Article
Biochemistry & Molecular Biology
Wei Liu, Xingqun Ma, Yingying Jin, Jie Zhang, Yang Li, Yuxia Tang, Yong Song, Shouju Wang
Summary: Ce6-biotin has higher binding affinity to biotin-receptor-positive tumor cells and exhibits stronger cytotoxicity with lower dark toxicity compared to its precursor, Ce6, making it a promising photosensitizer for BR-positive-tumor-targeting photodynamic therapy.
Article
Biochemistry & Molecular Biology
Lin Yue, Meihong Zheng, Imran Mahmood Khan, Zhouping Wang
Summary: The study developed a novel photodynamic antibacterial agent CS-Ce6 conjugates by combining cationic polysaccharide chitosan with photosensitizer Chlorin e6 for combating gram-positive and gram-negative bacteria. The results demonstrated that the photodynamic antibacterial effect of CS-Ce6 conjugates was positively correlated with the degree of substitution (DS). This research highlights the potential of CS-Ce6 conjugates as effective photodynamic bactericidal agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Til Bahadur Thapa Magar, Jusuk Lee, Ji Hoon Lee, Juhee Jeon, Pallavi Gurung, Junmo Lim, Yong-Wan Kim
Summary: A novel series of chlorin e6-curcumin derivatives were synthesized and tested for their photodynamic treatment (PDT) efficacy against human pancreatic cancer cell lines. Compound 17 showed excellent cellular internalization capability and higher phototoxicity compared to the parent compound Ce6. In pancreatic cell lines, 17 induced apoptosis in a dose-dependent manner and activated intrinsic apoptosis, resulting in cancer cell death. Structure-activity relationship studies revealed that the incorporation of additional methyl ester moiety and conjugation to the enone moiety of curcumin enhanced cellular uptake and PDT efficacy. In vivo PDT testing in melanoma mouse models demonstrated that 17-PDT greatly reduced tumor growth, indicating its potential as an effective photosensitizer for PDT anticancer therapy.
Article
Biotechnology & Applied Microbiology
Elizaveta I. Kozlikina, Kanamat T. Efendiev, Andrey Yu. Grigoriev, Olesia Y. Bogdanova, Igor S. Trifonov, Vladimir V. Krylov, Victor B. Loschenov
Summary: This paper presents the use of fluorescence diagnostics in the resection of pituitary adenomas. The study used chlorin e6 photosensitizer and a two-channel video system to detect high concentrations of chlorin e6 accumulation in tumor tissues, leading to a high degree of tumor resection.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Rajeev Shrestha, Shyam Kumar Mallik, Junmo Lim, Pallavi Gurung, Til Bahadur Thapa Magar, Yong-Wan Kim
Summary: Photodynamic therapy (PDT) can eliminate cancer cells and induce antitumor immune response by using Chlorin e6 (Ce6). Two efficient synthetic methods for preparing Ce6 from Spirulina platensis were described, and the phototoxic effect of Ce6 was investigated in vitro and its antitumor activity in vivo. The results showed that Ce6-PDT not only suppressed tumor growth at the injection site but also induced antitumor immunity through upregulating the expression of IFN-gamma, TNF-alpha, and IL-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lin Yue, Zhouping Wang, Meihong Zheng, Min Wang, Imran Mahmood Khan, Xiaowei Ding, Yin Zhang
Summary: In this study, Hydroxypropyl chitosan was used as a carrier of the photosensitizer chlorin e6 to develop a photodynamic antibacterial agent with good water solubility, high biocompatibility, and antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Chemical
Til Bahadur Thapa Magar, Rajeev Shrestha, Pallavi Gurung, Junmo Lim, Yong-Wan Kim
Summary: This study demonstrated the preparation of the second-generation photosensitizer Chlorin e6 using a rapid and green synthetic method. Ce6 showed significant photodynamic cytotoxicity against melanoma cells and was used for photoacoustic imaging of internal organs in mice. Ce6-PDT holds promise as a strategy for cancer therapy and non-invasive visualization of internal organs.
Article
Medicine, Research & Experimental
Tong-Fei Li, Hua-Zhen Xu, Yong-Hong Xu, Ting-Ting Yu, Jun-Ming Tang, Ke Li, Chao Wang, Xing-Chun Peng, Qi-Rui Li, Xue-Yu Sang, Mei-Yan Zheng, Yan Liu, Li Zhao, Xiao Chen
Summary: This study successfully addressed the limitations of Chlorin e6 (Ce6) in tumor photodynamic therapy by using functionalized superparamagnetic iron oxide nanoparticles as carriers. The nanoparticles significantly increased Ce6 uptake in melanoma cells, leading to enhanced therapeutic effects.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Fei Huang, Yu Li, Xing-Jie Zhang, Mei-Yu Lin, Gui-Yan Han, Hui-Ying Lin, Hui-Yun Lin, Zhenyuan Miao, Bu-Hong Li, Chun-Quan Sheng, Jian-Zhong Yao
Summary: Novel chlorin e6-based conjugate 10b, designed and synthesized as photosensitizer, showed strong phototoxicity against cancer cells by reducing efflux of intracellular photosensitizer and localizing in various organelles. It induced cell apoptosis, ROS production, autophagy, and cell cycle arrest. In vivo experiments demonstrated that 10b significantly inhibited tumor growth and prolonged survival time. Therefore, 10b has great potential as a promising photosensitizer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yulia A. Tereshkina, Lyubov Kostryukova, Elena G. Tikhonova, Yulia Yu Khudoklinova, Nadezhda A. Orlova, Alisa M. Gisina, Galina E. Morozevich, Pavel A. Melnikov, Vadim S. Pokrovsky
Summary: This study aimed to enhance the efficacy of photodynamic therapy using a modified phospholipid delivery system for chlorin e6. The modified nanoparticles, double-modified with ligands exhibiting targeting and cell-penetrating effects, induced apoptosis in tumor cells and showed increased accumulation in tumor tissue in a mouse model. The results demonstrate the effectiveness of enhancing the chlorin e6 phospholipid composition with targeting and cell-penetrating peptides.
Article
Chemistry, Applied
Tingsheng Yan, Wenxue Hui, Siyuan Zhu, Jinmei He, Zhonghua Liu, Jinju Cheng
Summary: In this study, researchers successfully developed a redox-responsive micelle for the co-delivery of chemotherapeutics and photosensitizers, with high tumor accumulation and near infrared imaging performance. This nanoplatform could fully exert the synergistic effect of DOX and PHA to improve the inhibition efficiency in vivo, showing great potential in image-guided treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Alessia Marconi, Edoardo Jun Mattioli, Filippo Ingargiola, Giulia Giugliano, Tainah Dorina Marforio, Luca Prodi, Matteo Di Giosia, Matteo Calvaresi
Summary: Chlorin e6 (Ce6) is a commonly used sensitizer in photodynamic (PDT) and sonodynamic (SDT) therapy. However, its low solubility in water hinders its clinical application. The interaction between Ce6 and human serum albumin (HSA) can improve its water solubility. Simulation experiments identified two binding pockets of Ce6 in HSA, namely the Sudlow I site and the heme binding pocket.
Article
Biochemistry & Molecular Biology
Meihan Fang, Jialu Wang, Sheng Fang, Xiaobo Zuo
Summary: Gliadin-carboxymethyl chitosan composite nanoparticles (GC NPs) co-encapsulated with natamycin (Nata) and theaflavins (TFs) were added to carboxymethyl chitosan (CMCS) films as an antioxidant, antifungal, and structural enhancer. The stability of GC NPs dispersion was maintained by electrostatic repulsion. Coencapsulation of TFs improved the photostability of Nata and the antioxidant activity of the NPs dispersion. The addition of Nata/TFs-GC NPs improved the properties and activities of CMCS films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Nanoscience & Nanotechnology
Arshadul Hak, Mohammad Sadik Ali, Sri Amruthaa Sankaranarayanan, Vinod Ravasaheb Shinde, Aravind Kumar Rengan
Summary: Photodynamic therapy is a localized noninvasive treatment for cancer, which is effective against a wide range of cancers with minimal side effects. Chlorin e6, an FDA approved second generation photosensitizer, has been improved through nanosystems to enhance its solubility and bioavailability. Combination therapies using Ce6-based nanosystems have shown promising results in cancer treatment.
ACS APPLIED BIO MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Bei Li, Yi Fu, Maodi Xie, Lei Feng, Xiaoya Niu, Lin Que, Zhen You
Summary: This paper presents a novel nanoparticle for liver cancer treatment, which achieves controlled release and killing of tumors through photothermal conversion and photodynamic therapy. The experimental results demonstrate the efficient anti-tumor effect of these nanoparticles and their ability to alleviate the tumor's anaerobic microenvironment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Minati Das, Mongoli Brahma, G. Krishnamoorthy
Summary: A molecular photoswitch, DHP, with independent paths of ESIPT and TICT was developed. By switching solvents, control over these processes was achieved, leading to different emissions from the molecule. The conclusions were established through synthesizing and studying derivatives of the molecule.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Review
Food Science & Technology
Dibyendu Das, Sanjib Sarkar, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna
Summary: Fermented soy foods have gained attention for their promising health benefits, particularly for their potential therapeutic effects against inflammation and related complications. Studies suggest that extracts from fermented soy foods possess anti-inflammatory properties by regulating the expression and activity of various inflammatory factors. These findings suggest that fermented soy foods have the potential to be used as anti-inflammatory agents in the future.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Dibyendu Das, Mir Ekbal Kabir, Sanjib Sarkar, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna
Summary: Soy protein has anti-diabetic properties and can prevent and control abnormalities related to diabetes, with a significant correlation between soy protein intake and lower prevalence of diabetes. Soy-derived peptides can also trigger anti-diabetic responses by modulating cell signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Sagar Barge, Dhananjay Jade, Selvaraj Ayyamperumal, Prasenjit Manna, Jagat Borah, Chandrasekar Moola Joghee Nanjan, Moola Joghee Nanjan, Narayan Chandra Talukdar
Summary: The study utilized in silico strategy to screen potential inhibitors for FKBP51, identifying compounds with good affinity and stability towards the protein. The selected compounds have the potential to be developed into therapeutic agents for stress and metabolic-related disorders.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Physical
Minati Das, Mongoli Brahma, G. Krishnamoorthy
Summary: The molecule DHP exhibits two independent reaction paths and emission maximum depending on the acidity and basicity of the solution, along with a complicated equilibrium involving multiple cations and anions, as well as the identification of various protonic species through experimental and computational methods.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Physical
Minati Das, Mongoli Brahma, Sophy A. Shimray, Francis A. S. Chipem, G. Krishnamoorthy
Summary: The reaction coordinates of a molecular photo-switch DHP were controlled by a nanoparticle and surfactant. The presence of silver nanoparticles induced a different emission process and suppressed the intramolecular proton transfer, while the addition of surfactants further altered the process. Different surfactants had different effects on the luminescence characteristics of DHP.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Medicinal
Sagar Barge, Barsha Deka, Bhaswati Kashyap, Simanta Bharadwaj, Raghuram Kandimalla, Aparajita Ghosh, Partha Pratim Dutta, Suman Kumar Samanta, Prasenjit Manna, Jagat C. Borah, Narayan Chandra Talukdar
Summary: This study investigated the potential anti-obesity effects of Lysimachia candida and its phytochemical astragalin, which were found to decrease body weight gain and blood lipid levels, as well as reduce the expression of adipogenic transcription factors. The compounds exhibited antiadipogenic activity both in vivo and in vitro, suggesting their potential for clinical use in managing obesity.
PHYTOTHERAPY RESEARCH
(2021)
Article
Environmental Sciences
Rubi Barman, Jadumoni Saikia, Firdaus Rahaman Gayen, Biswajit Saha, Prasenjit Manna, Saikat Haldar, Pallab Pahari, Siddhartha Proteem Saikia, Dipanwita Banik
Summary: This study characterized the physicochemical properties of crude seed kernel wax of Endocomia macrocoma subsp. prainii (EW) and compared it with bee wax (BW). The results showed that EW is a novel natural wax with industrial potential, similar to BW.
WASTE AND BIOMASS VALORIZATION
(2022)
Article
Biology
Prateek Singh, Rajat Ujjainiya, Satyartha Prakash, Salwa Naushin, Viren Sardana, Nitin Bhatheja, Ajay Pratap Singh, Joydeb Barman, Kartik Kumar, Saurabh Gayali, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Amit Lahiri, Susanta Kar, Vivek Bhosale, Mrigank Srivastava, Madhav Nilakanth Mugale, C. P. Pandey, Shaziya Khan, Shivani Katiyar, Desh Raj, Sharmeen Ishteyaque, Sonu Khanka, Ankita Rani, Promila, Jyotsna Sharma, Anuradha Seth, Mukul Dutta, Nishant Saurabh, Murugan Veerapandian, Ganesh Venkatachalam, Deepak Bansal, Dinesh Gupta, Prakash M. Halami, Muthukumar Serva Peddha, Ravindra P. Veeranna, Anirban Pal, Ranvijay Kumar Singh, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Syed Nasar Rahman, Gopika Selvakumar, Subramanian Venkatesan, Malay Kumar Karmakar, Harish Kumar Sardana, Anamika Kothari, Devendra Singh Parihar, Anupma Thakur, Anas Saifi, Naman Gupta, Yogita Singh, Ritu Reddu, Rizul Gautam, Anuj Mishra, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Yogendra Padwad, Vikram Patial, Vipin Hallan, Damanpreet Singh, Narendra Tirpude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Ramakrishna Sistla, Narender Kumar Balthu, Kiran A. Kumar, Siva Ranjith, B. Vijay Kumar, Piyush Singh Jamwal, Anshu Wali, Sajad Ahmed, Rekha Chouhan, Sumit G. Gandhi, Nancy Sharma, Garima Rai, Faisal Irshad, Vijay Lakshmi Jamwal, Masroor Ahmad Paddar, Sameer Ullah Khan, Fayaz Malik, Debashish Ghosh, Ghanshyam Thakkar, S. K. Barik, Prabhanshu Tripathi, Yatendra Kumar Satija, Sneha Mohanty, Md Tauseef Khan, Umakanta Subudhi, Pradip Sen, Rashmi Kumar, Anshu Bhardwaj, Pawan Gupta, Deepak Sharma, Amit Tuli, Saumya Ray Chaudhuri, Srinivasan Krishnamurthi, L. Prakash, Ch Rao, B. N. Singh, Arvindkumar Chaurasiya, Meera Chaurasiya, Mayuri Bhadange, Bhagyashree Likhitkar, Sharada Mohite, Yogita Patil, Mahesh Kulkarni, Rakesh Joshi, Vaibhav Pandya, Sachin Mahajan, Amita Patil, Rachel Samson, Tejas Vare, Mahesh Dharne, Ashok Giri, Sachin Mahajan, Shilpa Paranjape, G. Narahari Sastry, Jatin Kalita, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, RaviKumar Sahu, Prachurjya Dutta, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Elapavalooru V. S. S. K. Babu, Rajeev K. Sukumaran, Aishwarya R. Nair, Anoop Puthiyamadam, Prajeesh Kooloth Valappil, Adrash Velayudhan Pillai Prasannakumari, Kalpana Chodankar, Samir Damare, Ved Varun Agrawal, Kumardeep Chaudhary, Anurag Agrawal, Shantanu Sengupta, Debasis Dash
Summary: Data science has played a crucial role in the COVID-19 pandemic response, and this study demonstrates how a statistical and machine learning approach can be used to discriminate between SARS-CoV-2 infection and immune response to a whole virion vaccine. By analyzing serial antibody data and incorporating an ensemble ML model, the researchers were able to accurately classify potential infections and validate their findings through neutralization assays. This study highlights the importance of real-world vaccine effectiveness assessments for whole virion vaccines.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Food Science & Technology
Prasenjit Manna, Saikat Dewanjee, Swarnalata Joardar, Pratik Chakraborty, Hiranmoy Bhattacharya, Shrestha Bhanja, Chiranjib Bhattacharyya, Manas Bhowmik, Shovonlal Bhowmick, Achintya Saha, Joydeep Das, Parames C. Sil
Summary: This study revealed that CA has a protective effect against Dox-induced cardiotoxicity by suppressing oxidative stress and interfering with pathological signaling events. CA can potentially be used as an effective agent to alleviate Dox-induced cardiotoxicity in the future.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Simanta Bharadwaj, Shalini Gurumayum Devi, Pranamika Sarma, Barsha Deka, Sagar Ramrao Barge, Bhaswati Kashyap, Yunus Sheikh, Prasenjit Manna, Jagat C. Borah, Narayan Chandra Talukdar
Summary: This study showed that Premna herbacea and its active constituent, Verbascoside, have a beneficial effect on hepatic steatosis caused by a high fat diet. By regulating the AMPK/SREBP/ACC/HMGCR signaling pathways, Premna herbacea and Verbascoside can prevent and improve hepatic steatosis. This suggests that Premna herbacea may be a potential functional food for managing hepatic steatosis.
Article
Biochemistry & Molecular Biology
Dibyendu Das, Sanjib Sarkar, Anjum Dihingia, Nazim Uddin Afzal, Sawlang Borsingh Wann, Jatin Kalita, Saikat Dewanjee, Prasenjit Manna
Summary: This study examined the antidiabetic efficacy of popular fermented soybean foods from Northeast India. Results showed that aqueous extract of Hawaijar significantly augmented glucose utilization and improved glucose metabolism in cultured myotubes and diabetic rats. Chemical profiling suggests the possible role of bioactive proteins/peptides and isoflavones underlying the antihyperglycemic potential of Hawaijar. These findings may contribute to the development of food-based prophylactics/therapeutics for managing hyperglycemia.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Sanjib Sarkar, Mir Ekbal Kabir, Jatin Kalita, Prasenjit Manna
Summary: Mesoporous silica nanoparticles (MSNs) are extensively used in biomedical applications such as drug delivery, diagnosis, bio-sensing, and cell tracking due to their unique properties. MSNs have been extensively studied in drug delivery field due to their highly ordered mesopores, high surface area, stability, and biocompatibility. MSN-based nanocomposites have been utilized for delivering therapeutic molecules for diabetes management. This review focuses on the delivery of antidiabetic therapeutics with emphasis on the functionalization of MSNs and stimuli-responsive delivery.
Article
Nanoscience & Nanotechnology
Purna K. Boruah, Priyakshree Borthakur, Gayatri Neog, Benjamin Le Ouay, Nazim Uddin Afzal, Prasenjit Manna, Manash R. Das
Summary: This article describes the synthesis of porous 3D nitrogen-doped crumpled graphene nanoparticles (CGNPs) and their use as a platform for the sensitive detection of dopamine (DA) in complex biological media such as blood serum. The CGNPs were prepared by doping graphene oxide (GO) using ammonium hydroxide in a hydrothermal treatment. The system selectively detected DA with a limit of detection of 1.15 μM and a linearity range of 1 to 20 μM, and it showed good selectivity in the presence of various interfering species and in human blood serum.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Pranamika Sarma, Simanta Bharadwaj, Deepsikha Swargiary, Semim Akhtar Ahmed, Yunus Sheikh, Sagar Ramrao Barge, Prasenjit Manna, Narayan Chandra Talukdar, Jayanta Bora, Jagat Chandra Borah
Summary: This study conducted phytochemical investigation on traditional herb Wendlandia glabrata to explore its antihyperglycemic effect. The results showed that the enriched fraction of W. glabrata had significant blood glucose lowering potential and improved hepatic insulin resistance through regulating the AMPK/PEPCK/G6Pase signaling pathway.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
