Article
Integrative & Complementary Medicine
Yingzhan Tang, Jingyi Yu, Wen Zhao, Juyan Liu, Hongying Peng, Haoran Zhang, Zhenzhou Jiang, Qinwei Yu, Luyong Zhang
Summary: Total glucosides of Rhizoma Smilacis Glabrae (RSG) have potential application in the treatment of psoriasis and can improve the symptoms by regulating Th17 and Treg cell balance.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Article
Integrative & Complementary Medicine
Juanjuan Qiao, Gengyu Lu, Gang Wu, Hui Liu, Wanli Wang, Tianmao Zhang, Guoyong Xie, Minjian Qin
Summary: This study reveals the scientific basis for the processing of fresh medicinal materials for Smilacis Glabrae Rhizoma (SGR) slices, providing scientific information for the quality control and rational applications of SGR in herbal medicines and functional foods.
Article
Chemistry, Analytical
Xiangyi Su, Xuan Zhang, Chunhua Wang, Guige Hou, Hongjuan Li
Summary: The study investigated the adsorption kinetics of AST, ISO, and ENG on HPD-300 resin, showing that their adsorption processes conformed to a pseudo-second-order kinetics equation controlled by boundary layer diffusion and intraparticle diffusion. The adsorption isotherms were well-fitted by the Langmuir equation, with ENG showing significantly higher adsorption capacity compared to the other two compounds. The separation process was optimized through dynamic adsorption/desorption experiments, leading to an increase in purities and recoveries of AST, ISO, and ENG. Subsequent separation using preparative HPLC and silica gel chromatography resulted in purities of above 98% for the final products of AST, ISO, and ENG.
Article
Pharmacology & Pharmacy
Li Jia, Min Zhang, Pengli Wang, Liming Wang, Peng Lei, Ruijiao Du, Lifeng Han, Peng Zhang, Yuefei Wang, Miaomiao Jiang
Summary: Studies have shown that Alismatis rhizoma extract has therapeutic effects on metabolic syndrome by reducing levels of TG, TC, LDL-C, and UA. The mechanism involves influencing multiple metabolic pathways, regulating lipid composition, and improving bile acid secretion.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lu Wang, Sen Li, Jiaxin Li, Zhongzhe Cheng, Yulin Feng, Hui Ouyang, Zhifeng Du, Hongliang Jiang
Summary: In this study, a new method was used to investigate the metabolism of Alismatis Rhizoma triterpene extract, identifying a total of 233 constituents and revealing the major metabolic pathways of triterpenes in vivo. Additionally, the mutual transformation of known triterpenes in Alismatis Rhizoma extract was discovered for the first time.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Plant Sciences
Na-Ri Choi, Kangwook Lee, Mujin Seo, Seok-Jae Ko, Woo-Gyun Choi, Sang-Chan Kim, Jinsung Kim, Jae-Woo Park, Byung-Joo Kim
Summary: Gastrointestinal motility disorder (GMD) is a disease that inhibits the movement of the gastrointestinal tract, causing digestive problems and reducing the quality of life. Smilacis Glabrae Rhixoma (SGR), a traditional herbal medicine, has been used to improve digestion. Through network pharmacology, it was found that SGR has compounds and genes related to GMD. The study also showed that SGR extract can regulate pacemaker activity and improve gastric emptying, as well as restore the intestinal transit rate in GMD mice induced by acetic acid. These findings suggest that SGR can restore digestion by improving intestinal motility.
Article
Chemistry, Multidisciplinary
Xiao-Lin Qiu, Qing-Feng Zhang
Summary: The study investigated the hydrolysis of astilbin to produce taxifolin, with results showing faster hydrolysis with higher HCl concentration and temperature. The activation energy of the reaction under 1 mol L-1 aq. HCl was calculated at 148.6 kJ mol(-1). The reaction successfully produced taxifolin from Rhizoma Smilacis Glabrae with a simple purification method leading to a purity of 97.5%.
JOURNAL OF CHEMICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Christian Bailly
Summary: This study analyzed the pharmacological effects of major protostane triterpenoids extracted from Alisma species, commonly used in Asian traditional medicine. It revealed their roles in treating inflammatory and vascular diseases, and identified potential molecular targets and signaling pathways.
Article
Chemistry, Analytical
Xiao-Yan Chang, Jia-Shuo Wu, Fang-Qing Zhang, Zhuang-Zhuang Li, Wei-Yi Jin, Jing-Xun Wang, Wei-Hua Wang, Yue Shi
Summary: This study investigated the major bioactive compounds and potential mechanism of Alismatis Rhizoma decoction (ARD) in the treatment of hyperlipidemia. The results showed that alisol B 23-acetate, alisol C 23-acetate, and alisol B were the core effective components of ARD for treating hyperlipidemia. These compounds were potential farnesoid X receptor (FXR) agonists for the treatment of hyperlipidemia.
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mengxiang Dai, Sen Li, Qingxin Shi, Xingliang Xiang, Yuehui Jin, Sha Wei, Lijun Zhang, Min Yang, Chengwu Song, Rongzeng Huang, Shuna Jin
Summary: This study used advanced analytical techniques to identify the differences in triterpenes between crude Alismatis rhizoma and its processed forms. The results showed that new triterpenes were generated during processing, and some existing triterpenes increased or decreased.
Article
Pharmacology & Pharmacy
Haigang Li, Yi Zhou, Luanfeng Liao, Hongyi Tan, Yejun Li, Zibo Li, Bilan Zhou, Meihua Bao, Binsheng He
Summary: This study investigated the pharmacokinetic interactions of warfarin, Chuanxiong Rhizoma, and gut microbiota in a rat model. The results showed that Chuanxiong Rhizoma and its metabolites may affect the pharmacokinetic features of warfarin through gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Jing Meng, Jingzhuo Tian, Yong Zhao, Chunying Li, Yan Yi, Yushi Zhang, Jiayin Han, Lianmei Wang, Chen Pan, Suyan Liu, Chenyue Liu, Fang Wang, Xuan Tang, Dunfang Wang, Shasha Qin, Aihua Liang
Summary: Cheqianzi Decoction (CQD) has been found to reduce uric acid levels, treat hyperuricemia, and alleviate kidney damage. Network pharmacology analysis showed that CQD regulates inflammatory and apoptotic signaling pathways, suggesting its potential for treating hyperuricemia and kidney injury.
Article
Integrative & Complementary Medicine
Ren Qi, Liu Xiao-Qi, Zhou Xiao-Wen, Zhou Xuan, Fang Ge, Wang Bin, Wang Yan-Ping, Peng Dan-Hong, Li Xian-Tao
Summary: This study demonstrated the therapeutic effect of Huatan Jiangzhuo decoction (HJD) on high-fat diet-induced hyperlipidemia in rats by analyzing the transcriptome profile. The results showed potential mechanisms of lipid-lowering effects of HJD through downregulation of specific genes related to lipid metabolism.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Plant Sciences
Shan-Peng Ma, Wei-Ping Ma, Shi-Ning Yin, Xiang-Yue Chen, Xiao-Qing Ma, Bao-Hong Wei, Jing-Guang Lu, Hong-Bing Liu
Summary: This study found that Mulisan decoction has a good antiperspirant effect and can improve metabolism. These findings provide insights for further clinical research on immune improvement and antiperspirant effects.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Pan Yan, Lu Wang, Sen Li, Xuechen Liu, Yi Sun, Jianmei Tao, Hui Ouyang, Jianqing Zhang, Zhifeng Du, Hongliang Jiang
Summary: The study proposed a strategy to improve the structural annotation of prototypes and metabolites through characteristic ions and a QSRR model, identifying a total of 118 compounds, including 47 prototypes and 71 metabolites, with 61 unknown compounds reasonably characterized. The QSRR model built by GA-MLR showed excellent regression correlation (R-2 = 0.9966), demonstrating the effectiveness of the strategy in enhancing the annotation confidence of in vivo metabolites of TCM.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Toxicology
Yiyi Chen, Jiao Huo, Yunjie Liu, Zhu Zeng, Xuejiao Zhu, Xuxi Chen, Rui Wu, Lishi Zhang, Jinyao Chen
Summary: The study aimed to develop a novel and practical protocol for micronucleus test in rat peripheral blood using flow cytometry, with method validation. The FCM-based method consistently demonstrated highly sensitive responses for micronucleus detection and correlated well with traditional Giemsa staining method. This method provides an efficient system for micronucleus scoring with easy operation and low background.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Food Science & Technology
Rui Wu, Jinyao Chen, Lishi Zhang, Xin Wang, Yuexin Yang, Xiangnan Ren
Summary: This study characterized the profile of milk metabolites in human milk and cow, horse, and goat milk, identified significantly different metabolites, and analyzed main metabolic pathways. These findings could provide valuable data for assessing milk properties and improving formula quality.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2021)
Article
Environmental Sciences
Xiaomeng Li, Mengmei Ni, Zhirui Yang, Xuxi Chen, Lishi Zhang, Jinyao Chen
Summary: This study investigates the potential modes of action of BPA in reproductive/developmental toxicity, neurological toxicity, and proliferative effects on the mammary gland and the prostate using bioinformatics analysis and the QWOE approach. Common target genes and pathways involved in BPA-induced action are identified, with two potential estrogen receptor-related modes of action proposed. Further research is needed to improve the risk assessment of BPA.
ENVIRONMENTAL POLLUTION
(2021)
Article
Endocrinology & Metabolism
Mengmei Ni, Yingyao Wang, Rui Wu, Lishi Zhang, Xuebing Xu, Yuexin Yang, Jinyao Chen
Summary: The study found significant differences in the fat acid distribution of breast milk between different regions and lactation stages, with particular attention needed on unsaturated fatty acids and sn-2 position fatty acids, especially palmitic acid, when optimizing infant formula.
ANNALS OF NUTRITION AND METABOLISM
(2021)
Article
Environmental Sciences
Ting Zeng, Yanshan Liang, Jinyao Chen, Guodong Cao, Zhu Yang, Xingchen Zhao, Jinglin Tian, Xiong Xin, Bo Lei, Zongwei Cai
Summary: Under cadmium exposure, regardless of gender, the metabolic pathways primarily affected include the creatine pathway, amino acid metabolism especially tryptophan metabolism, aminoacyl-tRNA biosynthesis, and purine metabolism as the concentration of urinary cadmium increases. Specific biomarkers linked with nephrotoxicity such as creatine, creatinine, L-tryptophan, adenine, and uric acid were detected based on statistical analysis. The study outcome may provide valuable information for reflecting body burden and improving health policy for risk assessment.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Toxicology
Wuyang Yue, Xuxi Chen, Sifu He, Na Li, Lishi Zhang, Jinyao Chen
Summary: The well-known air pollutant PM2.5 poses a threat to public health by impairing pulmonary function, causing chronic obstructive pulmonary disease, and increasing the risk of lung cancer. This study investigated the lung injury induced by PM2.5 collected in Chengdu, showing that PM2.5 could induce pulmonary injury through the activation of the JAK-2/STAT-3 signaling pathway, leading to inflammatory responses and lung fibrosis.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xia Zhu, Zhu Zeng, Yiyi Chen, Ruirui Li, Xinyao Tang, Xuejiao Zhu, Jiao Huo, Yunjie Liu, Lishi Zhang, Jinyao Chen
Summary: The study found that low doses of individual mycotoxins did not show significant genotoxicity, but certain combinations of mycotoxins could induce genotoxicity in tissues. In peripheral blood, the combination of DON and FB1 significantly induced micronuclei, while ZEN in the liver might exacerbate the DNA-damaging effects of DON and FB1.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Toxicology
Zhirui Yang, Xiaomeng Li, Lin Tian, Yang Song, Yu Zhang, Jinyao Chen, Lishi Zhang
Summary: This study investigated the impact of cadmium exposure on liver function, finding that blood levels of iron, cadmium, and copper were positively correlated with elevated ALT levels, while blood copper was positively associated with AST levels. Additionally, the highest blood zinc quartile in the polluted area and blood magnesium quartile in the unpolluted area were associated with lower ALT levels.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Environmental Sciences
Xiaomeng Li, Mengmei Ni, Wei Xiong, Lin Tian, Lishi Zhang, Jinyao Chen
Summary: This study revealed the mechanism of BPA-induced female reproductive toxicity, including ERK activation, increased expression of CDKN3, and cell cycle arrest. With increasing BPA concentrations, increased relative mRNA and protein expressions of ERK and CDKN3, as well as an increased proportion of S phase and decreased proportion of G0/G1 phase were observed.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Environmental Sciences
Mengmei Ni, Xiaomeng Li, Lishi Zhang, Vikas Kumar, Jinyao Chen
Summary: This study evaluated the global scientific output of Bisphenol A (BPA) toxicity and identified hot spots and research trends. China and the United States were the most active contributors in this field, with the Chinese Academy of Sciences and the Dow chemical company conducting relatively more research. The annual publications on BPA toxicity have increased over the past three decades, with a shift in focus towards studying the toxic mechanisms at the cellular level and the toxicity of BPA analogs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Food Science & Technology
Yanjun Zhou, Haixia Sui, Yibaina Wang, Ling Yong, Lei Zhang, Jiang Liang, Jing Zhou, Lili Xu, Yanxu Zhong, Jinyao Chen, Yan Song
Summary: A duplicate diet collection method was used to estimate dietary exposure to glutamates in children aged 2-5 years in selected provinces of China. Results showed that glutamates content was highest in mixed meals, followed by powdered formula and milk and dairy products. The total mean daily dietary exposure for subjects was below the recommended daily intake by regulatory authorities, indicating a low risk of glutamates exposure in this group.
Article
Nutrition & Dietetics
Ya Yuan, Ignatius Man-Yau Szeto, Na Li, Hua Yang, Yunzheng Zhou, Biao Liu, Fang He, Lishi Zhang, Sufang Duan, Jinyao Chen
Summary: The study aimed to investigate the effects of dietary menaquinone-7 (MK-7) on bone accrual in growing Sprague-Dawley rats under calcium restriction. It was found that calcium deficiency reduced microbiome richness, disrupted microbiome composition, and increased the relative abundance of Parasutterella. Additionally, calcium insufficiency affected metabolite levels and metabolic profiles. MK-7 supplementation improved bone density, calcium content, and bone quality through modulation of metabolic pathways and gut microbiota composition. The gut-bone axis and MK-7 supplementation show promise in ameliorating calcium deficiency in children's bone quality.
Review
Environmental Sciences
Yue Cao, Jinyao Chen, Qian Bian, Junyu Ning, Ling Yong, Tong Ou, Yan Song, Sheng Wei
Summary: This meta-analysis investigates the genotoxicity of titanium dioxide nanoparticles (TiO2 NPs) and explores influencing factors. The results suggest that TiO2 NPs can induce DNA damage, chromosomal damage, and gene mutations, with rats and cancer cells showing higher susceptibility. The DNA damage response mechanism plays a key role in the genotoxicity induced by TiO2 NPs.
