Article
Biochemistry & Molecular Biology
Ajna Hamidovic, Fatimata Soumare, Aamina Naveed, John Davis, Jiehuan Sun, Nhan Dang
Summary: This study found that the levels of DHEA-sulfate significantly decrease in the mid-luteal subphase of the menstrual cycle, while the concentration of DHEA remains unchanged. These findings are significant for examining the associations between DHEA-sulfate levels and various disease states.
Article
Pharmacology & Pharmacy
Juan F. Garcia, Jesus Seco-Calvo, Soledad Arribalzaga, Raquel Diez, Cristina Lopez, M. Nelida Fernandez, Juan J. Garcia, M. Jose Diez, Raul de la Puente, Matilde Sierra, Ana M. Sahagun
Summary: The study investigated the availability of three doping substances on the Internet and found that these substances are easily accessible online without quality assurance and prescription requirements. There were significant differences in the availability of the products among different countries, with a low proportion of online pharmacies offering them.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Li-Te Lin, Kuan-Hao Tsui
Summary: The study revealed a weak positive association between serum DHEA-S and AMH levels in infertile women. Women in the highest DHEA-S quartile category (Q4) had significantly higher AMH levels, suggesting a positive correlation between these two hormones.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Electrochemistry
Miroslav Pohanka
Summary: Biosensors are important analytical devices, and aptamers as a new biorecognition element play a significant role in them. Aptamers are short sequences of DNA, RNA, and peptides with high affinity similar to antibodies. Aptasensors with immobilized aptamers serve as an alternative to biosensors based on antibodies and other bioreceptor molecules.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2022)
Article
Chemistry, Analytical
Clarice E. Froehlich, Jiayi He, Christy L. Haynes
Summary: Investigating the interactions between small, charged molecules and aptamers using surface plasmon resonance (SPR) is challenging due to low small molecule response and nonspecific electrostatic interactions. However, aptamers are increasingly used in sensors for small molecule detection, and a simple, direct SPR assay would greatly benefit sensor development. This study presents a method using streptavidin-biotin capture and a high-ionic-strength buffer to characterize the interaction between serotonin and an aptamer with SPR. Other methods, such as immobilization and thiol-coupling, were also investigated for comparison.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Lanting Qian, Sharmila Durairaj, Scott Prins, Aicheng Chen
Summary: The rapid growth of the pharmaceutical industry due to increasing human population has led to the need for advanced nanomaterial-based electrochemical sensors and biosensors for monitoring pharmaceutical pollutants. This review article surveys state-of-the-art sensors for detecting significant pharmaceutical compounds and highlights strategies for developing high-performance sensors tailored toward specific pharmaceuticals.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Kenneth R. Wehmeyer, Ryan J. White, Peter T. Kissinger, Andwilliam R. Heineman
Summary: The development of electrochemical affinity assays and sensors allows for selective and sensitive detection of target analytes, with recent advancements focusing on improving sensitivity and user-friendly features.
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 14, 2021
(2021)
Article
Chemistry, Analytical
Muhammad Kaleemullah, Sheraz Yousaf, Ibrahim A. Alsafari, H. H. Somaily, Jameel Rahman, Muhammad Shahid, Muhammad Ashraf, Muhammad Farooq Warsi
Summary: The study reports the synthesis and characterization of a non-enzymatic sensor for glucose detection, using doped and un-doped metal oxides and their composites with 2D layered materials. The materials showed excellent electrochemical sensitivity and linear response towards glucose detection, indicating potential for a new type of nanocomposite material.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Chenhui Wu, Yunkang Ma, Lihua Chen
Summary: In this study, a low-cost, portable, and reusable biosensor was developed for the rapid and selective quantization of tuberculosis gene in early-stage serum samples. The biosensor exhibited antifouling properties and could be used for complex biological systems. The biosensor, based on DNA double strand reversible bonding, showed a fast response with good linear concentration dependence on the target DNA. Furthermore, the biosensor could be reused after regeneration, reducing the overall cost.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Badrinath Jagannath, Madhavi Pali, Kai-Chun Lin, Devangsingh Sankhala, Pejman Naraghi, Sriram Muthukumar, Shalini Prasad
Summary: This work demonstrates the discovery, quantification, and validation of infection prognostic markers, IP-10 and TRAIL, in human sweat using wearable technology. It also shows the potential of a wearable SWEATSENSER device for continuous monitoring of infection markers.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Biochemistry & Molecular Biology
Riccarda Antiochia
Summary: During the COVID-19 pandemic, electrochemical biosensors have emerged as an interesting testing method for rapid point-of-care detection of SARS-CoV-2 infection. They offer advantages such as accuracy, low cost, miniaturization, and portability, allowing the detection of viral RNA and antigens.
BIOELECTROCHEMISTRY
(2022)
Review
Chemistry, Analytical
Jaya Baranwal, Brajesh Barse, Gianluca Gatto, Gabriela Broncova, Amit Kumar
Summary: Electrochemical sensors are widely used in various industries due to their variable reporting signals and low theoretical detection limits. This review article covers the latest advances and applications of electrochemical sensors in different industries, as well as the role of nanomaterials in their research and advancements.
Article
Environmental Sciences
M. Ramya, P. Senthil Kumar, Gayathri Rangasamy, V. Uma Shankar, G. Rajesh, K. Nirmala, A. Saravanan, Alagumalai Krishnapandi
Summary: Industrialization and globalization have led to the release of large quantities of toxic chemicals into the environment, highlighting the importance of developing sensitive, reliable, and cost-effective environmental pollutant sensor platforms. Progress has been made in recent years in expanding electrochemical sensors and biosensors using nanomaterials, with a focus on rapidly detecting emerging biomarkers in various applications. Numerous trends in the growth of nanotechnology-based electrochemical sensor platforms have been identified, showcasing the integration strategies, applications, specific properties, and future projections of nanostructured materials for advanced sensor platforms.
Article
Endocrinology & Metabolism
Yun Hu, Ying Wang, Ting-ting Cai, Lu Liu, Dong-mei Li, Jian-hua Ma, Bo Ding
Summary: Short-term intensive insulin therapy can increase serum testosterone levels in men with newly diagnosed type 2 diabetes, possibly due to enhanced conversion of DHEA to testosterone.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Analytical
Qiong Hu, Jianwen Wan, Zhiwen Liang, Shiqi Li, Wenxing Feng, Yiyi Liang, Yilin Luo, Xiaojing Cao, Yingming Ma, Dongxue Han, Li Niu
Summary: By taking advantage of target-assisted electrochemically mediated atom transfer radical polymerization (teATRP) for signal amplification, a simple and cost-effective electrochemical aptasensor is developed for sensitive and selective detection of low-abundance endotoxin. The aptamer receptor selectively captures endotoxin, and signal amplification is achieved through the dual amplification strategy of ATRP-initiated polymer chain grafting. This aptasensor shows high sensitivity with a detection limit of 1.2 fg/mL and has great potential for detecting low-abundance endotoxin and other glycan chain containing bio-targets.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tutku Beduk, Matilde Gomes, Jose Ilton De Oliveira Filho, Saptami Suresh Shetty, Walaa Khushaim, Ricardo Garcia-Ramirez, Ceren Durmus, Abdellatif Ait Lahcen, Khaled Nabil Salama
Summary: This article introduces a portable potentiostat device integrated with a laser-scribed graphene (LSG) sensor for the detection of BPA in water. The device is low-cost, practical, sensitive, and selective, providing high sensitivity and accuracy in BPA detection.
FRONTIERS IN CHEMISTRY
(2022)
Article
Cell Biology
Hichem Moulahoum, Faezeh Ghorbanizamani, Zineb Khiari, Mohamed Toumi, Yasmina Benazzoug, Kerem Tok, Suna Timur, Figen Zihnioglu
Summary: This study investigated the mechanism of action of Artemisia herba-alba (AHA) and its effects on diabetes-related liver damages. The results showed that AHA inhibited protein modification and AGE formation, reduced inflammation, oxidative stress, and apoptosis, and regulated the signaling pathways involved in liver damages caused by AGEs. The findings suggest that AHA has potential as a multitarget option in the therapy of diabetes and AGEs-related diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Ceren Durmus, Duygu Harmanci, Hichem Moulahoum, Kerem Tok, Faezeh Ghorbanizamani, Serdar Sanli, Figen Zihnioglu, Serap Evran, Candan Cicek, Ruchan Sertoz, Bilgin Arda, Tuncay Goksel, Kutsal Turhan, Suna Timur, Simge Balaban Hanoglu
Summary: An electrochemical immunosensor based on SARS-CoV-2 antibody cocktail-conjugated magnetic nanoparticles has been developed for sensitive and accurate detection of the SARS-CoV-2 virus and its variants. The antibody cocktail showed better performance compared to commercial antibodies, and could detect a wider range of variants.
Review
Chemistry, Analytical
Hichem Moulahoum, Faezeh Ghorbanizamani, Emine Guler Celik, Suna Timur
Summary: The evolution of biosensors and diagnostic devices has facilitated the development of sensing materials, strategies, and device structures. Polymeric composite materials, with their biocompatibility, flexibility, and low cost, show great promise in future lab-on-chip devices. They can also enhance the sensing capabilities of traditional 2D biosensors.
Article
Biochemical Research Methods
Hichem Moulahoum, Faezeh Ghorbanizamani, Zineb Khiari, Mohamed Toumi, Yasmina Benazzoug, Suna Timur, Figen Zihnioglu
Summary: This study explores the effects of two Artemisia plant extracts on mitigating AGEs and their induced cell redox dysregulation in the liver. The results demonstrate that Artemisia absinthium phytoniosomes have a significant anti-AGE effect and can restore cell dysfunction and protect against apoptosis. Network pharmacology and bioinformatics analyses provide insights into the underlying mechanisms.
PHYTOCHEMICAL ANALYSIS
(2022)
Review
Chemistry, Inorganic & Nuclear
Simge Balaban Hanoglu, Duygu Harmanci, Nursima Ucar, Serap Evran, Suna Timur
Summary: In recent years, magnetic nanoparticles (MNPs) have been widely used in various fields, including cancer detection, due to their beneficial properties. Detecting microRNAs (miRNAs) in biological samples is challenging, but MNPs provide an effective solution with their large surface areas and magnetic moments. This article discusses the synthesis and characterization methods of MNPs and their application in miRNA detection using biosensing systems, considering the challenges and prospects in terms of development stages, sensitivity, and selectivity.
Article
Biochemical Research Methods
Eda Celikbas, Ayca Saymaz, Hande Gunduz, Irem Koc, Ece Cakir, Alphan Sennaroglu, Safacan Kolemen, Havva Yagci Acar, Kubra Onbasli
Summary: Tumor-targeting nanoparticles and phototherapies are important trends in tumor-specific local therapy. In this study, brominated hemicyanine (Hemi-Br) was loaded onto folic acid (FA)-tagged, glutathione (GSH)-coated Ag2S quantum dots (AS-GSH QDs) to provide enhanced phototoxicity in folate receptor (FR)-positive cancer cells.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Analytical
Huseyin Furkan Kiyikci, Okan Avci, Yudum Tepeli Buyuksunetci, Suna Timur, Ulku Anik
Summary: A facile amperometric biosensor was developed using a Co/2Fe metal-organic framework (MOF) with oxidase mimicking properties for the detection of sialic acid (SA). The biosensor was constructed by immobilizing Co/2Fe MOF and N-acetylneuraminic Acid Aldolase (NANA-Aldolase) enzyme on a gold screen-printed electrode. The sensor showed a linear range of 0.02 mM-1.00 mM for SA concentration and a limit of detection of 0.026 mM. The developed biosensor was successfully applied for the detection of SA in GD3 ganglioside and HeLa cancer cell lines, providing a more practical and accurate system.
Review
Chemistry, Multidisciplinary
Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Suna Timur
Summary: The growing demand for personalized treatments and constant vital signs observation has led to the development of implantable biosensors that can temporarily or permanently be introduced into the human body. However, ensuring reliable functionality in the complex environment of the human body remains a critical challenge.
APPLIED SCIENCES-BASEL
(2023)
Article
Materials Science, Biomaterials
Mahshid Hashemkhani, Eda Celikbas, Minahil Khan, Alphan Sennaroglu, Havva Yagci Acar
Summary: The combination of PTT and PDT using theranostic NPs loaded with ALA shows promise in providing targeted tumor therapy with minimal side effects. MnO2 catalyzes H2O2 conversion to O-2, enhancing ROS generation and ALA-PDT efficiency. Ag2S quantum dots conjugated with BSA support MnO2 formation and stabilization, and can be used as an optically trackable PTT agent.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Analytical
Bilge Asci Erkocyigit, Ozge Ozufuklar, Aysenur Yardim, Emine Guler Celik, Suna Timur
Summary: Microfluidics plays a crucial role in lab-on-a-chip systems, allowing for manipulation of fluid behavior and control on a small platform. Paper-based microfluidic analytical devices (muPADs) have numerous advantages, especially in cancer biomarker detection, and have the potential to improve diagnosis and treatment outcomes.
Review
Chemistry, Analytical
Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Figen Zihnioglu, Tutku Beduk, Tuncay Goksel, Kutsal Turhan, Suna Timur
Summary: Minimally invasive approaches in cancer diagnosis, such as liquid biopsies using blood samples, provide valuable information about the tumor and its state. However, isolating and detecting markers in complex matrices is challenging. Advances in polymer synthesis have led to enhanced platforms for liquid biopsies analysis, improving biosensor performance through increased sensitivity, improved binding, and avoidance of non-specific interactions. Additionally, polymer-based materials aid in signal amplification for low-concentration targets. This technology plays an essential role in oncology and clinical biomedicine, as shown by its critical application in liquid biopsies diagnosis.
Review
Nanoscience & Nanotechnology
Mohd. Rahil Hasan, Pradakshina Sharma, Shariq Suleman, Shouvik Mukherjee, Emine Guler Celik, Suna Timur, Roberto Pilloton, Jagriti Narang
Summary: Integrating electronic applications with paper can expand the uses of paper substrates, but putting electronics on paper is not easy. However, methods like building electronic devices on a rough, absorbent surface of the paper have made significant progress in paper electronics.
ACS APPLIED BIO MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Mohd Rahil Hasan, Pradakshina Sharma, Shariq Suleman, Shouvik Mukherjee, Emine Guler Celik, Suna Timur, Roberto Pilloton, Jagriti Narang
Summary: Integrating electronic applications with paper substrates can expand the potential uses of paper. While paper has advantages such as being disposable, inexpensive, and environmentally friendly, its rough and porous surface poses a challenge for putting electronics on paper. However, there are methods to make electronic devices compatible with the absorbent surface of paper.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Abdellatif Ait Lahcen, Sandeep G. Surya, Tutku Beduk, Mani Teja Vijjapu, Abderrahman Lamaoui, Ceren Durmus, Suna Timur, Osama Shekhah, Veerappan Mani, Aziz Amine, Mohamed Eddaoudi, Khaled Nabil Salama
Summary: This review provides a detailed overview of the value of using porous materials as the core for synthesizing MIPs, covering the application of MOFs and COFs in developing sensor platforms. It discusses the synthesis process, the impact of morphological changes, and strategies for building sensors. The research advancements and applications of various types of MOF/COF-MIP-based sensors in environmental monitoring, food safety, and pharmaceutical analysis are described. The challenges and prospects of this research field are also discussed in detail.
ACS APPLIED MATERIALS & INTERFACES
(2022)
