Article
Multidisciplinary Sciences
Xiaodong Dang, Wenhui Zhao, Chen Li, Hua Yang, Dianzhen Li, Shanshan Zhang, Tianbo Jin
Summary: This study discovered an association between COL6A4P2 gene polymorphisms and lung cancer risk in the Chinese Han population, providing a foundational reference for personalized lung cancer prevention.
Article
Biochemistry & Molecular Biology
Yuhe Wang, Mingyue Chen, Faling Yi, Jinpeng Xu, Changchun Liu, Ziyi Zhang, Ping Wang, Tianbo Jin, Mingwei Chen
Summary: This study aimed to evaluate the association of single nucleotide polymorphisms (SNPs) of the glutaminase (GLS) gene with lung cancer susceptibility in the Chinese Han population. The results showed that GLS rs143584207 and rs6713444 were significantly associated with lung cancer susceptibility. Further subgroup and clinical information analyses revealed that these SNPs could reduce lung cancer susceptibility in different subgroups and had a protective effect on non-smokers and patients with advanced lung cancer. The findings suggest that GLS SNPs could be potential markers for the timely treatment of lung cancer in the Chinese Han population.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Biochemistry & Molecular Biology
Na Li, Zhigang Cui, Min Gao, Sixuan Li, Mingyang Song, Ying Wang, Lianwei Tong, Yanhong Bi, Ziwei Zhang, Shengli Wang, Baosen Zhou, Zhihua Yin
Summary: rs13252298 and rs1456315 in PRNCR1 may be genetic susceptibility factors for lung cancer in Chinese population. These results need to be confirmed by further studies.
DNA AND CELL BIOLOGY
(2021)
Article
Oncology
Giulia Peduzzi, Manuel Gentiluomo, Francesca Tavano, Paolo Giorgio Arcidiacono, Stefano Ermini, Pavel Vodicka, Ugo Boggi, Giulia Martina Cavestro, Gabriele Capurso, Luca Morelli, Anna Caterina Milanetto, Raffaele Pezzilli, Rita T. Lawlor, Silvia Carrara, Martin Lovecek, Pavel Souc, Feng Guo, Thilo Hackert, Faik G. Uzunoglu, Maria Gazouli, Andrea Parniczky, Juozas Kupcinskas, Maarten F. Bijlsma, Bas Bueno-de-Mesquita, Roel Vermeulen, Casper H. J. van Eijck, Krzysztof Jamroziak, Renata Talar-Wojnarowska, William Greenhalf, Domenica Gioffreda, Maria C. Petrone, Stefano Landi, Livia Archibugi, Marta Puzzono, Niccola Funel, Cosimo Sperti, Maria L. Piredda, Beatrice Mohelnikova-Duchonova, Ye Lu, Viktor Hlavac, Xin Gao, Martin Schneider, Jakob R. Izbicki, George Theodoropoulos, Stefania Bunduc, Edita Kreivenaite, Olivier R. Busch, Ewa Malecka-Panas, Eithne Costello, Francesco Perri, Sabrina Gloria Giulia Testoni, Giuseppe Vanella, Claudio Pasquali, Martin Oliverius, Hermann Brenner, Martin Loos, Mara Gotz, Konstantinos Georgiou, Alint Eross, Evaristo Maiello, Andrea Szentesi, Francesca Bazzocchi, Daniela Basso, John P. Neoptolemos, P. Eter Hegyi, Vytautas Kiudelis, Federico Canzian, Daniele Campa
Summary: Mitochondrial metabolism has been linked to PDAC risk, with genetic variability potentially playing a role. However, this study did not find significant associations between mtSNPs or n-mtSNPs and PDAC risk. Gene-level analysis highlighted three genes (TERT, SUGCT, and SURF1) that showed some association with PDAC, but not at a statistically significant level.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Respiratory System
Zexi Liao, Minhan Yi, Jiaxin Li, Yuan Zhang
Summary: This study investigates the association between SNP in DNA repair pathway and lung cancer risk. The findings reveal certain SNPs that are associated with increased or decreased risk of lung cancer. Furthermore, there are variations in the risk-associated SNPs among different ethnicities and lung cancer subtypes.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Oncology
Yuxin Wang
Summary: The study revealed that LRRC3B gene polymorphisms were associated with the risk of breast cancer, suggesting that LRRC3B variants might be helpful in predicting breast cancer progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shuyong Yu, Jiajia Cheng, Ping Li, Le Tian, Zhuang Chen, Zhaowei Chen, Yongyu Li, Jian Song
Summary: This study investigated the relationship between MMP8 gene polymorphism and colorectal cancer (CRC) risk in the Chinese Han population. The results showed that MMP8 rs3740938 was associated with an increased predisposition to CRC, particularly in older individuals, females, those with higher BMI, smokers, and drinkers. Furthermore, this gene variant was found to be associated with the pathological type of rectal cancer.
Article
Cell Biology
Hui Yang, Qiuyu Sun, Feifei Chong, Xiaoru Jiang, Yanli Wang, Kedi Xu, Yuanlin Zou, Linping Xu, Chunhua Song
Summary: The study revealed an association between MIR2052HG gene polymorphism and breast cancer susceptibility, particularly showing that the MIR2052HG rs34841297 A/- genotype may affect the proliferation, invasion, and migration of breast cancer cells by modulating interactions with miR-4456.
Article
Oncology
Rayjean J. Hung, Matthew T. Warkentin, Yonathan Brhane, Nilanjan Chatterjee, David C. Christiani, Maria Teresa Landi, Neil E. Caporaso, Geoffrey Liu, Mattias Johansson, Demetrius Albanes, Loic Le Marchand, Adonina Tardon, Gad Rennert, Stig E. Bojesen, Chu Chen, John K. Field, Lambertus A. Kiemeney, Philip Lazarus, Shanbeth Zienolddiny, Stephen Lam, Angeline S. Andrew, Susanne M. Arnold, Melinda C. Aldrich, Heike Bickeboeller, Angela Risch, Matthew B. Schabath, James D. McKay, Paul Brennan, Christopher Amos
Summary: Research suggests that an individual's genetic background may play a role in risk stratification for lung cancer and optimizing LDCT screening.
Article
Oncology
Rowland Pettit, Jinyoung Byun, Younghun Han, Quinn Ostrom, Cristian Coarfa, Melissa Bondy, Christopher Amos
Summary: Using Mendelian randomization analysis, we identified several heritable traits associated with the risk of lung cancer development. These effects vary based on histologic subtype and conditional third trait exposures, providing valuable insights for lung cancer research.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Genetics & Heredity
Yingying Yuan, Yachun Wang, Xiaodong Niu, Yungang Han, Wenbo Li, Meijin Cheng, Zheng Li, Jiao Tan, Yue Zhao, Wei Wang
Summary: This study provides a more precise estimation of the relationship between lncRNA H19 polymorphisms and cancer risk based on a meta-analysis of 53 studies. The results suggest that the rs2839698 polymorphism in H19 is associated with increased cancer risk in all participants. Stratification analysis reveals that certain mutations are linked to specific cancer types.
FRONTIERS IN GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Jian Xiao, Chuming Zhu, Peidong Ni, Wangwang Chen, Zengliang Li, Hao Fan, Xiang Ma, Zekuan Xu, Li Yang
Summary: The study found that the polymorphism rs61396151 in the SNHG5 gene is associated with a decreased risk of gastric cancer, but not with clinicopathological features. However, it was associated with overall survival rate, which was reversed after adjustments.
Article
Toxicology
Yuhui Yu, Liping Mao, Zhounan Cheng, Xiaoqi Zhu, Jiahua Cui, Xiaoyu Fu, Jingwen Cheng, Yan Zhou, Anni Qiu, Yang Dong, Xun Zhuang, Yihua Lu, Yulong Lian, Tian Tian, Shuangshuang Wu, Minjie Chu
Summary: This study identified five candidate regQTL-SNPs associated with lung cancer risk, among which the variant T allele of rs3768617 in the LAMC1 gene significantly increased the risk of lung cancer. Functional experiments demonstrated that rs3768617 modulated the expression patterns of miRNA-548b-3p and LAMC1, affecting lung cancer development. The findings suggest that regQTL-SNPs could offer a new perspective on the regulatory role of SNPs in lung cancer pathogenesis.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Oncology
Xuedong Wang, Kui Deng, Jing Tao, Juan Zou, Yiting Du, Li Dai
Summary: This study found that RIPK1 gene polymorphisms are associated with susceptibility to epithelial ovarian cancer (EOC) and clinical outcomes. Specifically, certain SNPs and genotypes variants are associated with early-onset EOC and better survival outcomes. Furthermore, the study also observed increased plasma levels of RIPK1 and reduced RIPK1 mRNA expression in EOC patients.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Juan Sainz, Francisco Jose Garcia-Verdejo, Manuel Martinez-Bueno, Abhishek Kumar, Jose Manuel Sanchez-Maldonado, Anna Diez-Villanueva, Ludmila Vodickova, Veronika Vymetalkova, Vicente Martin Sanchez, Miguel Inacio Da Silva Filho, Belem Sampaio-Marques, Stefanie Brezina, Katja Butterbach, Rob ter Horst, Michael Hoffmeister, Paula Ludovico, Manuel Jurado, Yang Li, Pedro Sanchez-Rovira, Mihai G. Netea, Andrea Gsur, Pavel Vodicka, Victor Moreno, Kari Hemminki, Hermann Brenner, Jenny Chang-Claude, Asta Foersti
Summary: Through a meta-analysis of genome-wide association study data, this study identified DAPK2 and ATG5 loci as being associated with colorectal cancer risk in European cohorts. Specifically, genetic variants within these loci were found to impact host immune responses and levels of inflammatory proteins, potentially contributing to cancer development. Additionally, no direct effect on autophagy flux was observed, indicating a complex relationship between genetic variants, immune responses, and cancer risk.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)