Article
Immunology
Elena G. Novoselova, Olga Glushkova, Sergey M. Lunin, Maxim O. Khrenov, Svetlana B. Parfenyuk, Tatyana Novoselova, Mars G. Sharapov, Alina E. Gordeeva, Vladimir Novoselov, Evgeny E. Fesenko
Summary: The study showed that both Thymulin and PRDX6 have positive effects in anti-diabetes and anti-inflammatory mechanisms. By evaluating various indicators such as blood glucose, body weight, cell counts, and inflammatory cytokine concentrations, it was found that Thymulin and PRDX6 can improve physiological impairments in diabetic mice.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ting Chen, Xiaoxiao Tan, Fan Xia, Ya Hua, Richard F. Keep, Guohua Xi
Summary: The study found that macrophages in the choroid plexus play a key role in the pathogenesis of hydrocephalus. Injection of Prx2 into the choroid plexus can alter the number, location, and immunophenotype of macrophages, while co-injection of clodronate liposomes can reduce the number of macrophages and attenuate Prx2-induced hydrocephalus and ventricular wall damage.
Article
Cardiac & Cardiovascular Systems
Jing Li, Cong Wang, Wenjing Wang, Lingzi Liu, Qingqing Zhang, Jun Zhang, Bo Wang, Shujing Wang, Li Hou, Chuanzhou Gao, Xiao Yu, Lei Sun
Summary: PRDX2 plays a protective role in AS progression by inhibiting VSMC phenotype alteration and function through the MAPK signaling pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Liwei Zhang, Zhiwei Wang, Mingxing Li, Peng Sun, Tao Bai, Wang Wang, Hualong Bai, Jianjun Gou, Zhiju Wang
Summary: HCG18 participates in vascular invasion of HCC by regulating macrophages and tumor stern cells through three key transcription factors, YBX1, ILF2, and HMGA1. The expression levels of core genes are associated with stem cell scores and tumor differentiation. High HCG18 expression indicates sensitivity to immune checkpoint therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shubhnita Singh, Ariane Bruder-Nascimento, Eric J. Belin de Chantemele, Thiago Bruder-Nascimento
Summary: The study demonstrates that CCL5 activates Nox1 in the vasculature, leading to vascular injury likely via NFkB and Erk1/2 pathways. CCR5 antagonists and Nox1 inhibitors are suggested as potential compounds to reduce cardiovascular risk associated with medical procedures and vascular diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yao Shi, Haojie Zhang, Shuang Li, Danqing Xin, Shiyang Li, Bing Yan, Shuanglian Wang, Chuanyong Liu
Summary: The study aimed to investigate the effects of procyanidin on colitis and the regulation of macrophage polarization. The results showed that procyanidin could alleviate colitis by preventing the polarization of macrophages to the proinflammatory type and downregulating proinflammatory factors. This study provides new insights into the pathogenesis and treatment of inflammatory diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Shengnan Wang, Lulu Zhao, Hong Liu, Ruilan Han, Yang Liu, Jie Gao, Ren Bu, Bing Li, Lijun Sun, Jian Hao, Jianrong Zhao, Gang Li
Summary: Vascular calcification is the main reason for the high incidence of cardiovascular disease in chronic kidney disease patients, and this study found that lanthanum hydroxide can inhibit the occurrence and development of vascular calcification by inhibiting the activation of hypoxia-inducible factor.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Cell Biology
Carlotta Tacconi, Catharina D. Commerford, Lothar C. Dieterich, Simon Schwager, Yuliang He, Kristian Ikenberg, Ekaterina Friebel, Burkhard Becher, Sonia Tugues, Michael Detmar
Summary: This study shows that CD169(+) lymph node macrophages play a protective role in breast cancer metastasis, and their expansion is linked to B cell expansion in tumor-draining lymph nodes. Depletion of these macrophages increases metastatic burden, highlighting the caution needed in targeting tumor-associated macrophages to avoid unintended consequences in tumor-draining lymph nodes.
Article
Biochemistry & Molecular Biology
Dahua Chen, Xiaoqi Dong, Dawei Chen, Jieqiong Lin, Ting Lu, Jianwei Shen, Hua Ye
Summary: This study found that the deletion of the Cdh1 gene may contribute to the occurrence and progression of NAFLD by promoting Akt phosphorylation and inhibiting the PPAR/PGC-1 alpha signaling pathway. The results of this study are of great significance for a better understanding of the pathogenesis of NAFLD and the development of related therapeutic strategies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Xiaoning Wei, Zhenbao Shen, Mengmeng Zhu, Mengyuan Fang, Shengnan Wang, Tingting Zhang, Baotong Zhang, Xiaoxiao Yang, Zhilin Lv, Yajun Duan, Meixiu Jiang, Chuanrui Ma, Qingshan Li, Yuanli Chen
Summary: Diabetes is a serious disease that poses significant health and economic burdens. The number of diabetes patients globally and in China is increasing rapidly.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xin He, Wei Yuan, Fei Liu, Juan Feng, Yanxia Guo
Summary: This study demonstrates the neuroprotective effects of ghrelin in 6-OHDA-induced PD models by improving autophagic flux dysfunction and restoring TFEB level. This effect is achieved through regulating the expression of autophagy-related proteins, increasing cell viability, and reducing the levels of apoptosis-related proteins.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Chen Wang, Haoyu Wu, Yuanming Xing, Yulan Ye, Fangzhou He, Qian Yin, Yujin Li, Fenqing Shang, John Y. -J. Shyy, Zu-Yi Yuan
Summary: Endothelial dysfunction and vascular smooth muscle cell plasticity play a critical role in the pathogenesis of hypertension and arterial stiffness. This study found that endothelial-derived microRNA-92a (miR-92a) promotes arterial stiffness by regulating the communication between endothelial cells and smooth muscle cells. Inhibition of miR-92a can ameliorate arterial stiffness and impaired vasodilation induced by Angiotensin II.
SCIENTIFIC REPORTS
(2022)
Article
Hematology
Caleb A. Padgett, Robert K. Batori, Andrew C. Speese, Cody L. Rosewater, Weston B. Bush, Cassandra C. Derella, Stephen B. Haigh, Hunter G. Sellers, Zachary L. Corley, Madison A. West, James D. Mintz, Brittany B. Ange, Ryan A. Harris, Michael W. Brands, David J. R. Fulton, David W. Stepp
Summary: Deletion of GAL3 normalizes microvascular endothelial function in obese db/db mice, likely through a NOX1-mediated mechanism. Pathological levels of GAL3, and in turn NOX1, are amenable to improvements in metabolic status.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Reproductive Biology
K. Zheng, Wenli Hong, Haifeng Ye, Ziqiong Zhou, Shuyi Ling, Yuan Li, Yuqing Dai, Zhisheng Zhong, Ziwei Yang, Yuehui Zheng
Summary: This study found that Chitosan Oligosaccharides (Cos) promoted the proliferation of ovarian germline stem cells (OGSCs) and improved ovarian function by regulating inflammatory factors. Macrophages also played an important role in this process. These findings provide new drug treatment options and methods for the prevention and treatment of premature ovarian failure and infertility.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Anna Alwani, Aneta Andreasik, Rafal Szatanek, Maciej Siedlar, Monika Baj-Krzyworzeka
Summary: Monocytes, as a type of blood cells, serve as a link between innate and adaptive immunity, being both precursors of macrophages and effector cells like phagocytes or cytotoxic cells. At the tumor site, monocytes/macrophages are important indicators for cancer recovery. The role of small regulatory miRNA in monocyte formation, maturation, and function is crucial.
