Using fluorescence microscopy to shed light on the mechanisms of antimicrobial peptides

Rigidification of the Escherichia coli cytoplasm by the human antimicrobial peptide LL-37 revealed by superresolution fluorescence microscopy

(2019) Yanyu Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hybrids made from antimicrobial peptides with different mechanisms of action show enhanced membrane permeabilization

(2019) Heidi M. Wade et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

HaloTag Assay Suggests Common Mechanism of E. coli Membrane Permeabilization Induced by Cationic Peptides

(2018) Zhilin Yang et al.   ACS Chemical Biology

Synthetic antimicrobial peptides delocalize membrane bound proteins thereby inducing a cell envelope stress response

(2018) Soraya Omardien et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Melittin-Induced Permeabilization, Re-sealing, and Re-permeabilization of E. coli Membranes

(2018) Zhilin Yang et al.   BIOPHYSICAL JOURNAL

Continuous detection of entry of cell-penetrating peptide transportan 10 into single vesicles

(2018) Md. Mizanur Rahman Moghal et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Antibiotic-Resistant Infection Treatment Costs Have Doubled Since 2002, Now Exceeding $2 Billion Annually

(2018) Kenneth E. Thorpe et al.   HEALTH AFFAIRS

Enumerating the economic cost of antimicrobial resistance per antibiotic consumed to inform the evaluation of interventions affecting their use

(2018) Poojan Shrestha et al.   Antimicrobial Resistance and Infection Control

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

(2018) Alessandro Cassini et al.   LANCET INFECTIOUS DISEASES

The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S

(2018) Michaela Wenzel et al.   mBio

Heterogeneous absorption of antimicrobial peptide LL37 in Escherichia coli cells enhances population survivability

(2018) Mehdi Snoussi et al.   eLife

Daptomycin–Phosphatidylglycerol Domains in Lipid Membranes

(2017) Mark A. Kreutzberger et al.   LANGMUIR

Lipid topology and electrostatic interactions underpin lytic activity of linear cationic antimicrobial peptides in membranes

(2017) David J. Paterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress induced in E. coli by the human antimicrobial peptide LL-37

(2017) Heejun Choi et al.   PLoS Pathogens

Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis

(2017) Kathi Scheinpflug et al.   Scientific Reports

Micro-patterned agarose gel devices for single-cell high-throughput microscopy of E. coli cells

(2017) David G. Priest et al.   Scientific Reports

Bacterial Spheroplasts as a Model for Visualizing Membrane Translocation of Antimicrobial Peptides

(2016) Lei Wei et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mode of Action of Antimicrobial Peptides on E. coli Spheroplasts

(2016) Yen Sun et al.   BIOPHYSICAL JOURNAL

Charge Distribution Fine-Tunes the Translocation of α -Helical Amphipathic Peptides across Membranes

(2016) Francis D.O. Ablan et al.   BIOPHYSICAL JOURNAL

Antimicrobial Peptides: Mechanisms of Action and Resistance

(2016) B. Bechinger et al.   JOURNAL OF DENTAL RESEARCH

Bacterial strategies of resistance to antimicrobial peptides

(2016) Hwang-Soo Joo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains

(2016) Anna Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lights, Camera, Action! Antimicrobial Peptide Mechanisms Imaged in Space and Time

(2016) Heejun Choi et al.   TRENDS IN MICROBIOLOGY

Imaging the antimicrobial mechanism(s) of cathelicidin-2

(2016) Viktoria A. F. Schneider et al.   Scientific Reports

Non-Membrane Permeabilizing Modes of Action of Antimicrobial Peptides on Bacteria

(2015) Marco Scocchi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Application of bacterial cytological profiling to crude natural product extracts reveals the antibacterial arsenal of Bacillus subtilis

(2015) Poochit Nonejuie et al.   JOURNAL OF ANTIBIOTICS

Complementary Effects of Host Defense Peptides Piscidin 1 and Piscidin 3 on DNA and Lipid Membranes: Biophysical Insights into Contrasting Biological Activities

(2015) Robert M. Hayden et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Single-cell, real-time detection of oxidative stress induced inEscherichia coliby the antimicrobial peptide CM15

(2015) Heejun Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of Daptomycin with Lipid Bilayers: A Lipid Extracting Effect

(2014) Yen-Fei Chen et al.   BIOCHEMISTRY

Modular analysis of hipposin, a histone-derived antimicrobial peptide consisting of membrane translocating and membrane permeabilizing fragments

(2014) Maria E. Bustillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane-active peptides: Binding, translocation, and flux in lipid vesicles

(2014) Paulo F. Almeida   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Physical Properties of Escherichia coli Spheroplast Membranes

(2014) Yen Sun et al.   BIOPHYSICAL JOURNAL

Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles

(2014) D. J. Paterson et al.   LAB ON A CHIP

Statistical Analysis of Peptide-Induced Graded and All-or-None Fluxes in Giant Vesicles

(2013) Sterling A. Wheaten et al.   BIOPHYSICAL JOURNAL

Translocation of Cationic Amphipathic Peptides across the Membranes of Pure Phospholipid Giant Vesicles

(2013) Sterling A. Wheaten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An early cytoplasmic step of peptidoglycan synthesis is associated to MreB inBacillus subtilis

(2013) Anne-Stéphanie Rueff et al.   MOLECULAR MICROBIOLOGY

Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules

(2013) P. Nonejuie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel histone-derived antimicrobial peptides use different antimicrobial mechanisms

(2012) Kathryn E. Pavia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The single-cell chemostat: an agarose-based, microfluidic device for high-throughput, single-cell studies of bacteria and bacterial communities

(2012) Jeffrey R. Moffitt et al.   LAB ON A CHIP

Segregation of molecules at cell division reveals native protein localization

(2012) Dirk Landgraf et al.   NATURE METHODS

Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ

(2011) P. Sass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37

(2011) K. A. Sochacki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of novel histone-derived antimicrobial peptides

(2009) Hoi See Tsao et al.   PEPTIDES

Buforins: Histone H2A-derived antimicrobial peptides from toad stomach

(2008) Ju Hyun Cho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Highly inclined thin illumination enables clear single-molecule imaging in cells

(2008) Makio Tokunaga et al.   NATURE METHODS

Structure–activity relations of parasin I, a histone H2A-derived antimicrobial peptide

(2008) Young Sook Koo et al.   PEPTIDES