Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part II. A mechanistic PBPK model for IR formulation comparison, proton pump inhibitor drug interactions, and administration with acidic juices

Published 2019 View Full Article

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Title
Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part II. A mechanistic PBPK model for IR formulation comparison, proton pump inhibitor drug interactions, and administration with acidic juices
Authors
Keywords
PBPK modelling, Dissolution, In vitro, -, in vivo, correlation, Mechanistic, Fruit juice, Proton pump inhibitor, Particle size distribution
Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 142, Issue -, Pages 435-448
Publisher
Elsevier BV
Online
2019-07-12
DOI
10.1016/j.ejpb.2019.07.011

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