Review
Endocrinology & Metabolism
Haigang Ding, Juan Zhang, Feng Zhang, Songou Zhang, Xiaozhen Chen, Wenqing Liang, Qiong Xie
Summary: Polycystic ovary syndrome has a wide range of negative impacts on women's health and is one of the most frequent reproductive systemic endocrine disorders. It is mainly caused by increased levels of androgen (hyperandrogenemia) and insulin resistance. Understanding the effects of these two factors on the pathophysiology of symptoms related to PCOS is crucial for further research and potential treatments.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Obstetrics & Gynecology
Josef Finsterer
Summary: Polycystic ovary syndrome (PCOS) is a multi-causal condition. Variations in mitochondrial DNA (mtDNA) are increasingly recognized as one of the genetic causes of PCOS. PCOS is associated not only with known syndromic mitochondrial disorders but also with non-syndromic mitochondrial disorders, and even with mtDNA variants exclusively causing PCOS. Further studies are needed to establish the causal link between mtDNA variants and PCOS.
REPRODUCTIVE SCIENCES
(2023)
Review
Endocrinology & Metabolism
Stefano Palomba, Carla Colombo, Andrea Busnelli, Donatella Caserta, Giovanni Vitale
Summary: This study comprehensively reviews the relationship between polycystic ovary syndrome (PCOS) and thyroid dysfunction by analyzing available evidence in nine main areas of interest. The results suggest that PCOS and thyroid disorders are closely related, and their coexistence may increase the reproductive and metabolic risk of patients. Regular screening for thyroid function and thyroid-specific autoantibodies in women with PCOS, particularly before and during pregnancy, is highly recommended.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Iman Al-Saleh
Summary: The study suggests that DEHP may contribute to PCOS, but further investigation is needed to understand the underlying mechanisms.
Article
Medical Laboratory Technology
Andrijana Milankov, Maja Milanovic, Natasa Milosevic, Jan Sudji, Sladana Pejakovic, Natasa Milic, Artur Bjelica, Milica Medic Stojanoska
Summary: This study investigated the association between phthalate exposure and the development of metabolic syndrome in women with polycystic ovary syndrome (PCOS). The results showed that phthalate concentrations were correlated with obesity, glucose and lipid impairment, and disrupted testosterone levels.
CLINICA CHIMICA ACTA
(2023)
Review
Endocrinology & Metabolism
Yujie Shang, Huifang Zhou, Ruohan He, Wentian Lu
Summary: This study found that diet is significantly related to improved fertility outcomes, reproductive endocrine, and clinical hyperandrogenism in women with PCOS. Low-carbohydrate diets were more effective in optimizing reproductive outcomes, while calorie restriction was critical in ameliorating hyperandrogenism. The positive effects were associated with the treatment duration, with longer duration leading to greater improvement.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Wenyu Dai, Jieyu Liu, Yan Qiu, Ziwei Teng, Sujuan Li, Jing Huang, Hui Xiang, Hui Tang, Bolun Wang, Jindong Chen, Haishan Wu
Summary: The prevalence of metabolic and immune disorders in women with bipolar disorder (BD) and polycystic ovary syndrome (PCOS) suggests a connection between the two diseases. Understanding the common features can contribute to the development of symptomatic treatments.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Mariela Edith Velazquez, Andrea L. Millan, Mailen Rojo, Giselle Adriana Abruzzese, Silvina Ema Cocucci, Andrea Elena Iglesias Molli, Gustavo Daniel Frechtel, Alicia Beatriz Motta, Gloria Edith Cerrone
Summary: Women with PCOS exhibited significantly longer absolute telomere length (aTL) compared to controls, which was associated with waist circumference, testosterone levels, obesity, and hyperandrogenism (HA) phenotype. Non-obese PCOS patients had the longest aTL, while HA-PCOS patients had the highest aTL. Interestingly, HA had a major effect on aTL in PCOS, with non-obese hyperandrogenic patients showing the longest telomeres and obese non-hyperandrogenic patients having the shortest telomeres.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marzena Jabczyk, Justyna Nowak, Pawel Jagielski, Bartosz Hudzik, Karolina Kulik-Kupka, Aleksander Wlodarczyk, Katarzyna Lar, Barbara Zubelewicz-Szkodzinska
Summary: This study aimed to determine the usefulness of new anthropometric indices and atherogenic indices in evaluating metabolic disorders, particularly glucose and insulin abnormalities, in women with polycystic ovary syndrome (PCOS). The results showed that most of the analyzed anthropometric measurements and atherogenic indices were significantly correlated with metabolic disorders, indicating their potential as useful tools for evaluating glucose and insulin abnormalities in PCOS women.
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Clinical Neurology
Rui Yang, Chang Gao, Yizhi Yan, Yongwei Huang, Jianli Wang, Chunmei Zhang, Xiaowei Ma, Nannan Li, Xiaoguo Du, Liqiang Zhang, Ying Wang, Rong Li, Jie Qiao
Summary: The prevalence of OSA in PCOS patients was 40%, with six cases (5%) being severe. Patients with OSA had higher BMI and blood pressure, lower anti-Mullerian hormone, and exhibited abnormal glucose and lipid metabolism. Logistic regression analysis found that higher BMI, elevated serum testosterone, and decreased HDL-C were correlated with the occurrence of OSA in these patients.
SLEEP AND BREATHING
(2022)
Article
Immunology
Xuping Zhu, Yanyu Li, Yanmin Jiang, Jisheng Zhang, Ru Duan, Lin Liu, Chao Liu, Xiang Xu, Lu Yu, Qian Wang, Fan Xiong, Chengming Ni, Lan Xu, Qing He
Summary: The imbalance of gut microbiota may be related to the occurrence and development of polycystic ovary syndrome, especially in patients with high LDLC levels. Actinomycetaceae, Enterobacteriaceae and Streptococcaceae may play an important role in the diagnosis and differentiation of subgroups in PCOS. The model established has good specificity and sensitivity for distinguishing PCOS patients from the control group.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Zhijing Na, Hongyu Jiang, Yaxin Meng, Bei Shi, Da Li
Summary: This study analyzed the association between leptin and polycystic ovary syndrome (PCOS). The results showed that serum leptin levels were significantly higher in patients with PCOS and were associated with multiple metabolic markers. Combined detection of leptin and anti-Mullerian hormone (AMH) had high accuracy in diagnosing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yan Han, Baiwei Lin, Wenjing Lu, Xu Wang, Wenshuai Tang, Xinge Tao, Han Cai, Chunmei He, Changqin Liu
Summary: The study found that time-restricted feeding can improve metabolic and endocrine disorders in PCOS mouse models, including weight reduction, decreased adiposity, improved glycolipid metabolism, and inhibition of cyst formation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dalal F. Al-Akabi, Hanadi A. Hafth
Summary: The study aimed to assess iron aberrations in PCOS patients and their relationship with sex hormones. Results showed a significant decrease in hepcidin, transferrin, and estradiol levels, along with a significant increase in iron, ferritin, progesterone, and testosterone levels in PCOS patients. This study revealed an imbalance in iron levels and its serum regulating parameters in PCOS women, and an effective correlation between iron status and sex hormones.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2023)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)