Article
Veterinary Sciences
Tomoyoshi Doki, Ken Takahashi, Nobuhisa Hasegawa, Tomomi Takano
Summary: The combination of nucleoside analog GS-441524 and triazole antifungal drug itraconazole has a synergistic antiviral effect against the feline infectious peritonitis virus (FIPV), which causes a fatal disease in cats.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Shih-Jung Yen, Hui-Wen Chen
Summary: In northern Taiwan, samples from cats suspected of feline infectious peritonitis showed that younger cats are at a significantly higher risk than older cats. There was no significant association between positivity rates and sex or breed. Positive cases had a lower A/G ratio and showed a high diversity in type I sequences, while type II sequences were more similar to coronaviruses from other species.
Article
Microbiology
Magdalena Dunowska, Sayani Ghosh
Summary: The study found that doxycycline can inhibit the replication of feline infectious peritonitis virus (FIPV) in vitro, with the inhibitory effect being dose-dependent. This supports future clinical trials of using doxycycline to treat FIP-affected cats.
Article
Veterinary Sciences
Michele Camero, Gianvito Lanave, Cristiana Catella, Maria Stella Lucente, Alessio Sposato, Viviana Mari, Maria Tempesta, Vito Martella, Alessio Buonavoglia
Summary: ERDRP has been shown to be highly effective against a type II FIPV in vitro, inhibiting viral replication in a dose-dependent manner. Further experiments are needed to determine if ERDRP is suitable for the treatment of FIPV in vivo.
BMC VETERINARY RESEARCH
(2022)
Article
Veterinary Sciences
N. Decaro, V Mari, G. Lanave, E. Lorusso, M. S. Lucente, C. Desario, M. L. Colaianni, G. Elia, F. Ferringo, F. Alfano, C. Buonavoglia
Summary: The study investigated the frequency of mutations associated with virulence in FIPV and FECV strains circulating in Italian cats. Mutations M1058L and S1060A were found to be present in FIPV strains, highlighting the importance of genetic signatures in the virulence shift of FECV/FIPV.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Virology
Yong-Yu Gao, Qian Wang, Xiang-Yu Liang, Shuang Zhang, Di Bao, Han Zhao, Shao-Bai Li, Kai Wang, Gui-Xue Hu, Feng-Shan Gao
Summary: This article reviews recent progress in FCoV research, including the etiological characteristics, epidemiology, clinical symptoms and pathological changes, pathogenesis, and current diagnosis, prevention, and treatment methods. It is hoped that this review will provide a reference for further research on FCoV and other coronaviruses.
Article
Virology
Sarah Cook, Diego Castillo, Sonyia Williams, Christine Haake, Brian Murphy
Summary: Feline infectious peritonitis (FIP) is caused by genetic variants of feline coronavirus (FCoV) and feline infectious peritonitis virus (FIPV), currently classified into two serotypes, I and II. While serotype II FIPV has been more extensively studied, recent advances include the development of a culture-adapted feline cell line for improved understanding of serotype I FIPV biology and research on coronavirus receptors in feline cells.
Review
Infectious Diseases
Saverio Paltrinieri, Alessia Giordano, Angelica Stranieri, Stefania Lauzi
Summary: Feline infectious peritonitis (FIP) and COVID-19, caused by coronaviruses, share some similar pathogenic and immunopathogenic events. Preventive measures recommended for preventing SARS-CoV-2 spread have also shown success in eradicating FIP in feline households. Additionally, the therapeutic compound GS-441524, effective against FIP, is the active form of Remdesivir used as a therapeutic option for COVID-19.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Veterinary Sciences
Jong-Chul Choi, Sung-Won Jung, In-Yeong Choi, Yeong-Lim Kang, Dong-Hun Lee, Sang-Won Lee, Seung-Yong Park, Chang-Seon Song, In-Soo Choi, Joong-Bok Lee, Changin Oh
Summary: Rottlerin has inhibitory effects on FCoV replication and affects different stages of FCoV activity. The use of liposome encapsulation technique improves its efficacy. Therefore, further investigation of rottlerin-liposome as a potential treatment for FCoV is suggested.
VETERINARY SCIENCES
(2023)
Article
Virology
Yoshikazu Tanaka, Eri Tanabe, Yuki Nonaka, Mitsuki Uemura, Tsuyoshi Tajima, Kazuhiko Ochiai
Summary: Feline coronaviruses (FCoVs) are a global infection in cats, causing severe systemic diseases. The current drugs for treating FIP are ineffective, highlighting the need to investigate host factors and replication functions for FCoV in order to develop effective drugs. Ionophore antibiotics, by altering the pH conditions in the endosomes, inhibit FCoV proliferation in vitro, showing potential as broad-spectrum anti-FCoV agents.
Article
Chemistry, Multidisciplinary
Jimmy Lu, Sizhu Amelia Chen, Muhammad Bashir Khan, Raelynn Brassard, Elena Arutyunova, Tess Lamer, Wayne Vuong, Conrad Fischer, Howard S. Young, John C. Vederas, M. Joanne Lemieux
Summary: Coronaviruses infect a variety of hosts in the animal kingdom, and GC376 has been shown to treat feline infectious peritonitis. The study found that GC373 and GC376 are drugs with strong inhibitory effects on SARS-CoV-2, and they also have strong inhibitory effects on FIPV M-pro, which is important for structure-guided drug design.
FRONTIERS IN CHEMISTRY
(2022)
Article
Virology
Diane D. Addie, Flora Bellini, Johanna Covell-Ritchie, Ben Crowe, Sheryl Curran, Mark Fosbery, Stuart Hills, Eric Johnson, Carrie Johnson, Steven Lloyd, Oswald Jarrett
Summary: The aim of this study was to determine if stopping FCoV faecal shedding with antivirals prevents FIP. The findings showed that early treatment with oral antivirals can prevent FIP by stopping the faecal shedding of FCoV.
Article
Infectious Diseases
Liang Xu, Shaotang Ye, Yulin Ding, Yuqing Xiao, Congwen Yao, Zhen Wang, Siqi Cai, Jiajun Ou, Jianwei Mao, Xuerui Hu, Song Cheng, Jingyu Wang, Gang Lu, Shoujun Li
Summary: A new rapid and highly sensitive method for clinical diagnosis of FIPV infection was explored in this study, based on the FIPV BS8 N protein monoclonal antibody. A combination method of indirect immunofluorescence assay (IFA) and nested reverse transcription polymerase chain reaction (RT-nPCR) was used to examine FIP-suspected clinical samples, and the results were 100% consistent with immunohistochemistry (IHC), indicating the potential of this method for rapid and accurate diagnosis of FIPV infection within 24 hours.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Microbiology
Rea Maja Kobialka, Arianna Ceruti, Michelle Bergmann, Katrin Hartmann, Uwe Truyen, Ahmed Abd El Wahed
Summary: Feline coronavirus is endemic in cat populations worldwide, and a rapid detection assay based on isothermal amplification technology has been developed for this virus. The results of the study show that this method has high sensitivity and specificity and can be considered a promising simple method for rapid detection.
Article
Pharmacology & Pharmacy
Ling Ma, Quanjie Li, Yongli Xie, Jianyuan Zhao, Dongrong Yi, Saisai Guo, Fei Guo, Jing Wang, Long Yang, Shan Cen
Summary: In this study, a cell-based assay for screening inhibitors against SARS-CoV-2 3CLpro was established using bioluminescence resonance energy transfer (BRET) technology. The assay was applied to screen a collection of known HIV/HCV protease inhibitors, and it was found that simeprevir showed the most potency against 3CLpro with the ability to bind to its active site pocket. This research demonstrates the feasibility of using the cell-based BRET assay for screening 3CLpro inhibitors and supports the potential of simeprevir for the development of such inhibitors.
ANTIVIRAL RESEARCH
(2022)
Article
Microbiology
Masayuki Amano, Yasushi Tojo, Pedro Miguel Salcedo-Gomez, Garth L. Parham, Prasanth R. Nyalapatla, Debananda Das, Arun K. Ghosh, Hiroaki Mitsuya
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Biochemistry & Molecular Biology
Sarah E. St John, Sakshi Tomar, Shaun R. Stauffer, Andrew D. Mesecar
BIOORGANIC & MEDICINAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Sakshi Tomar, Melanie L. Johnston, Sarah E. St. John, Heather L. Osswald, Prasanth R. Nyalapatla, Lake N. Paul, Arun K. Ghosh, Mark R. Denison, Andrew D. Mesecar
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Chemistry, Organic
Arun K. Ghosh, Prasanth R. Nyalapatla
Article
Chemistry, Medicinal
Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Heather L. Osswald, Cuthbert D. Martyr, Manabu Aoki, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Haydar Bulut, Debananda Das, Irene T. Weber, Hiroaki Mitsuya
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Organic
Arun K. Ghosh, Prasanth R. Nyalapatla
Article
Biology
Manabu Aoki, Hironori Hayashi, Kalapala Venkateswara Rao, Debananda Das, Nobuyo Higashi-Kuwata, Haydar Bulut, Hiromi Aoki-Ogata, Yuki Takamatsu, Ravikiran S. Yedidi, David A. Davis, Shin-ichiro Hattori, Noriko Nishida, Kazuya Hasegawa, Nobutoki Takamune, Prasanth R. Nyalapatla, Heather L. Osswald, Hirofumi Jono, Hideyuki Saito, Robert Yarchoan, Shogo Misumi, Arun K. Ghosh, Hiroaki Mitsuya
Article
Chemistry, Medicinal
Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Satish Kovela, Margherita Brindisi, Heather L. Osswald, Bhavanam Sekhara Reddy, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Shin-ichiro Hattori, Irene T. Weber, Hiroaki Mitsuya
Article
Chemistry, Medicinal
Arun K. Ghosh, Prasanth R. Nyalapatla, Satish Kovela, Kalapala Venkateswara Rao, Margherita Brindisi, Heather L. Osswald, Masayuki Amano, Manabu Aoki, Johnson Agniswamy, Yuan-Fang Wang, Irene T. Weber, Hiroaki Mitsuya
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Organic
Taber S. Maskrey, Tyler Kristufek, Matthew G. LaPorte, Prasanth R. Nyalapatla, Peter Wipf
Article
Microbiology
Shin-ichiro Hattori, Hironori Hayashi, Haydar Bulut, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Kazuya Hasegawa, Manabu Aoki, Arun K. Ghosh, Hiroaki Mitsuya
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Biochemistry & Molecular Biology
Arun K. Ghosh, Margherita Brindisi, Prasanth R. Nyalapatla, Jun Takayama, Jean-Rene Ella-Menye, Sofiya Yashchuk, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya
BIOORGANIC & MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)