Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 22, Issue 1, Pages 24-29Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2019.1645132
Keywords
Labiatae; Salvia miltiorrhiza; tanshinone diterpene derivatives; antiviral activity; isolation and purification; structure elucidation
Funding
- Fundamental Research Funds for CAMS/PUMC [2018RC350011]
- Drug Innovation Major Project [2018ZX09711001-008-002]
- Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences [2017-I2M-3-010]
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Two new naturally occurring products named salviamine G (1) and 4-methyl-9-(ethoxycarbonyl)-8-naphthoic acid (2) were isolated from the rhizomes of Salvia miltiorrhiza. Their structures were elucidated using spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1 and 2 were screened for their inhibitory activity against HSV-1 and influenza A (H3N2) using acyclovir (ACV, IC50 = 0.67 mu M) and oseltamivir (IC50 = 2.01 mu M) as a positive control. Compound 1 exhibited moderate inhibitory activity against HSV-1 and influenza A (H3N2) with IC50 values of 11.11 and 8.62 mu M, respectively.
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