Article
Biochemistry & Molecular Biology
Ramon Rial, Michael Gonzalez-Durruthy, Manuel Somoza, Zhen Liu, Juan M. Ruso
Summary: This study presents a computational analysis and experimental studies on the interaction between a benzothiazole (BTS) and lysozyme. The results suggest that the interactions are mainly based on aromatic, hydrophobic Van der Waals interactions. Mechanistic approaches show that the BTS ligand induces propagation of allosteric signals in lysozyme, leading to conformational changes.
Article
Biochemistry & Molecular Biology
Helena Ostergaard Rasmussen, Janni Nielsen, Angela de Poli, Daniel E. Otzen, Jan Skov Pedersen
Summary: This study investigates the effect of two phospholipids and one glycosaminoglycan on tau protein fibrillation. It is found that both cofactors can induce tau fibrillation, with similar final cross-sectional dimensions of the fibrils.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Physical
Michael Gonzalez-Durruthy, Ramon Rial, M. Natalia D. S. Cordeiro, Zhen Liu, Juan M. Ruso
Summary: This study investigates the interactions between beta-lactam antibiotics and fibrinogen through computational and experimental approaches, revealing similar binding affinities for the antibiotics. The incorporation of halogen atoms in dicloxacillin could potentially reduce off-target effects. Experimental validation supports computational results, offering new perspectives for rational drug design of beta-lactam antibiotics.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Daniel E. Otzen, Jannik Nedergaard Pedersen, Helena Ostergaard Rasmussen, Jan Skov Pedersen
Summary: Although the mode of interaction between the anionic surfactant sodium dodecyl sulfate (SDS) and proteins has been a subject of controversy, recent studies have conclusively supported the core-shell model, where denatured proteins cover the surface of SDS micelles. The formation of these structures depends on the SDS:protein ratio and molecular mass of the protein. SDS denaturation can be reversed by adding nonionic surfactants, and is generally reversible except under low pH conditions.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Balazs Mero, Kitti Koprivanacz, Anna Cserkaszky, Laszlo Radnai, Virag Vas, Gyongyi Kudlik, Gergo Gogl, Peter Sok, Adam L. Poti, Balint Szeder, Laszlo Nyitray, Attila Remenyi, Miklos Geiszt, Laszlo Buday
Summary: Tks4 scaffold protein is a crucial regulator of cell motility by being essential for podosome and invadopodia formation, as well as participating in the EGF signaling pathway. It shares structural similarities with p47(phox) in its N-terminal region and may be regulated by an intramolecular interaction similar to p47(phox).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mihaela Mic, Adrian Pirnau, Calin G. Floare, Mariana Doina Palage, Ovidiu Oniga, Gabriel Marc
Summary: The aim of this research was to obtain a supramolecular complex between a strong antioxidant compound and β-cyclodextrin to enhance its antioxidant activity. The inclusion complex was formed in aqueous solution with a 1:1 stoichiometry and an equilibrium constant was determined. Hydrophobic interactions were found to be the key interactions in the complex. H-1 NMR spectroscopy and 2D NMR suggested the orientation of the aromatic ring inside the β-cyclodextrin cavity. The antiradical activity of the complex was delayed compared to the free compound.
Article
Nutrition & Dietetics
Grazyna Budryn, Iwona Majak, Joanna Grzelczyk, Dominik Szwajgier, Alejandro Rodriguez-Martinez, Horacio Perez-Sanchez
Summary: Low acetylcholine level caused by high acetylcholinesterase (AChE) activity is a symptom of Alzheimer's disease (AD). AChE inhibitors, used in AD treatment, can lead to a cholinergic crisis with prolonged use. It is important to find safe natural AChE inhibitors. This study analyzed the inhibitory effect of 16 hydroxybenzoic acids on AChE using calorimetry and docking simulation. All tested compounds showed inhibition of ACh hydrolysis, with methyl syringinate exhibiting the best performance as a competitive inhibitor at the catalytic site. The tested compounds also interacted with binding sites known to block beta-amyloid plaques formation. The results indicate that the tested hydroxybenzoic acids have reversible and non-toxic effects, with activity at physiological concentrations.
Article
Pharmacology & Pharmacy
Borja Gomez-Gonzalez, Luis Garcia-Rio, Nuno Basilio, Juan C. Mejuto, Jesus Simal-Gandara
Summary: The formation of inclusion complexes between alkylsulfonate guests and a cationic pillar[5]arene receptor in water was investigated. The complexes were stabilized by electrostatic interactions and hydrophobic effects, with high hydrophobic guests showing higher binding constants. The alkyl chain of the guest was included in the hydrophobic aromatic cavity of the receptor, while the sulfonate groups were held in the multicationic portal by ionic interactions.
Article
Biochemistry & Molecular Biology
Huiling Wang, Mingfang Wang, Zefeng Nie, Shuang Qiu, Xiaoping Huang, Xiang Li, Yanfang Cui, Chunrong Liu, Changlin Liu
Summary: Cu/Zn superoxide dismutase (SOD1) plays a key role as an antioxidant enzyme in maintaining cellular reactive oxygen species (ROS) homeostasis and regulating gene expression. We found that SOD1 is involved in gene expression regulation in response to changes in cellular ROS levels through its binding to DNA and the binding is redox-dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sree Hima, Chandran Remya, C. Sadasivan, K. V. Dileep
Summary: This study investigated the effects of carboxylic acid derivatives such as cinnamic acid, 2,4-dichlorophenoxyacetic acid, and 3-(4-hydroxyphenyl)-propionic acid on fungal growth and α-amylase inhibitory activity. The results showed that these compounds can inhibit fungal growth, partially attributed to the inhibition of fungal α-amylase activity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Applied
Xuwei Liu, Jiayi Li, Agnes Rolland-Sabate, Serge Perez, Carine Le Bourvellec, Catherine M. G. C. Renard
Summary: This study investigated the interactions between different xylose-containing water-soluble hemicelluloses and procyanidins. The results showed that the strength of the interactions between hemicelluloses and procyanidins depended on their structure rather than other incidental properties.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Angel Pineiro, James Pipkin, Vince Antle, Rebeca Garcia-Fandino
Summary: Modified cyclodextrins (CDs) are used as enabling excipients in pharmaceutical formulations to improve solubility and stability of drugs. The affinity between CDs and drugs should be balanced for optimal formulation. This study investigates the effect of substitutions on complexation using sulphobutylether-beta-cyclodextrin and remdesivir as a case study, providing insights for the optimization of formulations based on modified CDs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Multidisciplinary Sciences
P. Bryant, G. Pozzati, A. Elofsson
Summary: Predicting the structure of protein complexes is extremely challenging. In this study, the authors utilize AlphaFold2 combined with optimized multiple sequence alignments to model interacting protein complexes, achieving state-of-the-art accuracy in predicting both the interaction status and mode of proteins.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Nikoletta Pechlivani, Katherine J. Kearney, Ramzi A. Ajjan
Summary: Targeting proteins involved in hypofibrinolysis represents a specific approach for developing effective and safe therapeutic agents to reduce thrombosis risk and improve clot instability in bleeding disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kanika Dhiman, Samir Kumar Nath, Ashish
Summary: The study demonstrates that CD4 can form dimeric structures in solution, and this association is reversible, resembling crystal-like binding. Through variable temperature SAXS experiments, the disruption of CD4 dimerization was achieved by D4-D4 interactions and small molecules binding to the D1 domain. The systematic communication network across the structural length of sCD4 senses self and other molecule binding, providing insights for developing CD4-reactive immunosuppressive agents.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Physical
Maria Lbadaoui-Darvas, Giovanni Garberoglio, Katerina S. Karadima, M. Natalia D. S. Cordeiro, Athanasios Nenes, Satoshi Takahama
Summary: This comprehensive review explores methods and applications of molecular simulations of interfacial systems, providing detailed insights into techniques and challenges in solid and fluid surfaces. The review also summarizes methods for estimating macroscopic properties of interfaces and extracting information about fluctuating liquid surfaces, demonstrating their application in atmospheric science, material science, and biophysics. The main goals are to guide practical questions in software, force fields, and select appropriate analysis methods, while highlighting the potential for molecular simulations to advance our understanding in applied science.
MOLECULAR SIMULATION
(2023)
Article
Chemistry, Medicinal
Michael Gonzalez-Durruthy, Riccardo Concu, Laura F. Osmari Vendrame, Mirkos Ortiz Martins, Ivana Zanella, Juan Manuel Ruso, Maria Natalia Dias Soeiro Cordeiro
Summary: This study combined molecular docking approaches and DFT ab initio simulations to investigate the key interactions of cyclodextrins (CDs) with potential pharmacological relevance and the multidrug resistance P-gp protein. The findings provide valuable insights into the CD docking mechanism and the role of P-gp in drug delivery.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Riccardo Concu, Maria Natalia Dias Soeiro Cordeiro, Martin Perez-Perez, Florentino Fdez-Riverola
Summary: This study developed a novel multi-target machine learning (MTML) quantitative structure-activity relationship (QSAR) model for predicting interactions between different drugs and enzyme targets. The model was based on a large dataset of drug-enzyme pairs and used topological drug features and artificial neural network (ANN) multi-layer perceptron (MLP). The validated model showed an overall accuracy of over 96%. To maximize its diffusion, a public and accessible web-based tool was developed for users to make their own predictions.
Article
Chemistry, Multidisciplinary
Manuel Somoza, Ramon Rial, Zhen Liu, Iago F. Llovo, Rui L. Reis, Jesus Mosqueira, Juan M. Ruso
Summary: This study successfully created doped Hydroxyapatite nanoparticles with magnetic properties using microfluidics and Gadolinium as a contrast agent for medical applications. Computational Fluid Dynamics (CFD) was used to ensure the system worked in the laminar regime and nanoparticles diffused uniformly. The biomaterials were characterized using XRD, FE-SEM, EDX, confocal Raman microscopy, and FT-IR, confirming the successful incorporation of Gadolinium. Magnetic characterization confirmed the paramagnetic behavior of the nanoparticles, showing the potential for advanced nanomaterials in theragnostic applications.
Article
Nanoscience & Nanotechnology
Juan M. Sieben, Damian Placente, Monica D. Baldini, Juan M. Ruso, Juan A. Laiuppa, Graciela E. Santillan, Paula V. Messina
Summary: This study proposes a framework for understanding the antimicrobial effect of biocompatible nano-hydroxyapatite/MoO(x) platforms based on their electroactive behavior. The electron transference capacity of these platforms was determined in the presence of pathogenic organisms, and their disruptive effect on the bacteria's cytoplasmic membrane was observed. The study suggests the existence of an extracellular electron transfer process that can be used to combat orthopedic infections associated with implants.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biology
Soumya Mitra, Amit Kumar Halder, Nilanjan Ghosh, Subhash C. Mandal, M. Natalia D. S. Cordeiro
Summary: Non-alcoholic fatty liver disease (NAFLD) is a major health hazard globally, and there are limited treatment options available. This study used cheminformatics and molecular modeling techniques to investigate the structural requirements of 3-benzamidobenzoic acid derivatives for their potency towards Farnesoid X receptor (FXR), providing important guidelines for designing novel FXR partial agonists for the management of NAFLD.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Amit Kumar Halder, Soumya Mitra, Maria Natalia D. S. Cordeiro
Summary: This article reviews the recent developments in the design of multi-target drugs for the treatment of major depressive disorders. Case studies focusing on design strategies and challenges are discussed. The authors suggest exploring potential biological targets and utilizing computational modeling techniques for further research.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Catia A. Bonito, Ricardo J. Ferreira, Maria-Jose U. Ferreira, Jean-Pierre Gillet, M. Natalia D. S. Cordeiro, Daniel J. V. A. dos Santos
Summary: In this study, the impact of four P-gp mutations on drug-binding and efflux-related signal-transmission mechanism was evaluated. The repacking of the transmembrane helices induced by mutations and ligands indicates P-gp's sensitivity to perturbations in the transmembrane region. Changes in drug-binding were observed as a consequence of transmembrane helices repacking, but were not always correlated with alterations in ligand binding mode and affinity. The changes in drug efflux are mostly related to changes in drug specificity rather than effects on signal-transmission mechanism.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Polymer Science
Hui Li, Ning Wang, Li Zhang, Yuanyuan Wei, Long Zhang, Yingxia Ma, Juan M. Ruso, Zhen Liu
Summary: In this study, a double-layer coating material for slow-release fertilizer was developed, using low-cost materials such as polyvinyl alcohol (PVA) and methylcellulose (MC) as the inner layer coating materials, and attapulgite doped into superabsorbent polymer poly acrylic acid (PAA) and polyacrylamide (PAM) grafted natural biodegradable lignin as the outer layer coating materials. The chemical structures, mechanical properties, hydrophilic properties, and water retention properties of the double-layer coating material on the urea particles' surface were investigated, and the synthesis parameters were optimized to achieve the best water absorption properties of the outer layer absorbent. Moreover, urea release was evaluated through dissolution experiments. The results demonstrated that the performance indicators of the inner coating liquid were better at a PVA concentration of 5 wt% and an MC addition amount of 2.0 g. Additionally, more urea molecules were released (>30 days) in the single-layer and double-coated fertilizers, with cumulative release rates of 92.36% and 85.10%, respectively. This research provides insights for the preparation of double-coated slow-release fertilizers, which can improve soil water retention and fertilizer utilization.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Catia A. Bonito, Ricardo J. Ferreira, Maria-Jose. U. Ferreira, Fernando Duraes, Emilia Sousa, Jean-Pierre Gillet, M. Natalia D. S. Cordeiro, Daniel J. V. A. dos Santos
Summary: A medicinal chemistry study combined in silico and in vitro methodologies to identify and characterize putative allosteric drug-binding sites (aDBSs) at the interface of the transmembrane-and nucleotide-binding domains (TMD-NBD) of P-glycoprotein. Two aDBSs were identified using in silico fragment-based molecular dynamics and were characterized in terms of size, polarity, and lining residues. Several compounds from a small library of thioxanthone and flavanone derivatives were found to decrease verapamil-stimulated ATPase activity, indicating allosteric efflux modulation in P-glycoprotein. Molecular docking and dynamics simulations provided insights into the binding mode of flavanone derivatives as allosteric inhibitors.
Article
Chemistry, Physical
Ramon Rial, Michael Gonzalez-Durruthy, Zhen Liu, Rui L. Reis, Juan M. Ruso
Summary: The binding mechanisms between a mixture of catanionic surfactants and dicloxacillin with lysozyme protein were studied. The results showed that dicloxacillin had stronger binding affinity than the surfactant, and there were synergistic and antagonistic effects between them. Experimental validation revealed that the presence of the catanionic mixture altered the absorption spectrum of lysozyme.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Environmental Sciences
Amit Kumar Halder, Ana S. Moura, M. Natalia D. S. Cordeiro
Summary: Manufactured substances known as endocrine disrupting chemicals (EDCs) released in the environment can cause severe eco and cytotoxicity at relatively low doses. This study introduces a new multitasking quantitative structure-toxicity relationship (QSTR) modeling approach for predicting the ecotoxicity of EDCs against 170 biological species. The developed QSTR models display high accuracies, and a multitasking consensus modeling approach further improves the predictive ability.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Alexandre P. P. Martin, Gary A. A. Bradshaw, Robyn J. J. Eisert, Emily D. D. Egan, Lena Tveriakhina, Julia M. M. Rogers, Andrew N. N. Dates, Gustavo Scanavachi, Jon C. C. Aster, Tom Kirchhausen, Marian Kalocsay, Stephen C. C. Blacklow
Summary: Notch signaling relies on ligand-induced proteolysis of the transmembrane receptor Notch to liberate a nuclear effector that drives cell fate decisions. Our study used proximity labeling with quantitative, multiplexed mass spectrometry to track the proteolysis and movement of Notch from the plasma membrane to the nucleus. The results showed that γ-secretase-mediated Notch cleavage occurs in an intracellular compartment and nuclear complex formation occurs within 45 minutes of inhibitor washout.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)