Article
Microbiology
Xiang Li, Jiepeng Huang, Tingting Yu, Xiaoting Fang, Liqin Lou, Shijun Xin, Ling Ji, Feizhao Jiang, Yongliang Lou
Summary: This study demonstrates that Fusobacterium nucleatum abundance is significantly higher in CRC tissues and is closely associated with CRC progression. F. nucleatum enhances CRC cell proliferation and migration through activating Cdk5 and the Wnt/beta-catenin signaling pathway, revealing a novel mechanism for CRC development.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Liang Zhang, Chuan-fu Ren, Zhi Yang, Long-bo Gong, Chao Wang, Min Feng, Wen-xian Guan
Summary: FOXS1 plays a role in promoting cell proliferation, migration, invasion, and metastasis in colorectal cancer through the Wnt/beta-catenin signaling pathway, making it a potential target for CRC treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yujing Liu, Chunyan Wang, Peiqiu Cheng, Shengan Zhang, Wenjun Zhou, Yangxian Xu, Hanchen Xu, Guang Ji
Summary: This study found that low FHL1 expression is associated with poor patient survival in colorectal cancer. Experimental results indicate that FHL1 acts as a tumor suppressor in CRC, primarily by inhibiting cell proliferation through regulating the Wnt/beta-catenin signaling pathway.
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Oncology
Jinlai Wei, Xiangru Zheng, Wenjun Li, Xiaoli Li, Zhongxue Fu
Summary: This study found that Sestrin2 inhibits the progression of colorectal cancer by suppressing cell proliferation, migration, and colony formation. It also affects the cancer stemness properties. This is achieved through downregulation of the Wnt signaling pathway. The findings suggest that Sestrin2 could be a promising therapeutic target for colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Pharmacology & Pharmacy
Sha Zeng, Li Chen, Qiang Sun, Hui Zhao, Han Yang, Shan Ren, Maolun Liu, Xianli Meng, Haibo Xu
Summary: The study shows that Scutellarin can suppress colitis-associated cancer in mice by inhibiting the Wnt/β-catenin signaling pathway, leading to alleviation of pathological symptoms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Yanlin Cai, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Shunliang Sheng, Jiayu Zhu
Summary: Globally, ovarian cancer ranks as the second most common cause of gynecologic-related cancer deaths among women, with a poor prognosis. Research has shown that downregulation of AHNAK in ovarian cancer cells can significantly inhibit cell growth and metastasis, partly by dampening the Canonical Wnt cascade. Therefore, AHNAK may serve as a biomarker and potential treatment target for ovarian cancer.
Article
Medicine, Research & Experimental
Guoqiang Yan, Shiquan Li, Meng Yue, Chenyao Li, Zhenhua Kang
Summary: The study revealed that KDM5B is abundantly expressed in colorectal cancer tissues and cells, and high KDM5B expression is associated with poor prognosis. KDM5B activates the Wnt/beta-catenin pathway by downregulating CCL14, promoting the progression of colorectal cancer.
Article
Chemistry, Multidisciplinary
Bowen Li, Hui Ming, Siyuan Qin, Li Zhou, Zhao Huang, Ping Jin, Liyuan Peng, Maochao Luo, Tingting Zhang, Kui Wang, Rui Liu, Yih-Cherng Liou, Edouard C. Nice, Jingwen Jiang, Canhua Huang
Summary: The heat shock 70 kDa protein 8 (HSPA8) is identified as an important regulator in the development of refractory BRAF V600E colorectal cancer (CRC), promoting the activation of the Wnt/beta-catenin signaling pathway and contributing to cancer metastasis and progression. HSPA8 may serve as a predictive biomarker and therapeutic target in clinical practice.
Article
Medicine, Research & Experimental
Wei Zhang, Xianhui Ruan, Yaoshuang Li, Jingtai Zhi, Linfei Hu, Xiukun Hou, Xianle Shi, Xin Wang, Jinpeng Wang, Weike Ma, Pengfei Gu, Xiangqian Zheng, Ming Gao
Summary: The study reveals that KDM1A regulates the stemness of thyroid cancer and promotes cancer progression through the Wnt/beta-catenin pathway. Inhibiting KDM1A can significantly inhibit thyroid cancer progression and enhance sensitivity to chemotherapy.
Article
Cell & Tissue Engineering
Yuhui Xu, Jiali Hu, Qiaoying Lv, Chenyi Shi, Mengdi Qiu, Liying Xie, Wei Liu, Bingyi Yang, Weiwei Shan, Yali Cheng, Bing Zhao, Xiaojun Chen
Summary: This study aimed to investigate the potential therapeutic effects and underlying mechanisms of mesenchymal stem cells (MSCs) on well-differentiated endometrial cancer (EC). The results demonstrated that endometrium-derived MSCs (eMSCs) had the highest inhibitory effect on EC cell viability and xenograft tumor growth compared to adipose-derived MSCs (AD-MSCs) and umbilical-cord-derived MSCs (UC-MSCs). The study also revealed that eMSCs inhibited EC cell proliferation and stemness through the DKK1-Wnt/beta-catenin signaling pathway. Furthermore, the combination of eMSCs and medroxyprogesterone acetate (MPA) showed enhanced inhibition of EC growth. These findings suggest that eMSCs may be a promising therapeutic strategy for young EC patients desiring fertility preservation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Shijun Yu, Li Li, Hui Cai, Bin He, Yong Gao, Yandong Li
Summary: In gastric cancer, overexpression of NELFE is negatively correlated with the prognosis of patients, and NELFE promotes proliferation and metastasis of GC cells both in vitro and in vivo. CSNK2B is identified as a downstream effector of NELFE, and Wnt/beta-catenin signaling may mediate the regulation of CSNK2B by NELFE. Additionally, NELFE, beta-catenin, and CSNK2B are all significantly upregulated in tumor tissues and their expression levels in GC are positively correlated with each other.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Reproductive Biology
Wenjing Hu, Min Li, Youguo Chen, Xinxian Gu
Summary: The research revealed that high expression of UBE2S in HGSOC is associated with poor prognosis. UBE2S promotes proliferation, migration, and invasion of ovarian cancer, and increases Olaparib resistance by activating the Wnt/β-catenin signaling pathway.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Juan Cai, Xueliang Zuo, Zhiqiang Chen, Wenying Zhao, Yiping Zhu, Zhengxiang Zhang, Xiaobing Ye
CANCER MANAGEMENT AND RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Yiping Zhu, Yinzhu Bian, Qun Zhang, Jing Hu, Li Li, Mi Yang, Hanqing Qian, Lixia Yu, Baorui Liu, Xiaoping Qian
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Yiping Zhu, Kai Li, Liang Yan, Yang He, Lu Wang, Lili Sheng
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2020)