Article
Food Science & Technology
Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Yongai Xiong, Xun Song, Nazim Hussain, Qinchang Zhu, Zhendan He
Summary: This review discusses the roles of microbiota and nanomaterials in cancer therapy, microbiota interventions via nanomaterials, microbial inspiration via nanomaterials, and challenges associated with using nanomaterials in humans and animals. The potential of nanomaterials to alter the cancer-causing microbiome/microbiota and their metabolites, as well as the cancer microenvironment, suggests novel strategies for cancer treatment. Further in vivo clinical trials are needed to determine the exact mechanisms of action in treating cancer with nanomaterials.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Oncology
Ana Isabel Alvarez-Mercado, Ana del Valle Cano, Mariana F. F. Fernandez, Luis Fontana
Summary: The set of microbes in our body, called microbiota, has a wide range of beneficial effects and is linked to a person's health. When there is a change in the composition of microbiota, it is called dysbiosis, which is associated with diseases. Microbiota exists in various parts of our body, with the intestinal microbiota being the most important and extensively studied. In recent years, it has been recognized that microbiota can have harmful effects and is considered as an environmental factor in the development of diseases, including cancer.
Article
Chemistry, Multidisciplinary
Ling Wang, Yi-Xuan Tu, Lu Chen, Yuan Zhang, Xue-Ling Pan, Shu-Qiao Yang, Shuai-Jie Zhang, Sheng-Hui Li, Ke-Chun Yu, Shuo Song, Hong-Li Xu, Zhu-Cheng Yin, Jun-Qiu Yue, Qian-Lin Ni, Tang Tang, Jiu-Liang Zhang, Min Guo, Shuai Zhang, Fan Yao, Xin-Jun Liang, Zhen-Xia Chen
Summary: Men have higher incidence and mortality rates of colorectal cancer (CRC) than women. This study explains the sexual dimorphism in CRC by examining sex-biased gut microbiota and metabolites. The results show that male mice and pseudo-germ mice receiving fecal samples from males have larger tumors and impaired gut barrier function. Changes in gut microbiota composition, including increased pathogenic bacteria and decreased probiotic bacteria, were observed in male mice and pseudo-germ mice. Sex-biased gut metabolites contribute to the sex dimorphism in CRC through glycerophospholipids metabolism pathway. Modulating sex-biased gut microbiota and metabolites could be a potential therapeutic strategy for CRC.
Review
Oncology
Kazutoshi Fujita, Makoto Matsushita, Marco A. A. De Velasco, Koji Hatano, Takafumi Minami, Norio Nonomura, Hirotsugu Uemura
Summary: The gut microbiome plays a crucial role in the development of diseases like prostate cancer. Gut dysbiosis caused by factors like diet leads to the leakage of gut bacterial metabolites, resulting in prostate cancer growth. Lifestyle factors, especially diet, impact the gut microbiome and are associated with prostate cancer risk. Alterations in the gut microbiome have been identified in patients with prostate cancer, highlighting the importance of considering the gut-prostate axis in screening and treating prostate cancer patients.
Review
Nutrition & Dietetics
Ana Fernandes, Ana Oliveira, Raquel Soares, Pedro Barata
Summary: This review examines the impact of ionizing radiation exposure on the gut microbiota, finding associations with reduced diversity and richness, increased abundance of pathogenic bacteria, and decreased beneficial bacteria. Larger population studies are needed to better understand these effects.
News Item
Multidisciplinary Sciences
Jeanne Erdmann
Summary: Faecal transplants have been effective in overcoming resistance to immunotherapies, leading to numerous trials investigating the link between cancer and the microbiome.
Review
Biology
Matthew J. Dalby
Summary: The role of gut microbiota in determining body fatness has received significant attention, but recent attempts to translate findings into humans have been unsuccessful. This review examines the mouse research that initiated this area of study and evaluates whether the results were supported by subsequent human studies.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Deeptashree Nandi, Sheetal Parida, Dipali Sharma
Summary: Despite global progress in early diagnosis and new therapeutic regimens, breast carcinoma remains a devastating threat, with high mortality rates. Breast cancer risk prediction models based on known risk factors are helpful, but many breast cancers occur in women with no/low known risk. The gut microbiome plays a significant role in breast cancer pathogenesis and metagenomic analysis has identified specific changes in the host microbial signature. This review discusses the microbial and metabolomic changes associated with breast cancer initiation and metastatic progression, as well as the bidirectional impact of breast cancer-related therapies on gut microbiota.
Review
Nutrition & Dietetics
Yoredy Sarmiento-Andrade, Rosario Suarez, Beatriz Quintero, Kleber Garrochamba, Sebastian Pablo Chapela
Summary: Obesity is a globally increasing pathology with many associated disorders. In recent years, there has been growing knowledge about the influence of the microbiota on obesity and its related pathologies. This review summarizes the biology and physiology of microbiota in obese patients, as well as the therapeutic applications of prebiotics, probiotics, and fecal microbiota transplantation.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
V Rossini, V Tolosa-Enguis, C. Frances-Cuesta, Y. Sanz
Summary: SARS-CoV-2 primarily affects the respiratory system, but it also targets the gastrointestinal tract. Prolonged gut disorders in COVID-19 patients are associated with decreased richness and diversity of the gut microbiota, immune deregulation, and delayed viral clearance. The composition and function of the gut microbiome may play a role in the progression of COVID-19. Strategies to modulate the gut microbiome are being investigated for population stratification and management of COVID-19 infection.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Oncology
Mong-Hong Lee
Summary: Research has shown that gut microbiota dysbiosis is linked to physiological changes and various diseases, including cancers. Advances in metagenome sequencing and multiomics studies have provided insights into the composition, taxonomic alterations, and host interactions of gut microbiota during tumorigenesis. However, the complexity of gut microbiota interactions still presents challenges in fully understanding the microbiota-cancer connections and their implications for cancer diagnosis, treatment, and prevention.
CANCER COMMUNICATIONS
(2021)
Editorial Material
Multidisciplinary Sciences
Bianca Nogrady
Summary: Interest in the gut microbiome is creating numerous career and funding opportunities across various fields.
Review
Nutrition & Dietetics
Ryan Leung, Mihai Covasa
Summary: This article reviews the role of gut bacteria in taste perception and functions, and discusses how intestinal dysbiosis can alter taste preference and food consumption.
Review
Biochemistry & Molecular Biology
Irmina Olejniczak-Staruch, Magdalena Ciazynska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Malgorzata Skibinska, Aleksandra Lesiak
Summary: Numerous scientific studies have shown significant skin and gut dysbiosis in patients with psoriasis, with changes in abundance of specific bacterial taxa. Treatments for psoriasis have been found to significantly influence skin and gut microbiome, with orally administered probiotics having a positive impact on the course of the disease. Further research is needed to understand the influence of microbiome on the development of inflammatory skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Pajau Vangay, Tonya Ward, Sarah Lucas, Lalit K. Beura, Dominique Sabas, Max Abramson, Lisa Till, Susan L. Hoops, Purna Kashyap, Ryan C. Hunter, David Masopust, Dan Knights
Summary: In this study, the differential effects of human gut microbiota from the United States and rural Thailand on the murine gut mucosa and immune system were assessed. The results suggest that Western-associated human gut microbes contribute to a pro-inflammatory immune response.
Article
Clinical Neurology
Jiali Zheng, Jingmeng Li, Tianduo Pei, Tianren Zhu, Io Hong Cheong, Sha Li, Xiaonan Wang, Brian J. Hall, Xiaoguang Li, Hui Wang
Summary: Elevated depressive symptoms and chronic lung disease (CLD) were found to be mutual risk factors in middle-aged and older Chinese adults. Early screening and treatment of depression is necessary to reduce the risk of CLD and related comorbidities, including new-onset depression, and to alleviate the disease burden of CLD and depression in China.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Nutrition & Dietetics
Jiali Zheng, Tianren Zhu, Guanghuan Yang, Longgang Zhao, Fangyu Li, Yong-Moon Park, Fred K. Tabung, Susan E. Steck, Xiaoguang Li, Hui Wang
Summary: Isocaloric substitution of plant-based protein for animal-based protein may have beneficial effects on preventing all-cause and cardiovascular disease-specific mortality, especially when substituting red and processed meat protein. However, more studies are needed, particularly regarding cancer incidence and other specific aging-related diseases.
Review
Nutrition & Dietetics
Jiali Zheng, Longgang Zhao, Jingwen Dong, Huiyi Chen, Donghui Li, Xuehong Zhang, Manal M. Hassan, Susan E. Steck, Xiaoguang Li, Yong-Bing Xiang, Hui Wang
Summary: Dietary factors play a crucial role in the risk of progression from NAFLD to HCC. Certain dietary patterns or individual foods with anti-inflammatory potential are associated with a reduced risk of NAFLD and HCC.
CLINICAL NUTRITION
(2022)
Article
Multidisciplinary Sciences
Julianne K. Bronk, Chiraag Kapadia, Xiaogang Wu, Bhavana Chapman, Rui Wang, Tatiana Karpinets, Xingzhi Song, Andrew M. Futreal, Jianhua Zhang, Ann H. Klopp, Lauren E. Colbert
Summary: This study demonstrates the feasibility and application of a noninvasive swab-based technique for WES analysis, which can be used to investigate dynamic tumor mutational changes during treatment and identify novel genes associated with radiation resistance.
Article
Oncology
Jiali Zheng, Fred K. Tabung, Jiajia Zhang, Bette Caan, James R. Hebert, Candyce H. Kroenke, Judith Ockene, Nitin Shivappa, Susan E. Steck
Summary: This study examined the association between post-diagnosis dietary inflammatory potential and mortality outcomes among post-menopausal women diagnosed with cancer. It found that a more anti-inflammatory diet plus supplements after a cancer diagnosis was associated with lower all-cause mortality, cancer mortality, and mortality from cardiovascular disease and other causes.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
A. K. Yoder, D. S. Lakomy, J. Wu, L. M. Andring, B. Fellman, L. E. Colbert, A. Jhingran, A. H. Klopp, P. Soliman, S. K. Peterson, L. L. Lin
Summary: This study aimed to compare the quality of life (QoL) in patients with uterine cancer who underwent surgery with or without radiation therapy. The results showed that there were differences in overall QoL between different treatment groups, with the external beam radiation therapy (EBRT) group reporting the lowest QoL and the brachytherapy group reporting the highest QoL.
Article
Oncology
Katherine Foster, Katelyn F. Handley, Deanna Glassman, Travis T. Sims, Sanaz Javadi, Sarah M. Palmquist, Mohammed M. Saleh, Bryan M. Fellman, Nicole D. Fleming, Priya R. Bhosale, Anil K. Sood
Summary: By analyzing CT scans and laparoscopic assessments of 109 patients with high-grade serous ovarian cancer, radiographic features unique to each morphologic subtype were identified, including large infiltrative plaques, mass-like metastases, and enhancing peritoneal lining. These findings provide valuable insights for the accurate diagnosis and classification of high-grade serous ovarian cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Lauren E. Colbert, Molly B. El Alam, Rui Wang, Tatiana Karpinets, David Lo, Erica J. Lynn, Timothy A. Harris, Jacob H. Elnaggar, Kyoko Yoshida-Court, Katarina Tomasic, Julianna K. Bronk, Julie Sammouri, Ananta Yanamandra, Adilene Olvera, Lily G. Carlin, Travis Sims, Andrea Y. Delgado Medrano, Tatiana Cisneros Napravnik, Madison O'Hara, Daniel Lin, Chike O. Abana, Hannah X. Li, Patricia J. Eifel, Anuja Jhingran, Melissa Joyner, Lilie Lin, Lois M. Ramondetta, Andrew M. Futreal, Kathleen M. Schmeler, Geena Mathew, Stephanie Dorta-Estremera, Jianhua Zhang, Xiaogang Wu, Nadim J. Ajami, Matthew Wong, Cullen Taniguchi, Joseph F. Petrosino, K. Jagannadha Sastry, Pablo C. Okhuysen, Sara A. Martinez, Lin Tan, Iqbal Mahmud, Philip L. Lorenzi, Jennifer A. Wargo, Ann H. Klopp
Summary: The tumor microbiota, specifically lactate-producing lactic acid bacteria, can affect tumor metabolism and lactate signaling pathways, leading to therapeutic resistance in various cancers. These findings suggest that lactate-producing lactic acid bacteria could be potential therapeutic targets across different types of cancer.
Meeting Abstract
Oncology
Julie Sammouri, Aradhana Venkatesan, Ann Klopp, Lilie Lin, Anuja Jhingran, Melissa Joyner, Patricia Eifel, Lauren Colbert
GYNECOLOGIC ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Jingwen Dong, Min Gao, Lin Li, Xiaoyu Pan, Sheng-Yin Chen, Jun Li, Stephanie A. Smith-Warner, Xiaoguang Li, Hui Wang, Jiali Zheng
Summary: This study examined the relationship between the overall inflammatory potential of diets and esophageal precancerous lesions (EPLs) and esophageal squamous-cell cancer (ESCC). The study found a positive association between the inflammatory potential of diets and the odds of EPLs and ESCC. Consuming anti-inflammatory foods may be beneficial in preventing EPLs and ESCC.
Meeting Abstract
Oncology
A. Seo, D. S. Lakomy, L. Colbert, A. Jhingran, M. M. Joyner, A. H. Klopp, L. Meyer, P. J. Eifel, L. L. Lin
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
K. Tomasic, M. B. El Alam, D. Lin, T. Karpinets, E. J. Lynn, A. Olvera, N. J. Ajami, L. L. Lin, A. Jhingran, P. J. Eifel, M. M. Joyner, P. Okhuysen, C. M. Taniguchi, A. H. Klopp, L. Colbert
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
M. B. El Alam, K. Tomasic, D. Lin, T. Karpinets, E. J. Lynn, A. Olvera, N. J. Ajami, L. L. Lin, A. Jhingran, P. J. Eifel, M. M. Joyner, P. Okhuysen, C. M. Taniguchi, A. H. Klopp, L. Colbert
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
L. M. Andring, C. Kelsey, J. Weng, G. S. Manzar, N. Bailard, B. Fellman, M. Domingo, J. Varkey, T. Foster-Mills, T. Kazantsev, L. L. Lin, A. Jhingran, L. Colbert, P. J. Eifel, A. H. Klopp, M. M. Joyner
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
T. Netherton, C. Nguyen, C. Cardenas, C. Chung, A. Klopp, L. Colbert, D. J. Rhee, C. Peterson, R. Howell, A. Aggarwal, H. Simonds, L. Court
RADIOTHERAPY AND ONCOLOGY
(2022)
