Article
Food Science & Technology
Danila Cianciosi, Tamara Y. Forbes-Hernandez, Jose M. Alvarez-Suarez, Johura Ansary, Denise Quinzi, Adolfo Amici, Maria D. Navarro-Hortal, Adelaida Esteban-Munoz, Jose Luis Quiles, Maurizio Battino, Francesca Giampieri
Summary: Chestnut and Eucalyptus honeys exhibited significant anti-inflammatory effects on LPS-stressed macrophages, reducing apoptosis, promoting wound healing, regulating antioxidant enzyme activities, and protecting mitochondrial respiration. These honeys modulated the expression of inflammatory biomarkers to decrease inflammation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Applied
Xiao Li, Zeliang Wei, Xingyue Wang, Feixia Duan, Lidan Xiong, Jingwen Li, Jing Tian, Lirong Jia, Hong Gao
Summary: Premna microphylla turcz leaf juice with polysaccharides (PMPs) extracted under alkaline conditions showed remarkable radical scavenging capability, especially in inhibiting the production of inflammatory cytokines, making them a promising non-toxic natural dietary supplement.
Article
Chemistry, Multidisciplinary
Mi-Bo Kim, Hyeju Lee, Terrence Vance, Sang Gil Lee
Summary: This study demonstrates that Busan-grown Agarum cribrosum ethanol extract (ACE) and its ethyl acetate (EtOAc) fraction exert inhibitory effects on LPS-induced inflammation and oxidative stress in macrophages.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Sergei A. Kozlovskiy, Evgeny A. Pislyagin, Ekaterina S. Menchinskaya, Ekaterina A. Chingizova, Yuriy E. Sabutski, Sergey G. Polonik, Galina N. Likhatskaya, Dmitry L. Aminin
Summary: In this study, 1,4-naphthoquinone thioglucoside derivatives U-286 and U-548 were found to inhibit inflammation induced by ATP/LPS via P2X7 receptors. These compounds were able to inhibit calcium influx and reactive oxygen species production, and showed antioxidant activity in mouse brain homogenate. They also decreased COX-2 enzyme activity, reduced the release of pro-inflammatory cytokines, and protected macrophage cells against the toxic effects of ATP and LPS.
Article
Medicine, Research & Experimental
Yuan Tian, Siqi Zhou, Reiko Takeda, Kazuma Okazaki, Marie Sekita, Kazuichi Sakamoto
Summary: The study demonstrates that the anti-inflammatory effect of amber extract on RAW 264.7 cells may be mediated by inhibiting NF-κB p65 signaling pathway, providing a potential pharmacological alternative for inflammation-related diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Food Science & Technology
Weiyang Kuang, Jiajia Yang, Zhiyuan Liu, Jinzi Zeng, Xuewei Xia, Xiaodan Chen, Saiyi Zhong, Riming Huang
Summary: Catechin may exert an anti-inflammatory effect through mediating cellular ferroptosis. It appears to influence ferroptosis by activating cysteine and methionine metabolism and glutathione metabolism, while inhibiting the ferroptosis pathway. Several proteins in these metabolic pathways, as well as GPX4 and SLC7A11, which are related to ferroptosis, may be relevant to catechin through molecular docking.
Article
Plant Sciences
Yuanru Zheng, Chunyang Tian, Chunlin Fan, Nishan Xu, Junjie Xiao, Xiaoyang Zhao, Zibin Lu, Huihui Cao, Junshan Liu, Linzhong Yu
Summary: This study found that Sheng-Mai Yin has significant anti-inflammatory effects, potentially achieved through inhibiting the NF-kappa B and STAT3 signal pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Applied
Zichao Wang, Lu Wang, Hongtao Huang, Qiuyan Li, Xiaoyuan Wang, Qi Sun, Qi Wang, Na Li
Summary: In this study, flavonoids were successfully extracted from Artemisia argyi stem, with a yield of 15.3 mg/g dry A. argyi stem. The flavonoid extract had a purity of 88.58% (w/w) and contained carbohydrates, proteins, and polyphenols. It demonstrated concentration-dependent scavenging effects on various radicals and exerted protective effects on stimulated macrophages. This research provides guidance for utilizing A. argyi as a plant-based diet and its flavonoid extract as antioxidant and anti-inflammatory ingredients to enhance the function and nutrition of foods.
Article
Food Science & Technology
Nawel Benbouguerra, Josep Valls-Fonayet, Stephanie Krisa, Francois Garcia, Cedric Saucier, Tristan Richard, Ruth Hornedo-Ortega
Summary: The study characterized the polyphenolic composition of grape skins from Merlot, Tannat, and Syrah varieties using UPLC-QqQ-MS. Changes in polyphenol content during ripening were observed, with an increase in anthocyanins and stilbenes, and a decrease in flavan-3-ols and procyanidins. The skin extracts showed strong antioxidant and anti-inflammatory properties, with significant inhibition of NO and ROS production in stimulated macrophages.
Article
Chemistry, Multidisciplinary
Jie-Wei He, Ping Guo, Li Yang, Jun-Wei He
Summary: In this study, six compounds were isolated from the flowers of Hosta plantaginea, and compounds 1-4 showed significant inhibition on NO production in LPS-induced RAW 264.7 cells. Additionally, compounds 1 and 3 were found to reduce the levels of inflammatory factors and phosphorylation of NF-kB p65, suggesting their potential as anti-inflammatory candidates.
Article
Biochemistry & Molecular Biology
Dahae Lee, Seoung Rak Lee, Ki Sung Kang, Ki Hyun Kim
Summary: The study evaluated the anti-inflammatory effects of compounds from white mulberry fruits in mouse RAW 264.7 macrophages. Compound cyclo(L-Pro-L-Val) (5) was identified as a potential therapeutic agent for inflammation-associated disorders as it significantly suppressed phosphorylations and activations of inflammatory mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jae Sik Yu, Sung Ho Lim, Seoung Rak Lee, Chang-Ik Choi, Ki Hyun Kim
Summary: The ethanol extract of white mulberry fruits and its derived fractions showed strong antioxidant and anti-inflammatory effects by inhibiting ROS generation and lowering iNOS expression, suggesting their potential as natural antioxidant and anti-inflammatory agents.
Article
Chemistry, Multidisciplinary
Kabyashree Phukan, Rajlakshmi Devi, Devasish Chowdhury
Summary: Green synthesis of nanoparticles is important for their therapeutic effects in biomedical applications. In this study, gold nano bioconjugates (GNBCs) were prepared from onion peels and their anti-inflammatory activity was investigated. The results showed that GNBCs had better therapeutic efficacy than the fractionate alone, reducing reactive oxygen species production, nitrite production, TNF-alpha production, and IL-6 production while maintaining satisfactory cell viability. Additionally, a caveolar-mediated endocytosis pathway was found to be prominent in the entry of GNBCs into macrophages.
Article
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras
Summary: Dysregulated inflammation and oxidative stress play significant roles in various diseases. Macrophages are crucial in immune responses and regulate inflammation by exhibiting different phenotypes. IsoPs, as biomarkers of oxidative stress, can promote an anti-inflammatory macrophage phenotype during inflammation, contributing to disease prevention and mitigation.
Article
Food Science & Technology
Hani Hafeeza Halim, Mohd Sabri Pak Dek, Azizah Abdul Hamid, Nazamid Saari, Mohd Izwan Mohd Lazim, Faridah Abas, Ahmad Ngalim, Amin Ismail, Ahmad Haniff Jaafar
Summary: This research evaluated the functional properties of young and mature coconut water from the four most popular coconut varieties in Malaysia. It was found that young Malaysian Yellow Dwarf (MYD) had the highest antioxidant and anti-aging activities, making it a potential novel source of natural functional ingredients for skin anti-aging.
Article
Biochemistry & Molecular Biology
Miah Roney, Abdul Rashid Issahaku, Md Shaekh Forid, A. K. M. Moyeenul Huq, Mahmoud E. S. Soliman, Mohd Fadhlizil Fasihi Mohd Aluwi, Saiful Nizam Tajuddin
Summary: Due to the increasing prevalence of bacterial infections and drug resistance, antibacterial therapy has become challenging. By conducting drug-likeness screening, researchers have identified 184 usnic acid derivatives with potential as anti-bacterial compounds. The pharmacokinetics prediction and molecular docking investigation led to the discovery of two compounds with strong binding affinity. Molecular dynamic simulation further confirmed the stability of these compounds. These substances hold promise as therapeutic candidates for antibacterial medication.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Plant Sciences
Audrey Siew Foong Kow, Leng Wei Khoo, Ji Wei Tan, Faridah Abas, Ming-Tatt Lee, Daud Ahmad Israf, Khozirah Shaari, Chau Ling Tham
Summary: C. nutans, a herbal plant used traditionally to treat skin rash, was found to exert anti-allergic effects by suppressing the IgG pathway and the release of mediators.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Rajibul Islam, Md. Selim Hossain, Phooi Yan Mock, Sze Wei Leong, Kok Wai Lam
Summary: Cancer remains a leading cause of death globally, and there is a projected increase in new cases. Current treatment options for cancer are limited, but the discovery of chromone scaffold compounds has sparked interest and research in recent years. This review provides an overview of the progress and developments in using chromone scaffold in cancer therapy, specifically targeting key kinase pathways. The potential of chromone-based therapies in the fight against cancer is highlighted, along with insights into future directions for development.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Plant Sciences
Nur Khaleeda Zulaikha Zolkeflee, Pei Lou Wong, M. Maulidiani, Nurul Shazini Ramli, Azrina Azlan, Faridah Abas
Summary: This study aims to investigate the antidiabetic potential of Muntingia calabura (MC) on a STZ-NA-induced diabetic rat model. Treatment with MC extract showed favorable serum creatinine, urea, and glucose lowering capacity. Metabolomic analysis identified nine biomarkers that distinguish between diabetic control and normal groups. The induction of diabetes altered various metabolic pathways, but treatment with MC extract improved carbohydrate metabolism and other metabolic pathways.
Article
Food Science & Technology
Nur Izzati Mohamed Nawawi, Giroon Ijod, Faridah Abas, Nurul Shazini Ramli, Noranizan Mohd Adzahan, Ezzat Mohamad Azman
Summary: This study investigated the effects of different drying processes and times on phenolic compounds and antioxidant activities of mangosteen pericarps (MP). Results showed that freeze-drying for 36 and 48 hours resulted in higher total anthocyanin content, while the 36-hour freeze-drying process exhibited higher total phenolic content, total flavonoid content, and reducing power. Therefore, the 36-hour freeze-drying process is a more efficient and energy-saving method for industrial applications, and the dried MP extracts could be used as an alternative to synthetic food colorants.
Article
Biotechnology & Applied Microbiology
Muna Mahmood Taleb Abadl, Anis Asyila Marzlan, Rabiha Sulaiman, Faridah Abas, Anis Shobirin Meor Hussin
Summary: Probiotic foods like kefir drinks have a positive impact on consumers' health and well-being. With the increasing antibiotic resistance of Salmonella worldwide, alternative methods are needed for preventing and treating infectious diseases in humans and animals. This study aimed to optimize the quality of coconut milk kefir drink and identify the peptides and metabolites present. The findings demonstrated the potential of coconut milk fermented with kefir grains as a functional healthy drink.
FERMENTATION-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Miah Roney, A. K. M. Moyeenul Huq, Mohd Fadhlizil Fasihi Mohd Aluwi, Saiful Nizam Tajuddin
Summary: This study identified the most potent curcumin analogs against DENV NS2B/NS3 protease through computational analysis. DB11672 was found to be the primary inhibitor of DENV NS2B/NS3 protease.
JOURNAL OF COMPUTATIONAL BIOPHYSICS AND CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Norashikin Roslan, Khairul Bariyyah Abd. Halim, Noraslinda Muhamad Bunnori, Mohd Fadhlizil Fasihi Mohd Aluwi, Karimah Kassim, Nurziana Ngah
Summary: In this study, the potential of theoretically designed thiourea derivatives as anticancer agents against EGFR-TK was evaluated using in silico techniques. Compound 13 exhibited the most potent inhibitory activity, with the lowest binding affinity compared to the positive control erlotinib. Molecular dynamics simulations showed that compound 13 had adequate compactness, uniqueness, and stability.
JOURNAL OF COMPUTATIONAL BIOPHYSICS AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Miah Roney, Amit Dubey, Muhammad Hassan Nasir, Aisha Tufail, Saiful Nizam Tajuddin, Mohd Fadhlizil Fasihi Mohd Aluwi, A. K. M. Moyeenul Huq
Summary: This work describes the in-silico examination of substances from the drug bank as potential EGFR inhibitors. The study identified a promising lead compound that showed high reactivity and stability in the EGFR protein binding pocket. However, further in-vitro and in-vivo experiments are needed to validate the findings.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Miah Roney, Abdul Rashid Issahaku, Akm Moyeenul Huq, Mahmoud E. S. Soliman, Saiful Nizam Tajuddin, Mohd Fadhlizil Fasihi Mohd Aluwi
Summary: The aim of this study is to discover more promising anti-cancer compounds against EGFR from marine natural products using computational approaches. Through molecular docking and drug-likeness analysis, phenolic acids with good binding energies and pharmacokinetics profiles were identified. Molecular dynamics simulation revealed the stability of the lead complex, suggesting its potential as a future drug for cancer treatment.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Miah Roney, Amit Dubey, Muhammad Hassan Nasir, Akm Moyeenul Huq, Aisha Tufail, Saiful Nizam Tajuddin, Normaiza Binti Zamri, Mohd Fadhlizil Fasihi Mohd Aluwi
Summary: In this study, computational methods were used to identify potential natural anti-dengue compounds. The results showed that dithymoquinone from N. sativa has anti-DENV activity. This finding suggests the possibility of developing new dengue treatments.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
A. K. M. Moyeenul Huq, Miah Roney, Abdul Rashid Issahaku, Suhaila Sapari, Fazira Ilyana Abdul Razak, Mahmoud E. S. Soliman, Mohd Fadhlizil Fasihi Mohd Aluwi, Saiful Nizam Tajuddin
Summary: Dengue fever is a major global health concern with no FDA approved medication. Researchers are exploring DENV NS5 RdRp protease as a potential therapeutic target and have discovered effective compounds from Momordica charantia L. through computational approaches. The lead compound Momordicoside-I showed good medication-like qualities and significant binding affinity towards the DENV-2 RdRp enzyme, highlighting its potential as a treatment for dengue fever.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biotechnology & Applied Microbiology
Khadija Ahmed Mousa, Khairul Naim Md. Padzil, Yaya Rukayadi, Nik Iskandar Putra Shamsudin, Faridah Abas
Summary: The study aimed to assess the effect of pH and temperature on the stability and mode of action of M. paradisiaca L. flower extract. The results showed that the extract had inhibitory effects on pathogenic bacteria and food spoilage, with different pHs and temperatures having varying effects. The extract exhibited antimicrobial activity and stability, making it a potential natural sanitizing agent for washing raw foodstuffs.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Kamal Rullah, Miah Roney, Zalikha Ibrahim, Nur Farisya Shamsudin, Deri Islami, Qamar Uddin Ahmed, Lam Kok Wai, Mohd Fadhlizil Fasihi Mohd Aluwi
Summary: This study explored the structural requirements and identified potential new inhibitor scaffolds for 5-lipoxygenase-activating protein (FLAP) inhibitors. Docking studies revealed key binding interactions with specific residues in the FLAP-binding site. A ligand-based QSAR model was developed, showing statistically significant results. Additionally, two 2D-QSAR models were developed using a genetic function approximation. HypoGen 1 was used for database mining to identify potential new FLAP inhibitors.
JOURNAL OF COMPUTATIONAL BIOPHYSICS AND CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
