Article
Endocrinology & Metabolism
Bo Mi Kim, Sung Eun Kim, Dong-Yun Lee, DooSeok Choi
Summary: In this study, 40 postmenopausal Korean women underwent 12 months of TSEC treatment, showing a significant increase in total hip bone mineral density and specific changes in the parameters of HSA. The findings suggest that TSEC treatment could potentially improve bone geometry in postmenopausal women, providing a promising option for fracture prevention and osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Walter Masson, Leandro Barbagelata, Pablo Corral, Juan P. Nogueira, Augusto Lavalle-Cobo, Alejandra Belardo
Summary: Elevated levels of lipoprotein(a) [Lp(a)] are independently associated with atherosclerotic cardiovascular disease, but this association has been less studied in postmenopausal women. This systematic review aimed to analyze the association between elevated Lp(a) levels and cardiovascular outcomes in postmenopausal women. Ten studies with 157,690 women were included in the analysis. The results showed varying associations between Lp(a) levels and cardiovascular outcomes, with some studies reporting a positive association, some reporting no association, and others reporting different results based on subgroups or outcomes evaluated.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Geriatrics & Gerontology
Petra Stute, Jo Marsden, Noor Salih, Angelo Cagnacci
Summary: Menopausal hormone treatment (MHT) is recommended for managing menopause symptoms, but the Women's Health Initiative (WHI) study showed an increased risk of breast cancer with MHT, leading to a decrease in its use globally. However, further evaluation considering different MHT regimens has shed light on a more nuanced understanding of the risk-benefit profile, particularly regarding progestogen type, prescription pattern, duration of use, and timing of initiation. This review provides a contextual interpretation of the WHI study and evaluates the impact of bioidentical MHT on the risk of chronic non-communicable diseases in post-menopausal women.
Article
Medicine, General & Internal
Jaehoon Lee, Yuntae Kim, Hyunji Park, Changsoo Kim, Sihyun Cho, Jongyoun Kim
Summary: This study investigated the association between different types of hormone replacement therapy (HRT) and atrial fibrillation (AF). The findings showed that current HRT users, except those using estradiol-only HRT, had significantly elevated AF risk, while past users who used estradiol plus progestin HRT had a reduced AF risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chenyue Qian, Jingjin Liu, Huadong Liu
Summary: Heart failure is a significant public health problem worldwide, and premenopausal women have lower rates of developing this disease, possibly due to the cardioprotective effect of estrogen. This review examines the presence of estrogen receptors in the cardiovascular system and their role in the cardioprotective effect, while highlighting the underlying mechanisms and potential treatment approaches for alleviating heart failure.
HEART FAILURE REVIEWS
(2023)
Article
Immunology
Hayoung Choi, Kyungdo Han, Bumhee Yang, Dong Wook Shin, Jang Won Sohn, Hyun Lee
Summary: This study aimed to evaluate the impacts of endogenous estrogen exposure and hormone replacement therapy (HRT) on the risk of nontuberculous mycobacterial pulmonary disease (NTM-PD) in postmenopausal women. The results showed no significant association between endogenous estrogen exposure and NTM-PD risk, but there was a dose-dependent relationship between the duration of HRT and the risk of NTM-PD.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Psychiatry
Hyewon Kim, Juhwan Yoo, Kyungdo Han, Mi Jin Park, Hyun Soo Kim, Jihyun Baek, Hong Jin Jeon
Summary: This study investigated the association between female reproductive factors and the development of newly diagnosed bipolar disorder (BD). The study found that later menopause and breastfeeding for more than one year were associated with a decreased risk of BD occurrence, while receiving hormone therapy was associated with an increased risk.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biology
Tianze Xu, Jing Cai, Lei Wang, Li Xu, Hongting Zhao, Fudi Wang, Esther G. Meyron-Holtz, Fanis Missirlis, Tong Qiao, Kuanyu Li
Summary: Postmenopausal atherosclerosis (AS) is linked to estrogen deficiency, but hormone replacement therapy (HRT) is ineffective in late postmenopausal women. This study suggests that aging-related iron accumulation inhibits the expression of estrogen receptor a (ERa), explaining the inefficacy of HRT. Iron and estradiol together downregulate ERa through Mdm2-mediated proteolysis, aggravating AS. Systemic iron chelation attenuates progressive AS in late postmenopausal mice triggered by estradiol. Immediate HRT after menopause, along with appropriate iron chelation, could provide benefits from AS.
Review
Medicine, General & Internal
Carol M. Mangione, Michael J. Barry, Wanda K. Nicholson, Michael Cabana, Aaron B. Caughey, David Chelmow, Tumaini Rucker Coker, Esa M. Davis, Katrina E. Donahue, Carlos Roberto Jaen, Martha Kubik, Li Li, Gbenga Ogedegbe, Lori Pbert, John M. Ruiz, James Stevermer, John B. Wong
Summary: Menopause is the stage when a person's menstrual cycle stops, defined as 12 months after the final menstrual period. The perimenopausal transition is characterized by variability in menstrual cycle length and increasing periods of amenorrhea, often accompanied by symptoms such as vasomotor dysfunction.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Allergy
Bright I. Nwaru, Syed A. Shah, Holly Tibble, Rebecca Pillinger, Susannah McLean, Dermot Ryan, Hilary Critchley, Catherine M. Hawrylowicz, Colin R. Simpson, Ireneous N. Soyiri, Francis Appiagyei, David Price, Aziz Sheikh
Summary: This study found that previous use of HRT, particularly for more than 2 years, combined HRT, and estrogen-only HRT, is associated with an increased risk of severe asthma exacerbation in perimenopausal/postmenopausal women with established asthma. Lean women and smokers are at greater risk than heavier women and nonsmokers, respectively.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Medicine, General & Internal
Ziyang Ren, Qian Yi, Leying Hou, Tzu Tsun Luk, Yiwen Qiu, Wei Xia, Yimin Zhu, Peige Song, Kazem Rahimi
Summary: This population-based prospective cohort study found a significant association between lactation and a lower risk of stroke, especially ischemic stroke. This emphasizes the importance of promoting breastfeeding as a targeted prevention strategy for stroke.
Article
Oncology
Kara A. Michels, Ashley M. Geczik, Doug C. Bauer, Louise A. Brinton, Diana S. M. Buist, Jane A. Cauley, Cher M. Dallal, Roni T. Falk, Trisha F. Hue, James V. Lacey, Andrea Z. LaCroix, Jeffrey A. Tice, Xia Xu, Britton Trabert
Summary: The study found that progestogens are generally not associated with colorectal cancer risk in postmenopausal women. These findings are consistent with prior research on circulating endogenous sex hormones, suggesting that sex hormones may not be major drivers of colorectal carcinogenesis in postmenopausal women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Medicine, Research & Experimental
Meijun Pan, Jing Zhou, Xinyao Pan, Jing Wang, Qing Qi, Ling Wang
Summary: Postmenopausal symptoms are systemic symptoms associated with estrogen deficiency after menopause. Hormonal therapy (HT) and non-HT are currently used to treat these symptoms, but the best regimen for balancing the benefits and risks is still unclear. This article reviews the characteristics, regimens, and side effects of drugs used in HT and non-HT, providing valuable information for clinical drug selection.
Review
Nutrition & Dietetics
Shengmin Yang, Qingjia Zeng, Xiaohong Huang, Zhen Liang, Hongpu Hu
Summary: The effects of isoflavones on blood lipid profile in postmenopausal females have conflicting results. This meta-analysis found that isoflavone consumption significantly reduced triglyceride concentrations and modestly increased HDL cholesterol concentrations. The effects were more significant in postmenopausal females under 65 years old.
ADVANCES IN NUTRITION
(2023)
Article
Medicine, General & Internal
Alison J. Huang, Steven R. Cummings, Peter Ganz, Michael Schembri, Harini Raghunathan, Eric Vittinghoff, Carolyn J. Gibson, Deborah Grady
Summary: This randomized clinical trial found that continuous use of NTG did not result in sustained improvements in hot flash frequency or severity relative to placebo and was associated with more early but not persistent headache.
JAMA INTERNAL MEDICINE
(2023)
Article
Rheumatology
Kaveh Ardalan, Donald M. Lloyd-Jones, Laura E. Schanberg
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2022)
Review
Cardiac & Cardiovascular Systems
Philip Greenland, Donald M. Lloyd-Jones
Summary: Coronary artery calcium testing is best utilized in selected patients at intermediate risk of ASCVD, where it can help reclassify risk effectively and improve the targeting of drug therapy.
Article
Geriatrics & Gerontology
Aladdin H. Shadyab, Joseph C. Larson, Stephen R. Rapp, Sally A. Shumaker, Candyce H. Kroenke, Jaymie Meliker, Nazmus Saquib, Farha Ikramuddin, Yvonne L. Michael, Joseph S. Goveas, Lorena Garcia, Jean Wactawski-Wende, Juhua Luo, Kathleen M. Hayden, Jiu-Chiuan Chen, Julie Weitlauf, Laura D. Baker
Summary: This study found that lower global cognitive function is associated with higher stress and depressive symptom severity during the COVID-19 pandemic. Higher depressive symptom severity during the pandemic is associated with cognitive decline, and lower global cognitive function during the pandemic is associated with lower odds of practicing safe hygiene.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Jonathan Fix, Macarius M. Donneyong, Stephen R. Rapp, Maryam Sattari, Beverly M. Snively, Jean Wactawski-Wende, Emily W. Gower
Summary: Predictors associated with pneumococcal and seasonal influenza vaccination among older women include race, health insurance, and residential area. The study emphasizes the need to improve access, education, and provider recommendations for vaccination.
PUBLIC HEALTH REPORTS
(2023)
Article
Oncology
Jessica L. Krok-Schoen, Michael L. Pennell, Nazmus Saquib, Michelle Naughton, Xiaochen Zhang, Aladdin H. Shadyab, Candyce H. Kroenke, Jennifer W. Bea, Lindsay L. Peterson, Tracy Crane, Jean Wactawski-Wende, Electra D. Paskett
Summary: Physical activity attenuates cancer-related declines in physical functioning, improves emotional well-being, and prolongs survival among older breast cancer survivors (>65 years). This study found that education, self-rated health, physical functioning, and social support were associated with physical activity in breast cancer survivors. Age, radiation therapy, and pain were also associated with the duration of physical activity.
JOURNAL OF GERIATRIC ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michael J. LaMonte, Joshua H. Gordon, Patricia Diaz-Moreno, Christopher A. Andrews, Daichi Shimbo, Kathleen M. Hovey, Michael J. Buck, J. Wactawski-Wende
Summary: There is an association between oral microbiota and blood pressure regulation as well as development of hypertension in postmenopausal women, suggesting that specific oral bacteria may be related to the risk of hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Bonnie C. Sachs, Sarah A. Gaussoin, Gretchen A. Brenes, Ramon Casanova, Rowan T. Chlebowski, Jiu-Chiuan Chen, Juhua Luo, Stephen R. Rapp, Aladdin H. Shadyab, Sally Shumaker, Jean Wactawski-Wende, Gretchen L. Wells, Kathleen M. Hayden
Summary: The relationship between optimism and cognitive functioning is not fully understood. This study found that less pessimism was associated with a lower risk of mild cognitive impairment (MCI) and dementia, while more optimism did not have a significant relationship with these conditions.
AGING & MENTAL HEALTH
(2023)
Article
Oncology
Kathy Pan, Aaron K. Aragaki, Yvonne Michael, Cynthia A. Thomson, Linda G. Snetselaar, Jean Wactawski-Wende, David O. Garcia, Christina M. Dieli-Conwright, Aladdin H. Shadyab, Nazmus Saquib, Rowan T. Chlebowski
Summary: This study found that women participating in the Women's Health Initiative dietary modification randomized trial had a lower rate of physical inactivity and spent more time in recreational physical activity compared to the control group.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Alexi Vasbinder, Richard K. Cheng, Susan R. Heckbert, Hilaire Thompson, Oleg Zaslavksy, Rowan T. Chlebowski, Aladdin H. Shadyab, Lisa Johnson, Jean Wactawski-Wende, Gretchen Wells, Rachel Yung, Lisa Warsinger Martin, Electra D. Paskett, Kerryn Reding
Summary: This study aimed to investigate the associations between biomarkers and long-term radiation-induced cardiovascular disease (RICVD) in breast cancer survivors. The results showed that a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting that oxidative DNA damage may be a potential pathway for RICVD.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Summary: Preterm birth is associated with increased risk of developing type 2 diabetes at an earlier age, but not with overall risk of incident type 2 diabetes. The association between preterm birth and type 2 diabetes may exist during early years but wane over time.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Medicine, General & Internal
Diddier Prada, Carolyn J. Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen, Gary Miller, Iuliana Ionita-Laza, Eric A. Whitsel, Andrea A. Baccarelli
Summary: Osteoporosis has a major impact on postmenopausal women, and it is influenced by environmental exposures. This study found that criteria air pollutants, such as PM10, NO, NO2, and SO2, were negatively associated with bone mineral density in postmenopausal women. Nitrogen oxides exposure was identified as the leading contributor to bone loss in this population.
Article
Oncology
Ana Babic, Qiao-Li Wang, Alice A. Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K. Tabung, Aladdin H. Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft, Howard D. Sesso, Julie E. Buring, Edward L. Giovannucci, JoAnn E. Manson, Meir J. Stampfer, Kimmie Ng, Charles S. Fuchs, Brian M. Wolpin
Summary: The study found that high levels of adiponectin in the prediagnostic period were associated with shorter survival among women with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR were associated with patient survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)