Article
Infectious Diseases
Wesley D. Kufel, Katie A. Parsels, Bruce E. Blaine, Jeffrey M. Steele, Robert W. Seabury, Elizabeth A. Asiago-Reddy
Summary: This study aimed to evaluate the incidence of serotonin toxicity among hospitalized patients who received linezolid with or without concurrent serotonergic agents. The results showed that even among patients who received multiple and high-dose serotonergic agents along with linezolid, the incidence of serotonin toxicity was exceedingly rare.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Rheumatology
Renata Baronaite Hansen, Titilola Falasinnu, Mikkel Faurschou, Soren Jacobsen, Julia F. Simard
Summary: This study aimed to determine whether diabetes mellitus (DM) increases the risk of end-stage renal disease (ESRD) in patients with systemic lupus erythematosus (SLE). The findings show that SLE patients with DM have a 3 times higher risk of developing ESRD compared to SLE patients without DM.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Fawzy Elbarbry, Nicholas Moshirian
Summary: This systematic review evaluates the evidence linking linezolid to serotonin toxicity when used alone or in combination with other serotonergic agents. The results show a low incidence of serotonin toxicity both in linezolid monotherapy and combination therapy, and symptom resolution is achieved in most cases after discontinuation of linezolid and serotonergic agents.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Rheumatology
Andrea Fava, Paride Fenaroli, Avi Rosenberg, Serena Bagnasco, Jessica Li, Jose Monroy-Trujillo, Derek Fine, Mohamed G. Atta, Michelle Petri
Summary: This study aims to elucidate the prognostic value of a history of class switch in pure membranous lupus nephritis (LN). The findings suggest that the conversion from proliferative to membranous LN, and vice versa, is frequent in SLE patients, and can occur at any time during the course of the disease. Evidence of prior proliferative LN is associated with a higher risk of end stage kidney disease (ESKD) in non-proliferative LN.
Article
Urology & Nephrology
Giovanni Maria Rossi, Umberto Maggiore, Francesco Peyronel, Paride Fenaroli, Marco Delsante, Giuseppe Daniele Benigno, Davide Gianfreda, Maria Letizia Urban, Zerai Manna, Lois Johanna Arend, Serena Bagnasco, Augusto Vaglio, Enrico Fiaccadori, Avi Z. Rosenberg, Sarfaraz Hasni, Lucio Manenti
Summary: Early biomarkers play an important role in predicting the risk of end-stage kidney disease (ESKD) or death in proliferative lupus nephritis (LN).
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Rakesh Mishra, Ramalingam Bethunaickan, Celine C. Berthier, Zhengzi Yi, Joshua J. Strohl, Patricio T. Huerta, Weijia Zhang, Anne Davidson
Summary: The study found significant disruption of renal circadian rhythms in mice with lupus nephritis, affecting multiple renal pathways including homeostasis, metabolism, and blood pressure regulation. Induction of remission therapy partially reversed this circadian dysregulation.
MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Savino Sciascia, Martina Cozzi, Alice Barinotti, Massimo Radin, Irene Cecchi, Roberta Fenoglio, Daniele Mancardi, Georgia Wilson Jones, Daniela Rossi, Dario Roccatello
Summary: Fibrosis is a pathological process that can affect the kidney, leading to persistent inflammation or long-term injury. Recently, there has been increasing attention on interstitial fibrosis and tubular atrophy as markers of injury severity, predictors of treatment response, and prognostic factors for renal outcome in lupus nephritis (LN). This review explores the mechanisms of fibrogenesis in LN and the importance of the chronicity index in predicting treatment response and renal prognosis. Understanding the cellular and molecular pathways involved in fibrosis in LN could help identify individuals at higher risk of chronic kidney disease and develop new therapeutic strategies for lupus patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xavier Cabana-Puig, Xin M. Luo
Summary: This protocol presents a quick and simple method to measure protein levels in urine, as well as a method to isolate kidney mononuclear cells and an immunohistochemical method to study protein deposition and leukocyte infiltration in the kidneys. These methods can help investigate the progression of chronic inflammation associated with lupus-prone mice kidneys.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Urology & Nephrology
Maliha Ahmed, Tanzy Love, Catherine Moore, Thu H. Le, Jerome Jean-Gilles, Bruce Goldman, Hae Yoon Grace Choung
Summary: Some patients without overt systemic lupus erythematosus (SLE) present with lupus nephritis-like biopsy findings. It remains unclear how to classify or treat these patients. Lupus-like nephritis (LLN) may be a manifestation of an autoimmune process that overlaps with SLE.
Article
Immunology
Fei-fei Chen, Xiao-tian Liu, Juan Tao, Zhao-min Mao, Hui Wang, Ying Tan, Zhen Qu, Feng Yu
Summary: The current study aimed to evaluate the activation of renal NLRP3 inflammasome pathway in Chinese lupus nephritis (LN) patients and its clinicopathological significances. It was found that expressions of NLRP3, ASC, caspase-1, IL-1 beta and IL-18 were significantly higher in the kidneys of LN patients, mainly in glomerular mesangial cells, podocytes, renal tubular epithelial cells, and macrophages. The expressions of NLRP3, ASC, caspase-1, and IL-1 beta were positively correlated with SLEDAI scores and renal pathological activity indices, while NLRP3 expression was negatively associated with chronicity scores. Furthermore, glomerular caspase-1 levels were positively correlated with foot process width, and podocyte injury markers were decreased significantly in LN patients with higher caspase-1 expression. The findings suggest that renal NLRP3 inflammasome is activated in LN patients and correlated with disease activity, which warrants further exploration.
CLINICAL IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Ioannis Parodis, Julius Lindblom, Nursen Cetrez, Leonardo Palazzo, Henri Ala, Frederic A. Houssiau, Christopher Sjoewall, Brad H. Rovin
Summary: In this study, we evaluated the efficacy of belimumab in preventing de novo renal flares and identified factors associated with renal flare occurrence. We found that Asian origin, positive baseline anti-double stranded DNA levels, and increasing mean prednisone dose during follow-up were associated with de novo renal flares.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Gema Maria Lledo-Ibanez, Marc Xipell, Manuel Ferreira, Manel Sole, Adriana Garcia-Herrera, Ricard Cervera, Luis F. Quintana, Gerard Espinosa
Summary: The role of repeat kidney biopsy in patients with lupus nephritis after achieving renal remission was assessed in this study. The results showed that repeat kidney biopsy can provide valuable information to guide immunosuppressive maintenance therapy.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Yuqiang Chen, Lisha Zhang, Qin Xue, Niansong Wang
Summary: This study explored the infection profile and risk factors for mortality in patients with end-stage renal disease (ESRD) attributable to systemic lupus erythematosus (SLE). The results showed that infections were common in these patients, and several risk factors were associated with higher mortality. The study recommended prompt initiation of antibiotics once infection is identified.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yi Zhang, Lingzhen Hu, Xiang Li, Liheng Chen, Xuyan Yang
Summary: Patients with active SLE had higher levels of serum Slit2, especially those with chronic kidney disease (CKD), indicating a potential correlation between serum Slit2 levels and disease activity in SLE. Moreover, renal expression of Slit2 and its receptor Robo1 were elevated in patients with lupus nephritis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Rheumatology
Christine B. Bernal, Leonid D. Zamora, Sandra V. Navarra
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2015)
Meeting Abstract
Rheumatology
V. Golder, R. Kandane-Rathnayake, A. Hoi, W. Louthrenoo, Y. An, Z. G. Li, S. F. Luo, S. Sockalingam, C. S. Lau, A. L. Lee, M. Y. T. Mok, A. Lateef, K. Franklyn, S. V. Navarra, L. Zamora, Y. -J. Wu, L. Hamijoyo, M. Chan, S. O'Neill, F. Goldblatt, M. Huq, M. Nikpour, E. F. Morand
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Rheumatology
Rangi Kandane-Rathnayake, Vera Golder, Worawit Louthrenoo, Shue-Fen Luo, Yeong-Jian Jan Wu, Zhanguo Li, Yuan An, Aisha Lateef, Sargunan Sockalingam, Sandra V. Navarra, Leonid Zamora, Laniyati Hamijoyo, Yasuhiro Katsumata, Masayoshi Harigai, Madelynn Chan, Sean O'Neill, Fiona Goldblatt, Yanjie Hao, Zhuoli Zhang, Jamal Al-Saleh, Munther Khamashta, Tsutomu Takeuchi, Yoshiya Tanaka, Sang-Cheol Bae, Chak Sing Lau, Alberta Hoi, Mandana Nikpour, Eric F. Morand
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2019)
Article
Rheumatology
Sandra V. Navarra, Leonid D. Zamora, Ma. Theresa M. Collante
CLINICAL RHEUMATOLOGY
(2020)
Article
Rheumatology
Leonid D. Zamora, Ma. Theresa M. Collante, Sandra V. Navarra
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2020)
Article
Rheumatology
Rangi Kandane-Rathnayake, Worawit Louthrenoo, Shue-Fen Luo, Yeong-Jian J. Wu, Yi-Hsing Chen, Vera Golder, Aisha Lateef, Jiacai Cho, Sandra Navarra, Leonid Zamora, Laniyati Hamijoyo, Sargunan Sockalingam, Yuan An, Zhanguo Li, Ricardo Montes, Shereen Oon, Yasuhiro Katsumata, Masayoshi Harigai, Yanjie Hao, Zhuoli Zhang, Madelynn Chan, Jun Kikuchi, Tsutomu Takeuchi, Fiona Goldblatt, Sean O'Neill, Sang-Cheol Bae, Chak S. Lau, Alberta Hoi, Chetan S. Karyekar, Mandana Nikpour, Eric F. Morand
Summary: This study examined medication use patterns in systemic lupus erythematosus (SLE) using data from a large multicenter longitudinal cohort. The results showed that most patients received combination treatment, with high persistence for glucocorticoids (GCs) and low persistence for immunosuppressants (IS). Patients with higher disease activity received more medication combinations but had lower IS persistence.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Vera Golder, Rangi Kandane-Rathnayake, Alberta Yik-Bun Hoi, Molla Huq, Worawit Louthrenoo, Yuan An, Zhan Guo Li, Shue Fen Luo, Sargunan Sockalingam, Chak Sing Lau, Mo Yin Mok, Aisha Lateef, Kate Franklyn, Susan Morton, Sandra Teresa V. Navarra, Leonid Zamora, Yeong-Jian Wu, Laniyati Hamijoyo, Madelynn Chan, Sean O'Neill, Fiona Goldblatt, Mandana Nikpour, Eric Francis Morand
ARTHRITIS RESEARCH & THERAPY
(2017)