4.5 Article

Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 2, Pages 313-316

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.11.042

Keywords

5-(4 '-Methoxyphenyl)-oxazole; Caenorhabditis elegans; Hatch inhibition

Funding

  1. 22nd Sasagawa Scientific Research
  2. Grants-in-Aid for Scientific Research [24590090, 25460152, 26460013] Funding Source: KAKEN

Ask authors/readers for more resources

5-(4'-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity. (C) 2014 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available