Article
Cardiac & Cardiovascular Systems
E. Aribas, F. Ahmadizar, U. Mutlu, M. K. Ikram, D. Bos, J. S. E. Laven, C. C. W. Klaver, M. A. Ikram, J. L. Roeters van Lennep, M. Kavousi
Summary: The study found that a more androgenic profile was associated with more microvascular damage in both women and men. However, among women, higher androgen levels were also associated with less macrovascular damage.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Bu B. Yeap, Ross J. Marriott, Leen Antonio, Yi X. Chan, Suchitra Raj, Girish Dwivedi, Christopher M. Reid, Bradley D. Anawalt, Shalender Bhasin, Adrian S. Dobs, Graeme J. Hankey, Alvin M. Matsumoto, Paul E. Norman, Terence W. O'Neill, Claes Ohlsson, Eric S. Orwoll, Dirk Vanderschueren, Gary A. Wittert, Frederick C. W. Wu, Kevin Murray
Summary: The study showed that lower serum testosterone levels were independently associated with higher all-cause and cancer-related mortality in middle-aged to older men, while lower SHBG levels were independently associated with lower all-cause, CVD-related, and cancer-related mortality. Confirmation of these associations and causality would require mechanistic studies and prospective trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Shuai Yuan, Lijuan Wang, Jing Sun, Lili Yu, Xuan Zhou, Jie Yang, Yimin Zhu, Dipender Gill, Stephen Burgess, Joshua C. Denny, Susanna C. Larsson, Evropi Theodoratou, Xue Li
Summary: This study used Mendelian randomization to investigate the associations between sex hormone binding globulin (SHBG), testosterone, and estradiol levels and disease outcomes. The results suggest a causal relationship between sex hormones and several health outcomes.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ali Alquraini
Summary: This study evaluated the efficacy of hexaconazole to bind with sex hormone-binding globulin (SHBG) and found that it has a stable molecular interaction with SHBG, leading to significant endocrine disruption during agricultural work.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yutang Wang
Summary: This study established criteria for low SHBG among US adults and found the estimated national prevalence to be 3.3% in men and 2.7% in women. Risk factors for this condition include higher BMI, diabetes, ethnicity, COPD, coronary heart disease, and smoking.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Nuozhou Liu, Ying Feng, Xinyao Luo, Xue Ma, Fang Ma
Summary: This study reveals an association between a proinflammatory diet and decreased levels of SHBG in women, particularly in premenopausal women.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Elif Aribas, Jeanine E. Roeters van Lennep, Yolanda B. De Rijke, Joop S. E. Laven, Mohammad Arfan Ikram, Robin P. Peeters, Maryam Kavousi
Summary: This study provides reference values for sex steroids and SHBG levels in men and women across different age groups, highlighting sex-specific trends with aging. These findings are important for investigating the impact of sex steroids and SHBG on health outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Clinical Neurology
Rob Molenberg, Chris H. L. Thio, Marlien W. Aalbers, Maarten Uyttenboogaart, Susanna C. Larsson, Mark K. Bakker, Ynte M. Ruigrok, Harold Snieder, J. Marc C. van Dijk
Summary: Using a 2-sample MR study, we found that genetic predisposition to elevated SHBG levels, with secondary lower BioT levels, is associated with an increased risk of aSAH in women.
Article
Endocrinology & Metabolism
Bingyan Xu, Wei Mo, Xiangliang Tan, Peizhen Zhang, Junlin Huang, Chensihan Huang, Dan Guo, Xueyun Wei, Yating Liu, Xuzhen Lei, Weijuan Dou, Jiayang Lin, Deying Liu, Linjie Yang, Yan Huang, Huijie Zhang, Yunfei Liao
Summary: This study found that lower levels of testosterone and free testosterone were associated with an increased risk of atrial fibrillation and bradyarrhythmia in men. Higher levels of free testosterone were associated with an increased risk of atrial fibrillation and ventricular arrhythmia. Higher SHBG concentrations were associated with an increased risk of atrial fibrillation, ventricular arrhythmia, and bradyarrhythmia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Xiaomin Hua, Heping Zhang, Wenru Yang, Guotao Liu, Suhua Zhang, Yingcui Wang
Summary: The purpose of this study was to establish a novel nomogram model for accurate detection of non-alcoholic fatty liver disease (NAFLD) in the Chinese population. The nomogram showed superior performance in predicting NAFLD and may serve as a cost-effective screening model.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ke Xu, Yicheng Fu, Buzi Cao, Mingyi Zhao
Summary: This study aims to evaluate the association between sex hormones and sex hormone-binding globulin (SHBG) with bone mineral density (BMD) in adolescents. The results show differences in the association of sex hormones with BMD in boys and girls, where an appropriate increase in serum testosterone levels may be beneficial for skeletal development in girls and keeping estradiol levels below a certain level in boys may be considered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Laura Brianso-Llort, Olga Simo-Servat, Lorena Ramos-Perez, Javier Torres-Torronteras, Cristina Hernandez, Rafael Simo, David M. Selva
Summary: The study found that red wine rich in resveratrol can reduce total cholesterol in both men and women, and only increase SHBG levels in women, which may be beneficial for cardiovascular protection. Further research is needed to explore the potential enhancement of SHBG by resveratrol in cardiovascular protection between women and men.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Hong Phan, Aline Richard, Mariana Lazo, William G. Nelson, Samuel R. Denmeade, John Groopman, Norma Kanarek, Elizabeth A. Platz, Sabine Rohrmann
Summary: This study found that lower total testosterone and higher free estradiol were associated with an increased risk of NAFLD in men, while other sex hormones showed no significant association with NAFLD or liver enzyme levels.
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Haojie Zhang, Chi Chen, Xuan Zhang, Yuying Wang, Heng Wan, Yi Chen, Wen Zhang, Fangzhen Xia, Yingli Lu, Ningjian Wang
Summary: This study aimed to investigate the association between sex hormone-binding globulin (SHBG) and renal function in a community-based Chinese population. Lower levels of SHBG were significantly associated with lower estimated glomerular filtration rate (eGFR) and a higher prevalence of low eGFR in Chinese men, independent of demographics, lifestyle, metabolic-related risk factors, and testosterone.
CHINESE MEDICAL JOURNAL
(2022)
Article
Immunology
Brandilyn A. Peters, David B. Hanna, Anjali Sharma, Kathryn Anastos, Donald R. Hoover, Qiuhu Shi, Caitlin A. Moran, Elizabeth A. Jackson, Maria L. Alcaide, Igho Ofotokun, Adaora A. Adimora, Sabina A. Haberlen, Mardge Cohen, Phyllis C. Tien, Katherine G. Michel, Steven R. Levine, Howard N. Hodis, Robert C. Kaplan, Michael T. Yin
Summary: In this cohort study, ever use of estrogen-based hormone therapy was associated with less progression of subclinical atherosclerosis over time in women with and without HIV. This suggests that hormone therapy may confer a similar cardiovascular benefit for both groups.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Sport Sciences
Frederik Lendeckel, Stephanie Zylla, Marcello Ricardo Paulista Markus, Ralf Ewert, Sven Glaeser, Henry Voelzke, Diana Albrecht, Nele Friedrich, Matthias Nauck, Stephan B. Felix, Marcus Doerr, Martin Bahls
Summary: This study found that CRF was inversely associated with leptin and chemerin in both sexes and positively associated with adiponectin only in men.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ines Zinterl, Till Ittermann, Sabine Schipf, Stefan Gross, Henryke Anspieler, Simon Kim, Ralf Ewert, Robin Buelow, Jens-Peter Kuehn, Markus M. Lerch, Henry Voelzke, Stephan Burkhard Felix, Martin Bahls, Giovanni Targher, Marcus Doerr, Marcello Ricardo Paulista Markus
Summary: This study investigated the association between low cardiorespiratory fitness and liver fat content in the general population. The findings suggest that lower VO2peak is significantly associated with higher LFC and serum GGT levels, indicating that low cardiorespiratory fitness might be a risk factor for hepatic steatosis.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Muhammad Naeem, Marcello R. P. Markus, Mohammed Mousa, Sabine Schipf, Marcus Doerr, Antje Steveling, Ali Aghdassi, Jens-Peter Kuehn, Marie-Luise Kromrey, Matthias Nauck, Giovanni Targher, Henry Voelzke, Till Ittermann
Summary: The study found that larger liver volume assessed by MRI was associated with an increased risk of all-cause mortality, and this association was consistent in different subgroups. Higher serum liver enzyme levels and FIB-4 score were also significantly associated with higher risk of all-cause mortality.
LIVER INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Stefanie M. Werhahn, Christian Becker, Meinhard Mende, Helge Haarmann, Kathleen Nolte, Ulrich Laufs, Samira Zeynalova, Markus Loeffler, Nikolaos Dagres, Daniela Husser, Marcus Doerr, Stefan Gross, Stephan B. Felix, Astrid Petersmann, Christoph Herrmann-Lingen, Lutz Binder, Martin Scherer, Gerd Hasenfuss, Burkert Pieske, Frank Edelmann, Rolf Wachter
Summary: In stable outpatients with cardiovascular risk factors, NT-proBNP is a better marker for prevalent and incident AF than for HF. The diagnostic value of NT-proBNP for HF in AF patients, especially with EF > 50%, is very limited.
Article
Endocrinology & Metabolism
Dominik Spira, Nikolaus Buchmann, Marcus Doerr, Marcello R. P. Markus, Matthias Nauck, Sabine Schipf, Joachim Spranger, Ilja Demuth, Elisabeth Steinhagen-Thiessen, Henry Voelzke, Till Ittermann
Summary: The study found a consistent association between fT3 and almost all markers of insulin resistance, but this effect appears to diminish with age, indicating a potential age-related modification of the interaction between thyroid function and glucose metabolism. Further studies are needed to clarify causal relationships.
EUROPEAN THYROID JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Luis R. Lopes, Maria-Angela Losi, Nabeel Sheikh, Cecile Laroche, Philippe Charron, Juan Gimeno, Juan P. Kaski, Aldo P. Maggioni, Luigi Tavazzi, Eloisa Arbustini, Dulce Brito, Jelena Celutkiene, Albert Hagege, Ales Linhart, Jens Mogensen, Jose Manuel Garcia-Pinilla, Tomas Ripoll-Vera, Hubert Seggewiss, Eduardo Villacorta, Alida Caforio, Perry M. Elliott
Summary: Common cardiovascular risk factors are associated with a more severe form of hypertrophic cardiomyopathy, suggesting the need for proactive management. There is an interaction between genotype and cardiovascular risk factors in certain traits.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Luisa Rotheudt, Eileen Moritz, Marcello R. P. Markus, Diana Albrecht, Henry Voelzke, Nele Friedrich, Edzard Schwedhelm, Gunter Daum, Ulf Schminke, Stephan B. Felix, Bernhard H. Rauch, Marcus Doerr, Martin Bahls
Summary: This study found that S1P was positively associated with higher carotid intima-media thickness (cIMT) in both men and women, and with a lower ankle-brachial index (ABI) in men. No association was found between S1P and the other investigated markers. This study provides important evidence for evaluating the suitability of S1P as a biomarker for vascular disease.
Correction
Multidisciplinary Sciences
Annika Reuser, Kristin Wenzel, Stephan B. Felix, Marcus Doerr, Martin Bahls, Stephanie Koenemann
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Anitha Pitchika, Marcello Ricardo Paulista Markus, Sabine Schipf, Alexander Teumer, Sandra Van der Auwera, Matthias Nauck, Marcus Doerr, Stephan Felix, Hans-Joergen Grabe, Henry Voelzke, Till Ittermann
Summary: The APOE gene polymorphism is associated with lipid profiles and carotid artery intima-media thickness (CCA-IMT). This study found that the APOE E2 allele is associated with lower CCA-IMT, while the E4 allele has no effect on CCA-IMT, plaques, myocardial infarction (MI), or stroke.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Marcello Ricardo Paulista Markus, Marcus Doerr
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ulrike Braisch, Wolfgang Koenig, Dietrich Rothenbacher, Michael Denkinger, Nele Friedrich, Stephan B. Felix, Till Ittermann, Marcus Dorr, Dhayana Dallmeier
Summary: This study aimed to determine the upper reference levels (URLs) of NT-proBNP in individuals aged 65 years and older. The analysis of data from two independent population-based cohorts revealed that NT-proBNP levels increase with age and are higher in women compared to men. The findings provide a reference for further investigation of age-specific NT-proBNP cut-off values in older adults.
Article
Obstetrics & Gynecology
Juliane Bauer, Madlen Steinbrueckner, Marcus Doerr, Martin Bahls, Thorsten Schmidt, Sabina Ulbricht
Summary: This study investigated sedentary behavior and physical activity levels in pregnant women. The results showed that pregnant women spent most of their day in sedentary activities, and only half of them met the recommendations for physical activity in the second and third trimester. The study suggests that sedentary behavior and physical activity should be given more attention in clinical practice and research to motivate pregnant women to adopt an active lifestyle.
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
(2023)
Article
Obstetrics & Gynecology
Guillermo Pierdant, Till Ittermann, Jennis Freyer-Adam, Ulrike Siewert-Markus, Hans Joergen Grabe, Marcus Doerr, Matthias Heckmann, Marek Zygmunt, Anja Erika Lange, Marcello Ricardo Paulista Markus
Summary: This study investigated the associations between the mother's socioeconomic and lifestyle factors, life satisfaction, and the delivery of a small for gestational age (SGA) infant. The study found that lower education and smoking during pregnancy were risk factors for delivering an SGA infant. Additionally, mothers of SGA infants were more frequently dissatisfied with their employment and financial status.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Cardiac & Cardiovascular Systems
R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Malarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Arnlov, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans-Peter Brunner-La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G. F. Cleland, James P. Cook, Simon de Denus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Doerr, Samuel C. Dudley, Gunnar Engstrom, Tonu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, Rene Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daniel F. Guobjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van der Harst, Asa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay-Tee Khaw, Marcus E. Kleber, Lars Kober, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried Maerz, John J. V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton-Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N. A. Palmer, Guillaume Pare, Markus Perola, Louis-Philippe Lemieux Perreault, Eliana Portilla-Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P. R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garoar Sveinbjornsson, Mari-Liis Tammesoo, Jean-Claude Tardif, Kent D. Taylor, Maris Teder-Laving, Alexander Teumer, Guomundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Voelker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges-Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie-Pierre Dube, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith
Summary: HERMES consortium aims to identify the genetic and molecular basis of heart failure, with 51 studies from 11 countries currently included. The studies predominantly recruited male participants with heart failure, and the mean age ranged from 54 to 84 years.
Article
Cardiac & Cardiovascular Systems
Mateusz Sokolski, Sander Trenson, Justyna M. Sokolska, Domenico D'Amario, Philippe Meyer, Nana K. Poku, Tor Biering-Sorensen, Mats C. Hojbjerg Lassen, Kristoffer G. Skaarup, Eduardo Barge-Caballero, Anne-Catherine Pouleur, Davide Stolfo, Gianfranco Sinagra, Klemens Ablasser, Viktoria Muster, Peter P. Rainer, Markus Wallner, Alessandra Chiodini, Pascal S. Heiniger, Fran Mikulicic, Judith Schwaiger, Stephan Winnik, Huseyin A. Cakmak, Margherita Gaudenzi, Massimo Mapelli, Irene Mattavelli, Matthias Paul, Irina Cabac-Pogorevici, Claire Bouleti, Marzia Lilliu, Chiara Minoia, Jeroen Dauw, Jerome Costa, Ahmet Celik, Nathan Mewton, Carlos E. L. Montenegro, Yuya Matsue, Goran Loncar, Michal Marchel, Aris Bechlioulis, Lampros Michalis, Marcus Dorr, Edgard Prihadi, Felix Schoenrath, Daniel R. Messroghli, Wilfried Mullens, Lars H. Lund, Giuseppe M. C. Rosano, Piotr Ponikowski, Frank Ruschitzka, Andreas J. Flammer
Summary: The study assessed the outcome of hospitalized COVID-19 patients with heart failure (HF) compared to those with other cardiovascular diseases and risk factors. It found that patients with HF had a higher in-hospital mortality rate, and acute HF events during hospitalization were associated with further increased mortality.