Article
Pharmacology & Pharmacy
Natalia Gomez-Casanova, Angela Martin-Serrano Ortiz, Irene Heredero-Bermejo, Javier Sanchez-Nieves, Jose Luis Copa-Patino, F. Javier de la Mata
Summary: The development of biofilms on different surfaces is a significant public health issue, and the resistance to antimicrobial drugs necessitates the search for compounds that can prevent cell adhesion and establishment of these complex communities. Zwitterionic modification of nanomaterials shows promise in preventing microbial adhesion and inhibiting biofilm formation in Candida albicans, Staphylococcus aureus, and Pseudomonas aeruginosa.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Immunology
Ruan Fourie, Jacobus Albertyn, Olihile Sebolai, Onele Gcilitshana, Carolina H. Pohl
Summary: The interaction between Candida albicans and Pseudomonas aeruginosa affects early biofilm formation and virulence of C. albicans in an infection model. Deletion of SET3 does not affect C. albicans morphology in the presence of P. aeruginosa, but it reduces virulence in a Caenorhabditis elegans infection model.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Jonggwan Park, Hyeongsun Kim, Hee-Kyoung Kang, Moon-Chang Choi, Yoonkyung Park
Summary: Lycosin-II, an antimicrobial peptide, exhibits antifungal activity against Candida albicans by damaging the fungal membrane and inducing oxidative stress. It also inhibits dual-species biofilm formation of Candida albicans and Staphylococcus aureus.
Article
Biochemistry & Molecular Biology
Josef Khun, Anna Machkova, Petra Kasparova, Myron Klenivskyi, Eva Vankova, Pavel Galar, Jaroslav Julak, Vladimir Scholtz
Summary: Non-thermal plasma (NTP) is a promising tool for inhibiting bacterial, viral, and fungal diseases. Two types of NTP sources based on cometary and point-to-ring discharges were studied and compared. The cometary discharge is less stable but forms smaller and rapidly emerging inhibition zones, while the point-to-ring discharge is more stable but provides larger affected but often not completely inhibited zones.
Article
Multidisciplinary Sciences
So Hyun Ahn, Amy J. Karlsson, William E. Bentley, Srinivasa R. Raghavan
Summary: In this study, 'artificial cells' with an architecture mimicking that of eukaryotic cells were created using common biopolymers. The cells were encapsulated in multi-compartment capsules and were used to observe the comparative growth of microbial cells from different kingdoms. The capsules also mimicked the 3-D environment cells naturally encounter during growth. The study showed that small molecules can permeate through the capsule walls and affect cell growth, and that bacteria can induce a morphological switch in adjacent fungal cells through signaling molecules.
Article
Biology
Min Lu, Yongli Li, Mei X. Wu
Summary: Multidrug-resistant bacteria pose a significant threat and are depleting treatment options. This study explores the combination of blue-laser and thymol to eradicate these bacteria, successfully preventing systematic dissemination in mice. The strategy leverages the unique properties of bacteria to transform harmless thymol into a powerful sterilizer when activated by blue-laser excitation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Microbiology
Laura J. Dunphy, Kassandra L. Grimes, Nishikant Wase, Glynis L. Kolling, Jason A. Papin
Summary: In a synthetic cystic fibrosis media, distinct species-specific metabolic signatures were revealed for Pseudomonas aeruginosa and Staphylococcus aureus, indicating potential nutrient competition's impact on community dynamics. Both bacteria consumed similar nutrients, suggesting metabolic competition's role in coinfection dynamics. Furthermore, unique metabolites produced by each species may serve as species-specific biomarkers for cystic fibrosis lung infections.
Article
Critical Care Medicine
Kenneth S. Brandenburg, Alan J. Weaver, S. L. Rajasekhar Karna, Kai P. Leung
Summary: This study characterized mixed species burn wound infections by inoculating burn surfaces with Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. The presence of biofilms from these pathogens in the wound led to burn depth progression, increased release of inflammatory mediators, and elevated circulating immune cells. The findings provide insights for developing new antimicrobials targeting biofilm-based wound infections.
Review
Chemistry, Medicinal
Graziana Bonincontro, Sarah Adriana Scuderi, Andreana Marino, Giovanna Simonetti
Summary: The synergistic effects of plant metabolites combined with conventional antimicrobials can effectively fight against drug-resistant infections caused by biofilms. This synergy can modify resistance mechanisms, reduce adverse effects, and achieve appropriate therapeutic effects at lower doses.
Article
Pharmacology & Pharmacy
Irfan A. Rather, Mohmmad Younus Wani, Majid Rasool Kamli, Jamal S. M. Sabir, Khalid Rehman Hakeem, Ahmad Firoz, Yong Ha Park, Yan Yan Hor
Summary: In this study, the antimicrobial potential of Lactobacillus metabolite extracts (LMEs) purified from four Lactobacillus strains was investigated against mono- and polymicrobial biofilms formed by C. albicans and S. aureus. The results showed that LMEKAU0021 effectively inhibited biofilm formation and affected the cell membrane integrity in both pathogens.
Article
Biochemistry & Molecular Biology
Viviana Teresa Orlandi, Eleonora Martegani, Fabrizio Bolognese, Enrico Caruso
Summary: Antimicrobial Photodynamic Therapy (aPDT) has gained attention for inhibiting microbial growth and spread. Boron-dipyrromethenes (BODIPYs) are promising photosensitizers for antimicrobial applications. This study found that neutral BODIPYs can effectively photoinactivate Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. One neutral compound (B9) showed the best photoinactivation of P. aeruginosa. Additionally, the compounds successfully inhibited biofilms of the three model microorganisms, with better results for S. aureus and P. aeruginosa.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2022)
Review
Immunology
Kara R. Eichelberger, James E. Cassat
Summary: Successful pathogens such as Staphylococcus aureus and Candida albicans exhibit metabolic flexibility to adapt to various host niches. Co-infection of these two microorganisms alters microbial metabolism, enhances virulence, and leads to the formation of polymicrobial biofilms. The metabolic changes induced during co-infection impact interactions with host immune cells, resulting in greater microbial survival and immune evasion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Anthony J. Fischer, Sachinkumar B. Singh, Mason M. LaMarche, Lucas J. Maakestad, Zoe E. Kienenberger, Tahuanty A. Pena, David A. Stoltz, Dominique H. Limoli
Summary: Staphylococcus aureus and Pseudomonas aeruginosa are both abundant in sputum cultures of cystic fibrosis patients. Contrary to common assumption, there is no rapid replacement of S. aureus by P. aeruginosa. Many CF patients have long-term coinfection with these organisms.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Mengli Chen, Ting Cheng, Chen Xu, Min Pan, Jiadi Wu, Tianming Wang, Daqiang Wu, Guiming Yan, Changzhong Wang, Jing Shao
Summary: Candida albicans and Candida glabrata play critical roles in biofilm formation, and combination therapy with antifungal agents can effectively alleviate oropharyngeal candidiasis by inhibiting hyphal growth and reducing fungal burden in tissues.
Article
Immunology
Wusheng Deng, Yanmei Lei, Xiujia Tang, Dingbin Li, Jinhua Liang, Jing Luo, Liuyuan Liu, Wenshu Zhang, Liumei Ye, Jinliang Kong, Ke Wang, Zhaoyan Chen
Summary: This study investigated whether DNase I can inhibit the early formation of biofilms in Pseudomonas aeruginosa- or Staphylococcus aureus-induced empyema models. The results showed that DNase I significantly inhibited early biofilm formation in a dose-dependent manner, without affecting bacterial growth. Therefore, DNase I has therapeutic potential against empyema biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tianming Wang, Weifeng Huang, Qiangjun Duan, Jian Wang, Huijuan Cheng, Jing Shao, Fang Li, Daqiang Wu
MOLECULAR BIOLOGY REPORTS
(2019)
Article
Microbiology
Wenyue Da, Jing Shao, Qianqian Li, Gaoxiang Shi, Tianming Wang, Daqiang Wu, Changzhong Wang
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Wenyue Da, Jing Shao, Qianqian Li, Gaoxiang Shi, Tianming Wang, Daqiang Wu, Changzhong Wang
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Qianqian Li, Juanjuan Liu, Jing Shao, Wenyue Da, Gaoxiang Shi, Tianming Wang, Daqiang Wu, Changzhong Wang
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Cell Biology
Jiadi Wu, Daqiang Wu, Kelong Ma, Tianming Wang, Gaoxiang Shi, Jing Shao, Changzhong Wang, Guiming Yan
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Microbiology
Daqiang Wu, Qiangjun Duan, Ganfei Xu, Yan Guan
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Juanjuan Liu, Qianqian Li, Changzhong Wang, Jing Shao, Tianming Wang, Daqiang Wu, Kelong Ma, Guiming Yan, Dengke Yin
Article
Cell Biology
Wenfan Wei, Biyu Zheng, Shengnan Zheng, Daqiang Wu, Yongkang Chu, Shenghao Zhang, Dongmei Wang, Xiaopeng Ma, Xing Liu, Xuebiao Yao, Chuanhai Fu
Summary: This study reveals the crucial role of the Cdc42 GTPase-activating protein (GAP) Rga6 in the monopolar growth of fission yeast spores. The absence of Rga6 leads to an increase in bipolar growth of spores. Rga6 decorates the non-growing cortical region, binds phosphatidylinositol 4,5-bisphosphate, and co-localizes with the phosphatidylinositol 4,5-bisphosphate-binding protein Opy1.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Cell Biology
Daqiang Wu, Yongkang Chu, Wenfan Wei, Ling Liu, Chuanhai Fu
Summary: This study used live-cell microscopy and an algorithm to quantitatively assess the mixing of parental mitochondria in fission yeast. The results showed that parental mitochondria mixed progressively during meiosis. The study also identified mitochondrial fission and the size of the conjugation neck as limiting factors in restricting mitochondrial mixing.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ting Cheng, Chen Xu, Daqiang Wu, Guiming Yan, Changzhong Wang, Tianming Wang, Jing Shao
Summary: The Chinese herbal compound sodium houttuyfonate (SH) has been shown to be effective in treating ulcerative colitis (UC) complicated by Candida albicans overgrowth, potentially by maintaining gut microbiota homeostasis and improving intestinal function.
Article
Immunology
Tian Zhuang, Mengxue Hu, Jian Wang, Longfei Mei, Xiaoxiao Zhu, Haitao Zhang, Feng Jin, Jing Shao, Tianming Wang, Changzhong Wang, Xiaojia Niu, Daqiang Wu
Summary: The study demonstrates that sodium houttuyfonate (SH) effectively reduces the bacterial burden and systemic inflammation in mice with Pseudomonas aeruginosa-induced pneumonia. SH ameliorates inflammatory gene expression and production of inflammatory proteins by regulating the TLR4/NF-kappa B pathway. It also improves the diversity of intestinal flora, suggesting a role in reducing inflammation-induced dysbiosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Physiology
Lei Zhang, Tian Zhuang, Mengxue Hu, Shuwen Liu, Daqiang Wu, Baozhong Ji
Summary: In this study, the metabolic utilization mechanism of the gut microbiota of Apriona swainsoni larvae was explored using multi-omics technology. The results showed that different gut segments had different combinations of dominant bacteria and genes, and the metaproteome and metabolome of the four gut segments were significantly different. The study also found gradient differences in cellulose and hemicellulose contents in different segments, indicating the metabolic characteristics of lignocellulose components in the gut segments. This research provides direct evidence of the role of the gut microbiome in the growth of A. swainsoni larvae. Evaluation: 8/10
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaomei He, Mengxue Hu, Cheng Song, Mengru Ni, Longyun Liu, Cunwu Chen, Daqiang Wu
Summary: The aim of this study was to investigate the effect and possible mechanism of Sodium new houttuyfonate (SNH) on macrophages against bacteria. The result showed that SNH effectively inhibited the inflammatory reaction of macrophages stimulated by Pseudomonas aeruginosa, improved the phagocytosis and killing effect of macrophages against P. aeruginosa, and repressed the TLR4/NF-kB pathway.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Guiming Yan, Yuanqing Si, Jing Shao, Tianming Wang, Changzhong Wang, Daqiang Wu
NATURAL PRODUCT COMMUNICATIONS
(2020)
Article
Biology
Yeye Zhao, Yuanqing Si, Longfei Mei, Jiadi Wu, Jing Shao, Changzhong Wang, Daqiang Wu
BMC RESEARCH NOTES
(2019)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
