Article
Biotechnology & Applied Microbiology
Paola Nitti, Sanosh Kunjalukkal Padmanabhan, Serena Cortazzi, Eleonora Stanca, Luisa Siculella, Antonio Licciulli, Christian Demitri
Summary: In this study, composite structures made of hydroxyapatite scaffold impregnated with a collagen slurry were designed to mimic bone tissue structure, with the addition of magnesium and silicon ions enhancing mechanical and biological properties. An innovative freeze-drying approach was developed to create open-pore structures for tissue regeneration. The biodegradation behavior of the scaffolds, particularly HA-Mg_Coll scaffolds, showed moderate weight loss and mechanical performance reduction due to collagen dissolution, while also protecting the ceramic structure until degradation, making them suitable candidates for bone remodeling.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Hamed Sahrapeyma, Azadeh Asefnejad, Mahmoud Azami, Esmaeil Sadroddiny
Summary: Novel nanosized designed ceramic powders, cerium (Ce) doped bioglass (BG) with various doped Ce content were successfully synthesized using sol-gel method for bone tissue engineering applications. Characterization techniques confirmed successful doping of Ce inside BG structure. Ce doped BG powders were encapsulated in collagen microspheres and loaded inside Poly(e-caprolactone) fibrous scaffold, showing acceptable bioactivity and high potential for bone tissue engineering applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Smadar E. Sharon, Adi Aharonov, Haim S. Mordechai, Javad Tavakoli, Mirit Sharabi
Summary: Multiscale micro-nano fibrous structures are a research area in material science that has gained attention in recent years. These structures, found in nature's materials, exhibit unique properties such as mechanical behaviors, high surface area to volume ratio, and multiscale biological functionalities. By systematically studying the mechanical effects of each constituent, we demonstrate the biomimetics of a multiscale composite material system and its influence on mechanical behavior. Fabrics made from various materials were characterized to understand the structure-function relationship in multiscale biomimetic constructs (MSBCs).
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Smadar E. Sharon, Adi Aharonov, Haim S. Mordechai, Javad Tavakoli, Mirit Sharabi
Summary: Multiscale micro-nano fibrous structures are a cutting-edge research area in material science, which have attracted the attention of scientists in recent years. These structures, widely distributed in nature's materials, possess fascinating and unique properties, including mechanical behaviors, high surface area to volume ratio, and special multiscale biological functionalities. We have demonstrated the biomimetics of a multiscale composite material system and investigated the mechanical effect of each constituent, gaining a comprehensive understanding of the structure-function relationship and the influence of material selection and structure.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Polymer Science
Sheikha A. Alkhursani, Mohamed Mohamady Ghobashy, Samera Ali Al-Gahtany, Abeer S. Meganid, Shady M. Abd El-Halim, Zubair Ahmad, Farhat S. Khan, Gamal Abdel Nasser Atia, Simona Cavalu
Summary: This review provides an overview of various biopolymer hydrogels used for bone and periodontal tissue regeneration, evaluates their advantages and disadvantages, and explores their potential for nanoscale fabrication and biofunctionalization. The study highlights the importance of enhancing biocompatibility and incorporating nanoparticles to improve scaffold stability and achieve more effective bone tissue regeneration.
Review
Engineering, Biomedical
A. Kavitha Sri, C. Arthi, N. R. Neya, G. S. Hikku
Summary: Regenerative medicine offers hope for reforming defective organs, particularly bones, through the use of tissue engineering technology. Scaffold materials, such as nano-HA/collagen complex that support cell attachment and growth, have shown promise in bone regeneration. Recent studies have found that nano-HA exhibits higher cell adherence and subsequent growth, making it an ideal scaffold material for minimizing the limitations of conventional bone regeneration methods. This review focuses on the use and fabrication of nano-HA/collagen complex as a scaffold material for bone regeneration.
BIOMEDICAL MATERIALS
(2023)
Article
Polymer Science
Yanping Zuo, Qiwen Li, Qiuchan Xiong, Jing Li, Chengfang Tang, Yaochao Zhang, Danyang Wang
Summary: Bone tissue engineering has been successful in repairing bone defects, but current materials have limitations. Biologic scaffolds made from nano-hydroxyapatite and collagen can overcome these limitations and promote tissue reconstruction. Introducing naringin, a natural flavonoid, into the scaffold enhances bone tissue regeneration potential.
Article
Chemistry, Multidisciplinary
Kilian E. Stockhausen, Mahan Qwamizadeh, Eva M. Woelfel, Haniyeh Hemmatian, Imke A. K. Fiedler, Silja Flenner, Elena Longo, Michael Amling, Imke Greving, Robert O. Ritchie, Felix N. Schmidt, Bjoern Busse
Summary: Bones adapt to mechanical environments through structural reorganization to maintain strength. Different types of osteons exhibit distinct characteristics that influence fracture resistance mechanisms.
Article
Engineering, Biomedical
Jung Hee Wee, Ki-Dong Yoo, Sung Bo Sim, Hyun Joo Kim, Han Joon Kim, Kyu Nam Park, Gee-Hee Kim, Mi Hyoung Moon, Su Jung You, Mi Yeon Ha, Dae Hyeok Yang, Heung Jae Chun, Jae Hoon Ko, Chun Ho Kim
Summary: Using a bimodal nano/micro composite fiber patch as a cardiac patch is a feasible strategy in cardiac tissue engineering. It improves mechanical properties and enhances cell compatibility, leading to improved retention of stem cells and enhanced cardiac function.
BIOMATERIALS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Matthew D. Davidson, Margaret E. Prendergast, Ehsan Ban, Karen L. Xu, Gabriel Mickel, Patricia Mensah, Abhishek Dhand, Paul A. Janmey, Vivek B. Shenoy, Jason A. Burdick
Summary: Fibrous hydrogel assemblies stabilized with photocrosslinking display strain-responsive properties that mimic natural ECM, allowing for applications in cell culture and tissue engineering. These materials can be processed into constructs with programmed shape changes through various methods, such as microtissue formation, bioprinting, and photopatterning.
Article
Materials Science, Multidisciplinary
Hun Kim, Yang-Ho Lee, Nam-Kwon Kim, Inn-Kyu Kang
Summary: Zirconia has great potential in dentistry and orthopedics due to its excellent mechanical strength and esthetics. In order to enhance its affinity with bone tissue, the bioactivity of the zirconia surface needs to be improved. This study introduced nano-hydroxyapatite (nHA) and type I collagen to the zirconia surface through chemical covalent bonding, resulting in greatly improved bioactivity.
Article
Materials Science, Biomaterials
Tien-Li Ma, Shang-Chih Yang, Ting Cheng, Mei-Yun Chen, Jo-Hsuan Wu, Shu-Lang Liao, Wei-Li Chen, Wei-Fang Su
Summary: Poly(gamma-benzyl-l-glutamate) (PBG) biomimetic scaffolds show potential as candidate materials for corneal nerve regeneration and neurotrophic keratopathy treatment. The PBG scaffolds containing aligned fibers guide the growth and extension of trigeminal ganglia cells, and demonstrate low immune response and neurogenesis induction in in vivo experiments.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Physical
Wataru Hatakeyama, Masayuki Taira, Tomofumi Sawada, Miki Hoshi, Yuki Hachinohe, Hirotaka Sato, Kyoko Takafuji, Hidemichi Kihara, Shinji Takemoto, Hisatomo Kondo
Summary: In this study, highly pressed nano-hydroxyapatite/collagen (P-nHAP/COL) composites were implanted in critical-size bone defects in rats. The results showed that P-nHAP/COL exhibited strong osteo-conductivity and promoted bone regeneration.
Review
Biochemistry & Molecular Biology
Lu Fan, Yanru Ren, Steffen Emmert, Ivica Vuckovic, Sanja Stojanovic, Stevo Najman, Reinhard Schnettler, Mike Barbeck, Katja Schenke-Layland, Xin Xiong
Summary: Synthetic bone substitute materials (BSMs) are replacing autologous grafting for bone tissue engineering (BTE). Collagen type I, a main component of bone matrix, has been crucial in the development of synthetic BSMs. However, collagen-based materials have limitations such as poor mechanical properties and fast degradation, hindering efficient bone replacement and clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Wenbo Liu, Xin Wang, Jinlei Su, Qingsong Jiang, Jing Wang, Yang Xu, Yudong Zheng, Zhihui Zhong, Hai Lin
Summary: The study evaluated collagen dura substitutes with potential regeneration ability, demonstrating their safety and performance in effectively repairing and regenerating dura. The substitutes showed suitable physicochemical properties and were resorbed over time along with newly regenerated dura in a rabbit model. Overall, the regenerative collagen dura substitutes are a promising option for dura repair and regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Engineering, Biomedical
Nhayoung Hong, Gi-Hoon Yang, JaeHwan Lee, GeunHyung Kim
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Gi-Hoon Yang, Hyeongjin Lee, GeunHyung Kim
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2018)
Article
Materials Science, Biomaterials
Hyeongjin Lee, Gi Hoon Yang, Minseong Kim, JaeYoon Lee, JunTae Huh, GeunHyung Kim
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Haeri Kim, Gi Hoon Yang, Chang Hyun Choi, Yong Suk Cho, GeunHyung Kim
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Engineering, Biomedical
Gi Hoon Yang, JiUn Lee, GeunHyung Kim
Review
Biochemistry & Molecular Biology
Gi Hoon Yang, Miji Yeo, Young Won Koo, Geun Hyung Kim
MACROMOLECULAR BIOSCIENCE
(2019)
Article
Chemistry, Multidisciplinary
YongBok Kim, Jun Young Lim, Gi Hoon Yang, Jun-Hyuk Seo, Hyun-Seung Ryu, GeunHyung Kim
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Jiyoung Hong, Miji Yeo, Gi Hoon Yang, GeunHyung Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Multidisciplinary
Eunjeong Choi, Seungkuk Bae, Dongyun Kim, Gi Hoon Yang, KyoungHo Lee, Hi-Jin You, Hyo Jin Kang, So-Jung Gwak, SangHyun An, Hojun Jeon
Summary: This study demonstrated the effectiveness of a PCL based fibrous scaffold embedded with decellularized bone extracellular matrix (bdECM) in promoting cell adhesion, proliferation, and osteogenic differentiation. The bdECM particles significantly influenced the surface characteristics of the scaffold and led to enhanced cell responses. The findings suggest that the bdECM/PCL scaffold has great potential as a biomedical device for hard tissue regeneration.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Gi Hoon Yang, MyungGu Yeo, Eunjeong Choi, Donggu Kang, Minseong Kim, Yunjoo Nam, So-Jung Gwak, Hye Hyun Yoo, Min-Jeong Park, Bongsu Jung, Woonhyeok Jeong, Hojun Jeon
Summary: The study found that different sizes of silica particles have varying effects on the physical and biological properties of polycaprolactone scaffolds. Particles with a size of 800 nm can improve the physical properties of the scaffold, while particles with a size of 100 nm can significantly enhance the biological properties of the scaffold.
MATERIALS & DESIGN
(2021)
Review
Engineering, Biomedical
Gi Hoon Yang, Yoon Bum Lee, Donggu Kang, Eunjeong Choi, Yoonju Nam, Kyoung Ho Lee, Hi-Jin You, Hyo Jin Kang, Sang Hyun An, Hojun Jeon
Summary: Exosomes are nano-sized vesicles carrying diverse biomolecules, serving as potential biomarkers in skin therapy. They play a crucial role in communication and regeneration of skin cells, but face challenges in engineering and commercialization. Further research is needed to overcome limitations and explore future perspectives in exosome technology for skin treatments.
BIOMATERIALS RESEARCH
(2021)
Article
Medicine, Research & Experimental
Gi Hoon Yang, Wonjin Kim, Juyeon Kim, GeunHyung Kim
Summary: An electric field-assisted 3D cell-printing process was developed to fabricate cell-laden fibers with alignment cues, leading to successful myotube formation and maturation. The cell-laden fibrous bundles can serve as in vitro drug testing models for various myogenic responses, showing potential applications in mimicking muscle tissue regeneration.
Article
Engineering, Biomedical
Gi Hoon Yang, Hojun Jeon, GeunHyung Kim
Article
Engineering, Biomedical
Gi Hoon Yang, Minseong Kim, GeunHyung Kim
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)