Article
Biochemistry & Molecular Biology
Ewelina A. Dziedzic, Jakub S. Gasior, Agnieszka Tuzimek, Justyna Paleczny, Miroslaw Kwasny, Marek Dabrowski, Piotr Jankowski
Summary: This study assessed the zinc nutritional status in patients with coronary artery disease using inductively coupled plasma optical emission spectrometry. The results showed no association between zinc and the severity of coronary artery disease, and there were no significant differences in zinc levels between patients with acute coronary syndrome and stable coronary artery disease. However, a significant negative correlation was observed between zinc content and serum triglyceride concentration, and patients with type 2 diabetes mellitus had lower hair zinc content.
Review
Medicine, General & Internal
Arnav Katira, Ravish Katira
Summary: Colchicine may play a key role in the prevention of cardiovascular events in patients with stable and unstable coronary artery disease, as it is associated with a reduction in the rate of myocardial infarction and other major cardiovascular outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Markus Malmberg, Jarmo Gunn, Paivi Rautava, Jussi Sipila, Ville Kyto
Summary: Patients with myocardial infarction have poorer short- and long-term outcomes compared to stable coronary artery disease patients after coronary artery bypass grafting (CABG). Higher risk of death continues also in stabilized first-year myocardial infarct survivors. Efficient secondary prevention and follow-up are important in the post-myocardial infarct population after CABG.
ANNALS OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ayman Elbadawi, Mohammed Elzeneini, Islam Y. Elgendy, Michael Megaly, Mohamed Omer, Ernesto Jimenez, Ravi K. Ghanta, Emmanouil S. Brilakis, Hani Jneid
Summary: This study used a nationwide database to analyze the trends and outcomes of isolated coronary artery bypass grafting after ST-elevation myocardial infarction. The results showed a decline in the use of this procedure, but no change in in-hospital mortality. A recent cohort study found that performing the grafting on day 2 had similar in-hospital mortality compared with day 3 or more, but lower rates of complications and shorter hospital stays.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Valentino Bianco, Arman Kilic, Thomas G. Gleason, Edgar Aranda-Michel, Yisi Wang, Forozan Navid, Ibrahim Sultan
Summary: The timing of coronary artery bypass grafting after acute myocardial infarction does not consistently affect postoperative outcomes. After adjusting for baseline patient characteristics, there was no statistically significant difference between timing cohorts for both mortality and major adverse cardiovascular and cerebrovascular event readmissions.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Yves Cottin, Rany Issa, Mourad Benalia, Basile Mouhat, Alexandre Meloux, Laura Tribouillard, Florence Bichat, Luc Rochette, Catherine Vergely, Marianne Zeller
Summary: The study found an association between serum OPG levels and coronary lesion complexity in patients with acute myocardial infarction, which was not influenced by factors such as hypercholesterolemia, cardiovascular history, and reduced glomerular filtration rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Marta Lozano-Prieto, David Adlam, Marcos Garcia-Guimaraes, Ancor Sanz-Garcia, Paula Vera-Tome, Fernando Rivero, Javier Cuesta, Teresa Bastante, Anna A. Baranowska-Clarke, Alicia Vara, Enrique Martin-Gayo, Miguel Vicente-Manzanares, Pilar Martin, Nilesh J. Samani, Francisco Sanchez-Madrid, Fernando Alfonso, Hortensia de la Fuente
Summary: The study found that specific miRNAs have significantly different expression in the plasma of SCAD and AT-AMI patients, and the combined expression of these four miRNAs can better distinguish between the two diseases. Functional analysis revealed an association of these miRNAs with blood vessel biology, TGF-beta pathway, and cytoskeletal traction force.
Article
Medicine, General & Internal
Tobias F. S. Pustjens, Marijke J. C. Timmermans, Saman Rasoul, Arnoud W. J. van't Hof
Summary: The study found that NSTE-ACS patients with MVD undergoing MV-PCI and CO-PCI had similar mortality rates at long-term follow-up, but the MV-PCI group showed improved event-free survival in terms of fewer coronary reinterventions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tae-Min Rhee, Hyung-Kwan Kim, Bong-Seong Kim, Kyung-Do Han, Hyun-Jung Lee, In-Chang Hwang, Heesun Lee, Jun-Bean Park, Yeonyee E. Yoon, Yong-Jin Kim, Goo-Yeong Cho
Summary: Limited data are available on the long-term outcomes in HCM patients with significant CAD requiring revascularization. This study showed that HCM patients who underwent coronary revascularization had a significantly higher risk of cardiovascular death, SCD, ischemic stroke, and heart failure compared to the non-HCM control group.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Joseph Hadaya, Yas Sanaiha, Zachary Tran, Peter Downey, Richard J. Shemin, Peyman Benharash
Summary: This study evaluated the impact of timing of coronary artery bypass grafting (CABG) on mortality and resource utilization in patients with acute coronary syndrome. The study found comparable in-hospital mortality for CABG performed on days 1-3 and 4-7, with higher rates on day 0 and after day 7. Additionally, CABG performed on days 4-7 had higher hospitalization costs. High-performing hospitals had similar CABG timing but lower mortality compared to others.
ANNALS OF THORACIC SURGERY
(2022)
Article
Endocrinology & Metabolism
Gilles Lemesle, Etienne Puymirat, Laurent Bonello, Tabassome Simon, Philippe-Gabriel Steg, Jean Ferrieres, Francois Schiele, Laurent Fauchier, Patrick Henry, Guillaume Schurtz, Sandro Ninni, Nicolas Lamblin, Christophe Bauters, Nicolas Danchin
Summary: This study aimed to investigate the relationship between diabetes mellitus (DM) status and the risk of heart failure (HF) occurrence in patients with coronary artery disease (CAD). The results showed that patients with DM had a significantly higher risk of HF, whether in the acute myocardial infarction (MI) phase or the chronic stable phase. Therefore, it is crucial to prevent HF occurrence in CAD patients with DM.
DIABETES & METABOLISM
(2022)
Article
Cell Biology
Chang Chen, Yequn Chen, Jiaxin Xiao, Yanhong Zhang, Zhaorui Yang, Peixuan Yang, Nan Lu, Kaihong Yi, Xiaojun Chen, Shaoxin Chen, Mary Clare O'Gara Msc, Michael O'Meara, Shu Ye, Xuerui Tan
Summary: There is an association between impaired fasting glucose level and a predisposition to severe coronary artery disease indicated by triple vessel disease or myocardial infarction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Soudeh Ghafouri-Fard, Mahdi Gholipour, Mohammad Taheri
Summary: miRNAs play a crucial role in the pathophysiological process of CAD, with up-regulated and down-regulated miRNAs associated with the development of CAD, which can be utilized for diagnostic and prognostic evaluation of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Sa Li, Jiaguo Zhan, Yucheng Wang, Patrick Kwabena Oduro, Felix Boahen Owusu, Jiale Zhang, Ling Leng, Ruiqiao Li, Shujie Wei, Jun He, Qilong Wang
Summary: Suxiao Jiuxin Pill (SJP) is an effective traditional Chinese medicine used for heart diseases. This study investigated the pharmacological effects of SJP in acute myocardial infarction (AMI) and the molecular pathways involved in coronary artery vasorelaxation. The results showed that SJP improved cardiac function and elevated ST segment in AMI rat models. Analysis of the compounds in SJP-treated rats' sera detected various non-volatile and volatile compounds. Network pharmacology analysis identified eNOS and PTGS2 as key drug targets, and SJP-induced coronary artery relaxation was mediated through the eNOS-NO pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Prakriti Gaba, Evald H. Christiansen, Per H. Nielsen, Sabina A. Murphy, Patrick T. O'Gara, Peter K. Smith, Patrick W. Serruys, A. Pieter Kappetein, Seung-Jung Park, Duk-Woo Park, Gregg W. Stone, Joseph F. Sabik, Marc S. Sabatine, Niels R. Holm, Brian A. Bergmark
Summary: Patients with left main coronary artery disease presenting with ACS have higher rates of early death, but the long-term all-cause mortality rates were similar between PCI and CABG in this high-risk subgroup. The advantages and disadvantages of PCI and CABG in terms of early stroke and long-term spontaneous MI and repeat revascularization were consistent regardless of ACS status.
Article
Geriatrics & Gerontology
Seraina Netzer, Patricia Chocano-Bedoya, Martin Feller, Camilla Janett-Pellegri, Lea Wildisen, Annina E. Buchi, Elisavet Moutzouri, Elena Gonzalez Rodriguez, Tinh-Hai Collet, Rosalinde K. E. Poortvliet, Vera J. C. Mc Carthy, Daniel Aeberli, Drahomir Aujesky, Rudi Westendorp, Terence J. Quinn, Jacobijn Gussekloo, Patricia M. Kearney, Simon Mooijaart, Douglas C. Bauer, Nicolas Rodondi
Summary: The loss of skeletal muscle function, strength, and mass is common in older adults, and it has significant socioeconomic impact. Subclinical hypothyroidism, which is prevalent in older adults, has been associated with reduced muscle strength. However, there hasn't been a randomized placebo-controlled trial to investigate the effect of treating subclinical hypothyroidism on muscle function and mass.
Article
Hematology
Marie Mean, Neal Breakey, Odile Stalder, Lorenzo Alberio, Andreas Limacher, Anne Angelillo-Scherrer, Pierre Fontana, Hans Jurg Beer, Nicolas Rodondi, Drahomir Aujesky, Bernhard Laemmle, Robert Escher
Summary: This study examined the prevalence of laboratory thrombophilic risk factors in elderly patients with VTE and their association with clinical outcomes. The results showed that 78% of patients had at least one risk factor, with elevated levels of various factors being the most common. The study also found significant associations between certain risk factors and VTE recurrence and death.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Oncology
Ossia M. Eichhoff, Corinne I. Stoffel, Jan Kasler, Luzia Briker, Patrick Turko, Gergely Karsai, Nina Zila, Verena Paulitschke, Phil F. Cheng, Alexander Leitner, Andrea Bileck, Nicola Zamboni, Anja Irmisch, Zsolt Balazs, Aizhan Tastanova, Susana Pascoal, Pal Johansen, Rebekka Wegmann, Julien Mena, Alaa Othman, Vasanthi S. Viswanathan, Judith Wenzina, Andrea Aloia, Annalisa Saltari, Andreas Dzung, Michael Krauthammer, Stuart L. Schreiber, Thorsten Hornemann, Martin Distel, Berend Snijder, Reinhard Dummer, Mitchell P. Levesque
Summary: The clinical management of NRAS-mutated melanomas is challenging due to resistance that arises through genetic, transcriptional, and metabolic adaptation. However, the adoption of a mesenchymal phenotype with a quiescent metabolic program in NRAS-mutated melanoma cells confers sensitivity to reactive oxygen species (ROS) induction, which can be inhibited by ROS inducers in combination with MAPK pathway inhibitors. The findings suggest that targeting both metabolic reprogramming and MAPK signaling could improve patient treatment in melanoma and other cancers.
Article
Cardiac & Cardiovascular Systems
Max Wagener, Oliver Reuthebuch, Dik Heg, David Tuller, Enrico Ferrari, Jurg Grunenfelder, Christoph Huber, Igal Moarof, Olivier Muller, Fabian Nietlispach, Stephane Noble, Marco Roffi, Maurizio Taramasso, Christian Templin, Stefan Toggweiler, Peter Wenaweser, Stephan Windecker, Stefan Stortecky, Raban Jeger
Summary: This study compares the mortality rates of different types of severe aortic stenosis (high-gradient, classical low-flow low-gradient, and paradoxical low-flow low-gradient) after transcatheter aortic valve implantation. The results show that patients with paradoxical low-flow low-gradient aortic stenosis have lower mortality rates than patients with classical low-flow low-gradient, but higher mortality rates than those with high-gradient.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Philipp F. Baumgartner, Martin Reiner, Andrea Wiencierz, Michael R. Coslovsky, Nicole G. Bonetti, Mark Filipovic, Stefanie Aeschbacher, Michael S. Kuhne, Christine Zuern, Nicolas Rodondi, Jolanda Oberle, Giorgio F. Moschovitis, Thomas G. Luscher, Giovanni Camici, Stefan Osswald, David Conen, Jurg H. Beer
Summary: This study found no strong evidence for an association between n-3 FA blood levels and AF type, but higher total n-3 FA levels and docosahexaenoic acid may be correlated with lower heart rate, and docosapentaenoic acid with lower heart rate variability triangular index.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Anand Kumar Sharma, Tongtong Wang, Alaa Othman, Radhika Khandelwal, Miroslav Balaz, Salvatore Modica, Nicola Zamboni, Christian Wolfrum
Summary: Emerging evidence suggests the existence of constant basal lipolysis and re-esterification of fatty acids. In this study, the role of lipolysis coupled to re-esterification under basal conditions was investigated. The results showed that DGAT1 and DGAT2 mediated re-esterification plays a role in regulating fatty acid oxidation and mitochondrial fuel utilization.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Livia Noemi Kolb, Alaa Othman, Lucia Rohrer, Jan Kruetzfeldt, Arnold von Eckardstein
Summary: Biomarkers are important for early detection and stratification of diabetes and its complications. In this study, we used NMR spectrometry to analyze metabolic parameters in plasma samples of healthy volunteers and diabetic patients. Our results showed independent associations between diabetes and branched-chain amino acids, lactate, linoleic acid, and HDL diameter. Additionally, we found imbalances in the concentrations of free cholesterol in different lipoprotein subclasses in diabetic subjects compared to non-diabetic controls, which may reflect disturbances in cholesterol transfer processes.
Article
Cardiac & Cardiovascular Systems
Miklos Rohla, Fabrice Temperli, George C. M. Siontis, Roland Klingenberg, Baris Gencer, Nicolas Rodondi, Sarah Bar, David Nanchen, Francois Mach, Jonas D. Haner, Thomas Pilgrim, Olivier Muller, Christian M. Matter, Thomas Luscher, Marco Roffi, Dik Heg, Stephan Windecker, Lorenz Raber
Summary: This study compared the outcomes of STEMI patients undergoing PCI according to total ischemic time. The results showed that PCI performed within 12 hours of symptom onset had better outcomes, while PCI performed later than 12 hours was associated with higher mortality and target lesion failure rates. However, there was no significant difference in outcomes between PCI performed later than 48 hours and PCI performed between 12-48 hours.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Endocrinology & Metabolism
Evie van der Spoel, Nicolien A. van Vliet, Rosalinde K. E. Poortvliet, Robert S. Du Puy, Wendy P. J. den Elzen, Terence J. Quinn, David J. Stott, Naveed Sattar, Patricia M. Kearney, Manuel R. Blum, Heba Alwan, Nicolas Rodondi, Tinh-Hai Collet, Rudi G. J. Westendorp, Bart E. Ballieux, J. Wouter Jukema, Olaf M. Dekkers, Jacobijn Gussekloo, Simon P. Mooijaart, Diana van Heemst
Summary: This study aims to investigate the incidence and determinants of spontaneous normalization of TSH levels in older adults with subclinical hypothyroidism. The study found that younger age, female sex, lower initial TSH level, higher initial free T4 level, absence of thyroid peroxidase antibodies, and a follow-up measurement in summer were independent determinants for TSH level normalization.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Clinical Neurology
Gian Marco De Marchis, Philipp Krisai, Laura Werlen, Tim Sinnecker, Stefanie Aeschbacher, Tolga D. Dittrich, Alexandros A. Polymeris, Michael Coslovksy, Manuel R. Blum, Nicolas Rodondi, Tobias Reichlin, Giorgio Moschovitis, Jens Wuerfel, Philippe A. Lyrer, Urs Fischer, David Conen, Peter Kastner, Andre Ziegler, Stefan Osswald, Michael Kuehne, Leo H. Bonati
Summary: In patients with atrial fibrillation, a model incorporating white matter lesion volume on baseline MRI and selected blood markers yielded new insights on residual stroke risk despite a high proportion of patients on oral anticoagulants. This may be relevant to develop further preventive measures.
Article
Engineering, Biomedical
Aymar Abel Ganguin, Ivo Skorup, Sebastian Streb, Alaa Othman, Paola Luciani
Summary: This study introduces a new therapeutic approach using cell-derived nanovesicles (cdNVs) to address the lack of effective treatments for liver fibrosis. The cdNVs from LX-2 cells exhibit concentration-dependent fibrosis regression, linked to their biomolecular corona. This makes cdNVs a promising candidate for the development of liver fibrosis resolving therapeutics.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Stephan Dobner, Thomas Pilgrim, Daniel Hagemeyer, Dik Heg, Jonas Lanz, Nicole Reusser, Christoph Graeni, Ali Afshar-Oromieh, Axel Rominger, Bettina Langhammer, David Reineke, Stephan Windecker, Stefan Stortecky
Summary: This study aims to determine the prevalence of ATTR-CM in elderly patients with severe aortic stenosis and evaluate the differences in clinical presentation and outcomes of patients with concomitant ATTR-CM undergoing transcatheter aortic valve implantation. The results showed that ATTR-CM was observed in 10.8% of patients with severe aortic stenosis, and elderly age, male sex, and prior carpal tunnel surgery were associated with the coexistence of ATTR-CM. However, there were no significant differences in peri-interventional risk and one-year clinical outcomes between patients with concomitant pathologies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Physiology
Alaa Othman, Mingxia Liu, Heiko Bode, Elena Boudyguina, Arnold von Eckardstein, John S. Parks, Thorsten Hornemann
Summary: ATP binding cassette transporter A1 (ABCA1) limits the formation of high density lipoproteins (HDL), and the loss of ABCA1 function leads to severe deficiency of HDL in Tangier disease patients. Hepatocyte-specific knockout of ABCA1 in mice (Abca1 HSKO) significantly reduces plasma HDL-cholesterol levels, indicating that hepatic ABCA1 plays a major role in the HDL phenotype. The impact of Tangier disease on plasma sphingolipid levels and the contribution of hepatic ABCA1 to plasma sphingolipids are still unknown.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Claudia Irene Maushart, Wenfei Sun, Alaa Othman, Adhideb Ghosh, Jael Rut Senn, Jonas Gabriel William Fischer, Philipp Madoerin, Rahel Catherina Loeliger, Robyn Melanie Benz, Martin Takes, Christoph Johannes Zech, Alin Chirindel, Felix Beuschlein, Martin Reincke, Damian Wild, Oliver Bieri, Nicola Zamboni, Christian Wolfrum, Matthias Johannes Betz
Summary: This study found that glucocorticoids affect energy expenditure in healthy men, but do not affect the activity of brown adipose tissue that generates heat in response to cold stimulation.
Article
Substance Abuse
Ludivine Clement, Baris Gencer, Olivier Muller, Roland Klingenberg, Lorenz Raeber, Christian M. Matter, Thomas F. Luescher, Stephan Windecker, Francois Mach, Nicolas Rodondi, David Nanchen, Carole Clair
Summary: Patients with diabetes have lower smoking cessation rates after acute coronary syndrome compared to those without diabetes, highlighting the importance of tailored secondary prevention programs. Cardiac rehabilitation may play a positive role in increasing smoking cessation rates.
NICOTINE & TOBACCO RESEARCH
(2023)
