Review
Neurosciences
Kiki P. van der Burg, Lachlan Cribb, Joseph Firth, Diana Karmacoska, Jerome Sarris
Summary: The findings suggest a strong association between omega-3 fatty acids and psychiatric outcomes in mood disorders, but inconsistent evidence for other nutrients and genetic factors influencing nutraceutical response in mood and psychotic disorders, requiring further research.
NUTRITIONAL NEUROSCIENCE
(2021)
Review
Psychiatry
Helena Sofia Antao, Ema Sacadura-Leite, Narcisa Maria Bandarra, Maria Luisa Figueira
Summary: Many studies have investigated the relationship between the omega-3 index and mental illnesses, but there is no consensus on the risk stratification or target value. This review summarizes published data on this association and proposes the omega-3 index as a risk factor for major depression, postpartum depression, psychosis, and dementia.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Flavie Courtaut, Virginie Aires, Niyazi Acar, Lionel Bretillon, Ida Chiara Guerrera, Cerina Chhuon, Jean-Paul Pais De Barros, Celine Olmiere, Dominique Delmas
Summary: The study found that supplementation with Resvega(R) significantly reduced laser-induced choroidal neovascularization (CNV) in mice compared with supplementations containing omega-3 or resveratrol alone. Proteomic approach confirmed that Resvega(R) could counteract the progression of AMD through a pleiotropic effect targeting key regulators of neoangiogenesis in retina cells in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Jose C. Florez, Ewan R. Pearson
Summary: The current pharmacological treatment for diabetes is largely based on algorithms, with little consideration for individual benefits. In this paper, the authors argue for a more precise approach to treatment selection, using genetic and metabolic biomarkers to improve therapeutic outcomes. While progress has been made in monogenic diabetes, further work is needed to implement precision treatment for type 2 diabetes. Collaboration and access to clinical trial data is expected to facilitate this progress.
Article
Behavioral Sciences
Mitchel Kappen, Marie -Anne Vanderhasselt, George M. Slavich
Summary: Currently, health research and healthcare rely on infrequent assessments which don't provide a complete view of clinical functioning. Novel health technologies that use speech enable continuous monitoring to detect and prevent health events. These technologies could extract health-relevant biosignals from smartphones, helping detect disorders and deliver tailored interventions. However, more research is needed to identify important speech signals and validate them against ground-truth outcomes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Martijn Arns, Hanneke van Dijk, Jurjen J. Luykx, Guido van Wingen, Sebastian Olbrich
Summary: The shift from one-size-fits-all psychiatry to personalized psychiatry emphasizes the importance of precision and stratified psychiatry, utilizing biomarkers to better guide patients to receive optimal treatment.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Psychiatry
Raffaella Zanardi, Dario Prestifilippo, Chiara Fabbri, Cristina Colombo, Eduard Maron, Alessandro Serretti
Summary: The treatment of depression is a major challenge for healthcare systems, but the integration of pharmacogenetic biomarkers into prescribing guidelines has led to a potential improvement in guiding prescriptions and may pave the way for the clinical application of polygenic predictors in the future. This advancement in precision psychiatry holds promise for personalized treatment options in depression.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2021)
Review
Oncology
Nayeralsadat Fatemi, Sascha Tierling, Hamidreza Aboulkheyr Es, Maryam Varkiani, Ehsan Nazemalhosseini Mojarad, Hamid Asadzadeh Aghdaei, Joern Walter, Mehdi Totonchi
Summary: Colorectal cancer, the second leading cause of cancer death worldwide, is closely associated with epigenetic changes such as DNA methylation. Studies have shown that DNA methylation markers have high accuracy and reproducibility in noninvasive biosamples, making them promising for early diagnosis and personalized treatment of CRC. Further research and development of methylation biomarkers and detection methods are crucial for CRC diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Christopher A. Lamb, Aamir Saifuddin, Nick Powell, Florian Rieder
Summary: Inflammatory bowel disease exhibits significant interindividual heterogeneity, and there is a need to identify accurate methods for predicting treatment response and disease course. Precision medicine strategies offer the potential to tailor treatments to individual patient needs, but further research and international cooperation are necessary to identify and validate relevant biomarkers.
Review
Pharmacology & Pharmacy
Chao Mei, Weijing Gong, Xu Wang, Yongning Lv, Yu Zhang, Sanlan Wu, Chunqi Zhu
Summary: Ovarian cancer is the most fatal disease among gynecologic malignant tumors. Tumor angiogenesis, regulated by multiple factors and pathways, plays a vital role in the development and progression of cancer. However, the efficacy of anti-angiogenic therapy is limited by low response rates and emerging drug resistance. This review focuses on the mechanisms, clinical trial outcomes, resistance mechanisms, biomarkers, and predictive models of anti-angiogenic therapy in ovarian cancer, providing insights into the prospect of precision medicine.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Caleigh Sawicki, Danielle Haslam, Shilpa Bhupathiraju
Summary: The aim of precision nutrition is to provide personalized dietary advice to improve the prevention or management of chronic disease. Advancements in technologies like genomics and metabolomics have increased interest in precision nutrition. It has three major applications in precision medicine: precise dietary assessments, understanding the mechanisms of diet-disease interactions, and personalized nutrition advice. Although there are challenges to overcome, precision nutrition has great potential in nutrition research and clinical application.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)
Article
Biochemical Research Methods
Shaima Belhechmi, Gwenael Le Teuff, Riccardo De Bin, Federico Rotolo, Stefan Michiels
Summary: This study aimed to find a compromise between the need for sparse model selection and the hierarchical constraint of biomarker-treatment interactions in high-dimensional data. Two weighting approaches and a group exponential Lasso method were proposed and compared with alternative methods. The results showed that the adaptive Lasso and group exponential Lasso methods outperformed their competitors in favoring the hierarchical constraint.
BMC BIOINFORMATICS
(2023)
Article
Health Care Sciences & Services
Tomonori Sasahira, Miyako Kurihara-Shimomura, Yudai Shimojjukoku, Kaori Shima, Tadaaki Kirita
Summary: Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the eighth most common malignancy globally. The development of molecular markers to eradicate OSCC is urgent. The complexity of OSCC etiology requires extensive research on driver genes and biomarkers for the advancement of precision medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Yajing Liu, Yanbing Zhou, Pu Chen
Summary: Lung cancer is a highly prevalent and deadly malignancy that requires personalized treatment strategies. Lung cancer organoids (LCOs) have the potential to faithfully replicate tumor characteristics and heterogeneity, providing a promising platform for anti-tumor drug discovery. Additionally, LCOs can enhance current precision medicine for lung cancer and overcome the limitations of current approaches.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Renata da Conceicao Silva Chaves, Odaleia Barbosa Aguiar, Arlinda B. Moreno, Andre R. Brunoni, Maria del Carmem B. Molina, Maria Carmen Viana, Isabela Bensonor, Rosane H. Griep, Maria de Jesus Mendes da Fonseca
Summary: This study found that consuming omega-3 fatty acids can reduce the risk of depressive episodes in adults and elderly adults, which is significant for the prevention and treatment of depression.
Review
Neurosciences
Fernanda C. Gabriel, Manoela Oliveira, Michael Berk, Elisa Brietzke, Felice N. Jacka, Beny Lafer
Summary: This review aims to summarize the relationship between nutrition and bipolar disorder (BD). Findings suggest that the intake of unsaturated fatty acids, seafood, folic acid, and zinc is associated with improved BD symptoms. The impacts of creatine, carnitine, vitamin D, inositol, or NAC supplementation on BD are variable and mainly non-significant. Promising results are associated with Coenzyme Q10 (Coq10) and probiotics. Overall, dietetic approaches might be included as part of BD treatment, and individuals with BD should choose healthy dietary lifestyles.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Neurosciences
Elysha Ringin, David W. Dunstan, Roger S. McIntyre, Michael Berk, Neville Owen, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Type 2 diabetes is more prevalent in bipolar disorder and is linked to cognitive deficits. This study explored the interaction between type 2 diabetes, bipolar disorder, and cognition, as well as the effect of age on cognitive performance in bipolar disorder with type 2 diabetes. The results showed that type 2 diabetes was associated with a negative impact on visuospatial memory in bipolar disorder. Processing speed and prospective memory were also negatively affected by type 2 diabetes, regardless of bipolar disorder diagnosis. Cognitive deficits were evident in bipolar disorder patients with type 2 diabetes compared to those without, and their cognitive performance remained stable or improved as they aged. In contrast, bipolar disorder patients without type 2 diabetes showed worse cognitive performance as they aged, but the age-related trajectory was similar to the psychiatrically healthy comparison group. The study suggests that comorbid type 2 diabetes may contribute to cognitive dysfunction in bipolar disorder, and bipolar disorder patients with type 2 diabetes may experience premature deterioration of cognitive functioning.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jacqueline Lake, Chiara C. Bortolasci, Amanda L. Stuart, Julie A. Pasco, Srisaiyini Kidnapillai, Briana Spolding, Trang T. T. Truong, Bruna Panizzutti, Zoe S. J. Liu, Olivia M. Dean, Tamsyn Crowley, Mark Richardson, Jee Hyun Kim, Michael Berk, Lana J. Williams, Ken Walder
Summary: This study utilized gene expression signature technology and pharmacoepidemiology to identify potential drugs for treating mood disorders. The results showed that metformin, an FDA-approved diabetes treatment, had transcriptional effects similar to commonly used mood disorder drugs, and retrospective cohort study found evidence of its protective effect against the onset of mood disorders. These findings demonstrate the potential of combining gene expression signature technology with pharmacoepidemiology to discover novel drugs for mood disorders.
PHARMACOPSYCHIATRY
(2023)
Article
Psychiatry
Jessica Emily Green, Michael Berk, Mohammadreza Mohebbi, Amy Loughman, Amelia J. McGuinness, David Castle, Mary Lou Chatterton, Joahna Perez, Philip Strandwitz, Eugene Athan, Christopher Hair, Andrew A. Nierenberg, John F. Cryan, Felice Jacka
Summary: This study evaluated the feasibility, acceptability, and safety of fecal microbiota transplantation (FMT) as a treatment for major depressive disorder. The results suggest that FMT is a feasible, acceptable, well-tolerated, and safe treatment for depression, supporting further research on its clinical efficacy.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Gregory Roebuck, Michael Mazzolini, Mohammadreza Mohebbi, Julie A. A. Pasco, Amanda L. L. Stuart, Malcolm Forbes, Michael Berk, Lana Williams
Summary: This study investigated the effect of anxiety disorders on bone mineral density (BMD) and found a significant association between anxiety disorders and reduced BMD in men, which may be mediated by comorbid mood disorders.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Medicine, Research & Experimental
Monojit Debnath, Michael Berk
Summary: The neurodevelopmental origin of schizophrenia is influenced by parental exposure to environmental adversities and alterations in immune and stress-regulatory pathways. Maternal immune activation, induced by maternal infections, has been identified as a key pathway in the development of schizophrenia. However, the role of paternal immune activation and the underlying mechanisms are still not well understood. This article highlights the potential mechanisms linking paternal immune activation and the risk of schizophrenia and proposes the possibility of bi-parental immune priming as a risk mechanism. Understanding these mechanisms will have important implications for the etiology and prevention of schizophrenia.
MEDICAL HYPOTHESES
(2023)
Article
Psychiatry
Aswin Ratheesh, Dylan Hammond, Caroline Gao, Steven Marwaha, Andrew Thompson, Jessica Hartmann, Christopher Davey, Stanley Zammit, Michael Berk, Patrick McGorry, Barnaby Nelson
Summary: Establishing staging models with transdiagnostic validity can advance early intervention efforts and enhance understanding of common underpinnings of mood, psychotic, and anxiety disorders. However, there is a lack of well-supported operationalizations for such models, particularly in community-based samples. This study aimed to explore the inter-relationships among symptom stages and common risk factors to develop data-informed transdiagnostic stages. The findings suggest that anxiety, psychotic, and depressive symptoms could be combined to form a transdiagnostic stage, which can aid in prognostication and indicated prevention in youth mental health.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Chemistry, Medicinal
Zheng Wang, Danhua Zhang, Yanli Du, Yin Wang, Tingting Huang, Chee H. H. Ng, Huimin Huang, Yanmeng Pan, Jianbo Lai, Shaohua Hu
Summary: The effectiveness of pharmacotherapy for bipolar depression with mixed features defined by DSM-5 is currently unclear in clinical treatment guidelines. This study evaluated the efficacy of quetiapine monotherapy and compared combination therapies of quetiapine plus valproate or lithium in patients who responded insufficiently to quetiapine alone. The results showed that quetiapine monotherapy appeared to be effective, and combining with either valproate or lithium had positive effects for insufficient responders.
Review
Substance Abuse
Clara Lo, Mansee Mane, Jee Hyun Kim, Michael Berk, Richard R. Sharp, Kendall H. Lee, Jason Yuen
Summary: DBS as a treatment for substance use disorder (SUD) is being explored due to the limitations of current treatment modalities. Ethical concerns include informed consent and risks/benefits of DBS compared to traditional methods. Legal issues may arise from the criminalization of substance use and familial consent. Given the lack of clinical guidelines, general medico-legal principles should be considered for responsible use of DBS, and incorporating the IDEAL framework is recommended for future research.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2023)
Article
Psychiatry
Elysha Ringin, David W. Dunstan, Roger S. McIntyre, Neville Owen, Michael Berk, Susan L. Rossell, Mats Hallgren, Tamsyn E. Van Rheenen
Summary: This study examined the impact of physical activity and sedentary behavior on cognitive function in individuals with bipolar disorder. The results showed a negative association between physical activity and passive sedentary behavior with cognitive function, and a positive association between mentally-active sedentary behavior and cognitive function. These associations were stronger in individuals with bipolar disorder.
MENTAL HEALTH AND PHYSICAL ACTIVITY
(2023)
Review
Biochemistry & Molecular Biology
Jacqueline Kaiser, Kevin Nay, Christopher R. Horne, Luke M. Mcaloon, Oliver K. Fuller, Abbey G. Muller, Douglas G. Whyte, Anthony R. Means, Ken Walder, Michael Berk, Anthony J. Hannan, James M. Murphy, Mark A. Febbraio, Andrew L. Gundlach, John W. Scott
Summary: Current pharmacological treatments for bipolar disorder are inadequate and lack revolutionary therapies due to limited efficacy, burdensome side-effects, and a poor understanding of the underlying disease mechanisms. Targeting the CaMKK2 enzyme shows promise as a new treatment strategy for bipolar disorder, as it is associated with the disease and its behaviors can be ameliorated by increasing CaMKK2 activity with lithium.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Melissa O'Shea, Emma E. Houston, David Skvarc, Hannah Capon, Shane Mclver, Michael Berk, Jill Harris, Belinda Chandler, Subhadra Evans
Summary: This study reports on a pragmatic preference trial with adults diagnosed with depression or anxiety, comparing the longer-term outcomes between those who completed a group CBT program and those who completed a group CBT program with an adjunct therapeutic yoga program. The findings show that participants in the combined CBT+Yoga group had sustained reductions in anxiety and depression, with significantly superior outcomes when compared to those receiving group CBT alone.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Neurosciences
Samantha E. Russell, Anna L. Wrobel, Melanie M. Ashton, Alyna Turner, Mohammadreza Mohebbi, Michael Berk, Sue Cotton, Seetal Dodd, Chee H. Ng, Gin S. Malhi, Olivia M. Dean
Summary: This study aimed to investigate the impact of post-traumatic stress disorder on treatment outcomes in patients with bipolar disorder. The results showed no significant differences in symptoms and functioning between patients with bipolar disorder alone and those with comorbid bipolar disorder and post-traumatic stress disorder.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Clinical Neurology
R. Barnes, D. Skvarc, P. B. Fitzgerald, M. Berk, O. M. Dean, S. Dodd, T. Schriemer, A. B. Singh
Summary: This study compares the effects of once and twice daily rTMS treatment for depression, and finds similar remission rates between the two groups. However, twice daily treatment requires a shorter length of hospital stay, which has significant cost implications.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Mathematical & Computational Biology
Ashlea Segal, Linden Parkes, Kevin Aquino, Andrew Zalesky, Ben J. Harrison, Jeggan Tiego, Murat Yucel, Leah Braganza, Chao Suo, Mark Bellgrove, Alex Fornito, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Christopher Davey, Carles Soriano-Mas, Narcis Cardoner, Michael Berk, Sue Cotton, Andre F. Marquand
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2023)
