Review
Health Care Sciences & Services
Mariangela Manfredi, Lieve Van Hoovels, Maurizio Benucci, Riccardo De Luca, Carmela Coccia, Pamela Bernardini, Edda Russo, Amedeo Amedei, Serena Guiducci, Valentina Grossi, Xavier Bossuyt, Carlo Perricone, Maria Infantino
Summary: uPAR is a membrane-bound glycoprotein, and its bioactive form, suPAR, is primarily expressed on the surface of immunologically active cells. Higher levels of suPAR have been associated with disease severity, relapse, and mortality in various inflammatory diseases. This review summarizes the current literature on the potential role of suPAR as a biomarker in autoimmune rheumatic and non-rheumatic diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Immunology
Yao-Chin Wang, Muh-Shi Lin, Abel Po-Hao Huang, Chieh-Chen Wu, Woon-Man Kung
Summary: This systematic review and meta-analysis demonstrate an increased risk of dementia among participants with systemic rheumatic diseases (SRDs), except for rheumatoid arthritis (RA).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Maria Vassilaki, Cynthia S. Crowson, John M. Davis, Stephanie Q. Duong, David T. Jones, Aivi Nguyen, Michelle M. Mielke, Prashanthi Vemuri, Elena Myasoedova
Summary: Rheumatoid arthritis (RA) is not associated with cognitive decline and dementia risk, but RA patients show more abnormal cerebrovascular pathology on neuroimaging.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Jessica Maiuolo, Carolina Muscoli, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Sara Paone, Sara Ilari, Rocco Mollace, Ernesto Palma, Vincenzo Mollace
Summary: Rheumatoid arthritis is a chronic autoimmune disease that affects joints, but can also result in extra-articular manifestations such as nerve disorders. Research on the pathophysiological basis of microvascular disease associated with RA is ongoing.
Review
Computer Science, Artificial Intelligence
Ashik Mostafa Alvi, Siuly Siuly, Hua Wang
Summary: Efficient detection of neurological abnormalities is crucial in clinical diagnosis for modern medical applications. EEG, as a non-invasive and inexpensive method, is widely used to diagnose neurological diseases. This paper provides a comprehensive survey on recent studies using EEG signals to detect diseases such as Dementia, Mild Cognitive Impairment, Alzheimer's, Schizophrenia, and Parkinson, focusing on key components of EEG signal processing, algorithms used, and signal processing techniques.
ARTIFICIAL INTELLIGENCE REVIEW
(2022)
Article
Clinical Neurology
Andrea Pilotto, Viviana Cristillo, Stefano Cotti Piccinelli, Nicola Zoppi, Giulio Bonzi, Davide Sattin, Silvia Schiavolin, Alberto Raggi, Antonio Canale, Stefano Gipponi, Ilenia Libri, Martina Frigerio, Michela Bezzi, Matilde Leonardi, Alessandro Padovani
Summary: Long-term neurological manifestations have been observed in both hospitalised and non-hospitalised COVID-19 patients. Factors such as age, comorbidities, and severity of SARS-CoV-2 infection are independent predictors of long-term neurological symptoms in survivors after 6 months of hospitalisation.
NEUROLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Pan Shen, Xuan Deng, Zhishuo Hu, Zhe Chen, Yao Huang, Ke Wang, Kai Qin, Ying Huang, Xin Ba, Jiahui Yan, Liang Han, Shenghao Tu
Summary: Immune checkpoint inhibitors have revolutionized cancer treatment but are associated with immune-related adverse events, including various rheumatic diseases. Early diagnosis and treatment of these adverse events are crucial for improving cancer patients' survival rates.
FRONTIERS IN MEDICINE
(2021)
Article
Psychiatry
Bethany McDowell, Calum Marr, Clive Holmes, Christopher J. Edwards, Christopher Cardwell, Michelle McHenry, Gary Meenagh, Bernadette McGuinness
Summary: This study found that cognitive impairment is common in older adults with rheumatoid arthritis, and is associated with higher disease activity. The importance lies in emphasizing the control of inflammation to slow down cognitive decline.
Review
Gastroenterology & Hepatology
Annacarla Finucci, Maria Chiara Ditto, Simone Parisi, Richard Borrelli, Marta Priora, Cristina Realmuto, Enrico Fusaro
Summary: Rheumatic manifestations are common extra-intestinal manifestations in patients with inflammatory bowel disease, causing a significant reduction in quality of life. Various imaging techniques can aid in identifying the nature of these manifestations, while a multidisciplinary approach can lead to early diagnosis and better clinical outcomes.
MINERVA GASTROENTEROLOGY
(2021)
Review
Neurosciences
Sneha R. Sharma, Yu Chen
Summary: The association between rheumatoid arthritis and dementia or cognitive impairment is still uncertain, as studies have produced mixed results. Further research is needed to clarify the possible shared biological underpinnings of these two conditions.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Immunology
Siyuan Fan, Jiuliang Zhao, Bo Hou, Mange Liu, Jingwen Niu, Yan Zhou, Chenhui Mao, Haitao Ren, Feng Feng, Mengtao Li, Xiaofeng Zeng, Yicheng Zhu, Hongzhi Guan
Summary: The clinical and neuroimaging characteristics of rheumatoid meningitis (RM) in Chinese patients were analyzed retrospectively. Among 933 patients with rheumatoid arthritis (RA), six patients were identified with RM. Headache, hyperacute focal neurological deficits, and seizures were the most common symptoms. Meninges were affected in all patients and cerebral parenchyma in one patient. The lesions were generally located in the frontoparietal region. Immunotherapy, including tocilizumab, showed good response in most patients. RM in Chinese patients share similar characteristics and respond well to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Rheumatology
Mitsuhiro Akiyama, Waleed Alshehri, Keiko Yoshimoto, Yuko Kaneko
Summary: Recent technological progress has advanced our understanding of human immunology through the discovery of T follicular helper (Tfh) and T peripheral helper (Tph) cells. These cells play critical roles in B cell differentiation and maturation, with differences in their functional properties. In various rheumatic and musculoskeletal diseases, the contribution of Tfh and Tph cells varies, with Tph cells predominating in peripheral inflammatory lesions and Tfh cells predominating in affected lesions of IgG4-related disease. This review provides an overview of these novel T cell subsets and their involvement in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Elizabet Mendez Eirin, Yago Suarez Ourens, Jose Luis Guerra Vazquez
Summary: Autoimmune rheumatic diseases can lead to cardiovascular complications that require early detection and treatment. Cardiac involvement in these patients may result in unfavorable prognosis, highlighting the importance of appropriate management.
Review
Immunology
Maurizio Cutolo, Stefano Soldano, Alberto Sulli, Vanessa Smith, Emanuele Gotelli
Summary: Vitamin D, a steroid hormone, has complex influences on the immune system and may affect various clinical conditions. Its serum concentrations fluctuate seasonally due to UV-B exposure, and low levels of 25OHD are implicated in the pathogenesis and clinical manifestations of diseases like rheumatoid arthritis and systemic sclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Daniel Pankowski, Kinga Wytrychiewicz-Pankowska, Konrad Janowski, Ewa Pisula
Summary: The study found that patients with RA have greater impairment of cognitive functioning compared to healthy controls, with effect sizes varying depending on the assessment method used. It also highlighted potential biases, lack of replication, and inconsistencies in reporting data as possible confounding factors, suggesting further recommendations for assessment methods, research directions, and clinical implications.
Biographical-Item
Clinical Neurology
Bruno Kusznir Vitturi, Wilson Luiz Sanvito
JOURNAL OF NEUROLOGY
(2019)
Letter
Clinical Neurology
Bruno Kusznir Vitturi, Antonio Jose da Rocha, Sergio Rosemberg
ACTA NEUROLOGICA BELGICA
(2020)
Article
Neurosciences
Bruno Kusznir Vitturi, Wilson Luiz Sanvito
ARQUIVOS DE NEURO-PSIQUIATRIA
(2019)
Article
Clinical Neurology
B. Kusznir Vitturi, R. Jose Gagliardi
REVUE NEUROLOGIQUE
(2020)
Article
Clinical Neurology
Bruno Kusznir Vitturi, Ada Pellegrinelli, Berenice Cataldo Oliveira Valerio
ACTA NEUROLOGICA BELGICA
(2020)
Article
Neurosciences
Bruno Kusznir Vitturi, Wilson Luiz Sanvito
ARQUIVOS DE NEURO-PSIQUIATRIA
(2020)
Article
Clinical Neurology
Bruno Kusznir Vitturi, Enrico Stefano Suriano, Ana Beatriz Pereira de Sousa, Dawton Yukito Torigoe
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2020)
Article
Clinical Neurology
Bruno Kusznir Vitturi, Rubens Jose Gagliardi
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Bruno Kusznir Vitturi, Rubens Jose Gagliardi
NEUROLOGICAL SCIENCES
(2020)
Letter
Clinical Neurology
Bruno Kusznir Vitturi
ACTA NEUROLOGICA BELGICA
(2021)
Article
Neurosciences
Bruno Kusznir Vitturi, Rubens Jose Gagliardi
ARQUIVOS DE NEURO-PSIQUIATRIA
(2020)
Biographical-Item
Clinical Neurology
Bruno Kusznir Vitturi, Wilson Luiz Sanvito
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Bruno Kusznir Vitturi, Alexandre In Han Kim, Lucas Pari Mitre, Ada Pellegrinelli, Berenice Cataldo Oliveira Valerio
Summary: Patients with MG experience social, professional, and mental disadvantages, with many facing unemployment or reduced income after diagnosis, only a small percentage receiving financial support and satisfactory social support, and a high prevalence of neuropsychiatric symptoms.
NEUROLOGICAL SCIENCES
(2021)
Meeting Abstract
Clinical Neurology
E. Suriano, A. Beatriz Pereira de Souza, B. Kusznir Vitturi, D. Yukito Torigoe
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2019)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)