Review
Surgery
H. Wilson, V Mocanu, W. Sun, J. Dang, U. Jogiat, J. Kung, N. Switzer, C. Wong, S. Karmali
Summary: This study found that fundoplication is more effective than medical therapy in terms of improving histopathologic BE disease regression and disease progression. More randomized trials comparing medical management and surgical intervention are needed to determine the optimal delivery and timing of these interventions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Gastroenterology & Hepatology
Bashar J. Qumseya, Yazan Qumsiyeh, Sandeep A. Ponniah, David Estores, Dennis Yang, Crystal N. Johnson-Mann, Jeffrey Friedman, Alexander Ayzengart, Peter V. Draganov
Summary: After analyzing 10 studies, it was found that the prevalence of BE is high in patients undergoing EGD after SG, with no significant correlation with postoperative GERD symptoms. Most cases of BE were observed after 3 years.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Medicine, General & Internal
Jin Lin Tan, Mohamed Asif Chinnaratha, Richard Woodman, Rory Martin, Hsiang-Ting Chen, Gustavo Carneiro, Rajvinder Singh
Summary: This study conducted a systematic review and meta-analysis to evaluate the performance of AI in detecting early Barrett's neoplasia. The results showed that AI is highly accurate in detecting early Barrett's neoplasia, especially in patients with high-grade dysplasia and above.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Richard Phillips, Wladyslaw Januszewicz, Nastazja D. Pilonis, Maria O'Donovan, Tarek Sawas, David A. Katzka, Rebecca C. Fitzgerald, Massimiliano di Pietro
Summary: Patients with BE-IND have a high risk of neoplastic progression and need close monitoring. BE length is associated with neoplastic progression.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Gastroenterology & Hepatology
Nour Hamade, Amrit K. Kamboj, Rajesh Krishnamoorthi, Siddharth Singh, Leslie C. Hassett, David A. Katzka, Charles J. Kahi, Hala Fatima, Prasad G. Iyer
Summary: Through analysis of multiple studies, a statistically significant inverse correlation was found between neoplasia detection rate and post-endoscopy Barrett's neoplasia, indicating that with an increase in neoplasia detection rate, post-endoscopy Barrett's neoplasia decreases. Further studies are needed to validate this correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Medicine, General & Internal
Peter M. M. Stawinski, Karolina N. N. Dziadkowiec, Lily A. A. Kuo, Juan Echavarria, Shreyas Saligram
Summary: Barrett's esophagus (BE) is a premalignant mucosal transformation characterized by the replacement of esophageal squamous epithelium with metaplastic columnar epithelium. It is associated with an increased risk of esophageal adenocarcinoma and is often caused by gastroesophageal reflux disease. Screening for BE is selective based on risk factors and is not recommended for the general population. Diagnosis involves endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. This review provides a comprehensive overview of the epidemiology, pathogenesis, screening, and advanced techniques for detecting and eradicating Barrett's esophagus.
Article
Oncology
Yue Chen, Chenyu Sun, Yile Wu, Xin Chen, Sujatha Kailas, Zeid Karadsheh, Guangyuan Li, Zhichun Guo, Hongru Yang, Lei Hu, Qin Zhou
Summary: The use of PPI is negatively associated with the risk of progression to HGD/EAC in BE patients, and the risk of HGD/EAC can be reduced with the prolonged use of PPI. Sensitivity analysis showed the stable results of this meta-analysis, and no publication bias was detected.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Jinjia Zhang, Huadong Wu, Rongying Wang
Summary: A meta-analysis was conducted to assess the effect of NSAIDs on Barrett's esophagus risk, showing that NSAIDs could reduce the risk of Barrett's esophagus, especially in females.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, R. Maurizio Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-esophageal reflux (GER) symptoms are associated with an increased odds of Barrett's esophagus (BE), especially when the symptoms occur weekly. However, GER symptoms have low sensitivity and specificity for predicting BE, except for a strong association with long segment BE. Screening individuals with weekly GER symptoms may be beneficial to rule out long segment BE.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Manuela Estevinho, Rolando Pinho, Joao Carlos Silva, Joao Correia, Pedro Mesquita, Teresa Freitas
Summary: Hybrid argon plasma coagulation (hAPC) is a novel technique that combines conventional argon plasma coagulation and waterjet submucosal expansion. This meta-analysis evaluated the efficacy and safety of hAPC in Barret's esophagus (BE) ablation and as an adjunct to colonic endoscopic mucosal resection (EMR). The results showed high percentages of endoscopic and histologic remission after hAPC for BE, along with low rates of adverse events and recurrence. Similarly, hAPC-assisted EMR had low rates of adverse events and recurrence. Further trials comparing hAPC with standard strategies are needed to support its use for these indications.
Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Jian Wan, Xuan Wang, Yujie Zhang, Min Chen, Min Wang, Kaichun Wu, Jie Liang
Summary: This systematic review and meta-analysis focused on the incidence and risk factors for advanced neoplasia in inflammatory bowel disease (IBD) patients with indefinite for dysplasia (IND) and low-grade dysplasia (LGD). The pooled incidences of advanced neoplasia in IND and LGD patients were found to be similar, indicating the need for rigorous surveillance. Risk factors for advanced neoplasia included primary sclerosing cholangitis, aneuploidy, and other factors. Further research is needed to validate these findings.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Yan-Lin Du, Ru-Qiao Duan, Li-Ping Duan
Summary: The study found a significant inverse relationship between Hp, especially the CagA-positive Hp strain, and BE, but no significant difference in Hp infection prevalence was observed between BE patients and the GERD control group. Hp was negatively correlated with long-segment BE and associated with a reduced risk of dysplasia, but had no correlation with short-segment BE.
BMC GASTROENTEROLOGY
(2021)
Review
Oncology
Zhanwei Zhao, Zifang Yin, Chaojun Zhang
Summary: A large meta-analysis including 62 studies found that smoking, alcohol consumption, obesity, short sleep duration, and proton pump inhibitors use were associated with an increased risk of BE, while intake of aspirin, vitamin C, folate, and fiber could reduce the risk. Most included studies were of high quality and lifestyle modifications were shown to have a significant impact on reducing BE risk.
Review
Oncology
Lunan Li, Zhongsheng Cao, Chenjing Zhang, Wensheng Pan
Summary: The effect of PPIs on reducing the incidence of EAC and HGD in BE patients has not been confirmed, although some studies suggest a potential protective effect. Additional research with more patients is required to reach a definitive conclusion.
TRANSLATIONAL CANCER RESEARCH
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Babu P. Mohan, Ravishankar Asokkumar, Shahab R. Khan, Rajesh Kotagiri, Gurusaravanan Kutti Sridharan, Saurabh Chandan, Naveen Ravikumar, Suresh Ponnada, Mahendran Jayaraj, Douglas G. Adler
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Ranjit Makar, Muthena Maklad, Hamza Aziz, Daisy S. Lankarani, Bipin Saud, Mahendran Jayaraj, Shahid Wahid, Gordon Ohning
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Daisy S. Lankarani, Ranjit Makar, Hamza Aziz, Muthena Maklad, Mahendran Jayaraj, Gordon Ohning
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Mahendran Jayaraj, Babu P. Mohan, Ranjit Makar, Ritika Ohri, Daisy S. Lankarani, Gordon Ohning
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Review
Gastroenterology & Hepatology
Babu P. Mohan, Shahab R. Khan, Sushruth Trakroo, Suresh Ponnada, Mahendran Jayaraj, Ravishankar Asokkumar, Douglas G. Adler
Review
Gastroenterology & Hepatology
Annie S. Hong, Wen Yuan Yu, Jenny M. Hong, Chad L. Cross, Mohamed Azab, Gordon Ohning, Mahendran Jayaraj
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Review
Surgery
Rajesh Krishnamoorthi, Mahendran Jayaraj, Viveksandeep Thoguluva Chandrasekar, Dhruv Singh, Joanna Law, Michael Larsen, Andrew Ross, Richard Kozarek, Shayan Irani
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2020)
Review
Surgery
Rajesh Krishnamoorthi, Chandra S. Dasari, Viveksandeep Thoguluva Chandrasekar, Harshith Priyan, Mahendran Jayaraj, Joanna Law, Michael Larsen, Richard Kozarek, Andrew Ross, Shayan Irani
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2020)
Review
Gastroenterology & Hepatology
Jagpal Singh Klair, Mahendran Jayaraj, Viveksandeep Thoguluva Chandrasekar, Harshith Priyan, Joanna Law, Arvind R. Murali, Dhruv Singh, Michael Larsen, Shayan Irani, Richard Kozarek, Andrew Ross, Rajesh Krishnamoorthi
Review
Gastroenterology & Hepatology
Banreet Singh Dhindsa, Harmeet Singh Mashiana, Amaninder Dhaliwal, Babu P. Mohan, Mahendran Jayaraj, Harlan Sayles, Shailender Singh, Gordon Ohning, Ishfaq Bhat, Douglas G. Adler
ENDOSCOPIC ULTRASOUND
(2020)
Review
Gastroenterology & Hepatology
Babu P. Mohan, Ravishankar Asokkumar, Shahab R. Khan, Rajesh Kotagiri, Gurusravanan Kutti Sridharan, Saurabh Chandan, Naveen P. G. Ravikumar, Suresh Ponnada, Mahendran Jayaraj, Douglas G. Adler
ENDOSCOPY INTERNATIONAL OPEN
(2020)
Review
Gastroenterology & Hepatology
Mahendran Jayaraj, Babu P. Mohan, Harmeet Mashiana, Rajesh Krishnamoorthi, Douglas G. Adler
ANNALS OF GASTROENTEROLOGY
(2019)
Review
Gastroenterology & Hepatology
Ramprasad Jegadeesan, Muhammad Aziz, Madhav Desai, Tharani Sundararajan, Venkata Subhash Gorrepati, Viveksandeep Thogulva Chandrasekar, Mahendran Jayaraj, Pratiksha Singh, Ahmed Saeed, Tarun Rai, Abhishek Choudhary, Alessandro Repici, Cesare Hassan, Lorenzo Fuccio, Prateek Sharma
ENDOSCOPY INTERNATIONAL OPEN
(2019)
Review
Gastroenterology & Hepatology
Babu P. Mohan, Mahendran Jayaraj, Ravishankar Asokkumar, Mohammed Shakhatreh, Parul Pahal, Suresh Ponnada, Udayakumar Navaneethan, Douglas G. Adler
ENDOSCOPIC ULTRASOUND
(2019)