Toxic effects of triptolide on adrenal steroidogenesis in H295R cells and female rats

A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis

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The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation

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An intracrine view of sex steroids, immunity, and metabolic regulation

(2018) Katya B. Rubinow   Molecular Metabolism

Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids

(2017) Petra Strajhar et al.   TOXICOLOGY

Assessment of the endocrine-disrupting effects of short-chain chlorinated paraffins in in vitro models

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Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy

(2016) Xin Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Adrenocortical endocrine disruption

(2016) Philip W. Harvey   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Role of methotrexate chronotherapy in collagen-induced rheumatoid arthritis in rats

(2016) X. Wang et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells

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Ventilatory, metabolic, and thermal responses to hypercapnia in female rats: effects of estrous cycle, ovariectomy, and hormonal replacement

(2015) Danuzia A. Marques et al.   JOURNAL OF APPLIED PHYSIOLOGY

Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats

(2015) Anna Guldvang et al.   REPRODUCTIVE TOXICOLOGY

Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC–MS based metabolomics study

(2015) Bo Ma et al.   TOXICOLOGY

Assessment of Testicular Corticosterone Biosynthesis in Adult Male Rats

(2015) Naoyuki Maeda et al.   PLoS One

Inadequate corticosterone levels relative to arthritic inflammation are accompanied by altered mitochondria/cholesterol breakdown in adrenal cortex: a steroid-inhibiting role of IL-1β in rats

(2014) Christine Wolff et al.   ANNALS OF THE RHEUMATIC DISEASES

Gene expression profiling and pathway analysis of hepatotoxicity induced by triptolide in Wistar rats

(2013) Jiaying Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: A natural approach in the management of stress and metabolic disorders?

(2013) Lindie Schloms et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-Angiogenic Effect of Triptolide in Rheumatoid Arthritis by Targeting Angiogenic Cascade

(2013) Xiangying Kong et al.   PLoS One

Effect of Triptolide on T-Cell Receptor Beta Variable Gene mRNA Expression in Rats With Collagen-Induced Arthritis

(2012) Jixi Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Effect of triptolide on estradiol release from cultured rat granulosa cells

(2012) Juan Zhang et al.   ENDOCRINE JOURNAL

Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells

(2012) Slavko Komarnytsky et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats

(2011) Jian Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells

(2011) Lindie Schloms et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Triptolide induces adverse effect on reproductive parameters of female Sprague-Dawley rats

(2010) Jing Liu et al.   DRUG AND CHEMICAL TOXICOLOGY

The effect of valproate and levetiracetam on steroidogenesis in forskolin-stimulated H295R cells

(2010) Kristine Von Krogh et al.   EPILEPSIA

Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats

(2010) Li Liu et al.   TOXICOLOGY

In Vitro and in Silico Approaches for Analyzing the Toxicological Effect of Triptolide on Cx43 in Sertoli Cells

(2008) Bin Ni et al.   TOXICOLOGY MECHANISMS AND METHODS