Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 14, Issue -, Pages 6539-6553Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S208489
Keywords
oleic acid; nanostructured lipid carrier; neutrophil; reactive oxygen species; superoxide; elastase
Funding
- Ministry of Science Technology [MOST 106-2320-B-255-003-MY3, MOST 107-2320-B-182A-008-MY3, MOST 104-2320-B-255-004-MY3]
- Ministry of Education [EMRPD1G0231, EMRPD1H0381]
- Chang Gung Memorial Hospital, Taiwan [CMRPF1F0011similar to3, CMRPF1F0061similar to3, CMRPF1G0241similar to3, BMRP450]
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Aim: This paper reports on the incorporation of oleic acid (OA) within nanostructured lipid carriers (OA-NLC) to improve the anti-inflammatory effects in the presence of albumin. Materials and methods: NLCs produced via hot high-shear homogenization/ultrasonication were characterized in terms of particle size, zeta potential, and toxicity. We examined the effects of OA-NLC on neutrophil activities. Dermatologic therapeutic potential was also elucidated by using a murine model of leukotriene B4-induced skin inflammation. Results: In the presence of albumin, OA-NLC but not free OA inhibited superoxide generation and elastase release. Topical administration of OA-NLC alleviated neutrophil infiltration and severity of skin inflammation. Conclusion: OA incorporated within NLC can overcome the interference of albumin, which would undermine the anti-inflammatory effects of OA. OA-NLC has potential therapeutic effects in topical ointments.
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