Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 2, Pages 313-316Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.11.042
Keywords
5-(4 '-Methoxyphenyl)-oxazole; Caenorhabditis elegans; Hatch inhibition
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Funding
- 22nd Sasagawa Scientific Research
- Grants-in-Aid for Scientific Research [24590090, 25460152, 26460013] Funding Source: KAKEN
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5-(4'-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity. (C) 2014 Elsevier Ltd. All rights reserved.
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