Article
Radiology, Nuclear Medicine & Medical Imaging
Keith B. Quencer, Abhilasha Singh, Anu Sharma
Summary: Primary hyperaldosteronism (PA) is the most common secondary form of hypertension in middle-aged adults. Treatment options depend on the extent of aldosterone secretion, with unilateral cases treated surgically and bilateral cases treated medically. Adrenal vein sampling (AVS) is crucial in determining the appropriate treatment approach, but there is variability in AVS techniques and guidelines regarding its use in young patients with unilateral adrenal findings on imaging.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Endocrinology & Metabolism
Adina F. Turcu, Richard Auchus
Summary: Recent studies have shown that primary aldosteronism (PA) has a higher prevalence among hypertensive patients than previously assumed, with the most common subtypes being aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). Screening and distinguishing between different subtypes can be costly, and it is important to assess the likelihood of benefit from imaging and adrenal vein sampling before embarking on these studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Seung-Eun Lee, Sung Woon Park, Min Sun Choi, Gyuri Kim, Jee Hee Yoo, Jiyeon Ahn, Ji Eun Jun, Hong Suk Park, Dongho Hyun, Sung Ki Cho, Seong Eun Ko, Beom-Jun Kim, Jong Woo Kim, Hyun-Ki Yoon, Jung-Min Koh, Seung Hun Lee, Jae Hyeon Kim
Summary: AV/IVC index may assist in diagnosing PA subtype in the case of unilateral AVS failure according to the study findings.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Marta Araujo-Castro, Miguel Paja Fano, Marga Gonzalez Boillos, Eider Pascual-Corrales, Ana Maria Garcia Cano, Paola Parra Ramirez, Patricia Martin Rojas-Marcos, Almudena Vicente Delgado, Anna Casteras, Albert Puig, Inigo Garcia Sanz, Patricia Diaz Guardiola, Cristina Robles Lazaro, Miguel Antonio Sampedro Nunez, Raquel Guerrero-Vazquez, Maria del Castillo Tous, Theodora Michalopoulou Alevras, Susana Tenes Rodrigo, Felicia A. Hanzu
Summary: The purpose of this study was to evaluate the diagnostic accuracy of the NP-59 adrenal scintigraphy for subtyping diagnosis of primary aldosteronism (PA), with the results of adrenal venous sampling (AVS) or adrenalectomy as the gold standard. The study found that NP-59 scintigraphy results combined with CT/MRI information may be useful for PA subtyping, but their diagnostic accuracy is only moderate.
Article
Endocrinology & Metabolism
Gregory A. Kline, Alexander Ah-Chi Leung, Davis Sam, Alex Chin, Benny So
Summary: Repeat adrenal vein sampling (AVS) shows moderate correlation in biochemical results and diagnostic lateralization between the first and second procedures, indicating high repeatability and success rate in patients with primary aldosteronism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Fabrizio Buffolo, Jacopo Pieroni, Federico Ponzetto, Vittorio Forestiero, Denis Rossato, Paolo Fonio, Antonello Nonnato, Fabio Settanni, Paolo Mulatero, Giulio Mengozzi, Silvia Monticone
Summary: This study assessed the impact of asymmetrical cortisol secretion on the lateralization index during adrenal venous sampling, and the effectiveness of metanephrines as a normalization factor for aldosterone levels. The results showed that 18% of patients with primary aldosteronism had asymmetrical cortisol secretion, and the use of metanephrines as a normalization factor improved the accuracy of diagnosis compared to aldosterone to cortisol lateralization index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Davis Sam, Gregory A. Kline, Benny So, Janice L. Pasieka, Adrian Harvey, Alex Chin, Stefan J. Przybojewski, Alexander A. Leung
Summary: The study found that patients with unilateral PA and normal adrenal imaging had favorable outcomes following adrenalectomy, with a majority of patients showing complete or partial response in both biochemical and clinical outcomes. Therefore, patients with lateralizing disease should be considered for surgery even if their adrenal imaging appears normal.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Giulio Ceolotto, Giorgia Antonelli, Brasilina Caroccia, Michele Battistel, Giulio Barbiero, Mario Plebani, Gian Paolo Rossi
Summary: This study compared the selectivity index of androstenedione, metanephrine, and normetanephrine with cortisol in patients with primary aldosteronism, finding that androstenedione and metanephrine outperformed cortisol in verifying the success of adrenal vein sampling.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Masatoshi Ogata, Hironobu Umakoshi, Tazuru Fukumoto, Yayoi Matsuda, Maki Yokomoto-Umakoshi, Hiromi Nagata, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The study suggests that a significant left adrenal vein absolute aldosterone gradient may indicate unilateral excess aldosterone, especially in patients with spontaneous hypokalemia or left unilateral disease on computed tomography. This finding can be a useful tool in diagnosing the left unilateral subtype of primary aldosteronism during adrenal vein sampling.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Pathology
Nicola Sawyer, Paul Glendenning, Samuel D. Vasikaran, Michael M. Page, Sze Ling Wong, Jun Yang, Markus P. Schlaich, Greg Van Schie, Damon A. Bell
Summary: The objective of this study was to determine the clinical and biochemical success rates of adrenalectomy in patients with unilateral primary aldosteronism (PA), subtyped by adrenal vein sampling (AVS), using the Primary Aldosteronism Surgical Outcome (PASO) criteria. Clinical and biochemical outcomes were evaluated retrospectively in patients who underwent adrenalectomy according to AVS between September 2017 and September 2020. Follow-up data were collected through questionnaires, clinic letter reviews, and examination of pathology and radiological reports. The results showed high clinical and biochemical success rates in patients who underwent adrenalectomy for unilateral PA in Western Australia, but further standardization of post-operative follow-up care is needed.
Article
Cardiac & Cardiovascular Systems
Gian Paolo Rossi, Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultze Kool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Margill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Vin Cent Wu, Zuzana Kratka, Teresa M. Seccia, Livia Lenzini
Summary: This study aimed to determine the rate of drug-resistant arterial hypertension in patients with primary aldosteronism (PA) and investigate the diagnostic performance of adrenal vein sampling (AVS). The results showed that resistant hypertension was common in PA patients, and AVS-guided adrenalectomy effectively resolved treatment-resistant hypertension.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Wei Liu, Jingjing Zhang, Yaling Yang, Yinxin Jin, Zaizhao Li, Liting You, Jianguang Luo, Xin Su
Summary: The study demonstrated that ACTH stimulation had significant effects on increasing catheterization selectivity in simultaneous bilateral AVS, reducing the rate of unsuccessful catheterization. Lateralization changes were observed in patients after ACTH stimulation, with those showing consistent lateralization exhibiting a more severe phenotype.
HORMONE AND METABOLIC RESEARCH
(2021)
Article
Endocrinology & Metabolism
Sophie Dream, Sandra Park, Tina W. Yen, William Rilling, Lisa Rein, Kara Doffek, James W. Findling, Steven B. Magill, Srividya Kidambi, Douglas B. Evans, Tracy S. Wang
Summary: This study investigates the utility of AV epinephrine levels in assessing successful AV cannulation for patients with primary aldosteronism. The results show that measuring epinephrine levels can help determine the success of AV catheter placement during AVS, thereby preventing unnecessary repeat AVS.
ENDOCRINE PRACTICE
(2022)
Article
Endocrinology & Metabolism
Eleftheria Gkaniatsa, Augustinas Sakinis, Magnus Palmer, Andreas Muth, Penelope Trimpou, Oskar Ragnarsson
Summary: The study found that imaging studies inaccurately predicted laterality in a significant number of young patients with PA. In contrast to current clinical guidelines, the results support the use of AVS for subtype evaluation in young adults with PA, including patients 35 years or younger.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Minggang Huang, Di Yang, Yan Zhang, Yuqing Zhang, Yue Mu
Summary: This study investigates the feasibility of dual-energy CT energy imaging parameters as a novel biomarker in identifying bilateral adrenal dominant lesions in patients with primary aldosteronism (PA). The results show that the dual-energy CT energy spectrum imaging parameters have high sensitivity and specificity in distinguishing bilateral adrenal lesions, and can serve as a complementary method to adrenal venous sampling (AVS) in the diagnosis of PA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Hiba Obeid, Stanley M. Chen Cardenas, Shafaq Khairi, Adina F. Turcu
Summary: Primary aldosteronism (PA) is a common but underestimated secondary cause of hypertension, associated with increased cardiovascular and renal morbidity compared to primary hypertension. Early identification and targeted therapy are crucial in reducing the morbidity and mortality in a large hypertensive population. Unilateral adrenalectomy is the preferred treatment for lateralized PA, while medical therapy with mineralocorticoid receptor antagonists is offered to bilateral PA patients and those who are not surgical candidates. Novel therapies are being developed as alternative options for PA treatment. This review article discusses the individualized therapy for patients with PA.
ENDOCRINE PRACTICE
(2023)
Article
Chemistry, Analytical
Xue Zhang, Qin Wei, Xin Meng, Lili Zhao, Zhaosheng Liu, Yanping Huang
Summary: A new strategy utilizing a dendrimer-like structure of boron materials based on octavinyl-polyhedral oligomeric silsesquioxanes (Ov-POSS) was suggested to improve boronate avidity with good accessibility of sites. The resulting Ov-POSS cross-linked boron monolith showed significantly stronger affinity for glycoproteins compared to the Ov-POSS-free monolith. The developed microfluidic platform, which integrated multiple functions, demonstrated high efficiency and high-throughput analysis for post-translational modification proteomics.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Donghao Wang, Weizhe Zhang, Xiaofan Zhang, Mingzhu Li, Qiong Wu, Xin Li, Lili Zhao, Qiang Yuan, Yin Yu, Jing Lu, Jimin Zhao, Zigang Dong, Kangdong Liu, Yanan Jiang
Summary: Esophageal squamous cell carcinoma (ESCC) has a high mortality rate worldwide, and new effective treatments are urgently needed. This study investigated the effects of Daurisoline, a natural compound, on ESCC and identified its mechanism of action. Daurisoline inhibited ESCC growth by suppressing the ERK1/2 signaling pathway, making it a potential MEK inhibitor for ESCC treatment.
MOLECULAR CARCINOGENESIS
(2023)
Review
Genetics & Heredity
Lili Zhao, Tao Li, Meijuan Dang, Ye Li, Hong Fan, Qian Hao, Dingli Song, Jialiang Lu, Ziwei Lu, Yating Jian, Heying Wang, Xiaoya Wang, Yulun Wu, Guilian Zhang
Summary: This study found a significant association between the MTHFR rs1801133 (677C > T) gene mutation and an increased risk of ischemic stroke, particularly in the Asian, Hispanic, or Latin population and middle-aged and elderly individuals.
FRONTIERS IN GENETICS
(2023)
Article
Obstetrics & Gynecology
Huijuan Wang, Yinmin Shi, Jiying Ma, Wenxia Wang, Jianrong Gao, Lili Zhao, Ting Zhao, Guifeng Ding
Summary: This study evaluates the global alterations of protein expression and N-glycosylations in the placentas of healthy pregnant women and patients with early-onset and late-onset severe preeclampsia (PE), and suggests that changes in glycosylation may affect the molecular function of proteins and contribute to the pathogenesis of PE.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2023)
Article
Plant Sciences
Lijuan Huang, Leilei Ding, Wenjuan Wang, Lili Zhao, Xin Zhao, Puchang Wang
Summary: Paspalum wettsteinii shows adaptive responsiveness to drought stress, with mild drought stress improving growth and photosynthesis, while extreme drought stress decreasing physiological and biochemical parameters. Moderate and severe drought stress responses depend on exposure time. Short-term drought stress enhances photosynthesis and antioxidant capacity, but these parameters are inhibited with longer exposure time.
ACTA PHYSIOLOGIAE PLANTARUM
(2023)
Article
Chemistry, Multidisciplinary
Jing Chen, Qun Zhao, Hang Gao, Lili Zhao, Huiying Chu, Yichu Shan, Zhen Liang, Yukui Zhang, Lihua Zhang
Summary: Chemical cross-linking mass spectrometry (CXMS) is a powerful technology for analyzing protein complexes. However, in vivo CXMS studies have been limited by cross-linking biocompatibility and data analysis. In this study, a glycosidic bond-based MS-cleavable cross-linker called trehalose disuccinimidyl ester (TDS) was designed and synthesized, which simplified the cross-linked peptides into conventional single peptides via selective cleavage. TDS showed high biocompatibility and accuracy, enhancing the cross-linking identification accuracy and throughput.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Electrical & Electronic
Liwei Liu, Xiaoting Zhang, Yan Wang, Ruicong Chen, Lili Zhao, Bin Cui
Summary: In this study, Sr0.7Bi0.2TiO3-based ceramics with excellent dielectric temperature stability and energy storage efficiency were prepared by a two-step sintering process. The introduction of NNT and the design of a core-shell structure enhanced the relaxation behavior and temperature stability of the ceramics. The obtained ceramics showed promising energy storage performance and could be applied in dielectric ceramic capacitors.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Agriculture, Multidisciplinary
Ruixiang Zhao, Junjian Ran, Xiaoli Ruan, Hanxiao Du, Gang Li, Lili Zhao, Junliang Sun, Xinhong Liang
Summary: This study investigated the effects of fermentation and dynamic simulated digestion on the biotransformation and antioxidant potential of apple polyphenols. The polyphenol content of fermented apple pulp was significantly higher compared to non-fermented pulp, and the antibacterial activity improved after fermentation. The antioxidant potential of apple pulp also increased after fermentation and digestion. The findings suggest that fermented and digested apple polyphenols have better bioavailability and can be beneficial for the absorption of active substances.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Plant Sciences
Yue-Ming Luo, Shu-Dong Yang, Miao-Yu Wen, Bing Wang, Jia-Hui Liu, Si-Ting Li, Yu-Yan Li, Hong Cheng, Li-Li Zhao, Shun-Min Li, Jian-Jun Jiang
Summary: Through network pharmacology and deep RNA-seq analysis, this study identified c-Jun as a potential target of Triptolide (TPL) and suggested that Per1 related circadian rhythm signaling is involved in TPL induced renal toxicity.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Endocrinology & Metabolism
Daniel A. Dumesic, Adina F. Turcu, Haiping Liu, Tristan R. Grogan, David H. Abbott, Gwyneth Lu, Devyani Dharanipragada, Gregorio D. Chazenbalk
Summary: Ovarian and adrenal steroidogenesis play a role in endocrine-metabolic dysfunction in polycystic ovary syndrome (PCOS). Comparing PCOS patients with normal-weight controls, elevated serum levels of total/free testosterone (T) and androstenedione (A4) were observed in PCOS patients, along with greater android/gynoid fat mass. Adrenal steroids were not significantly associated with body fat distribution, but reduced cortisol levels correlated with diminished android fat mass in PCOS patients, suggesting a protective effect against preferential abdominal fat deposition.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Review
Neurosciences
Chengcheng Dai, Changhong Tan, Lili Zhao, Yi Liang, Guohui Liu, Hang Liu, Yuke Zhong, Zhihui Liu, Lijuan Mo, Xi Liu, Lifen Chen
Summary: Impairments in systematic and regional glucose metabolism exist in patients with Parkinson's disease (PD) and are associated with various mechanisms that lead to energy supply insufficiency, neurotransmitter dysregulation, and dopaminergic neuron loss. This review discusses the glucose metabolism impairment in PD, its pathophysiological mechanisms, and available therapies targeting glucose metabolism impairment in PD.
BRAIN RESEARCH BULLETIN
(2023)
Article
Pharmacology & Pharmacy
Xihua Yang, Yongqin Liang, Lili Zhao, Lixia Chen, Yongming Yang, Jing Wang, Lei Yan, Shengwan Zhang, Xianping Liu, Huayi Zhang
Summary: This study aimed to investigate the effect of brazilin on breast cancer invasion and metastasis. The results showed that brazilin inhibited the proliferation and invasion of breast cancer cells, as well as significantly decreased the number of metastatic nodules in the lungs. In addition, brazilin also increased the average survival days and spleen index in the mice. These findings suggest that brazilin may have potential as a new therapeutic agent for breast cancer.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Xuhu Lin, Lili Zhao, Xi Liu, Jianwen Chen
Summary: Video frame interpolation (VFI) aims to generate intermediate frames between successive frames. Existing learning-based methods often suffer from limited reference regions and complex motions. This paper proposes a novel motion-aware VFI network (MVFI-Net) which overcomes these issues by introducing a motion-aware convolution operation and incorporating pyramid structure. Experimental results demonstrate that the proposed method achieves state-of-the-art performance on diverse benchmarks.
COMPUTER VISION - ACCV 2022, PT III
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Lili Zhao, Ting Wang, Hong-Li Zhang, Zi-Hua Li, Qing-Qing Luo, Kun-He Zhang
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)