow size distribution (70-90 nm) in a short synthesis time (10 min).
CERAMICS INTERNATIONAL
(2023)
Article
Nanoscience & Nanotechnology
M. Mayakkannan, V. Siva, A. Murugan, A. Shameem, S. Thangarasu, S. Asath Bahadur
Summary: Nanosized ternary transition metal ferrite (NiMnFe2O4) was successfully synthesized by a microwave-assisted combustion method. The structure, elemental composition, surface morphology, and optical properties of the nanoparticles were analyzed using XRD, FTIR, SEM, and UV-Visible diffuse reflectance spectra. The electrochemical properties of the prepared metal ferrite were studied by EIS, GCD, and CV, showing a specific capacitance of 476 F/g.
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
(2023)
Review
Biochemistry & Molecular Biology
Yalda Khazaei-poul, Shohreh Farhadi, Sepideh Ghani, Safar Ali Ahmadizad, Javad Ranjbari
Summary: Peptides are versatile tools in biological fields and can be used for various purposes, such as drug design, diagnostics, vaccines, and agriculture. Cyclic peptides, in particular, offer advantages like selective binding, higher potency, and stability compared to linear peptides. This paper provides an overview of the categories, synthesis methods, and diverse applications of cyclic peptides, including their roles as pro-apoptotic and anti-microbial agents, targeting ligands in drug delivery, and in agricultural and therapeutic applications.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Materials Science, Ceramics
Marta Maria Gonzalez-Barrios, Marina Tabuyo-Martinez, Vanessa Cascos, Oscar Juan Dura, Jose Antonio Alonso, David Avila-Brande, Jesus Prado-Gonjal
Summary: The combination of microwaves with other classical synthetic methods provides a powerful tool for the preparation of metal oxides and metal chalcogenides. This approach allows for significant modification of reaction kinetics by reducing the processing time to minutes and minimizing energy consumption. Microwave chemistry routes have been used to produce potential thermoelectric compounds such as SnS1-xSex and Zn0.98M0.02O (M = Al, Ga) in just a few minutes. The microwave synthesis method also produces high-quality phases.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Organic
Christopher Berube, Alexandre Borgia, Normand Voyer
Summary: We report the first total synthesis of the macrocyclic decapeptide stylopeptide II, which was achieved using an efficient methodology with oxime resin as solid support. The synthesis was performed at gram-scale without the generation of any detectable undesired side products, demonstrating the general applicability and large-scale synthesis acceleration of this method.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Organic
Pak-Lun Lam, Yue Wu, Ka-Leung Wong
Summary: Fmoc-Dab(Mtt)-OH has poor coupling efficiency and undergoes rapid lactamization during solid-phase peptide synthesis. A multi-time and preincubation-free protocol using the coupling reagent DEPBT can achieve complete incorporation, but alternative building blocks are recommended to avoid this costly and tedious procedure.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Physical
Rakesh V. Kusurkar, Rahul H. Rayani, Deepa R. Parmar, Divyang R. Patel, Mrugesh J. Patel, Nilesh O. Pandey, Vishwanath Zunjar, Jigar Y. Soni
Summary: In this study, new phenyl substituted 3-chloro 2-azetidinone derivatives were successfully synthesized using a microwave-assisted synthesis method. The synthesized compounds exhibited promising antimicrobial activity, with compound 8c showing the strongest antibacterial and antifungal effects against Escherichia coli and Aspergillus niger.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Multidisciplinary
Yu Gao, Yuzhi Liu, Donglei Zou
Summary: This article reviews the application of microwave irradiation in synthesis and catalytic oxidation, including microwave irradiation alone, microwave with catalysts, microwave-Fenton, microwave-peralcohol, microwave-photochemistry, microwave-electrochemistry, and microwave-sonochemistry. Engineering for upscaling microwave irradiation is also presented.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Environmental Sciences
Umar Asim, Syed M. Husnain, Naseem Abbas, Faisal Shahzad, Shagufta Zafar, Sherif A. Younis, Ki-Hyun Kim
Summary: In this study, a flower-like porous 8-MnO2 nanostructure was synthesized and used for adsorptive removal of strontium and cesium from wastewater. The 8-MnO2 nanosorbent showed higher affinity for strontium and selective adsorption towards strontium in the two-solute system. It also exhibited stable adsorption performance under different environmental variables and good regenerability.
Article
Chemistry, Applied
Monika Kijewska, Michalina Zawadzka, Miko Laj, Piotr Stefanowicz
Summary: This study presents a fast, simple, and efficient method for the synthesis of lactosylated peptides using microwave-assisted synthesis and boronate affinity chromatography. The researchers successfully synthesized modified peptides from β-lactoglobulin and applied the functionalized resin for enrichment of lactosylated peptides in human serum albumin samples.
Article
Chemistry, Multidisciplinary
Abdussalam K. Qaroush, Ahed W. Alsayyed, Ala'a F. Eftaiha, Feda'a M. Al-Qaisi, Bader A. Salameh
Summary: Herein, an organocatalyzed synthetic pathway for the preparation of (a)cyclic ureas from their parent primary aliphatic or aromatic mono-/diamines with propylene carbonate (PC) as a carbonylating agent (CAT) obtaining reasonable to very good yields with high selectivity. The method fulfills nine out of twelve green chemistry principles, making it a green and efficient approach for the synthesis of urea compounds. The absence of solvent, energy-efficient pathway, ease of synthesis and separation, fast reaction times, and minimal use of organic solvents are the key advantages of this method. The applicability of the method for primary amines showcases its high chemoselectivity for the synthesis of urea compounds.
Article
Environmental Sciences
Farwa Arshad, Nazish Parveen, Sajid Ali Ansari, Javed Alam Khan, Md Sk Palashuddin
Summary: In this study, nanorod-shaped Mn3O4 supported with amorphous carbon (Mn3O4/AC) was synthesized by the microwave method for supercapacitor application. The as-prepared electrode material exhibited excellent capacitance performance, attributed to the excellent redox behavior of Mn3O4 and the presence of amorphous carbon.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)