Article
Hematology
Dennis A. Eichenauer, Horst Muller, Leonard Elger, Helen Goergen, Michael Fuchs, Stefanie Kreissl, Boris Boll, Volker Diehl, Bastian von Tresckow, Peter Borchmann, Andreas Engert
Summary: NHL after cHL is a rare event that primarily affects older individuals, with a five-year event-free survival and overall survival estimates of 36.9% and 44.2% respectively.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Danbee Kang, Sang Eun Yoon, Dongwook Shin, Jin Lee, Yun Soo Hong, Se Kyung Lee, Jeong Eon Lee, Yeon Hee Park, Jin Seok Ahn, Eliseo Guallar, Won Seog Kim, Jungho Lee, Seok Jin Kim, Juhee Cho
Summary: Research suggests that women with breast cancer have a higher risk of developing NHL, especially in younger age groups and those receiving hormone therapy.
BLOOD CANCER JOURNAL
(2021)
Article
Oncology
Allini Mafra, Mathieu Laversanne, Mary Gospodarowicz, Paulo Klinger, Neimar De Paula Silva, Marion Pineros, Eva Steliarova-Foucher, Freddie Bray, Ariana Znaor
Summary: Global patterns of non-Hodgkin lymphoma (NHL) in 2020 were evaluated using the GLOBOCAN 2020 database. The study found that Eastern Asia, Northern America, and South-Central Asia had the highest number of NHL cases. Incidence rates were higher in men than in women, with the highest rates in Australia, New Zealand, Northern America, Northern Europe, and Western Europe. The highest mortality rates were found in regions in Africa, Western Asia, and Oceania.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Medicine, General & Internal
Pauline Brice, Eric de Kerviler, Jonathan W. Friedberg
Summary: Classical Hodgkin lymphoma is a relatively common lymphoma that is generally considered highly curable with standard first-line chemotherapy and radiotherapy, although some patients may not be cured or may experience late toxic effects leading to premature death. Recent changes in the gold standard of chemotherapy, now often including immunotherapy in relapse settings, have further impacted treatment outcomes.
Article
Oncology
Gertraud Maskarinec, Sayaka M. Brown, Jordyn Lee, David Bogumil, Catherine Walsh, Christopher A. Haiman, Veronica Wendy Setiawan, Yurii B. Shvetsov, Loic Le Marchand
Summary: This study found an association between T2D and NHL incidence in several subgroups but not in the total population, and identified excess body weight in early life as a predictor of NHL incidence.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
H. Dean Hosgood, Meghan Davitt, Richard Cawthon, Stephanie J. Weinstein, Batel Blechter, Jason Y. Y. Wong, Mohammad L. Rahman, Wei Hu, Satu Mannisto, Demetrius Albanes, Nathaniel Rothman, Qing Lan
Summary: This study suggests that a higher fraction of mitochondrial DNA with breaks is associated with an increased risk of non-Hodgkin lymphoma (NHL).
Article
Environmental Sciences
Lemaan Rana, Sarah Dahlberg, Craig Steinmaus, Luoping Zhang
Summary: A systematic review and meta-analysis of human epidemiological studies revealed a potential causal link between benzene exposure and non-Hodgkin lymphoma, especially for diffuse large B-cell lymphoma.
LANCET PLANETARY HEALTH
(2021)
Article
Oncology
Yeong Hak Bang, Joon Ho Shim, Kyung Ju Ryu, Yeon Jeong Kim, Myung Eun Choi, Sang Eun Yoon, Junhun Cho, Bon Park, Woong-Yang Park, Won Seog Kim, Seok Jin Kim
Summary: This study investigated the feasibility of exosomal mRNA sequencing for monitoring disease status and predicting outcomes in non-Hodgkin lymphoma (NHL) patients. The results demonstrated that exosomal mRNA expression profiles could serve as biomarkers for NHL patients, providing more reliable predictions of treatment outcomes compared to circulating tumor DNA (ctDNA) mutations.
Article
Health Care Sciences & Services
Sonia Guadalupe Barreno-Rocha, Sandra Guzman-Silahua, Ernesto German Cardona-Munoz, Maria Guadalupe Zavala-Cerna, David Eduardo Munoz Gaytan, Carlos Riebeling-Navarro, Benjamin Rubio-Jurado, Arnulfo Hernan Nava-Zavala
Summary: A retrospective cohort study was performed on patients diagnosed with Non-Hodgkin Lymphoma. The presence of autoantibodies was observed in 30 out of 39 patients, while 9 patients did not have autoantibodies. However, there were no statistically significant differences between the two groups in terms of clinical, demographic, staging, and prognosis characteristics. Further research on a broader panel of autoantibodies is needed to explore the relationship between their presence and the clinical outcome of patients.
Review
Veterinary Sciences
Joana N. R. Dias, Ana S. Andre, Sandra I. I. Aguiar, Solange Gil, Luis Tavares, Frederico Aires-da-Silva
Summary: The new era of immune-oncology presents challenges and opportunities, with the use of a canine model in cancer immunotherapy drug development being widely recognized. Comparative research between human and canine NHL can provide valuable insights into treatment strategies. Additionally, the canine model may help bridge the gap between preclinical studies and clinical trials.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: This study assessed the association between historic environmental pollutant emissions and chemical mixtures in house dust with non-Hodgkin lymphoma (NHL). The results showed a significant positive association between RSEI scores and NHL in long-term residents in Detroit, while significant inverse associations were found in two other study centers. These findings highlight the importance of considering historic and cumulative environmental exposures and using residential histories for diseases with long latency periods like NHL.
ENVIRONMENTAL RESEARCH
(2023)
Article
Dermatology
A. Goyal, D. O'Leary, K. Goyal, N. Rubin, M. Janakiram
Summary: Patients with mycosis fungoides (MF) have an increased risk of developing various types of cancers, with those developing non-Hodgkin lymphoma (NHL), lung cancer, and bladder cancer tending to be diagnosed at earlier stages and showing better 5-year overall survival. Regular pigmented-lesion-focused skin examinations are recommended for MF patients, along with smoking cessation counseling and ensuring up-to-date cancer screenings. Regular imaging and lab testing for second malignancy screening require further study and expert consensus.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Oncology
Liwei Lv, Yuanbo Liu
Summary: Non-Hodgkin lymphoma (NHL) is a common hematological malignant tumor that can be diagnosed through invasive tissue biopsies, which have limitations in clinical applications. To overcome these limitations, liquid biopsies (LBs) have been proposed and shown to be applicable for diagnosis, treatment, prognosis, and monitoring of NHL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhen Han, Hong Xu, Meiqing Zhao, Fanjing Jing, Hongwei Xue, Shuxin Xiao
Summary: There is a lack of consensus regarding the association between diabetes mellitus (DM) and the prognosis of patients with non-Hodgkin lymphoma (NHL). A meta-analysis of cohort studies showed that DM is associated with poor survival in patients with B-cell NHL, but the association becomes non-significant in metformin users.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Public, Environmental & Occupational Health
Jarle Jakobsen, Marit B. Veierod, Tom K. Grimsrud, Sophie Dorothea Fossa, Bato Hammarstrom, Kristina Kjaerheim
Summary: Firefighters diagnosed with prostate cancer at a younger age and with better prognostic factors compared to the general population may indicate increased diagnostic intensity in occupations undergoing health check-ups, potentially contributing to higher incidence of PCa in these occupations.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Infectious Diseases
Anna E. Coghill, Jianwen Fang, Zhiwei Liu, Chien-Jen Chen, Ruth F. Jarrett, Henrik Hjalgrim, Carla Proietti, Kelly J. Yu, Wan-Lun Hsu, Pei-Jen Lou, Chen-Ping Wang, Yingdong Zhao, Denise L. Doolan, Allan Hildesheim
Summary: This study examined the IgG antibody responses against 115 EBV peptide sequences in 316 cancer-free adults and identified eight EBV peptide sequences that appear to play a role in immunogenicity. This finding is important for understanding the role of EBV in B-cell immunity in humans.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Carolina Porras, Joshua N. Sampson, Rolando Herrero, Mitchell H. Gail, Bernal Cortes, Allan Hildesheim, Jean Cyr, Byron Romero, John T. Schiller, Christian Montero, Ligia A. Pinto, John Schussler, Karla Coronado, Monica S. Sierra, Jane J. Kim, Catherine M. Torres, Loretto Carvajal, Sarah Wagner, Nicole G. Campos, Rebecca Ocampo, Troy J. Kemp, Michael Zuniga, Douglas R. Lowy, Carlos Avila, Stephen Chanock, Ariane Castrillo, Yenory Estrada, Gloriana Barrientos, Cindy Monge, Maria Y. Oconitrillo, Aimee R. Kreimer
Summary: Vaccination of adolescent girls with HPV vaccines is essential for preventing cervical cancer. Studies suggest that a single dose of the vaccine may provide long-lasting protection and reduce the risk of cervical cancer. Large trials are currently underway to compare the efficacy of one versus two doses of different HPV vaccines in preventing new HPV infections.
Article
Medical Laboratory Technology
Geng-Hang Chen, Zhiwei Liu, Kelly J. Yu, Anna E. Coghill, Xiao-Xia Chen, Shang-Hang Xie, Dong-Feng Lin, Qi-Hong Huang, Yu-Qiang Lu, Wei Ling, Chu-Yang Lin, Zi-Jian Lu, Yu-Ying Fan, Lin-Quan Tang, Joshua N. Sampson, Hui Li, Ann D. King, Jaap M. Middeldorp, Allan Hildesheim, Su-Mei Cao
Summary: This study evaluated the performance of nasopharynx swab EBV DNA as a reflex test to triage high-risk individuals for nasopharyngeal carcinoma (NPC). The results showed that the swab test had promising potential in reducing referral rate without significantly compromising sensitivity compared to serology-only screening programs.
CLINICAL CHEMISTRY
(2022)
Article
Oncology
Jaimie Z. Shing, Shangying Hu, Rolando Herrero, Allan Hildesheim, Carolina Porras, Joshua N. Sampson, John Schussler, John T. Schiller, Douglas R. Lowy, Monica S. Sierra, Loretto Carvajal, Aimee R. Kreimer
Summary: A long-term follow-up study was conducted to evaluate the efficacy of HPV vaccination against cervical intraepithelial neoplasia caused by non-preventable HPV types. The study found that clinical unmasking could attenuate the long-term effectiveness of HPV vaccination in reducing high-grade diseases. However, the net benefit of vaccination for cervical cancer prevention is still considerable.
Article
Infectious Diseases
Monica S. Sierra, Sabrina H. Tsang, Carolina Porras, Rolando Herrero, Joshua N. Sampson, Bernal Cortes, John Schussler, Sarah Wagner, Loretto Carvajal, Wim Quint, Aimee R. Kreimer, Shangying Hu, Ana Cecilia Rodriguez, Byron Romero, Allan Hildesheim
Summary: This study estimated the prevalence and incidence of HPV infections in young adult women. The results showed that the incidence of HPV infections peaked at age 20 and steadily declined with age. The study also found that the incidence of HPV infections peaked within a year after first sexual intercourse and decreased over time. These findings suggest that HPV vaccination could be beneficial for young adult women in preventing cervical cancer and precancerous lesions.
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Article
Infectious Diseases
Romain Fantin, Rolando Herrero, Allan Hildesheim, Cristina Barboza-Solis, Amada Aparicio, D. Rebecca Prevots, Ruth M. Pfeiffer, Mitchell H. Gail
Summary: This study used a Poisson regression model to analyze ecologic data from Costa Rica and estimated vaccine effectiveness. The results showed that two doses of the vaccine were highly effective, with an effectiveness ranging from 93% to 100% against SARS-CoV-2 infection.
BMC INFECTIOUS DISEASES
(2022)
Article
Oncology
Ilona Argirion, Jalen Brown, Sarah Jackson, Ruth M. Pfeiffer, Tram Kim Lam, Thomas R. O'Brien, Kelly J. Yu, Katherine A. McGlynn, Jessica L. Petrick, Ligia A. Pinto, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang, Mei-Hsuan Lee, Jill Koshiol
Summary: This study investigated the role of circulating immunologic markers in predicting the progression of liver disease in individuals chronically infected with hepatitis C virus (HCV). The findings suggest that these markers play an important role in predicting HCV-related cirrhosis even 11 years after enrollment.
Article
Oncology
Loretto J. Carvajal, Jaimie Z. Shing, Juan C. Vanegas, Emmanuel Gonzalez, Diego Guillen, Monica S. Sierra, Allan Hildesheim, Carolina Porras, Rolando Herrero, Guillermo Torres, Meredith S. Shiels, Alejandro Calderon, Aimee R. Kreimer
Summary: This study investigated the incidence and trends of head and neck cancer in Costa Rica, specifically focusing on the potentially human papillomavirus (HPV)-related and HPV-unrelated head and neck squamous cell carcinomas (HNSCC). The findings showed a decreasing incidence of HNSCC overall, but an increasing trend for HPV-related HNSCCs. This study is important for understanding the epidemiology of head and neck cancer and the impact of HPV.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
W. K. Jacky Lam, Ann D. King, Jacob A. Miller, Zhiwei Liu, Kelly J. Yu, Melvin L. K. Chua, Brigette B. Y. Ma, Ming Yuan Chen, Benjamin A. Pinsky, Pei-Jen Lou, John K. S. Woo, Wan-Lun Hsu, Julia Simon, Denise L. Doolan, Tim Waterboer, Edwin P. Hui, Hui Li, Raymond K. Tsang, Kenneth C. W. Wong, Julian P. Goh, Alexander C. Vlantis, Qi Yong Ai, Lun M. Wong, Victor Abdullah, Jin Ching Lin, Chien-Jen Chen, Ruth M. Pfeiffer, Quynh-Thu Le, Anne W. M. Lee, Mingfang Ji, Sumei Cao, Jun Ma, Anthony T. C. Chan, K. C. Allen Chan, Allan Hildesheim
Summary: A meeting of experts in November 2021 discussed the performance and cost-effectiveness of EBV-based approaches for screening early stage nasopharyngeal carcinoma. Both serum EBV antibody and plasma EBV DNA testing methods were found to be favorable. Additionally, the use of MRI was recommended to increase the sensitivity of NPC detection without greatly impacting the cost-effectiveness of the screening program.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Jessica L. Petrick, Andrea A. Florio, Jane Zen, Yanyu Wang, Andrew T. Gewirtz, Ruth M. Pfeiffer, Sarah Loftus, Jon Inglefield, Jill Koshiol, Baiyu Yang, Kelly Yu, Allan Hildesheim, Chien-Jen Chen, Hwai- Yang, Mei-Hsuan Lee, Katherine A. McGlynn
Summary: Research findings suggest that gut barrier dysfunction may lead to liver exposure to bacterial products from the gut, promoting liver diseases such as hepatitis and hepatocellular carcinoma. This study investigated the association between biomarkers of gut barrier dysfunction and HCC risk in HBV/HCV carriers. The results showed that a doubling of antiflagellin IgA or LBP levels in the blood was associated with a significantly increased risk of HBV-related HCC, while other markers did not show the same association.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Hakon Valen, Rune Becher, Gunn Elisabeth Vist, Jorn Andreas Holme, Ibrahimu Mdala, Ida-Kristin Orjasaeter Elvsaas, Jan Alexander, Vigdis Underland, Bendik Christian Brinchmann, Tom Kristian Grimsrud
Summary: This systematic review analyzed 14 cohort studies and 1 case-control study, finding increased cancer risk and mortality after cancer diagnosis for exclusive users of Swedish snus. Cancer risk evaluation was only possible for men due to lack of data for women. The report revealed an association between snus use and increased risk of esophageal, pancreatic, stomach, and rectal cancer, as well as mortality after cancer diagnosis. Confidence in the risk estimates varied from moderate, to low, to very low.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Leif Aage Strand, Inger Rudvin, Jan Ivar Martinsen, Elin Anita Fadum, Tom K. Grimsrud
Summary: In a cohort study of 28,300 Navy servicemen, vessel crews showed higher cancer incidence and mortality than land-based personnel. The study extended the follow-up to investigate changes in cancer risk and temporal trends. Results showed that overall, vessel crews had higher cancer incidence and mortality, especially for cancers with poor prognosis.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Niki Marjerrison, Tom K. Grimsrud, Johnni Hansen, Jan Ivar Martinsen, Karl-Christian Nordby, Raymond Olsen, Marit B. Veierod, Kristina Kjaerheim
Summary: The study aimed to develop indicators for specific firefighting exposures and examine associations with urinary tract cancer (UTC), including bladder cancer. The findings did not show clear dose-response associations between the exposure indicators and UTC, indicating the need for future studies with more cases.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Kathy Baisley, Troy J. Kemp, Aimee R. Kreimer, Partha Basu, John Changalucha, Allan Hildesheim, Carolina Porras, Hilary Whitworth, Rolando Herrero, Charles J. Lacey, John T. Schiller, Eric Lucas, Paul Mutani, Joakim Dillner, Jackton Indangasi, Richard Muwonge, Richard J. Hayes, Ligia A. Pinto, Deborah Watson-Jones
Summary: A study in Tanzania found that one dose of HPV vaccine might provide sufficient protection against persistent HPV infection. A one-dose schedule would reduce costs, simplify vaccine delivery, and expand access to the vaccine.
LANCET GLOBAL HEALTH
(2022)