Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 22, Pages 5367-5371Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.09.031
Keywords
Nandina domestica Thunb; Berberidaceae; Caffeoyl glucosides; Vascular inflammatory disorders
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Funding
- Global R&D Center (GRDC) Program through a National Research Foundation of Korea (NRF) Grant - Korean Government [NRF-2010-0078]
- National Fisheries Research and Development Institute (NFRDI) [RP-2015-AQ-072]
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Endothelial dysfunction is a key pathological feature of many inflammatory diseases, including sepsis. In the present study, a new caffeoyl glucoside (1) and two known caffeoylated compounds (2 and 3) were isolated from the fruits of Nandina domestica Thunb. (Berberidaceae). The compounds were investigated for their effects against lipopolysaccharide (LPS)-mediated endothelial inflammatory responses. At 20 mu M, 1 and 2 inhibited LPS-induced hyperpermeability, adhesion, and migration of leukocytes across a human endothelial cell monolayer in a dose-dependent manner suggesting that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to treat vascular inflammatory disorders. (C) 2015 Elsevier Ltd. All rights reserved.
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