Article
Infectious Diseases
Juan M. Bustamante, Angel M. Padilla, Brooke White, Lisa D. Auckland, Rachel E. Busselman, Stephanie Collins, Elizabeth L. Malcolm, Briana F. Wilson, Ashley B. Saunders, Sarah A. Hamer, Rick L. Tarleton
Summary: The trypanocidal compound benznidazole (BNZ) was tested for its ability to prevent new infections in dogs. The study found that the current prophylaxis regimen did not impact the incidence of new infections. Further research is needed to determine if a more rigorous and potent dosing regimen can achieve immediate benefits of prophylaxis.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Parasitology
Eleonora Lima Alves Cunha, Fernanda Karoline Vieira da Silva Torchelsen, Katia da Silva Fonseca, Lucas Resende Dutra Sousa, Paula Melo Abreu Vieira, Claudia Martins Carneiro, Kelerson Mauro de Castro Pinto, Rosalia Morais Torres, Marta De Lana
Summary: Treatment with the combination of benznidazole and itraconazole improved or stabilized the clinical condition of dogs infected with a benznidazole-resistant strain of Trypanosoma cruzi, reducing inflammation and fibrosis.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Microbiology
Juliana Magalhaes Chaves Barbosa, Yasmin Pedra Rezende, Tatiana Galvao de Melo, Gabriel de Oliveira, Cynthia Machado Cascabulho, Evelyn Nunes Goulart da Silva Pereira, Anissa Daliry, Kelly Salomao Salem
Summary: Chagas disease, caused by Trypanosoma cruzi, affects millions of people in Latin America. The current treatment options have limitations, and combined therapy with amiodarone and benznidazole shows promise in reducing parasitemia and improving cardiac damage in acutely infected mice.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Juliana Magalhaes Chaves Barbosa, Yasmin Pedra-Rezende, Luiza Dantas Pereira, Tatiana Galvao de Melo, Helene Santos Barbosa, Joseli Lannes-Vieira, Solange Lisboa de Castro, Anissa Daliry, Kelly Salomao
Summary: The combination treatment of Bz + AMD can attenuate the damage caused by T. cruzi infection in cardiac cells and have a certain control effect on parasite replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Food Science & Technology
Diana Zapparoli, Thaina Valente Bertozzo, Marcela Alexandrino, Daniela Filadelfo Sanches, Isabella Neves Aires, Suzane Manzini, Maria Izabel Merino de Medeiros, Cilmery Suemi Kurokawa, Rodrigo Mattos dos Santos, Simone Baldini Lucheis
Summary: This study identified the risk of Trypanosoma cruzi infection in acai ice cream and highlights the need for quality control and good manufacturing practices to ensure the safe consumption of acai-derived products.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mudasir Nabi Peerzada, Aysha Gaur, Amir Azam
Summary: This review discusses drug development strategies for human African and American trypanosomiasis, highlighting the most promising compounds identified through various approaches and emphasizing the potential of molecular hybridization in preventing the development of resistance.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Pathology
Kirsten A. Landsgaard, Sarai M. Milliron, Mayane Faccin, Clark A. Broughton, Lisa D. Auckland, John F. Edwards, Sarah A. Hamer, Martha E. Hensel
Summary: American trypanosomiasis, caused by Trypanosoma cruzi, can affect both the heart and the central nervous system. This study reports 4 cases of dogs with disseminated trypanosomiasis and CNS involvement, confirmed by qPCR. Clinical signs included lethargy, respiratory distress, tetraparesis, and seizures. CNS lesions included meningeal congestion, spinal cord necrosis with hemorrhage, and meningoencephalitis, indicating the need to consider trypanosomiasis as a differential diagnosis for dogs with CNS signs in endemic areas.
VETERINARY PATHOLOGY
(2023)
Article
Chemistry, Medicinal
Raquel Durao, Catia Ramalhete, Ana Margarida Madureira, Eduarda Mendes, Noelia Duarte
Summary: Human African trypanosomiasis and American trypanosomiasis are neglected tropical diseases caused by protozoan parasites. They have spread worldwide due to human migration, military interventions, and climate changes. Finding new drugs from higher plants is a valuable approach to treat these diseases.
Article
Pharmacology & Pharmacy
Robert P. Hunter, Roy Madigan
Summary: This study evaluated the effectiveness of four different formulations of itraconazole and amiodarone. The results showed high variability in serum concentration of itraconazole within the treatment groups, and dosing with the compounded suspensions proved to be challenging.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Biology
Aline Antunes Maciel Bortoluzzi, Izabela Virginia Staffen, Fernanda Weyand Banhuk, Aline Griebler, Patricia Karoline Matos, Thais Soprani Ayala, Edson Antonio Alves da Silva, Maria Helena Sarragiotto, Ivania Teresinha Albrecht Schuquel, Tereza Cristina Marinho Jorge, Rafael Andrade Menolli
Summary: The study investigated the anti-Trypanosoma cruzi activity of Lonchocarpus cultratus root extracts, revealing that the dichloromethane extract showed the highest activity against all tested forms of the parasite, with IC50 values very close to benznidazole. Additionally, both extracts exhibited varying degrees of cytotoxicity against mammalian cells.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemical Research Methods
Jennifer Rokhsar, Brinkley Raynor, Justin Sheen, Neal Goldstein, Michael Levy, Ricardo Castillo-Neyra
Summary: This study investigates the use of the insecticide fluralaner to control the transmission of Trypanosoma cruzi. The results show that in regions with high prevalence, treating dogs with fluralaner can reduce transmission, but in regions with low prevalence, it may increase transmission. Therefore, field trials are necessary before widespread implementation of fluralaner treatment.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Review
Chemistry, Medicinal
Igor Jose dos Santos Nascimento, Thiago Mendonca de Aquino, Edeildo Ferreira da Silva-Junior
Summary: This review discusses the development of cruzain and rhodesain inhibitors in the past 10 years, which could serve as a basis for the discovery of new trypanocidal drugs in the future.118 studies on inhibitors of cruzain and rhodesain were identified, indicating the potential for developing new treatments against Chagas disease and sleeping sickness.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Review
Immunology
Aline Maria Vasconcelos Queiroz, Johny Wysllas de Freitas Oliveira, Claudia Jassica Moreno, Diego M. A. Guerin, Marcelo Sousa Silva
Summary: Current research focuses on using VLP technology to develop vaccines against trypanosomatids, a family of protozoa causing neglected tropical diseases. This approach offers potential to combat diseases such as Chagas disease, leishmaniasis, and sleeping sickness, by targeting protozoan antigens.
Review
Pharmacology & Pharmacy
Gustavo Benaim, Alberto E. Paniz-Mondolfi, Emilia Mia Sordillo
Summary: Repurposing approved drugs for neglected diseases is a accepted strategy, with amiodarone showing promising trypanocidal and leishmanicidal activity through multiple mechanisms.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Microbiology
Juan M. Bustamante, Brooke E. White, Gregory K. Wilkerson, Carolyn L. Hodo, Lisa D. Auckland, Wei Wang, Stephanie McCain, Sarah A. Hamer, Ashley B. Saunders, Rick L. Tarleton
Summary: This study demonstrates that higher dose, intermittent administration of benznidazole can effectively treat Trypanosoma cruzi infection. Administration twice a week, for more than 4 months, provides the best chance for parasitological cure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Letter
Public, Environmental & Occupational Health
Muhammad Mainuddin Patwary, Md. Zahidul Haque, Mondira Bardhan, Alfonso J. Rodriguez-Morales
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2023)
Article
Virology
Seung Hyun Park, Sung Hwi Hong, Kwanghyun Kim, Seung Won Lee, Dong Keon Yon, Sun Jae Jung, Ziad Abdeen, Ramy Abou Ghayda, Mohamed Lemine Cheikh Brahim Ahmed, Abdulwahed Al Serouri, Waleed Al-Herz, Humaid O. Al-Shamsi, Sheeza Ali, Kosar Ali, Oidov Baatarkhuu, Henning Bay Nielsen, Enrico Bernini-Carri, Anastasiia Bondarenko, Ayun Cassell, Akway Cham, Melvin L. K. Chua, Sufia Dadabhai, Tchin Darre, Hayk Davtyan, Elena Dragioti, Barbora East, Robert Jeffrey Edwards, Martina Ferioli, Tsvetoslav Georgiev, Lilian A. Ghandour, Harapan Harapan, Po-Ren Hsueh, Saad I. Mallah, Aamer Ikram, Shigeru Inoue, Louis Jacob, Slobodan M. Jankovic, Umesh Jayarajah, Milos Jesenak, Pramath Kakodkar, Nathan Kapata, Yohannes Kebede, Yousef Khader, Meron Kifle, David Koh, Visnja Kokic Males, Katarzyna Kotfis, Ai Koyanagi, James-Paul Kretchy, Sulaiman Lakoh, Jinhee Lee, Jun Young Lee, Maria da Luz Lima Mendonca, Lowell Ling, Jorge Llibre-Guerra, Masaki Machida, Richard Makurumidze, Ziad A. Memish, Ivan Mendoza, Sergey Moiseev, Thomas Nadasdy, Chen Nahshon, Silvio A. Namendys-Silva, Blaise Nguendo Yongsi, Amalea Dulcene Nicolasora, Zhamilya Nugmanova, Hans Oh, Atte Oksanen, Oluwatomi Owopetu, Zeynep Ozge Ozguler, Konstantinos Parperis, Gonzalo Emanuel Perez, Krit Pongpirul, Marius Rademaker, Nemanja Radojevic, Anna Roca, Alfonso J. Rodriguez-Morales, Enver Roshi, Khwaja Mir Islam Saeed, Ranjit Sah, Boris Sakakushev, Dina E. Sallam, Brijesh Sathian, Patrick Schober, P. Shaik Syed Ali, Zoran Simonovic, Tanu Singhal, Natia Skhvitaridze, Marco Solmi, Kannan Subbaram, Kalthoum Tizaoui, John Thato Tlhakanelo, Julio Torales, Junior Smith Torres-Roman, Dimitrios Tsartsalis, Jadamba Tsolmon, Duarte Nuno Vieira, Sandro G. Viveiros Rosa, Guy Wanghi, Uwe Wollina, Ren-He Xu, Lin Yang, Kashif Zia, Muharem Zildzic, Jae Il Shin, Lee Smith
Summary: The novel coronavirus, SARS-CoV-2, has caused the highly contagious COVID-19 disease which has severely impacted developed and low- to middle-income countries. Nonpharmaceutical interventions (NPIs) such as social distancing, quarantine, and personal hygiene measures have been widely employed. A survey of 92 countries/territories found that quarantine and isolation at designated places were associated with lower incidence and mortality rates, while the use of sanitizer for personal hygiene reduced incidence. Mask deprivation was common regardless of economic level, and higher incidence and mortality were observed in countries/territories with higher economic levels.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Ranjit Sah, Abdelmonem Siddiq, Abdullah Reda, Abdelaziz Abdelaal, Bijaya Kumar Padhi, Aroop Mohanty, Mohammed Amir Rais, Antonio Cascio, Alfonso J. Rodriguez-Morales
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2023)
Editorial Material
Public, Environmental & Occupational Health
D. Katterine Bonilla-Aldana, Julian Ruiz-Saenz, Marlen Martinez-Gutierrez, Wilmer Villamil-Gomez, Hugo Mantilla-Meluk, German Arrieta, Darwin A. Leon-Figueroa, Vicente Benites-Zapata, Joshuan J. Barboza, Agueda Munoz-Del-Carpio-Toia, Oscar H. Franco, Maritza Cabrera, Ranjit Sah, Jaffar A. Al-Tawfiq, Ziad A. Memish, Fatma A. Amer, Jose Antonio Suarez, Andres F. Henao-Martinez, Carlos Franco-Paredes, Alimuddin Zumla, Alfonso J. Rodriguez-Morales
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Editorial Material
Public, Environmental & Occupational Health
Alfonso J. Rodriguez-Morales, Aula Abbara, Francine Ntoumi, Nathan Kapata, Peter Mwaba, Dorothy Yeboah-Manu, Markus Maeurer, Osman Dar, Ibrahim Abubakar, Alimuddin Zumla
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Editorial Material
Public, Environmental & Occupational Health
Avinash Sharma, Brian McCloskey, David S. Hui, Aayushi Rambia, Adam Zumla, Tieble Traore, Shuja Shafi, Sherif A. El-Kafrawy, Esam I. Azhar, Alimuddin Zumla, Alfonso J. Rodriguez-Morales
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Microbiology
Cristina Aguirre, Jaime David Acosta-Espana, Sheila Jissela Patajalo-Villata, Alfonso J. Rodriguez-Morales
Summary: We reported the first case of coinfection with Curvularia hawaiiensis and Mycobacterium tuberculosis necrotising pneumonia in a 16-year-old female patient. It is crucial to carefully examine patients with tuberculosis, as they may rarely be coinfected with unusual fungi.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Immunology
Sarya Swed, Haidara Bohsas, Hidar Alibrahim, Amine Rakab, Wael Hafez, Bisher Sawaf, Rais Mohammed Amir, Ahmed Sallam Motawei, Ahmed Aljabali, Sheikh Shoib, Ismail Atef Ismail Ahmed Ibrahim, Sondos Hussein Ahmad Almashaqbeh, Ebrahim Ahmed Qaid Shaddad, Maryam Alqaisi, Ahmed Abdelrahman, Sherihan Fathey, Rene Hurlemann, Mohamed E. G. Elsayed, Joshuan J. Barboza, Aroop Mohanty, Alfonso J. Rodriguez-Morales, Bijaya Kumar Padhi, Ranjit Sah
Summary: This study aims to evaluate the attitudes of the general Arabic population towards monkeypox disease, fears, and vaccine adoption, and compare them to those of the COVID-19 pandemic. The results showed that most participants were more concerned about COVID-19 than monkeypox, and had inadequate knowledge about monkeypox disease. Immediate action is needed to address this issue and enhance learning and information dissemination about monkeypox.
Article
Infectious Diseases
Kovy Arteaga-Livias, Vicky Panduro-Correa, Jorge L. Maguina, Jorge Osada, Ali A. Rabaan, Kiara Lijarza-Ushinahua, Joshuan J. Barboza, Walter Gomez-Gonzales, Alfonso J. Rodriguez-Morales
Summary: This study aimed to understand the compliance and factors associated with the use of the clinical practice guidelines for antibiotic prophylaxis in gynecological surgeries in two hospitals in Huanuco, Peru. The results showed low compliance with the guidelines, indicating inadequate antimicrobial prophylaxis in the hospitals studied.
Article
Public, Environmental & Occupational Health
Santa Kumar Das, Abhinav Bhattarai, Simran Kc, Sangam Shah, Kiran Paudel, Sakchhyam Timsina, Sunraj Tharu, Laba Rawal, Dawin A. Leon-Figueroa, Alfonso J. Rodriguez-Morales, Joshuan J. Barboza, Ranjit Sah
Summary: Although no confirmed human monkeypox cases have been reported in Nepal, the country is at risk of an outbreak. A study was conducted to assess the knowledge and attitude of Nepalese healthcare workers regarding monkeypox. It revealed a low level of knowledge and a negative attitude, highlighting the need for education and awareness.
FRONTIERS IN PUBLIC HEALTH
(2023)
Letter
Infectious Diseases
Muhammad Mainuddin Patwary, Juvair Hossan, Sharif Mutasim Billah, Md Pervez Kabir, Alfonso J. Rodriguez-Morales
NEW MICROBES AND NEW INFECTIONS
(2023)
Article
Infectious Diseases
Gulden Eser-Karlidag, Enrique Chacon-Cruz, Yasemin Cag, Jose Arturo Martinez-Orozco, Humberto Gudino-Solorio, Raul Adrian Cruz-Flores, Andrea Gonzalez-Rodriguez, Daniela Martinez-Nieves, Mario Gomez-Zepeda, Andrea Calderon-Suarez, Huelya Caskurlu, Antonio Cascio, Ricardo Fernandez, Greisha M. Gonzales, Pedro Palma, Corneliu Petru Popescu, Roman Stebel, Botond Lakatos, Eva Nagy, Massimiliano Lanzafame, Amani El-Kholy, Buse Tuncer, Iva Christova, Stefka Krumova, Alexandre Naime Barbosa, Juan Pablo Escalera-Antezana, Ruben Castillo-Quino, Carlos Eduardo Gonzales-Flores, Miriam Moreira-Flores, Marcelo Felipe Batallanos-Huarachi, Christian Gomez-Davila, Rusmir Baljic, Tarsila Vieceli, Olumuyiwa Elijah Ariyo, Mireia Cairo Llobell, Osasona Oluwadamilola Gideon, Augustus Osborne, Umran Elbahr, Philippe Bossi, Antonella Tammaro, Alfonso J. Rodriguez-Morales, Hakan Erdem
Summary: In this study, 647 confirmed Mpox cases were investigated. The study found that Mpox is commonly transmitted through sexual contact, and the main symptoms include rashes, lymphadenopathy, and fever. Furthermore, there is a high association between HIV infection and Mpox. Therefore, it is important to enhance our understanding of this disease and implement effective public health measures to control its spread.
NEW MICROBES AND NEW INFECTIONS
(2023)
Editorial Material
Infectious Diseases
Maryam Shafaati, Hitesh Chopra, Priyanka, Rekha Khandia, Om Prakash Choudhary, Alfonso J. Rodriguez-Morales
NEW MICROBES AND NEW INFECTIONS
(2023)
Article
Immunology
Raushan Kumar Chaudhary, L. Ananthesh, Prakash Patil, Uday Venkat Mateti, Sanjit Sah, Aroop Mohanty, Rama S. Rath, Bijaya Kumar Padhi, Sumira Malik, Kadhim Hussein Jassim, Moustafa A. Al-Shammari, Yasir Waheed, Prakasini Satapathy, Joshuan J. Barboza, Alfonso J. Rodriguez-Morales, Ranjit Sah
Summary: This study identified key genes and pathways associated with H5N1 infection in humans through protein-protein interaction and functional enrichment analysis. These hub genes and pathways play important roles in the diagnosis, prognosis, and treatment of H5N1 infection.
Article
Medicine, General & Internal
Walter Gomez-Gonzales, Anthony Alvarado-Garcia, Marytte Suarez-Mamani, Bernardo Damaso-Mata, Vicky Panduro-Correa, Jorge L. Maguina, Samuel Pecho-Silva, Ali A. Rabaan, Alfonso J. Rodriguez-Morales, Kovy Arteaga-Livias
Summary: This study investigated the presence of antibiotic-resistant bacteria on cell phones of vendors in a Peruvian market and identified associated factors. The results showed that 92.1% of the cell phones had bacterial growth, predominantly Gram-positive bacteria. 17% of the cultures exhibited resistance to at least three antibiotics. Factors associated with antibiotic-resistant bacteria on cell phones included a short distance between customers and vendors, lack of a cell phone case, and having a touchscreen.
MEDICINA-LITHUANIA
(2023)