Review
Pharmacology & Pharmacy
Sha-Sha Guo, Zhen-Guo Wang
Summary: Salvia miltiorrhiza, a perennial herb with high medicinal value in China, contains Salvianolic acid B (Sal-B) which has been shown to exhibit anticancer activity by targeting multiple cell signaling pathways to inhibit tumor growth and metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zhao Yang, Jingshu Qi, Dabing Ping, Xin Sun, Yanyan Tao, Chenghai Liu, Yuan Peng
Summary: Organ fibrosis is a common pathological change that leads to organ failure. Currently, there are no drugs directly targeting the fibrotic process, but Salvia miltiorrhiza and its active ingredients have shown promising anti-fibrotic effects, providing potential therapeutic options for fibrotic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agricultural Engineering
Wei Zhou, Shen Li, Itay Maoz, Qi Wang, Man Xu, Yue Feng, Xiaolong Hao, Zhiyan Du, Guoyin Kai
Summary: The study identified SmJRB1 as an activator that enhances the accumulation of phenolic acids in Salvia miltiorrhiza, by promoting the activation of RAS1 gene and interacting with JAZ proteins, indicating a potential regulatory mechanism for phenolic acid biosynthesis. Further research is needed to fully understand the specific mechanisms involved.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Brahmam Kapalavavi, Ninad Doctor, Baohong Zhang, Yu Yang
Summary: Subcritical water extraction (SBWE) of APIs from Salvia miltiorrhiza showed increased extraction efficiency with higher temperatures, especially for tanshinone I. The reproduction inhibition rate of SBWE herbal extracts on Caenorhabditis elegans was higher than that of traditional herbal decoction extracts. SBWE is a more efficient and environmentally friendly method for extracting APIs from medicinal herbs, compared to traditional herbal decoction.
Article
Plant Sciences
Wei Zhou, Shuai Wang, Yafang Shen, Yunhui Liu, Itay Maoz, Xiankui Gao, Chengan Chen, Tingyao Liu, Can Wang, Guoyin Kai
Summary: In this study, a YE-responsive transcriptional factor SmSCR1 was identified in Salvia miltiorrhiza, which can enhance tanshinone accumulation and affect the growth and development of hairy roots. Furthermore, it was found that SmSCR1 can bind to the promoter of SmCPS1 to induce its expression.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Huan Zhao, Bing Han, Xuan Li, Chengtao Sun, Yufei Zhai, Man Li, Mi Jiang, Weiping Zhang, Yi Liang, Guoyin Kai
Summary: Salvia miltiorrhiza contains active components that have anti-breast cancer effects through various mechanisms, including apoptosis induction, autophagy and cell cycle arrest, anti-metastasis, formation of cancer stem cells, and enhancement of antitumor immunity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Materials Science, Paper & Wood
Haibo Liu, Jiaqian Wang, Yonglin He, Wenwen Zhang, Lei Lei, Long Chen, Yalan Chen, Jing Zhu, Juncai Tu, Kun Li
Summary: In this study, a series of techniques were employed to investigate the binding properties of 3,4-dihydroxybenzaldehyde with human serum albumin and the structural changes of human serum albumin under simulated physiological conditions. The results showed that 3,4-dihydroxybenzaldehyde quenched the intrinsic fluorescence of human serum albumin through a static mechanism and had a strong affinity with human serum albumin at high concentrations. The study also revealed that 3,4-dihydroxybenzaldehyde induced conformational changes of human serum albumin.
Article
Plant Sciences
Arpine Ayvazyan, Lenard Deutsch, Christian Zidorn, Brigitte Kircher, Serhat S. Cicek
Summary: This study compared the tanshinone profiles of Salvia miltiorrhiza roots and Salvia glutinosa roots and found that S. miltiorrhiza had higher concentrations of most tanshinones. However, S. glutinosa contained danshenol A, dehydroabietic acid, and (+)-pisiferic acid, which showed strong antiproliferative and cytotoxic effects. These findings highlight the potential value of investigating closely related species for the discovery of new biologically active lead compounds.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Xiaohu Guo, Xiaoxi Meng, Yan Li, Changqing Qu, Yingying Liu, Mengyang Cao, Xiaoyan Yao, Fei Meng, Jing Wu, Huasheng Peng, Daiyin Peng, Shihai Xing, Weimin Jiang
Summary: This study investigates the molecular mechanisms of Salvia miltiorrhiza after Sweating treatment using proteomics, revealing differential protein expression and potential pharmacological variations at the proteome level.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Yue Chen, Yanting Wang, Juan Guo, Jian Yang, Xiaodan Zhang, Zixuan Wang, Ying Cheng, Zewei Du, Zhechen Qi, Yanbo Huang, Mans Dennis, Yukun Wei, Dongfeng Yang, Luqi Huang, Zongsuo Liang
Summary: By performing comparative transcriptomic and proteomic analyses, researchers have found that SmWRKY61 is a key factor in the high accumulation of tanshinones in Salvia castanea. Overexpression of SmWRKY61 in Salvia miltiorrhiza significantly increases the content of tanshinones and regulates the expression levels of tanshinone pathway genes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yunyun Li, Yunli Tong, Jun Ye, Caijuan Zhang, Bin Li, Suying Hu, Xiaoshan Xue, Qian Tian, Yueyue Wang, Lin Li, Junfeng Niu, Xiaoyan Cao, Donghao Wang, Zhezhi Wang
Summary: In this study, the BBX gene family of Salvia miltiorrhiza was systematically investigated. 27 SmBBXs genes were identified and classified into five evolutionary branches. Promoter analysis suggested the involvement of SmBBXs in the regulation of light responses, hormones, stress signals, and tissue-specific development. Transcriptome analysis revealed different expression patterns of SmBBXs under abiotic stresses and plant hormones, indicating their essential roles in growth and development. Transient expression analysis showed nuclear localization of SmBBX1, SmBBX4, SmBBX9, SmBBX20, and SmBBX27. Transcriptional activation assay demonstrated the transactivation activities of SmBBX1, SmBBX4, SmBBX20, and SmBBX24, while SmBBX27 had none. These findings provide a foundation for further research on the role of SmBBXs in the development of Salvia miltiorrhiza.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Jingyin Kong, Songjun Li, Yingting Li, Min Chen
Summary: Placenta-mediated pregnancy complications (PMPCs), such as preeclampsia (PE), fetal growth restriction (FGR), and recurrent spontaneous abortion (RSA), occur in approximately 5% of pregnancies and are caused by abnormal placenta development. Synthetic drugs have limitations in treating PMPCs due to their adverse effects. Salvia miltiorrhiza (S. miltiorrhiza) shows potential in treating PMPCs through its cardiovascular benefits, including anticoagulation, vasodilation, antioxidation, and endothelial protection. This review provides comprehensive insights on S. miltiorrhiza, its phytochemical constituents, pharmacological activities, and PMPCs, which could contribute to the development of promising drugs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Heyu Yang, Haimei Chen, Yang Ni, Jingling Li, Yisha Cai, Binxin Ma, Jing Yu, Jiehua Wang, Chang Liu
Summary: In this study, the mitogenome of Salvia miltiorrhiza was assembled using PacBio and Illumina sequencing technologies, revealing two major conformations and nine repeats that can mediate recombination. A total of 55 genes were predicted, and phylogenetic analysis showed congruence with the APG IV system. Nucleotide substitution rates analysis indicated positive selection in certain genes. These findings provide a foundation for future studies on the evolution of the Salvia mitogenome and molecular breeding of S. miltiorrhiza.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ying-Jie Ren, Yan-Gang Cao, Meng-Nan Zeng, Qin-Qin Zhang, Yan-Ling Liu, Chen He, Xu Chen, Xi-Ling Fan, Xiang-Da Li, Xiao-Ke Zheng, Wei-Sheng Feng
Summary: A series of diterpenoid quinones from Salvia miltiorrhiza were found to have therapeutic effects on acute lung injury by increasing cell viability and reducing inflammation.
Review
Biochemistry & Molecular Biology
Xin-Yang Jiang, Jin-Yue Liang, Si-Yuan Jiang, Pan Zhao, Feng Tao, Jia Li, Xin-Xia Li, Dong-Sheng Zhao
Summary: Garlic polysaccharides, as one of the effective components of garlic, have various bioactivities, including immune-enhancing, hepatoprotective, and antioxidant activities. The extraction, isolation, structural characteristics, and bioactivities of garlic polysaccharides have drawn significant attention from researchers worldwide.
CARBOHYDRATE RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Bin Wang, Xiaoxuan Fan, Qianwen Sun, Qingxiang Zhang, Yue Kong, Qingyan Meng, Dongsheng Zhao, Beibei Mao, Yan Liu, Pan Zhao, Lu Zhang, Peizheng Yan
Summary: Asthma, a common chronic respiratory disease, can be controlled by drug intervention at the autophagy level, especially under cold conditions. The Xiaoqinglong decoction (XQLT) showed improvements in inflammation and autophagy levels in an asthmatic rat model.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ke-Jie Li, Yang-Yang Liu, Dong Wang, Pei-Zheng Yan, De-Chao Lu, Dong-Sheng Zhao
Summary: This article summarizes the available information on Radix Asteris (RA) in ancient Chinese medicine books and modern research literature, including its botanical properties, traditional uses, chemical composition, pharmacological activity, toxicity, and quality control. Studies have shown that RA has various pharmacological activities and is considered to be a promising medicinal plant. However, there is a lack of research on its toxicity and the consistency of its components, indicating the need for further in-depth studies.
Article
Biochemistry & Molecular Biology
Zhen Li, Shengguang Wang, Xinyu Wang, Peng Gao, Shiming Zhang, Yingning Mo, Dongsheng Zhao, Long Dai
Summary: This study is the first to report scientific evidence for the positive pharmacodynamic interactions between puerarin and metformin. Treatment with either puerarin or metformin alone did not bring the dysregulated biomarkers to normal levels, but the combination of the two did.
Review
Biochemistry & Molecular Biology
Beibei Mao, Qi Zhang, Li Ma, Dong-Sheng Zhao, Pan Zhao, Peizheng Yan
Summary: The mammalian target of rapamycin (mTOR) is a crucial protein kinase involved in various cellular processes. Inhibitors of mTOR have shown antiviral, anti-inflammatory, and antiproliferative effects and have been applied in the research of different diseases.
Article
Chemistry, Medicinal
Si-wei Rao, Yuan-yuan Duan, Dong-sheng Zhao, Cheng-jun Liu, Shao-hua Xu, Dong Liang, Feng-xiang Zhang, Wei Shi
Summary: The study revealed that MT can cause liver injury by affecting multiple metabolic pathways, and specific genes and metabolites can serve as biomarkers for MT-induced hepatotoxicity.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao Lin, Xian-Kun Lu, Kai-Hao Zhu, Xin-Yang Jiang, Jiong-Chao Chen, Pei-Zheng Yan, Dong-Sheng Zhao
Summary: This study aimed to optimize the ultrasonic-assisted aqueous two-phase synchronous extraction process of carbohydrates and polyphenols from artichoke bud, evaluate their antioxidant activities in vitro, and analyze their composition using HPLC. The results showed that both carbohydrates and polyphenols in artichoke bud exhibited strong antioxidant activities.
Article
Biochemistry & Molecular Biology
Yangyang Liu, Dongsheng Zhao, Chenghua Zhang, Hui Fang, Qingsitong Shen, Zhixian Wang, Jiangying Cao
Summary: Aminopeptidase N (APN) inhibitors, particularly pyrazoline-based hydroxamate derivatives, have shown significant potential as antitumor agents. Compound 14o exhibited the strongest inhibitory activity against APN, with IC50 value three orders of magnitude better than that of the positive control bestatin. Furthermore, compound 14o demonstrated potent anti-proliferative activities against tumor cells and anti-angiogenic activity.
Article
Spectroscopy
Tianmei Niu, Xiaojing Zhu, Dongsheng Zhao, Huifen Li, Peizheng Yan, Lulu Zhao, Wenguang Zhang, Pan Zhao, Beibei Mao
Summary: This study investigated the interaction mechanism between myricitrin and human serum albumin (HSA) using spectroscopic methods, molecular docking techniques, and molecular dynamic simulations. The results showed that the interaction between HSA and myricitrin exhibited a static fluorescence quenching mechanism, with binding processes being spontaneous and mainly driven by hydrogen bonding, hydrophobic interactions, and electrostatic interactions. The binding of myricitrin also altered the conformation of HSA. The findings provide valuable insights for the application of myricitrin in the food and pharmaceutical industries.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Pharmacology & Pharmacy
Huiru Liu, Wenwen Meng, Dongsheng Zhao, Zhihui Ma, Wenguang Zhang, Zhi Chen, Zhengguo Li, Pan Zhao
Summary: The objective of this study was to investigate the effects and molecular mechanisms of total flavonoids from Cortex Juglandis Mandshuricae (TFC) on preventing alcohol-induced chronic liver injury and regulating gut microbiota in mice. The results showed that oral administration of TFC significantly attenuated alcoholic liver injury in mice. TFC improved lipid accumulation in mice with chronic alcoholic liver injury through activation of the AMPK/PPAR alpha pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Chun-Yong Sun, Le-Le Yang, Pan Zhao, Pei-Zheng Yan, Jia Li, Dong-Sheng Zhao
Summary: This study systematically investigated the mechanism of Cynarine in the treatment of Nonalcoholic Fatty Liver Disease (NAFLD) using network pharmacology, molecular docking, and cell experiments. The results demonstrate that Cynarine can target 48 genes related to NAFLD, with CASP3, TP53, MMP9, ELANE, and NOTCH1 playing significant roles. The analysis also reveals that the PI3K-Akt signaling pathway, cell cycle, and MAPK signaling pathway may be the main pathways through which Cynarine prevents and treats NAFLD. Additionally, molecular docking studies confirm the binding activity between Cynarine and therapeutic targets. Cell experiments corroborate the ability of Cynarine to reduce fat deposition and decrease ALT and AST levels in NAFLD model cells. Inhibition of AKT1 and MAPK1 expression by Cynarine is also observed.
Article
Food Science & Technology
Liwen Dou, Hui Han, Binbin Yang, Cuixia Lin, Shaobin Pan, Qingjun Li, Peizheng Yan, Dongsheng Zhao, Xianbing Chang, Jia Li
Summary: This research demonstrates the improved electrochemical performance of a sensor through the modification of multi-walled carbon nanotubes (MWCNT) with Au and 2,6-dioctadecylaminopyridine (DODMA) for the detection of quercetin and caffeic acid. The study emphasizes the significance of electrode modifications, showing that MWCNT-Au and DODMA greatly enhance the sensor's electroactivity. Optimal conditions were determined for quercetin detection (pH 4, enrichment potential of 0.28 V, and enrichment time of 15 min) and caffeic acid detection (pH 2.20). The sensor exhibited excellent linearity within two distinct concentration ranges for caffeic acid and demonstrated high recovery rates in honeysuckle tea. These promising results suggest potential applications for this sensor platform in detecting other bioactive compounds.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Chemistry, Medicinal
Qi Zhang, Peizheng Yan, Pan Zhao, Dongsheng Zhao, Heran Cao, Jing Lu, Beibei Mao
Summary: This study utilized MLN0128 as a ligand to target mTOR, and designed several potential small molecule PROTACs using diverse intermediate linkage chains with pomalidomide. The PROTAC compounds showed mTOR inhibitory activity and suppressed MCF-7 cell proliferation.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Medicine, General & Internal
Chun-Yong Sun, Pan Zhao, Pei-Zheng Yan, Jia Li, Dong-Sheng Zhao
Summary: This research investigates the mechanisms of Lonicera japonica Flos (LJF) against nonalcoholic fatty liver disease (NAFLD) using network integration and experimental pharmacology. Through prediction and molecular docking studies, the study confirms the involvement of LJF in the down-regulation of key targets related to NAFLD. In vitro experiments further supported the therapeutic potential of LJF for NAFLD.
MEDICINA-LITHUANIA
(2022)
Article
Biochemistry & Molecular Biology
Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang
Summary: This study employed a combination of spectroscopic techniques and molecular modeling to investigate the interaction between a library of flavonoids and gliadin, revealing the structure-affinity relationship and the impact of flavonoids on the structure and microenvironment of gliadin. The results demonstrated the critical structural elements affecting the binding affinity and the formation of flavonoid-gliadin complexes through static quenching mechanism, pointing to the importance of hydrophobic interactions and hydrogen bonds in their binding process.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)