Recent tau-targeted clinical strategies for the treatment of Alzheimer's disease

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

(2016) Marianna Karina Gorsky et al.   Scientific Reports

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

The Role of Tau Oligomers in the Onset of Alzheimer's Disease Neuropathology

(2014) María del Carmen Cárdenas-Aguayo et al.   ACS Chemical Neuroscience

O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers

(2014) Scott A. Yuzwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance

(2013) Erin E. Congdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ-independent processes—rethinking preclinical AD

(2013) Gaël Chételat   Nature Reviews Neurology

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Passive tau immunotherapy diminishes functional decline and clears tau aggregates in a mouse model of tauopathy

(2010) Allal Boutajangout et al.   Alzheimers & Dementia

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN