Article
Parasitology
Carolin Vegvari, Federica Giardina, Sumali Bajaj, Veronica Malizia, Robert J. Hardwick, James E. Truscott, Antonio Montresor, Sake J. de Vlas, Luc E. Coffeng, Roy M. Anderson
Summary: Annual deworming treatment for adolescent girls can significantly reduce the prevalence of moderate and heavy infections, while deworming treatment for women of reproductive age during pregnancy and lactation has a limited effect and may not achieve the desired target. Continued school-based treatment could indirectly reduce the force of infection on women of reproductive age and potentially eliminate morbidity in this group. Monitoring of interventions targeting women of reproductive age is recommended to assess effectiveness.
PARASITES & VECTORS
(2021)
Article
Chemistry, Inorganic & Nuclear
Robert B. Jordan
Summary: Renewed interest in the lanthanide contraction arises from its potential impact on the properties and applications of Ln(III) compounds, as well as the associated theory. To comprehend this effect, understanding the normal relationship between contraction and the number of 4f electrons (n) is crucial. Recent data on ionic radii demonstrate a linear dependence on n for coordination numbers (CNs) of 6, 8, and 9, following the normal trend. Deviations from this trend suggest the influence of other interactions in the system. The suggestion of a curved variation fitted by a quadratic function has gained popularity in recent years.
INORGANIC CHEMISTRY
(2023)
Review
Medicine, General & Internal
Charles Raine, Ian Giles
Summary: This article reviews the relationship between sex hormones and rheumatoid arthritis (RA), including studies in basic science, epidemiology, and clinical trials. The results indicate that declining estrogen and/or progesterone levels in menopause and post-partum appear to increase the risk and severity of RA.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, Rachel Mandelbaum, Marsha Baker, Lihong Ma, Intira Sriprasert, Christina E. Dancz, Richard S. Legro
Summary: In vitro studies have shown that 5 alpha-androstane-3,17-dione (5 alpha-A) plays an important role in the formation of dihydrotestosterone (DHT) from androstenedione (A). However, there has been a lack of available assays to quantify 5 alpha-A. This study developed a specific and sensitive radioimmunoassay to measure 5 alpha-A levels in serum and genital skin. The findings suggest that 5 alpha-A is an important intermediate in DHT formation in genital skin and may play a significant role in the conversion of A to androsterone glucuronide in women with polycystic ovary syndrome (PCOS).
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Steven S. Witkin, Iara Moreno Linhares
Summary: The microbial composition of the human vagina differs from other mammals due to unique vaginal constituents and individual variations. Immune reactions, environmental factors, and personal history can greatly influence the composition of vaginal microbiota, resulting in a wide definition of a "normal" microbiota.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xin He, Margaret Banker, Muraly Puttabyatappa, Vasantha Padmanabhan, Richard J. Auchus
Summary: This study characterizes the levels of 11-oxygenated androgens (11oAs) in normal human pregnancy and neonatal period. The results show that 11 beta-hydroxyandrostenedione (11OHA4) and 11-ketoandrostenedione (11KA4) are the dominant 11oAs in pregnancy and cord blood. The concentration of 11KA4 increases during pregnancy, and in cord blood, it exceeds the concentrations of both 11OHA4 and 11KT.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Health Care Sciences & Services
Krishna Parekh, Hannah Debra Kravets, Rebecca Spiegel
Summary: Anti-seizure medications (ASMs) are ineffective in preventing seizure recurrence in more than 30% of epilepsy patients. Premenopausal women with epilepsy (WWE) face even greater challenges in treatment due to hormonal fluctuations during the menstrual cycle that can impact seizure frequency and intensity. The interaction between enzyme-inducing ASMs and hormonal contraceptives may result in both loss of seizure control and contraceptive failure. Pregnancy-induced changes in liver and kidney function can accelerate metabolism and elimination of ASMs, leading to breakthrough seizures.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
K. J. Steinman, G. A. Montano, T. R. Robeck
Summary: This study found that cortisol may be a useful predictor of perinatal loss, while cortisol and androstenedione were useful for distinguishing failed to thrive pregnancies. Similarly, both testosterone and estradiol levels during early loss and false pregnancy differed from normal pregnancies.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Sabrina Buoro, Enrico Tombetti, Ferruccio Ceriotti, Caterina Simon, Diego Cugola, Michela Seghezzi, Francesco Innocente, Silvia Maestroni, Maria del Carmen Baigorria Vaca, Valentina Moioli, Giulia Previtali, Barbara Manenti, Yehuda Adler, Massimo Imazio, Antonio Brucato
Summary: The study aimed to establish reference intervals for pericardial fluid, showing high levels of nucleated cells, proteins, albumin, and LDH, consistent with inflammatory exudates in other biological fluids.
Article
Multidisciplinary Sciences
Fang Chen, Yingxin Gong, Yu Xie, Lei Zhu, Limei Chen, Jingjing Xiao, Ninghong Jiang, Li Sun, Long Sui
Summary: This study aimed to provide normal references for uterine size in Chinese reproductive-aged women and conducted a detailed statistical description of the anatomical parameters of the uterus. The study revealed the influence of parity and age on uterine measurements, with thinner myometrium in nulliparous women and larger extrauterine measurements in parous or primiparous women. Weight and BMI were positively correlated with extrauterine measurements and myometrial thickness.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Alex Zhu, Juan Andino, Stephanie Daignault-Newton, Zoey Chopra, Aruna Sarma, James M. M. Dupree
Summary: There is an age-related decline in male testosterone production. It is important to use age-specific cutoffs for low testosterone levels in the evaluation of young men presenting with testosterone deficiency.
JOURNAL OF UROLOGY
(2022)
Article
Psychiatry
Anouk E. de Wit, Erik J. Giltay, Marrit K. de Boer, Fokko J. Bosker, Aviva Y. Cohn, Willem A. Nolen, Ursula B. Kaiser, Hadine Joffe, Brenda W. J. H. Penninx, Robert A. Schoevers
Summary: This study found that plasma androgens within the physiological range have limited effects on depressive disorders in women, with only a slightly higher level of free testosterone in women with current MDD compared to those who never had MDD.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Cell Biology
Michal Gur, Tamir Edri, Sally A. Moody, Abraham Fainsod
Summary: Retinoic acid (RA) is a crucial signal for regulating developmental processes in vertebrate embryos. Inhibiting RA biosynthesis causes various defects in gastrulation, including delayed progression and rostral migration, as well as altered morphogenetic movements and gene expression patterns. These effects are likely due to impaired fibronectin deposition, compromised blastocoel separation, and reduced non-canonical Wnt signaling activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Par Myrelid, Johan D. Soderholm
Summary: This article is linked to papers by Quinn et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Monika A. Sarkar, Ayako Suzuki, Manal F. Abdelmalek, Katherine P. Yates, Laura A. Wilson, Nathan M. Bass, Ryan Gill, Marcelle Cedars, Norah Terrault
Summary: In young women with NAFLD, higher testosterone levels are associated with increased disease severity, particularly in the youngest age group. Elevated testosterone levels may pose a greater risk for NASH and NASH fibrosis, as well as abdominal adiposity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Obstetrics & Gynecology
F. Sultana, S. R. Davis, R. J. Bell, S. Taylor, R. M. Islam
Summary: The association between endogenous testosterone blood concentrations and cognitive performance among postmenopausal women remains inconclusive due to the imprecision of testosterone measurement and the methodological heterogeneity of the included studies.
Article
Obstetrics & Gynecology
Z. N. Azene, S. R. Davis, J. J. McNeil, A. M. Tonkin, D. J. Handelsman, R. M. Islam
Summary: This study investigated the association between estrone and sex hormone binding globulin (SHBG) concentrations with lipid concentrations in older postmenopausal women. The results showed that estrone and SHBG are associated with lipid concentrations in older women, with SHBG providing additional clinical predictive utility for the assessment of cardiometabolic disease risk.
Review
Obstetrics & Gynecology
S. R. Davis
Summary: This article summarizes some of the known information about testosterone in women, including its actions, consequences of depletion and replacement. It is not a comprehensive review of the literature in this field, but provides some informative insights.
Article
Obstetrics & Gynecology
F. Sultana, S. R. Davis, A. M. Murray, R. L. Woods, J. J. McNeil, R. M. Islam
Summary: This study aimed to explore the associations between sex hormones and cognitive performance in older women. The results showed no associations between sex hormones and cognitive performance, but a correlation was found between low sex hormone binding globulin concentrations and better processing speed.
Letter
Obstetrics & Gynecology
S. R. Davis
Review
Endocrinology & Metabolism
Sasha Taylor, Rakibul M. Islam, Robin J. Bell, Chandima Hemachandra, Susan R. Davis
Summary: This study aims to investigate the associations between endogenous testosterone blood concentrations and muscle mass, strength, and performance in community dwelling women. The review found that there is no association between total testosterone and muscle mass, strength, or performance in women. Although calculated free or bioavailable testosterone showed a positive association with lean muscle mass, no association was found for muscle strength or performance.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Robin J. Bell, Penelope J. Robinson, Marina A. Skiba, Rakibul M. Islam, Chandima Hemachandra, Susan R. Davis
Summary: A large-scale study found that endometriosis has a significant impact on sick leave and work ability in women, including those without severe symptoms.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
M. Jahangirifar, E. Fooladi, S. R. Davis, R. M. Islam
Summary: Refugee and asylum seeker women at midlife and beyond face various health challenges, including menopausal symptoms, sexual dysfunctions, and pelvic floor disorders. However, there is limited global knowledge about the prevalence and risk factors of these neglected health issues in this population.
Article
Endocrinology & Metabolism
Jo Wrigglesworth, Ian H. Harding, Rakibul M. Islam, Phillip G. D. Ward, Robyn L. Woods, Robin J. Bell, John J. McNeil, Elsdon Storey, Gary Egan, Anne M. Murray, Ruth E. Trevaks, Stephanie A. Ward, Susan R. Davis, Joanne Ryan
Summary: This study investigated the relationship between circulating sex hormones and structural brain ageing in older women. The findings showed that women with higher levels of DHEA had higher baseline brain ageing, but this association was not significant after controlling for age and other potential confounding factors. Estrone, testosterone, and sex-hormone binding globulin were not associated with brain ageing. Further studies on circulating sex hormones and brain health in postmenopausal women are needed.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Anne R. Cappola, Richard J. Auchus, Ghada El-Hajj Fuleihan, David J. Handelsman, Rita R. Kalyani, Michael McClung, Cynthia A. Stuenkel, Michael O. Thorner, Joseph G. Verbalis
Summary: Multiple changes occur in various endocrine systems as individuals age. The understanding of age-related changes and their clinical management is developing. This statement reviews the current research in different endocrine axes and conditions specific to older individuals, including available therapies, clinical trials, key points, and scientific gaps. The goal is to inform future research to improve prevention and treatment strategies for age-associated endocrine conditions in older individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Susan R. Davis, Karen Magraith
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Endocrinology & Metabolism
David J. Handelsman, Matti Gild, Roderick Clifton-Bligh, Naomi Speers, Dorothy Kouzios, Melissa C. McMartin, Reena Desai
Summary: This study investigated the prevalence of thyroid hormone (TH) abuse among Australian athletes undergoing antidoping tests for WADA-compliant sports. The results showed that only 4 per 1000 athletes had biochemical thyrotoxicosis, and the prevalence of TH usage based on the doping control forms was also 4 per 1000 athletes. These estimates were consistent with international competition data and lower than the estimated T4 prescription rates in the age-matched Australian population.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Endocrinology & Metabolism
David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn G. A. Stuckey, Nandini Shankara-Narayana, Ann J. Conway, Warrick J. Inder, Robert Mclachlan, Carolyn Allan, Alicia J. Jenkins, David Jesudason, Karen Bracken, Gary A. Wittert
Summary: The T4DM study shows that testosterone treatment for men with impaired glucose tolerance or newly diagnosed diabetes reduces the risk of diabetes and improves sleep apnea diagnosis during the study period, but these effects disappear after the study. There is also evidence of androgen dependence in some men receiving prolonged injectable testosterone treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Andrology
David J. Handelsman, Amanda Idan, Sue Sleiman, Fey Bacha, Georgina V. Long, Alexander M. Menzies, Tejnei Vaishnav, Noosha Litkouhi, Xanthie Volckmar, William Ledger, Antoinette Anazodo
Summary: The effects of non-cytotoxic and immunotherapy drugs on human testicular function in cancer patients have not been systematically studied. This study aimed to investigate the effects of these drugs in cancer patients who had not undergone gonadotoxic treatment. The results showed that non-cytotoxic and immunotherapy drugs moderately affected testicular exocrine function (sperm production) and its hormonal correlates (follicle-stimulating hormone, inhibin B), but had minimal impact on testicular endocrine function (testosterone, luteinizing hormone).