Synthesis, characterization and anticancer activity of new Zn(II) and MoO22+ complexes of 2-amino-4,6-mercaptotriazine

The preparation of new complexes containing 2-amino-4,6-mercaptotriazine (HAT) [Zn(AT)(2)(H2O)(2)], [Zn(bpy) (AT)Cl(H2O)], [Zn(PPh3)(2)(AT)Cl(H2O)] and cis-[Mo2O5(AT)(2)] is reported. The structures of these complexes are discussed using IR, NMR, UV-Vis, and EI-mass spectra, elemental analysis, molar conductivity and thermal measurements. HAT coordinates to the central metal ions through the deprotonated cyclic-N(1) and amino-N(2) or mercapto-S(6) atoms (AT(-)) in mononegative bidentate manner. The stoichiometries and the formation constants of Zn(II) complexes in solution were calculated using Job's method. The anticancer activities of some of the complexes were examined against The human breast cancer MDA-MB231 cell line. The IC50 values for cell growth proliferation were ranged from 24.57 +/- 0.2 to 49.89 +/- 0.4 mu M, while that for the standard reference drug, cisplatin, was 8.72 +/- 0.5 mu M.