Article
Food Science & Technology
Jianxin Song, Yiming Yan, Xiaodong Wang, Xihong Li, Ye Chen, Lu Li, Wenhan Li
Summary: This study analyzed fatty acids, amino acids, and organic acids in three colored quinoas (white, red, black) using untargeted and targeted metabolomics. Significant differences were found in the content of these compounds among the quinoas, with specific compounds characterizing each color variety. Principal component analysis was used to identify key components that differentiate the different quinoa colors.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Lord Abbey, Raphael Ofoe, Lokanadha Rao Gunupuru, Mercy Ijenyo
Summary: The study found that the frequency of application of MSW compost has a significant impact on plant metabolic profiles, with compost application increasing soil fertility and enhancing levels of amino acids, phospholipids, and organic acids in plants.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Sami Saad, Rana Saad, Isabelle Goemaere, Roxane Cuyaubere, Marie Borderie, Vincent Borderie, Nacim Bouheraoua
Summary: This retrospective study compared the outcomes of accelerated corneal crosslinking (A-CXL) and iontophoresis corneal crosslinking (I-CXL) in the treatment of progressive keratoconus. The results showed that A-CXL was more effective than I-CXL in stabilizing the condition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Romina Mayra Lasagni Vitar, Filippo Bonelli, Paolo Rama, Giulio Ferrari
Summary: Keratoconus is a progressive corneal degeneration characterized by structural changes in the cornea. It is a multifactorial disease associated with genetic, environmental, nutritional, and metabolic factors. Nutritional and metabolic imbalances can greatly influence the initiation and progression of keratoconus.
Review
Ophthalmology
Julia Polido, Maria Emilia dos Xavier Santos Araujo, Joao G. Alexander, Thiago Cabral, Renato Ambrosio Jr, Denise Freitas
Summary: The translated content is about corneal crosslinking techniques for pediatric keratoconus. The article mentions different crosslinking protocols and corneal enhancers, and there is still controversy over their safety and efficacy in the pediatric population.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Plant Sciences
Tilen Zamljen, Aljaz Medic, Robert Veberic, Metka Hudina, Jerneja Jakopic, Ana Slatnar
Summary: In this study, the individual sugars, organic acids, capsaicinoids, and total phenolic content in the pericarp, placenta, and seeds of different cultivars of Capsicum annuum, Capsicum chinense, and Capsicum baccatum were analyzed using HPLC/MS. The results showed variations in metabolite content between different cultivars and different fruits, with the 'Cayenne' cultivar exhibiting the highest total phenolic and capsaicinoid content in the placenta. Among the cultivars studied, 'Habanero Orange' showed the least variability in metabolites among its fruits.
Article
Medicine, General & Internal
Maryam Eslami, Farhad Ghaseminejad, Paul J. Dubord, Sonia N. Yeung, Alfonso Iovieno
Summary: This study analyzed the long-term topographic and refractive outcomes of corneal cross-linking (CXL) in keratoconus. The results showed improvements in corrected distance visual acuity, spherical and cylindrical refraction, average and steepest keratometry, and corneal aberrations over the follow-up period. The improvement was more pronounced in patients with more severe keratoconus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Geriatrics & Gerontology
Sunil S. Adav, Yulan Wang
Summary: Metabolomics is a cutting-edge technology that provides a comprehensive quantitative profile of metabolites, offering insights into the aging process. Aging is a natural inevitable process influenced by genetics, metabolism, and environmental factors. Despite being relatively new in aging research, the integration of multi-omics data can help understand the complex aging process.
Review
Ophthalmology
Hamza Pasha, Laura Palazzolo, Gaurav Prakash, Vishal Jhanji
Summary: Recent research on corneal collagen crosslinking (CXL) has focused on modifying treatment protocols to maximize corneal stability and shorten procedure time. Accelerated protocols have shown success but concerns remain about long-term corneal stability. Pulsed protocols may enhance the long-term efficacy of accelerated designs.
CURRENT OPINION IN OPHTHALMOLOGY
(2021)
Article
Cell Biology
Yong Zhou, Zhenrong Xie, Zunyue Zhang, Jiqing Yang, Minghui Chen, Fengrong Chen, Yuru Ma, Cheng Chen, Qingyan Peng, Lei Zou, Jianyuan Gao, Yu Xu, Yiqun Kuang, Mei Zhu, Dingyun You, Juehua Yu, Kunhua Wang
Summary: This study found that plasma metabolites undergo significant changes during heroin withdrawal, with the majority recovering after months but some not fully recovering. The findings suggest a link between metabolic perturbations and heroin withdrawal.
Article
Ophthalmology
Jie Wu, Junyi Wang, Liqiang Wang, Yifei Huang
Summary: This study showed that retinoic acid can increase corneal stiffness by upregulating TG2 expression for crosslinking. Experimental and microscopic results confirmed that retinoic acid increased collagen density in the cornea and increased its elastic modulus.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Food Science & Technology
Yoshio Tamura, Shinji Iwatoh, Kazutoshi Miyaura, Yonathan Asikin, Miyako Kusano
Summary: The study found that taste-related amino acids, sugars, fatty acids, and nucleic acids accumulate with aging of pork, while aroma compounds such as benzeneacetaldehyde and 2,5-dimethyl-3-(3-methylbutyl)-pyrazine also increase during this process. Additionally, amino acids in raw meat can contribute to the generation of specific aroma compounds through the Maillard reaction.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Raja Ganesan, Ki Tae Suk
Summary: Intestinal microbiota-derived microbial metabolites play significant roles in alcoholic fatty liver disease (AFLD) and non-AFLD (NAFLD), influencing the metabolic pathways and phenotypic expression of the diseases. Short-chain fatty acids (SCFAs) and bile acids (BAs) are important markers for fatty liver inflammation and liver carcinogenesis in both AFLD and NAFLD. Clinical investigations have shown the immunoregulatory capacity of SCFAs and BAs, which depend on dietary components. Variations in signaling, metabolic, and epigenetic states of SCFAs and BAs can have both beneficial and detrimental effects. This review focuses on discussing the signaling and interplay of SCFAs and BAs with the gut microbiome in AFLD and NAFLD, aiming to define altered key metabolites and their roles in pathogenesis, serving as potential biomarkers for metabolic disorders. The therapeutic applications of SCFAs and BAs profiles and metabolisms are also highlighted.
PROCESS BIOCHEMISTRY
(2022)
Review
Ophthalmology
Grace A. Borchert, Stephanie L. Watson, Himal Kandel
Summary: Increasing oxygen availability during epithelium-on CXL can improve visual acuity, reduce maximum keratometry, and induce corneal flattening in patients with keratoconus.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Engineering, Biomedical
Ayesha Gulzar, Erdost Yildiz, Humeyra N. Kaleli, Muhammad A. Nazeer, Noushin Zibandeh, Anjum N. Malik, Ayse Y. Tas, Ismail Lazoglu, Afsun Sahin, Seda Kizilel
Summary: This study proposes a new method for corneal crosslinking using a ruthenium-based water-soluble photoinitiator and visible light. The results demonstrate that the ruthenium-based approach has superior biomechanical properties, biocompatibility, and optical transparency compared to the riboflavin/UV-A method. It offers a promising non-surgical therapy option for all ectatic corneal pathologies.
ACTA BIOMATERIALIA
(2022)