Article
Clinical Neurology
Vilde Elisabeth Mikkelsen, Ole Solheim, Oyvind Salvesen, Sverre Helge Torp
Summary: The study found that histological features of GBMs may be underestimated when the amount of viable tissue on slides is limited, with most grading features being dependent on tissue amount. Therefore, it is important to consider sampling errors in grading diffuse astrocytic tumors.
ACTA NEUROCHIRURGICA
(2021)
Article
Oncology
Cong Li, Shaoyan Xi, Yingshen Chen, Chengcheng Guo, Ji Zhang, Qunying Yang, Jian Wang, Ke Sai, Jing Zeng, Jing Wang, Zhiqiang Zhang, Chao Ke, Zhongping Chen
Summary: This study aimed to investigate the histopathological characteristics of recurrent gliomas and their clinical significance. The histopathological patterns of recurrent gliomas were found to be related to survival time after reoperation. Primary WHO low-grade or IDH1 mutant gliomas showed a survival benefit mainly on later recurrence.
Article
Biochemistry & Molecular Biology
Huawei Jin, Zhenhua Yu, Tian Tian, Guoping Shen, Weian Chen, Miao Fan, Qun He, Dandan Dai, Xuan Zhang, Dawei Liu
Summary: This study characterized a Chinese glioma cohort using integrative genomic approaches and found molecular differences among patients in different WHO grades. Comparisons of genomic features between glioblastoma (GBM) patients and low-grade glioma (LGG) patients revealed upregulated pathways related to genome integrity and immune cell infiltration in GBM. The study also identified potential prognostic biomarkers in GBM through the analysis of somatic mutations and copy number variations.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemical Research Methods
Maria Giovanna Lizio, Zhiyu Liao, Dustin W. Shipp, Radu Boitor, Raluca Mihai, James S. Sharp, Matthew Russell, Hazem Khout, Emad A. Rakha, Ioan Notingher
Summary: The new technique combining auto-fluorescence spectral imaging and Raman spectroscopy allows for fast intraoperative assessment of excision margins in breast conserving surgery, providing information regarding tumor location within 45 minutes.
BIOMEDICAL OPTICS EXPRESS
(2021)
Review
Oncology
Tara Ma, Caitlin R. Semsarian, Alexandra Barratt, Lisa Parker, Nirmala Pathmanathan, Brooke Nickel, Katy J. L. Bell
Summary: Mammographic screening has led to increased diagnosis and treatment of DCIS. We aimed to identify epidemiological evidence to inform discussion on new management strategies for low-risk DCIS.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Cindy Franklin, Axel Wetter, Hideo Andreas Baba, Jens Theysohn, Johannes Haubold, Ioana Cosgarea, Eva Hadaschik, Elisabeth Livingstone, Lisa Zimmer, Ingo Stoffels, Joachim Klode, Georg Lodde, Jan-Malte Placke, Dirk Schadendorf, Selma Ugurel
Summary: This study assessed the frequency and outcome of CT-guided biopsy in skin cancer patients with radiologically unclear lesions. Results showed a significant proportion of patients with skin cancer metastasis confirmed by CTGB, as well as benign tissue changes and other cancer entities. For patients receiving BRAF/MEK inhibitors, CTGB was effective in confirming suspicious lesions as skin cancer metastasis and leading to treatment changes.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenting Rui, Haopeng Pang, Qian Xie, Yin Wang, Shaofeng Duan, Yan Ren, Zhenwei Yao
Summary: Textural analysis of MRI textures on T1-weighted brain volume with gadolinium contrast enhancement images can differentiate between grade II and grade III gliomas, and is correlated with Ki-67 labeling index and isocitrate dehydrogenase 1 mutation.
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
(2021)
Article
Chemistry, Multidisciplinary
Yangcenzi Xie, Xiaoming Su, Yu Wen, Chao Zheng, Ming Li
Summary: This study reports an artificial intelligent surface-enhanced Raman spectroscopy (SERS) strategy for accurate diagnosis and assessment of breast cancer. The deep learning algorithm trained with SERS spectra achieved a 100% prediction accuracy for different breast cancer subtypes, and when combined with similarity analysis, it can evaluate the surgical outcomes.
Article
Multidisciplinary Sciences
Kenric Tam, Yazeed Alhiyari, Shan Huang, Albert Han, Oscar Stafsudd, Ramesh Shori, Maie St John
Summary: This study demonstrates that Dynamic Optical Contrast Imaging (DOCI) can accurately identify cancer margins and perineural invasion in a murine model of head and neck cancer, aiding in guiding tumor resection.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Manju Dabass, Sharda Vashisth, Rekha Vig
Summary: This paper proposes a convolutional neural network-based technique for automated classification of cancer grades and tissue structures in colon histopathological images. The proposed technique utilizes several modules to extract features and address gradient vanishing issues, and employs various preprocessing techniques to improve network generalizability. Performance evaluation using multiple datasets and expert verification shows competitive results in cancer grade classification and tissue structure classification.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Oncology
Ling-Rui Li, Bo Du, Han-Qing Liu, Chuang Chen
Summary: Artificial intelligence technology plays a crucial role in the diagnosis of thyroid cancers by extracting and analyzing image information, helping to achieve personalized medical strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
M. A. Aswathy, M. Jagannath
Summary: Breast cancer is a leading cause of death in women globally, prompting a focus on healthcare informatics for the classification of breast cancer images. An automatic classification system utilizing SVM classifier and integrated features was proposed and analyzed for accuracy using UCSB and BreakHis datasets. SVM classifier demonstrated higher accuracy compared to other models for breast cancer detection.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Article
Chemistry, Analytical
Adriana P. Mamede, Ines P. Santos, Ana L. M. Batista de Carvalho, Paulo Figueiredo, Maria C. Silva, Maria P. M. Marques, Luis A. E. Batista de Carvalho
Summary: Breast cancer is the most common cancer worldwide in 2021, and early diagnosis and treatment intervention have contributed to a decrease in mortality rate. Spectral histopathology, especially FTIR spectroscopy, has shown great potential as a valuable complement to histopathological analysis, improving the accuracy of diagnosis. This study used FTIR and Raman microspectroscopy to analyze breast cancer tissue samples and successfully constructed two classification models that accurately discriminated between cancerous and normal tissue. The results highlight the potential of spectral histopathology, particularly FTIR, for routine use in pathology laboratories.
Article
Biotechnology & Applied Microbiology
Maria Mangini, Maria Antonietta Ferrara, Gianluigi Zito, Stefano Manago, Alberto Luini, Anna Chiara De Luca, Giuseppe Coppola
Summary: Circulating tumor cells (CTCs), which retain tumor properties and heterogeneity, have high potential clinical values. However, the detection and characterization of CTCs face challenges due to their rarity and difficulty in distinguishing them from white blood cells. Efficient and rapid methods are needed to capture the broad spectrum of tumor cells circulating in the blood.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Glauco Baiocchi, Carlos Eduardo Mattos Cunha Andrade, Reitan Ribeiro, Renato Moretti-Marques, Audrey Tieko Tsunoda, Vanessa Alvarenga-Bezerra, Andre Lopes, Ronaldo Lucio Rangel Costa, Lillian Yuri Kumagai, Levon Badiglian-Filho, Carlos Chaves Faloppa, Henrique Mantoan, Louise De Brot, Ricardo Dos Reis, Bruna Tirapelli Goncalves
Summary: This study aims to investigate the impact of sentinel lymph node biopsy without systematic lymphadenectomy on oncological outcomes in endometrial cancer, and evaluate its effects on patient quality of life.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Cardiac & Cardiovascular Systems
Kai Wang, Xiang-Qian Gao, Tao Wang, Lu-Yu Zhou
Summary: Circular RNA (circRNA) is a stable closed-loop structure that can bind and inhibit the function of microRNA (miRNA). Research has shown that circRNA plays an important role in cell senescence, proliferation, apoptosis, and signaling pathways, making it a potential biomarker and therapeutic target for cardiovascular diseases.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Psychology, Clinical
Jinping Xu, Wenfei Li, Tongjian Bai, Jiaying Li, Jinhuan Zhang, Qingmao Hu, Jiaojian Wang, Yanghua Tian, Kai Wang
Summary: This study found that electroconvulsive therapy (ECT) can selectively induce structural plasticity of the amygdala and hippocampal sub-regions in patients with major depressive disorder (MDD), and these changes are associated with the antidepressant effects of ECT. Additionally, the volume of the hippocampus-amygdala transition area (HATA) can serve as a potential biomarker to predict the effectiveness of ECT.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Huai-Dong Pan, Cui-E Wu, Jia-Hao Chen, Yan Li, Xiu-Qing Zhang, Qing-Hu Teng, Kai Wang, Fu-Pei Liang
Summary: A pair of 2D MOFs were synthesized using 2-hydroxyisophthalic acid as the ligand. They showed similar structural characteristics but had differences in coordination geometry and linkage between the building units.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Physical
Xiangwei Qu, Jingrui Ma, Pai Liu, Kai Wang, Xiao Wei Sun
Summary: This work investigates the voltage sweep behavior of quantum dot light-emitting diodes (QLEDs). It is found that red QLEDs with ZnMgO electron transport layer (ETL) experience a drop in efficiency under consecutive voltage sweeps, while devices with ZnO ETL show an increase in efficiency. The analysis reveals that the efficiency drop in ZnMgO devices is related to hole leakage mediated by trap states on ZnMgO nanoparticles. Furthermore, the hole leakage also causes rapid lifetime degradation of ZnMgO devices.
Article
Cell Biology
Rishi R. Agrawal, Delfina Larrea, Yimeng Xu, Lingyan Shi, Hylde Zirpoli, Leslie G. Cummins, Valentina Emmanuele, Donghui Song, Taekyung D. Yun, Frank P. Macaluso, Wei Min, Steven G. Kernie, Richard J. Deckelbaum, Estela Area-Gomez
Summary: Traumatic brain injury (TBI) can lead to neurodegenerative diseases such as Alzheimer's disease (AD) through mechanisms that remain incompletely characterized. Similar cellular metabolic alterations and modulated cleavage of amyloid precursor protein (APP) are observed in both AD and TBI models. Increased levels of C-terminal fragment of APP (C99) in AD cell models promote the formation of transient lipid raft domains in the endoplasmic reticulum (ER) known as mitochondria-associated ER membranes (MAM domains), which significantly modulate cellular lipid homeostasis. This study provides evidence that alterations in the regulation of MAM and lipid metabolic pathways may contribute to the connection between TBI and AD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Emad Iranmanesh, Jucai Zhai, Congwei Liao, Zihao Liang, Yong Zhao, Hang Zhou, Shengdong Zhang, Charalampos Doumanidis, Anand Prakash Dwivedi, Kai Wang
Summary: This work presents a piezotronic n-p-n bipolar heterojunction transistor (PBJT) for low power AI-sound recognition. It consists of an organic polymer as Base and two inorganic piezoelectric semiconductor ZnO layers as Emitter and Collector, forming a vertically-stacked heterogeneous n-p-n BJT. The device can provide either current or voltage as an output signal and has demonstrated low frequency sound detection, mapping, and recognition using machine learning AI.
IEEE ELECTRON DEVICE LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Chao Gao, Qi Yang, Yihong Qi, Tao Ma, Kuiren Su, Zhou Zhou, Xin Jin, Kai Wang
Summary: This paper reports on a photoelectric integrated device (PID) called dual photodiode-body-biased MOSFETs (PD-MOS) for eye-tracking applications. The CMOS-processed device exhibits low dark current, high gain, wide dynamic range, and low noise current, outperforming other types of photodetectors. It shows great potential for eye tracking in augmented reality, virtual reality, and mixed reality applications.
IEEE ELECTRON DEVICE LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Xianda Zhou, Lei Lu, Yang Liu, Kai Wang, Yufeng Guo, Hanbin Ma, Jun Yu, Arokia Nathan, Johnny K. O. Sin
Summary: In the field of emerging heterogeneous power integration applications, power devices need to be fabricated on metal/glass/organics. Amorphous oxide semiconductors (AOSs) have become the dominant semiconductor material for low-temperature fabrication. The tradeoff between specific ON-resistance (R-ON,sp) and breakdown voltage (BV) in AOSs is discussed and found to be different from that in commonly used single-crystal semiconductors. An analytical model is developed to describe the unique dependence of carrier mobility on carrier concentration in AOSs, showing that R-ON,sp is proportional to BV4. Additionally, the use of a heavily doped drift region under a two-dimensional condition, such as reduced surface field (RESURF) condition, can resolve the issue of mobility degradation.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Neurosciences
Chen Chen, Jinying Han, Shuang Zheng, Xintong Zhang, Haibo Sun, Ting Zhou, Shunyin Hu, Xiaoxiang Yan, Changqing Wang, Kai Wang, Yajuan Hu
Summary: Changes in resting-state EEG microstate parameters were observed in patients with disorders of consciousness (DOCs) after high-definition transcranial direct current stimulation (HD-tDCS), indicating an improvement in consciousness. Specifically, the duration and coverage of class C microstates significantly increased in the responsive group (RE), while these changes have not been reported in the non-responsive group (N-RE). Our findings suggest that EEG neural signatures can be used to assess consciousness states, and that improvement in brain activity dynamics is associated with the recovery of DOCs.
Article
Chemistry, Multidisciplinary
Tianqi Zhang, Pai Liu, Fangqing Zhao, Yangzhi Tan, Jiayun Sun, Xiangtian Xiao, Zhaojing Wang, Qingqian Wang, Fankai Zheng, Xiao Wei Sun, Dan Wu, Guichuan Xing, Kai Wang
Summary: This article introduces a method to enhance electron and hole injection in green InP QLEDs by introducing an electric dipole layer, which forms a strong electric field to facilitate efficient hole hopping, leading to an increase in external quantum efficiency and luminance.
NANOSCALE ADVANCES
(2023)
Article
Psychology, Clinical
Dandan Li, Long Zhang, Tongjian Bai, Bensheng Qiu, Chunyan Zhu, Kai Wang
Summary: This study aimed to investigate the modulatory effect of common variations in the oxytocin receptor gene (OXTR) on reward circuitry function and its relationship with empathy. Using functional connectivity and spontaneous local activity analyses in the nucleus accumbens (NAcc), the results showed that individuals with the rs2268493 TT genotype had lower functional connectivity between the NAcc and the medial prefrontal cortex (mPFC) as well as the inferior frontal gyrus (IFG). These findings suggest that common OXTR variations have a modulatory effect on the connection between the NAcc and the central hubs of empathic networks, providing insights into the neural basis of the modulatory effect of OXTR on empathic behavior.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2023)
Article
Biochemical Research Methods
Hongje Jang, Yajuan Li, Anthony A. A. Fung, Pegah Bagheri, Khang Hoang, Dorota Skowronska-Krawczyk, Xiaoping Chen, Jane Y. Y. Wu, Bogdan Bintu, Lingyan Shi
Summary: Stimulated Raman scattering (SRS) enables high signal-to-noise ratio imaging of metabolic dynamics, but its spatial resolution is limited. We developed an Adam optimization-based pointillism deconvolution (A-PoD) algorithm to achieve super-resolved SRS imaging. A-PoD was applied to compare nanoscopic distributions of proteins and lipids in cells and subcellular organelles. The A-PoD-coupled DO-SRS method allowed for the differentiation of newly synthesized lipids in lipid droplets and revealed metabolic changes in brain samples.
Article
Materials Science, Composites
Zhenyu Wu, Kang Wang, Lin Shi, Xiaoying Cheng, Yanhong Yuan
Summary: In this paper, the impact resistance and damage tolerance of triaxial braid structure laminates at different positions were studied. Results showed that the triaxial braided fabric with quasi-isotropic properties on the impact side caused more significant matrix cracks and larger damage areas. The study provided valuable reference for failure analysis and structure optimization of composite laminates.
POLYMER COMPOSITES
(2023)
Article
Biochemical Research Methods
Zhi Li, Chloe Nguyen, Hongje Jang, David Hoang, SoeSu Min, Ellen Ackerstaff, Jason A. Koutcher, Lingyan Shi
Summary: A multimodal imaging platform integrating DO-SRS, TPF, and SHG imaging is presented in this study to directly visualize and quantify the metabolic activities of TNBC subtypes at a subcellular level. It enables the differentiation of TNBC subtypes based on their level of de novo lipogenesis, protein synthesis, cytochrome c metabolic heterogeneity, and lipid unsaturation rates. Additionally, this platform provides spatial distribution mapping of NAD[P]H and flavin signals, as well as observation of collagen fiber orientations in TNBC tissues.
BIOMEDICAL OPTICS EXPRESS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Lingyan Shi, Hongje Jang
ACCOUNTS OF MATERIALS RESEARCH
(2023)