Journal
HYPERTENSION IN PREGNANCY
Volume 38, Issue 4, Pages 245-251Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10641955.2019.1667381
Keywords
Preeclampsia; pre-existing medical disorder; risk factors; case-control study
Funding
- National Natural Science Foundation of China [81573262]
- Fundamental Research Funds for the Central Universities [2016YXZD042]
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Objective: We sought to explore pre-existing medical disorders as risk factors for preeclampsia as thoroughly as possible. Methods: A case-control design. A group of 1,652 patients were identified as the preeclampsia group, and another randomly selected 4,500 patients were identified as the non-preeclampsia group. Results: Mature ovarian teratoma (adjusted odds ratio [OR] 7.69, 95% CI 1.58-37.53), uterine fibroids (adjusted OR 2.24, 95% CI 1.28-3.92) and pregestational hypothyroidism (adjusted OR 5.17, 95% CI 2.43-11.00), were significantly correlated with preeclampsia. Conclusions: Mature ovarian teratoma, uterine fibroids and pregestational hypothyroidism may also contribute to the incidence of preeclampsia.
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