Article
Engineering, Biomedical
Yanlin Su, Lian Zeng, Rongli Deng, Bing Ye, Shuo Tang, Zekang Xiong, Tingfang Sun, Qiuyue Ding, Weijie Su, Xirui Jing, Qing Gao, Xiumei Wang, Zhiye Qiu, Kaifang Chen, Daping Quan, Xiaodong Guo
Summary: Repairing the nerve-rich periosteum is crucial for treating bone defects. This study investigates the effects of an endogenous electric field coupled with 2D black phosphorus electroactive periosteum on bone regeneration through nerves. The electrically active periosteum promotes the neuroprotective phenotype of Schwann cells, enhances the function of sensory neurons, regulates vesicle transport, and stimulates osteogenic transformation of bone marrow stem cells. In vivo studies confirm that the electrically active periosteum promotes nerve-induced osteogenic repair, offering a potential clinical approach for bone regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ahad M. Siddiqui, Frederic Thiele, Rachel N. Stewart, Simone Rangnick, Georgina J. Weiss, Bingkun K. Chen, Jodi L. Silvernail, Tammy Strickland, Jarred J. Nesbitt, Kelly Lim, Jean E. Schwarzbauer, Jeffrey Schwartz, Michael J. Yaszemski, Anthony J. Windebank, Nicolas N. Madigan
Summary: The spinal cord has limited regenerative abilities after injury, which may be attributed to various factors. The use of biomaterials, such as the hydrogel scaffold developed in this study, shows promise in treating spinal cord injuries. Animals implanted with this scaffold showed better hindlimb recovery compared to the control group, likely due to increased axon growth. The number of immune cells, scarring, and ECM deposits were similar in all conditions. This study provides a novel scaffold construct for future neuroprosthetics and cell and ECM delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Mi Shen, Wei Tang, Zhenghui Cheng, Qi Zhang, Zixin Chen, Yingchao Tian, Yawen Zhang, Qianru He, Haiyan Shi, Hui Zhu, Han Wu, Yuhua Ji, Fei Ding
Summary: This study provides a proteomic view of the differential phenotype of mouse SNdSCs and MNdSCs. The data may serve as a valuable source for studying the biological characteristics and roles of these two SC phenotypes in nerve-specific regeneration.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Chaofan Zhang, Yunzhi Lin, Chun Hoi Yan, Wenming Zhang
Summary: This review discusses the role of adipokines in obesity-induced osteoarthritis and highlights potential signaling pathways. Adipokines play important roles in regulating inflammation, matrix remodeling, and cell apoptosis. Pharmaceutical interventions targeting these pathways have shown promising results. However, further research is needed to understand the complexity and interactions of these pathways.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Zhiyang Xu, Changyu Huang, Yiming Lin, Yongfa Chen, Xinyu Fang, Zida Huang, Chaofan Zhang, Zhenzhen Zhang, Wenming Zhang
Summary: Comparing the clinical outcomes of culture-negative periprosthetic joint infection (CN PJI) with those of culture-positive periprosthetic joint infection (CP PJI), it was found that the treatment success rate was similar between the two groups, but the CN PJI group may have a higher incidence of antibiotic-related complications.
ORTHOPAEDIC SURGERY
(2022)
Article
Infectious Diseases
Xinyu Fang, Yuanqing Cai, Xiaoqing Chen, Changyu Huang, Yiming Lin, Zida Huang, Chaofan Zhang, Ying Huang, Wenbo Li, Wenming Zhang
Summary: This study aimed to analyze the pathogenic bacteria spectrum in invasive and primary osteoarticular infection and compare the pathogen detection rate of metagenomic next-generation sequencing (mNGS) and microbial culture. The results showed that mNGS could significantly increase the pathogen detection rate in primary osteoarticular infection, while the improvement in invasive osteoarticular infection was limited. Therefore, mNGS is a promising tool for pathogen detection in invasive osteoarticular infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Neurosciences
Zhaoyang Wu, Haiqi Ding, Yang Chen, Changyu Huang, Xiaoqing Chen, Hongxin Hu, Yongfa Chen, Wenming Zhang, Xinyu Fang
Summary: A novel understanding of peripheral nerve injury is the epithelial-mesenchymal transition (EMT), which refers to the dedifferentiation and transformation of Schwann cells after nerve injury. Long-term EMT is the primary cause of fibrosis in tissue organs. A study investigated the potential mechanism of neurofibrosis in chronic degeneration of nerve injury and the effects of motor neurons (MNs) transplantation on neurofibrosis and nerve injury repair. The results showed that even 3 months after nerve injury, the distal nerve maintained high levels of transforming growth factor and transcriptional repressor, which formed a positive feedback loop promoting sustained EMT state and neurofibrogenesis. MNs transplantation inhibited EMT and promoted proximal axon growth, while the removal of transplanted MNs reactivated EMT. In conclusion, EMT can explain distal neurofibrosis and may be a potential therapeutic target. MNs transplantation can alleviate neurofibrogenesis in chronic degeneration by regulating EMT reversibly.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Hongxin Hu, Jian Mei, Yuanqing Cai, Haiqi Ding, Susheng Niu, Wenming Zhang, Xinyu Fang
Summary: This study used a two-sample Mendelian randomization method to investigate the causal relationship between osteoporosis and Alzheimer's disease (AD). The results showed no significant causal effect of osteoporosis on AD, regardless of the removal of potentially pleiotropic SNPs. The results were confirmed to be reliable and stable by sensitivity analysis. Although there is no bidirectional causal relationship, osteoporosis and AD share similar pathogenesis and pathways.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Immunology
Jian Mei, Penghui Wei, Linjie Zhang, Haiqi Ding, Wenming Zhang, Yusen Tang, Xinyu Fang
Summary: This study used genetic tools to investigate the causal relationship between Ankylosing Spondylitis (AS) and stroke. The findings suggest that AS is not associated with overall stroke risk, but may be linked to specific subtypes (cardioembolic and large artery stroke).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Tengbin Shi, Xinyu Fang, Changyu Huang, Weiming Li, Ruijin You, Xu Wang, Chun Xia, Wenming Zhang
Summary: Conversion hip arthroplasty showed successful mid-term clinical results in cases of failed internal fixation of intertrochanteric fractures. However, long stem arthroplasty carries a greater risk of complications, particularly intraoperative femur fractures.
ORTHOPAEDIC SURGERY
(2023)
Review
Orthopedics
Changyu Huang, Haiqi Ding, Yiming Lin, Zeyu Zhang, Xinyu Fang, Yanshu Chen, Yang Chen, Chaofan Zhang, Wenbo Li, Wenming Zhang, Zida Huang
Summary: This article reports a case of prosthetic joint infection caused by Coxiella burnetii and discusses the diagnosis and treatment methods. Molecular diagnostic techniques can accurately diagnose Coxiella infection, and surgical revision and medication treatment can effectively alleviate the patient's symptoms.
ORTHOPAEDIC SURGERY
(2023)
Article
Medicine, General & Internal
Chaofan Zhang, Ziyu Liu, Yunzhi Lin, Yuanqing Cai, Xuehui Zhang, Zida Huang, Ying Huang, Wenbo Li, Xinyu Fang, Wenming Zhang
Summary: This study explores the quality of life and pain experienced by patients after revision surgery for periprosthetic joint infection. The overall quality of life was generally satisfactory, although persistent pain was prevalent, it was mostly mild. Preoperative factors such as PMN%, VAS, and hospital stay were associated with postoperative pain.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Chaofan Zhang, Yongbin Li, Yunzhi Lin, Xuehui Zhang, Zida Huang, Guochang Bai, Yao Wan, Wenming Zhang, Xinyu Fang, Wenbo Li
Summary: The safety and efficacy of joint replacement surgery in HIV patients were studied. Retrospective review of 21 HIV patients and 27 non-HIV patients who underwent arthroplasties revealed that the hospital stay of HIV patients was significantly lower and there were no significant complications in both groups at the last follow-up. The study concluded that joint replacement surgery in HIV patients is safe and effective, with optimization of patients and strict adherence to protection measures being key.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Yuanqing Cai, Haiqi Ding, Xiaoqing Chen, Yang Chen, Changyu Huang, Chaofan Zhang, Zida Huang, Ying Huang, Wenbo Li, Wenming Zhang, Xinyu Fang
Summary: In this study, a metagenomic next-generation sequencing (mNGS)-based diagnostic strategy was reported for the diagnosis of Mycoplasma periprosthetic joint infection (PJI). The largest number of Mycoplasma PJI cases were accurately diagnosed by mNGS and verified by optimized microbial culture methods and (or) 16S PCR. The positive rates of optimized microbial culture methods and 16S PCR were 57.14% and 71.43% respectively, and targeted treatment effectively controlled the infections in all cases. This standardized and optimized procedure based on mNGS provides a useful diagnostic strategy for Mycoplasma PJI and may also be applicable to rare bacterial PJI.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Yuanqing Cai, Xiaoqing Chen, Changyu Huang, Yang Chen, Chaofan Zhang, Zida Huang, Wenming Zhang, Yusen Tang, Xinyu Fang
Summary: This study aimed to investigate the role of N-6-methyladenine (m(6)A) modification in periprosthetic joint infection (PJI). Samples were collected from PJI and aseptic failure patients, and m(6)A levels and expression of m(6)A-related genes were measured. Differential m(6)A-modified mRNAs were identified, and pathway analysis indicated the involvement of m(6)A modification in infection, immune response, bone metabolism, and cell death in PJI. This study demonstrated the significance of m(6)A modification as a potential therapeutic target for PJI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jian Mei, Hongxin Hu, Si Zhu, Haiqi Ding, Zida Huang, Wenbo Li, Bin Yang, Wenming Zhang, Xinyu Fang
Summary: The clinical value of metagenomic next-generation sequencing (mNGS) in the diagnosis of polymicrobial periprosthetic joint infection (PJI) was explored in this study. The results showed that mNGS can improve the diagnostic efficiency of polymicrobial PJI, and the combination of culture and mNGS is a promising method for diagnosing polymicrobial PJI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)